LOCUS       NM_001184973            2029 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus osteoclast associated Ig-like receptor (Oscar),
            mRNA.
ACCESSION   NM_001184973 XM_001066538 XM_218174
VERSION     NM_001184973.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. doi:
            10.3389/fphar.2020.635927. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Barrow,A.D., Raynal,N., Andersen,T.L., Slatter,D.A., Bihan,D.,
            Pugh,N., Cella,M., Kim,T., Rho,J., Negishi-Koga,T., Delaisse,J.M.,
            Takayanagi,H., Lorenzo,J., Colonna,M., Farndale,R.W., Choi,Y. and
            Trowsdale,J.
  TITLE     OSCAR is a collagen receptor that costimulates osteoclastogenesis
            in DAP12-deficient humans and mice
  JOURNAL   J Clin Invest 121 (9), 3505-3516 (2011)
   PUBMED   21841309
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Ishikawa,S., Arase,N., Suenaga,T., Saita,Y., Noda,M., Kuriyama,T.,
            Arase,H. and Saito,T.
  TITLE     Involvement of FcRgamma in signal transduction of
            osteoclast-associated receptor (OSCAR)
  JOURNAL   Int Immunol 16 (7), 1019-1025 (2004)
   PUBMED   15184345
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Kim,N., Takami,M., Rho,J., Josien,R. and Choi,Y.
  TITLE     A novel member of the leukocyte receptor complex regulates
            osteoclast differentiation
  JOURNAL   J Exp Med 195 (2), 201-209 (2002)
   PUBMED   11805147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474101.1.
            
            On or before May 29, 2010 this sequence version replaced
            XM_218174.5, XM_001066538.2.
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2029
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /note="osteoclast associated Ig-like receptor"
                     /db_xref="GeneID:292537"
                     /db_xref="RGD:1559897"
     exon            1..110
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..877
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /note="osteoclast associated receptor; osteoclast
                     associated, immunoglobulin-like receptor"
                     /codon_start=1
                     /product="osteoclast-associated immunoglobulin-like
                     receptor precursor"
                     /protein_id="NP_001171902.1"
                     /db_xref="GeneID:292537"
                     /db_xref="RGD:1559897"
                     /translation="MVLLLILQLSTLCELSLPWPVCHADFTSPVPLASYPKPWLGAHP
                     AAIVTPGINVTLICRAPQPAWGFGLFKTGLATPLLLRNVSIGLAEFFLEKVTSVQEGS
                     YHCRYRKTDWGPGVWSQPSNALELLVTDQLPRPSLVAIPGPVVAPETTVSLRCAGRIP
                     GMSFALYRADVATPLQYIDSVQPWADFLLNSANAPGTYYCYYHTPSSPYVLSERSQPL
                     VISSEGSGSLDYTQGNLVRLGLAGLVLICLGIIVTFDWHSRRSAFVRLLPQQNWV"
     exon            111..143
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /inference="alignment:Splign:2.1.0"
     exon            144..443
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /inference="alignment:Splign:2.1.0"
     exon            444..725
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2029
                     /gene="Oscar"
                     /gene_synonym="RGD1559897"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagagggta aaaggcaggg ccagcctttc cccagctcca ctgagagtgc ccgccatggt
       61 cctgttgctg atactccagc tgtctactct ctgtgagctg tccctcccct ggcctgtgtg
      121 tcatgctgac ttcacatcac cagtgcccct agcctcatac cccaagccat ggctgggggc
      181 tcatcctgct gcaattgtga ctcctggaat caatgtaact ttgatttgcc gtgcacccca
      241 acctgcctgg ggatttggac tcttcaaaac tggccttgcc acccctctgc tcctccggaa
      301 tgtgtccatt gggctggctg agttcttcct ggaaaaggtg acttcggtcc aggagggcag
      361 ttatcactgc cgctaccgca agacagactg ggggcctggt gtctggtctc agcccagtaa
      421 tgctctggaa ctgctggtaa cggatcagct acccagacca tcactggtgg caattcctgg
      481 gcctgtggtg gccccagaaa ccactgtaag cctgcgctgt gcaggccgca taccaggcat
      541 gagttttgcg ctgtaccgcg cggatgtggc aacccctctg cagtacatcg actctgtgca
      601 gccctgggct gacttccttc tgaacagcgc gaatgcacct ggcacctact attgctatta
      661 ccacaccccc tctagcccct atgtgctatc agagcgcagc cagccactgg tcatcagttc
      721 cgaaggttct ggctccttgg actataccca gggaaacctc gtgcgtttgg ggctggcagg
      781 actggtcctc atctgcttgg gcatcatagt tactttcgat tggcacagca ggcgctctgc
      841 ctttgttcgt ctcctgcccc agcaaaactg ggtataggcc tgtgcgatgg gaagagactt
      901 cctggagacg gacagagaaa ctgggactct tggtgaccag cccctccgga acactctaag
      961 cttccagact ccactggatt aattattctt cacctcagta ttaggcttgt tgaaggatta
     1021 aaggaagtga ccggcctgtg gtaaatgatg ttcagttaat gttagtgacc ttgtcctccc
     1081 ttgaaaacct ctatttcctt catgtgtctt atctccaccc ccccccactc cacctctcgt
     1141 ttctttcttc atggctatgt tgggatcata ggttcattct accacaccca gcaaaatata
     1201 tagttacgta ttttaaggga tgatacgcat gcctcagcct gtgtgcaaag gtgaaaagac
     1261 aacttccagg aattgatttt ctctgtccat cctgtgggtc ccagggtttg aactcagact
     1321 gttagttagg cttatccaca agaactttac ccactgagcc atctggctgg ctcctggtaa
     1381 tttttttttt tttttacatg tatgagtgtt ttgcctgtat gcatggtgtc acttgaaggc
     1441 ctcgctcccc aaggaagcca gaaaaaggca tctgatccct tggaattaga gttacagatg
     1501 tgtgtgagcc accaccatgt gggtgctagg agctccaacc caggtcctct ggaagattag
     1561 ccagtactct tttttttttt ttctttttct atttttcgga gctggggact gaacccaggg
     1621 ccttgtgctt gctaggcaag cactctacca ctgagctaaa tccccaaccc ctagccagta
     1681 ctcttaactg ctaaaccacc tctccagggg cccaaatcta taggattaaa atacccactc
     1741 tctcttctct tccaatgttt tgggggtttt gcttgtttgt ttgtttggtt tttagtgcaa
     1801 ggtattaaac tctcgtcctt ctagtttacc cctatgctac aactccatct ccctggtaat
     1861 ttttaaaata ttaataatta attacagtct tattctgtaa cttaagatga cttgaacttg
     1921 aataaatgtt tctgcctcgg gctcttgaat atcagaatta caggtatgag ccacggtact
     1981 cagcctgaaa tctttttttt ttttgaattg tgtttactac actggaatt
//
