LOCUS       NM_001013079            2749 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus oxysterol binding protein-like 2 (Osbpl2), mRNA.
ACCESSION   NM_001013079 XM_215965
VERSION     NM_001013079.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Zheng,Y.Q., Jin,M.F., Suo,G.H., Wu,Y.J., Sun,Y.X. and Ni,H.
  TITLE     Proteomics for Studying the Effects of Ketogenic Diet Against
            Lithium Chloride/Pilocarpine Induced Epilepsy in Rats
  JOURNAL   Front Neurosci 14, 562853 (2020)
   PUBMED   33132826
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2749)
  AUTHORS   Wang,H., Ma,Q., Qi,Y., Dong,J., Du,X., Rae,J., Wang,J., Wu,W.F.,
            Brown,A.J., Parton,R.G., Wu,J.W. and Yang,H.
  TITLE     ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for
            Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)
  JOURNAL   Mol Cell 73 (3), 458-473 (2019)
   PUBMED   30581148
REFERENCE   3  (bases 1 to 2749)
  AUTHORS   Hynynen,R., Suchanek,M., Spandl,J., Back,N., Thiele,C. and
            Olkkonen,V.M.
  TITLE     OSBP-related protein 2 is a sterol receptor on lipid droplets that
            regulates the metabolism of neutral lipids
  JOURNAL   J Lipid Res 50 (7), 1305-1315 (2009)
   PUBMED   19224871
REFERENCE   4  (bases 1 to 2749)
  AUTHORS   Suchanek,M., Hynynen,R., Wohlfahrt,G., Lehto,M., Johansson,M.,
            Saarinen,H., Radzikowska,A., Thiele,C. and Olkkonen,V.M.
  TITLE     The mammalian oxysterol-binding protein-related proteins (ORPs)
            bind 25-hydroxycholesterol in an evolutionarily conserved pocket
  JOURNAL   Biochem J 405 (3), 473-480 (2007)
   PUBMED   17428193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091208.1.
            
            On Mar 26, 2005 this sequence version replaced XM_215965.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091208.1, SRR8487231.79230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2749
                     /gene="Osbpl2"
                     /note="oxysterol binding protein-like 2"
                     /db_xref="GeneID:296461"
                     /db_xref="RGD:1311312"
     exon            1..61
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..195
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1610
                     /gene="Osbpl2"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 2"
                     /protein_id="NP_001013097.1"
                     /db_xref="GeneID:296461"
                     /db_xref="RGD:1311312"
                     /translation="MNGEEEFFDAVTGFDSDNSTGEFSEANKITGMIDLDTSKSTRSG
                     KHGERSPQENGIQKHRTALPAPMFTRSDFSVWSILKKCIGLELSKITMPIAFNEPLSF
                     LQRITEYMEHVYLIHRASNQSQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYE
                     LIREDLGFRFISEQVSHHPPISAFYSEGLNQDFMFHGSIYPKLKFWGKSVEAEPRGTI
                     TLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEILNHRTGDKCILHFKPCGLFG
                     KELHRVEGYIQDKNRKKLFIMYGKWTECLWGIDPVSYESFKKQEKRGDHARKAKSDDA
                     PEKVNSDVPGNMADDVPVAQETVQVIPGSKLLWRINSRPPNSAQMYNFTSFTVSLNEL
                     ESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARKERAKEEAEWRTR
                     WFSPGNNPYTGAPDWLYAGHYFERNFSDCPDIY"
     exon            196..337
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..413
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..548
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..646
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..829
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..937
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1027
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1151
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1292
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1416
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1507
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..2719
                     /gene="Osbpl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggccgcagg cgggggcggg gcggccgtgg gggtcggtgg cgccgcgggg accgcgttcc
       61 gatttccagg atctacacaa cttctacata aatatagatc agagatgatc cagtaggagg
      121 accaaactcc aggacggtga cagccttgtc actgaaggat gaacggggag gaagagttct
      181 ttgatgccgt cacaggcttt gattctgata attctacagg ggaattttca gaggcaaata
      241 aaattactgg gatgattgac ttggatacca gcaaaagtac taggagtgga aaacatgggg
      301 agagatcacc acaagagaat ggaattcaga agcacaggac agccctgcct gctcccatgt
      361 tcaccagaag tgacttcagc gtgtggagta tcctgaagaa atgcattggc ttggaactgt
      421 caaagatcac aatgccgatt gccttcaatg agcccctgag cttcctgcag cggattacgg
      481 agtacatgga gcatgtgtat ctcattcaca gagcctcaaa ccagtcccag cccctggaaa
      541 ggatgcagtc tgtagctgcc tttgcggtct cggctgtggc ttcccagtgg gagagaactg
      601 gcaaaccctt taacccgctc ttgggggaga catatgagtt gatcagggaa gacttagggt
      661 tcagatttat atctgagcag gtcagtcatc accctcctat aagtgcattt tattcagaag
      721 gtctcaatca agacttcatg ttccatggtt ccatctaccc aaagctgaaa ttctggggca
      781 agagtgtgga ggctgagccc cgggggacca tcacactgga actgctcaaa cataatgaag
      841 cctacacctg gaccaacccc acctgctgtg tacacaatgt catcctgggg cagctatgga
      901 tagaacagta tgggatagtg gagatcctaa atcacagaac tggagataag tgcatactgc
      961 acttcaagcc ttgtggactg ttcgggaagg agcttcacag agttgaaggg tacattcagg
     1021 acaagaatag gaagaagctc tttataatgt atggcaagtg gacagagtgc ttgtggggca
     1081 tagatcctgt ttcatatgaa tcctttaaga agcaagagaa gagaggtgac catgccagga
     1141 aggccaaatc ggatgatgcc ccagagaaag ttaacagtga tgtgcctggc aatatggcag
     1201 atgatgttcc tgtggctcag gagactgtgc aagtcatccc tggcagtaag ctactctgga
     1261 ggatcaacag ccggcccccc aactctgctc agatgtacaa cttcaccagc ttcactgtga
     1321 gtctcaatga gttggagtca ggaatggaga agaccctgcc acccacagat tgccgcctcc
     1381 gtcctgacat ccgtggcatg gagaatggca acatggatct ggccagtcag gagaaggagc
     1441 gactagagga aaagcagcga gaggccagaa aagaacgtgc caaagaggaa gcagagtggc
     1501 ggaccaggtg gttctctcca ggcaataacc cctacacagg agctcctgac tggctgtatg
     1561 ccggccatta ctttgaacgt aatttctcag actgcccaga catctactaa gtaaggcctg
     1621 tgagcctaga aggaggcctg taaggttgga atcctcaagt agcatctgag ctttatggtg
     1681 gcagacacca gcttttgcag ccacaattgt ggaggtagcc tcggacatga tggaggacct
     1741 cagtgagcct ctggttgccc cgcgcttcac tatgttgcag ccccttcatg aagctccagt
     1801 tgggccttca cattcactga gacctcagaa ctccacaatc ctctcacagg taacagagta
     1861 cacaaggcca gctgagctgg cagcacactc tgttacaaaa tgtgtaagga aggaagaacc
     1921 agcagggcct gtgtgttcca ctcaaggctg tggcgtgagt tctggaagag tttcaaaccc
     1981 agacccaagg aggggaacaa aagtatcctg tggccagggt cccctttgtt gtggaaagca
     2041 acatggaatg aagtgacaag cctccagatt ctgtattttc taccaatctt gaaaaaggta
     2101 aagattactt tagaaaatat ttaaattgaa actacttgaa tgatctgcta aagtgcagca
     2161 aacacataat caccactgtg tactgtccaa acaaagtgtc cctgtgccaa gccagagtgg
     2221 caggaacact gacttagatg aagaacgccc tgggctactc ctgccttgga ggccctgcct
     2281 ctagccacag cacttcatag cttcaccgtc actgtggacc acgcctgttt ctaaggtcat
     2341 ttcttcactc acctcgcctg tgtgccctcc ctctccccca aagtcttgtg tttggttccc
     2401 cactgtgcat gtttcagtcc aggcaagtta catttggttg tgtgcaatgg aaggtcagaa
     2461 gcaagatcta cttacctggt gtcattaaaa ttgttttaat acaagtaggg tgtgttcacc
     2521 tctgcattcc tgtcacatga tggactttat gtaaaaatgg tgacaccaag gctcacagtg
     2581 gagctctttg catcaaagat aatctactgt gtacacatat ctgtgcgttc atacagtgtg
     2641 cccttgtaaa tgagaaggta tgattactat gtccaggctt ccaaacagcc tctgtcatta
     2701 aaacactttg aaaagccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
