LOCUS       NM_001100510            1295 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus O-sialoglycoprotein endopeptidase (Osgep), mRNA.
ACCESSION   NM_001100510 XM_001064067 XM_214163
VERSION     NM_001100510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Wan,L.C., Maisonneuve,P., Szilard,R.K., Lambert,J.P., Ng,T.F.,
            Manczyk,N., Huang,H., Laister,R., Caudy,A.A., Gingras,A.C.,
            Durocher,D. and Sicheri,F.
  TITLE     Proteomic analysis of the human KEOPS complex identifies C14ORF142
            as a core subunit homologous to yeast Gon7
  JOURNAL   Nucleic Acids Res 45 (2), 805-817 (2017)
   PUBMED   27903914
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Yao,M., Akiyama,K., Tan,Y., Sarker,A.H., Ikeda,S., Alam,S.S.,
            Tsutsui,K., Yoshida,M.C. and Seki,S.
  TITLE     Genomic structure of the rat major AP endonuclease gene (Apex) with
            an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a
            processed Apex pseudogene (Apexp1)
  JOURNAL   Acta Med Okayama 53 (6), 245-252 (1999)
   PUBMED   10631378
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Akiyama,K., Seki,S., Oshida,T. and Yoshida,M.C.
  TITLE     Structure, promoter analysis and chromosomal assignment of the
            human APEX gene
  JOURNAL   Biochim Biophys Acta 1219 (1), 15-25 (1994)
   PUBMED   8086453
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158592.1.
            
            On or before Jun 4, 2008 this sequence version replaced
            XM_001064067.1, XM_214163.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158592.1, SRR8487226.118690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1295
                     /gene="Osgep"
                     /note="O-sialoglycoprotein endopeptidase"
                     /db_xref="GeneID:290028"
                     /db_xref="RGD:1308578"
     exon            1..204
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1097
                     /gene="Osgep"
                     /EC_number="2.3.1.234"
                     /note="probable O-sialoglycoprotein endopeptidase;
                     probable tRNA threonylcarbamoyladenosine biosynthesis
                     protein Osgep; Prsmg1/Gcpl1; O-sialoglycoprotease;
                     pasteurella haemolytica metalloprotease homolog with
                     glycoprotein substrates/gpc-like protein 1; t(6)A
                     synthase; N6-L-threonylcarbamoyladenine synthase; t(6)A37
                     threonylcarbamoyladenosine biosynthesis protein Osgep;
                     probable tRNA N6-adenosine threonylcarbamoyltransferase"
                     /codon_start=1
                     /product="tRNA N6-adenosine threonylcarbamoyltransferase"
                     /protein_id="NP_001093980.1"
                     /db_xref="GeneID:290028"
                     /db_xref="RGD:1308578"
                     /translation="MPAVLGFEGSANKIGVGVVRDGTVLANPRRTYVTAPGTGFLPGD
                     TARHHRAVILDLLQEALTEAGLTPKDIDCIAYTKGPGMGAPLASVAVVARTVAQLWNK
                     PLLGVNHCIGHIEMGRLITGAVNPTVLYVSGGNTQVISYSEHRYRIFGETIDIAVGNC
                     LDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDAAQRM
                     LATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSKEALIVGGVGCNVRLQEMMATM
                     CQERGAQLFATDERFCIDNGAMIAQAGWEMFQAGHRTPLQDSGITQRYRTDEVEVTWR
                     D"
     exon            205..324
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            325..500
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            501..596
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            597..646
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            647..725
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            726..791
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            792..882
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            883..958
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1057
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1271
                     /gene="Osgep"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggtccct tcgcttggtt ctgggtcgtt catcgcggtg ccggttacag ctagtccttc
       61 agttccacga tcccgaatca cggggtatca tgcccgcggt gctggggttc gaaggcagcg
      121 ccaacaagat tggcgtgggc gtggtccgcg acggcacggt gctggcgaac ccgcggcgca
      181 catacgtcac ggccccgggc accggtttcc ttccaggtga cacggccagg caccaccgag
      241 ctgtcatcct agacctactg caggaggcgc taacagaggc agggttaacc cccaaggaca
      301 tcgattgcat tgcttacacc aaaggtcctg gcatgggagc cccactggct tccgtagctg
      361 ttgttgcccg cactgtggcc cagttgtgga ataagccttt gctaggcgtg aaccactgca
      421 taggccacat tgaaatgggc cgcctcatca ctggagccgt caacccaact gtcttgtatg
      481 tcagcggagg aaatactcag gtgatttcct actcagaaca tcgttaccgc atctttgggg
      541 aaactattga tattgctgtg ggaaattgtt tggatcgttt tgcccgggtg ctgaagattt
      601 ccaatgaccc aagtccaggc tacaacattg agcagatggc aaagcgaggc aagaagctag
      661 tggagctgcc atacaccgtg aaggggatgg acgtctcgtt ctcagggatc ctgtccttca
      721 tcgaggatgc agcacagcga atgctggcca cgggagagtg tactcctgaa gatctgtgtt
      781 tctccttaca ggagactgtg tttgcaatgc tggtggagat cacagagcga gccatggcgc
      841 actgtggctc caaagaagcc ctcatcgtcg ggggagttgg atgtaacgta cggctgcagg
      901 agatgatggc aacaatgtgc caggagcggg gagcccagct ctttgcaaca gatgagaggt
      961 tctgcattga caatggagcc atgatagcac aagctggctg ggagatgttt caggctgggc
     1021 acaggacccc tctccaagat tctgggatca ctcagaggta taggacagat gaagtagaag
     1081 tgacgtggag ggactaacac catctacagg aaaagaagag cttttcagga gagtgttgaa
     1141 cttggagcga gtcttggtga tgccctgggc tctcctctcc tctggcaagg atacggactc
     1201 catataaggc ttagggtccc tgtggaagcc caacatgact caataataaa aattggtttg
     1261 tatgttgata aaaaaaaaaa aaaaaaaaaa aaaaa
//
