LOCUS       NM_172023               3051 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus oxysterol binding protein-like 1A (Osbpl1a),
            mRNA.
ACCESSION   NM_172023
VERSION     NM_172023.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Suchanek,M., Hynynen,R., Wohlfahrt,G., Lehto,M., Johansson,M.,
            Saarinen,H., Radzikowska,A., Thiele,C. and Olkkonen,V.M.
  TITLE     The mammalian oxysterol-binding protein-related proteins (ORPs)
            bind 25-hydroxycholesterol in an evolutionarily conserved pocket
  JOURNAL   Biochem J 405 (3), 473-480 (2007)
   PUBMED   17428193
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Johansson,M., Lehto,M., Tanhuanpaa,K., Cover,T.L. and Olkkonen,V.M.
  TITLE     The oxysterol-binding protein homologue ORP1L interacts with Rab7
            and alters functional properties of late endocytic compartments
  JOURNAL   Mol Biol Cell 16 (12), 5480-5492 (2005)
   PUBMED   16176980
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Kaiser,S.E., Brickner,J.H., Reilein,A.R., Fenn,T.D., Walter,P. and
            Brunger,A.T.
  TITLE     Structural basis of FFAT motif-mediated ER targeting
  JOURNAL   Structure 13 (7), 1035-1045 (2005)
   PUBMED   16004875
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Xu,Y., Liu,Y., Ridgway,N.D. and McMaster,C.R.
  TITLE     Novel members of the human oxysterol-binding protein family bind
            phospholipids and regulate vesicle transport
  JOURNAL   J Biol Chem 276 (21), 18407-18414 (2001)
   PUBMED   11279184
REFERENCE   6  (bases 1 to 3051)
  AUTHORS   Nishi,N., Shoji,H., Miyanaka,H. and Nakamura,T.
  TITLE     Androgen-regulated expression of a novel member of the aldo-keto
            reductase superfamily in regrowing rat prostate
  JOURNAL   Endocrinology 141 (9), 3194-3199 (2000)
   PUBMED   10965890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB089316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB089316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3051
                     /gene="Osbpl1a"
                     /note="oxysterol binding protein-like 1A"
                     /db_xref="GeneID:259221"
                     /db_xref="RGD:628888"
     exon            1..112
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            113..295
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3027
                     /gene="Osbpl1a"
                     /note="ORP-1; OSBP-related protein 1"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 1"
                     /protein_id="NP_742020.1"
                     /db_xref="GeneID:259221"
                     /db_xref="RGD:628888"
                     /translation="MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSK
                     SNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVMLLLE
                     YNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSAL
                     LSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHG
                     TEMKHILVGNKVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNS
                     YRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIEEHSA
                     YSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKD
                     MLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETL
                     ATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPAN
                     SGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITM
                     PVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKP
                     FNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGK
                     SVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCV
                     LNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNT
                     EEKKTSKQASTSEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVL
                     NEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDW
                     KTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY"
     exon            296..381
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            382..456
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            457..568
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            569..654
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..799
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            800..861
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            862..906
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            907..980
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1044
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1143
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1266
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1348
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1455
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1618
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1775
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1851
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1986
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2084
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2267
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2375
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2465
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2592
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2709
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2833
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2924
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3043
                     /gene="Osbpl1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatcctgg accgtcctcg tgagagtggc cctcgtgggt gaccggcgtc cagtgggcgc
       61 ggcccggcct gtggtggagg ccgcctcagg agcgggaccc gcaatcccgc aggcccagct
      121 gtgagcacgt tatgctgctg ggtgagagct ccacttctgt ttttcagtcc agaaatgaac
      181 acagaagccg agcagcagct tctccatcac gccaggaatg gcaatgctga agaagtgagg
      241 aagctgctgg aagccatggc gcgggctgaa gtggtcgctg acattgactg taaaggaaga
      301 agtaagtcta acttgggctg gacacctctt catctggcat gctattttgg acacaaacaa
      361 gtggtccagg atctgttgaa ggctggtgcc aaagtgaaca tgttaaatga catgggggac
      421 acgccgctgc accgagctgc cttcacagga cgaaaggagc tagtaatgct tcttttagaa
      481 tataatgctg acactactgt cgtaaatgga agtggacaga cagcaaaaga agccacccat
      541 gacaaagaaa tcagacaaat gcttgaagct gtggaaagga ctcaacaaag aaagcttgaa
      601 gaattgcttc taggagcagc tagagaagga agaacagctg aagtgtcagc tctgctcagc
      661 aggcccaatc ctcctgatgt gaactgctca gatcagttag gaaatactcc cttgcactgt
      721 gcagcctacc gggcccacaa gcagtgtgtc ttaaagcttc tgagaagtgg agctgacccc
      781 agcctgaaga acaagaacga tcagaaacct cttgaccttg cccatggcac tgaaatgaaa
      841 catatccttg ttggtaataa ggttgtccac aaagccctga aacgctttga aggccctctc
      901 tggaagagtt caagattttt tggctggaag ttattctggg tagtgttaga acacggcgtc
      961 ctttcctggt acaggaagca gcctgatgca gtccataatt cttaccgcca aggatgcaaa
     1021 cacctgactc aagcggtgtg cacggtgaaa cctacagatg gctgcctctt ctctgtccga
     1081 tgctttgatg acaccgttca tggctttcgg gttcctaaga acagcctaca gcaatcgaga
     1141 gagaagtggc tggaagcaat tgaagaacat tctgcataca gcactcacta ctgctcccag
     1201 gatcaggtga ctgatgatga agaggaagat gtagcttctg ccatggacct gaaggagtcc
     1261 ttagcgagag cacaaacatg tcaacagaga ctagataggg aaatttacaa ctttctcaaa
     1321 atgattaagg agtgcgatgt ggccaaagat atgcttccat catttcttca gaaagctgac
     1381 gtgctctccg aagcttctag agagacttgt gtggcgctga gtgactgtct taatctcttc
     1441 actaaacagg aaggggtaag gaattttaaa ttggaacagg agcaagaaaa aaacaaaatt
     1501 ttgtcagaag cgctggagac tttagccact gagcatcatg aactagaacg atccctggtt
     1561 gaaggatctc cgcctgtcag catccttagt gaggacgagt tctatgatgc actgtcaggg
     1621 tccgagtccg aggggtcgct gacttgtctg gaagctgtga cagcacgcgc ctttgaagag
     1681 aacgaagtgc ctgcgaacag cgggaagcac agaatgtccg aagggaagga ctgtggcgga
     1741 ggagatgcgc tctccaacgg cattaaaaag cacagaacaa gcctgccatc acccatgttc
     1801 tccagaaatg acttcagcat ctggagcatc ctcaggaaat gcattgggat ggaactgtcc
     1861 aagatcacaa tgccagtcat ctttaatgag cctctgagct ttctgcagcg gctgactgag
     1921 tacatggagc acacttacct catccacaaa gccagctcat tctctgatcc tgtggaaagg
     1981 atgcagtgtg tggctgcatt tgctgtgtct gccgttgctt ctcagtggga gcgcactggg
     2041 aaacccttca acccacttct gggagagact tacgaattag ttcgagatga ccttggattt
     2101 aggctcatct cagagcaggt cagccaccac ccccccatca gtgcattcca tgcagaagga
     2161 ctcaacaacg atttcatctt ccatggctca atttacccca agctgaagtt ctggggcaag
     2221 agtgtagaag cagaacctaa agggaccatc accttggagc ttttagaaca caacgaagca
     2281 tacacatgga caaaccccac ctgctgtgtg cataacatca tcgtgggcaa actctggatc
     2341 gaacagtatg gcaatgtgga aatcataaac cacaagactg gggacaagtg tgtgttgaat
     2401 tttaagccat gtggtctttt tggcaaggaa ttacacaaag ttgaaggcta catacaagat
     2461 aaaagcaaaa agaaactctg tgctctctac gggaagtgga ccgagtgctt gtacagtgta
     2521 gaccctgcca cttttgacgc ttacaaaaaa aacgataaga aaaacacaga agagaagaag
     2581 accagcaaac aggcaagcac atctgaggag tctgacgaaa tgccagtgcc ggactctgag
     2641 agcgtatttg ttattcctgg cagtgcgctc ctgtggcgga tagccccgcg gcctcccaac
     2701 tctgctcaga tgtataattt taccagcttt gccatggtct tgaatgaggt agacaaggag
     2761 atggagaccg tgattcccaa gactgactgc aggctgcggc ctgacatcag agccatggag
     2821 aacggagaga tagatcaagc tagtgaagaa aaaaaacgac tcgaggaaaa acaaagagca
     2881 gcccgcaaaa acaggtccaa gtcagaagag gactggaaga caaggtggtt tcatcaaggc
     2941 cctaacccct acagtggagc acaggactgg atttattctg gcagctactg ggacagaaac
     3001 tacttcaatt tgcctgatat ttattaaagt gcagagaagt ccaaaaaaaa a
//
