LOCUS       NM_001107232            4094 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus oxysterol binding protein 2 (Osbp2), mRNA.
ACCESSION   NM_001107232 XM_001066915 XM_039092015 XM_223556
VERSION     NM_001107232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4094)
  AUTHORS   Udagawa,O., Ito,C., Ogonuki,N., Sato,H., Lee,S., Tripvanuntakul,P.,
            Ichi,I., Uchida,Y., Nishimura,T., Murakami,M., Ogura,A., Inoue,T.,
            Toshimori,K. and Arai,H.
  TITLE     Oligo-astheno-teratozoospermia in mice lacking ORP4, a
            sterol-binding protein in the OSBP-related protein family
  JOURNAL   Genes Cells 19 (1), 13-27 (2014)
   PUBMED   24245814
REFERENCE   2  (bases 1 to 4094)
  AUTHORS   Loilome,W., Wechagama,P., Namwat,N., Jusakul,A., Sripa,B., Miwa,M.,
            Kuver,R. and Yongvanit,P.
  TITLE     Expression of oxysterol binding protein isoforms in
            opisthorchiasis-associated cholangiocarcinoma: a potential
            molecular marker for tumor metastasis
  JOURNAL   Parasitol Int 61 (1), 136-139 (2012)
   PUBMED   21763455
REFERENCE   3  (bases 1 to 4094)
  AUTHORS   Suchanek,M., Hynynen,R., Wohlfahrt,G., Lehto,M., Johansson,M.,
            Saarinen,H., Radzikowska,A., Thiele,C. and Olkkonen,V.M.
  TITLE     The mammalian oxysterol-binding protein-related proteins (ORPs)
            bind 25-hydroxycholesterol in an evolutionarily conserved pocket
  JOURNAL   Biochem J 405 (3), 473-480 (2007)
   PUBMED   17428193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before May 1, 2021 this sequence version replaced
            XM_039092015.1, NM_001107232.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.55220.1,
                                           SRR26643290.44880.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               JAXUCZ010000014.1  82969735-82970368   c
            635-843             JAXUCZ010000014.1  82928620-82928828   c
            844-1100            JAXUCZ010000014.1  82831858-82832114   c
            1101-1293           JAXUCZ010000014.1  82822251-82822443   c
            1294-1411           JAXUCZ010000014.1  82821523-82821640   c
            1412-1466           JAXUCZ010000014.1  82819817-82819871   c
            1467-1613           JAXUCZ010000014.1  82819400-82819546   c
            1614-1859           JAXUCZ010000014.1  82818189-82818434   c
            1860-1980           JAXUCZ010000014.1  82816958-82817078   c
            1981-2084           JAXUCZ010000014.1  82816639-82816742   c
            2085-2180           JAXUCZ010000014.1  82816471-82816566   c
            2181-2356           JAXUCZ010000014.1  82816219-82816394   c
            2357-2583           JAXUCZ010000014.1  82810435-82810661   c
            2584-4094           JAXUCZ010000014.1  82808693-82810203   c
FEATURES             Location/Qualifiers
     source          1..4094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4094
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /note="oxysterol binding protein 2"
                     /db_xref="GeneID:305475"
                     /db_xref="RGD:1310505"
     exon            1..634
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2726
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /codon_start=1
                     /product="oxysterol-binding protein 2"
                     /protein_id="NP_001100702.1"
                     /db_xref="GeneID:305475"
                     /db_xref="RGD:1310505"
                     /translation="MGKAAALSRGGGCAGRSRGLSSLFTVVPCLSCHTAAPGMNSSTL
                     GSGPAPKPQFQPVQAPERELLSEQVCQPISEPRSEPGSQTTFVPQPLGAGQESESLGL
                     WPGSGPNTKASPELPSPPRSTAESLPKPESKAGPKTQSVLRPGQSKTSAGSPVSGTSV
                     PMVSPPLDSYKGWLFKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLASA
                     HFETEDSCGILLCNGARTYHLKASSEVDRQQWITVLELAKAKAIRVMNTQSDDSGDDD
                     EEPAAPADNSDLHHTLKTLSLKLDDLGTCNDLIAKHGAALQRSLNELDSLKIPSESGE
                     KLKVVNERATLFRITSNAMINACKDFLELAEIHSRKWQRALNYEQEQRVHLEETIEQL
                     AKQHNSLERAFCNTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTSFIT
                     VITEAKEDRKPEGGPGTTSVDWTSADNVLDGASFMPKDSCKVKRRVRIPDKPNYSLNL
                     WSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVA
                     AFSVSSYSTTVHRIAKPFNPMLGETFELDRLEDMGLRSLCEQVSHHPPSAAHHVFSKH
                     GWSLWQEITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWID
                     QSGDIEIVNHKTKDRCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQME
                     CSKIVHSSPSSDGKQKTVYQTLPAKLLWRKYPLPENAENMYYFSELALTLNEQEEGVA
                     PTDSRLRPDQRLMERGRWDEANTEKQRLEEKQRLNRRRRLESCTAGCGGEEEKESDGY
                     SPLWFEKRLDPLTGEMACIYKGGYWEAKEKKDWHMCPNIF"
     exon            635..843
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1100
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1293
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1411
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1466
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1613
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1859
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1980
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2084
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2180
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2356
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2583
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..4094
                     /gene="Osbp2"
                     /gene_synonym="RGD1309479"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcggcgct cggccgcgct cgggtccaca gctctatggg gaaagcggcc gctctaagcc
       61 gaggcggcgg ctgcgctggc cgctcccgcg ggctctcgtc gctgttcacg gttgtgccct
      121 gtctgtcctg ccacacggcg gcgccgggca tgaactcgtc cacgttgggc tcagggccgg
      181 cgccaaagcc tcaattccag cctgtacagg caccagagcg ggagttgctg tcggaacagg
      241 tgtgtcagcc aatttctgag ccgagatccg aacctgggtc ccagacgacg tttgtgccac
      301 agcccttagg ggctgggcag gaatcggaat cactgggatt gtggccgggg tctgggccca
      361 ataccaaagc ttcaccagag ctgccatccc cgccgcgatc aacagcagag agtttgccca
      421 aacccgagtc taaggcgggg ccgaagaccc agtctgttct gcgaccagga cagtcaaaga
      481 cttctgccgg gagtccagtg tcagggacta gtgtcccaat ggtctcacca cctctggaca
      541 gctacaaggg ctggctcttc aagtggacta actacctgaa gggctaccag cgccgctggt
      601 tcgtgcttgg caatggcctg ctatcctact acagaaacca gggtgaaatg gcccacacct
      661 gccgtggaac catcaacctg gcctccgcgc acttcgaaac agaggactct tgtggaatct
      721 tgctatgcaa cggggcaagg acctaccacc tcaaggccag ctcagaggtg gaccgtcagc
      781 aatggatcac cgttctggag ttggccaagg ccaaggctat ccgtgtgatg aacactcagt
      841 cagatgactc tggggacgac gacgaagagc ctgctgcccc tgctgacaac agtgatctcc
      901 accacactct taagaccctc tcactgaagc tagacgacct cggcacgtgc aatgacctca
      961 ttgccaagca tggcgctgcc ctccagcgct ccctgaatga gctggacagt cttaagatcc
     1021 catcagagag tggggagaag ctgaaggttg tgaacgagcg ggccaccctc ttccgcatca
     1081 catcaaatgc tatgatcaac gcctgtaagg acttcctgga actagcggag attcacagcc
     1141 ggaaatggca gcgggctctg aattatgagc aggagcaacg agtccacctg gaggaaacca
     1201 ttgagcagtt ggccaagcag cacaacagtc ttgaacgggc cttctgcaac acccctggcg
     1261 ggccagccag ctccagcaag agcttcagcg agggaagctt cttgacttcc aaaggggaga
     1321 acagtgaaga agatgaagat actgagtact ttgatgccat ggaagactcc acatctttca
     1381 tcaccgtaat caccgaggcc aaggaagaca gaaagcctga gggtggacct gggacgacct
     1441 ctgtggactg gacctcagca gataatgtat tagatggtgc ctcattcatg cccaaggatt
     1501 catgcaaagt gaagaggcga gtccggatcc ctgacaaacc caactatagc cttaacctct
     1561 ggagcatcat gaagaattgc attggccgag agctctcccg gatccccatg ccggtgaact
     1621 tcaatgagcc cctgtccatg ctccagcgac ttacagagga cctcgagtac caccacctgc
     1681 tggacaaggc ggtgaactgc accagctctg tggagcagat gtgcctggtg gctgccttct
     1741 cggtgtcctc ctactccacc accgtgcacc gcatcgccaa gcccttcaac ccgatgctgg
     1801 gggagacctt cgagttggat cgcctggagg acatgggcct gcgttctctc tgcgagcagg
     1861 tgagccatca ccccccgtct gctgcccacc acgtgttctc taagcatggc tggagcctct
     1921 ggcaggagat caccatcgcc agcaagttcc gggggaaata catctccatc atgccacttg
     1981 gtgccatcca cctcgaattc caggccagtg gcaatcacta cgtgtggagg aagagtacct
     2041 ccactgtgca caacatcatc gtgggcaagc tctggattga ccagtcaggg gacattgaga
     2101 ttgtgaacca caagaccaag gaccggtgcc agctgaagtt cgtgccctac agctacttct
     2161 ccaaagaggc agcccgaaag gtgactggag tggtgagcga cagccagggc aaggcccact
     2221 acgtgctgtc aggttcctgg gatgagcaga tggagtgttc taagattgtg cacagcagcc
     2281 ccagctctga tgggaagcag aaaaccgtgt accagacgct gccagccaag ctgctatgga
     2341 ggaaataccc actgccggag aacgcggaga acatgtacta tttctcggag ctggccctga
     2401 ccctcaacga gcaggaggag ggcgtggcgc ccaccgacag ccgcctgcgg ccggaccagc
     2461 ggctgatgga gaggggccgc tgggacgagg ccaacaccga gaagcagcgc ctggaggaga
     2521 agcagcgcct gaaccggcga cggcggctgg agtcgtgcac ggccggctgt ggcggggagg
     2581 aagagaagga gtcagatggc tattcgccgc tgtggttcga gaagaggctg gacccgctga
     2641 ccggggagat ggcctgcata tacaagggcg gctactggga ggccaaggag aagaaggact
     2701 ggcacatgtg ccccaacatc ttctgagcca ctcctgcgga aaatacaggc acctgcactg
     2761 cctgtcagac ttttctttaa tgcacccgat ttaatacaga acccaccaat gcgtgtgtgc
     2821 gcacgcgcgt gaccacaccg cttaagaagg ggtaagggct gacctgggtt cttgccagcc
     2881 ccaggtcgcc gggtcacgtg tgcccgttgt tatcattgac ttgggcccca tgggcaccct
     2941 agttcccagt taccacaact caggccggct ggccgggcca tgggctgccc aggtcactaa
     3001 ccccaaccca gggaggaaat atttccctcc tagggagcct cttttgactt ttttaagaaa
     3061 aaaaaatatc catttctttc caacgatgag gtttagtaaa tatttttagc acatcactta
     3121 gaagactcac tttccaagtg ttcgttcttg ccacagaacg gttctggcaa gaagcccgtt
     3181 tttaaagacc tgaggaagcc aggccccttt gaatggggaa cacttcaaac acagcccggc
     3241 tttctagctg gactgtccaa gctccaggag cgcaacaccc gcagagacag caggaagcct
     3301 ggctggccgg cccagcatgg catgcagagc ccgaaggggg aaggcagtca aaggcagccg
     3361 cccccccccc cccgtgccag gccttggcca tggtggggca gtatcccagt cccaaagagg
     3421 ccaggaaggg ctgaaaggca gggcccttag gtgcttcctg cccaagaatc aggcccccaa
     3481 atcagcaata aggaacaaac ccttccttta gcctgggctg gtgacccagg ctcccaacac
     3541 ctggcctccc gccttgtcct tcggcggcat cagggtgcct cactccgaag tcctgacatc
     3601 tttatttgcc taatttatat atatatatga tatacaaata tatatgacat agctattttg
     3661 cttaaatttc tatgatacgt gaaagtgaaa aatgatgaag acagactgcc tgtctgagtt
     3721 tggcctcctg ccagccccgc cctctccttg tagccctccc agtggcttct gccaacctta
     3781 gaaatgaaac ctgcccctca gaccctctgc ctccaaccca tctcacttca gtttgatctg
     3841 gaaagttcat tgcagggcct ttctttctac tccaggcctg gttttgtttt ttgttttgtt
     3901 ttttattaaa aaagaaaaag aaaacaccac gtatgaaatg ccttacaatg cccactctag
     3961 agagggggtg ggaagggcgg gggagggaag gtcactcggt ctccctcaga gctggaatgt
     4021 accccttccc agcaggctga gcaagcaagc accttctgat cataataaaa accttggttc
     4081 tggagttttc caca
//
