LOCUS       NM_001108927            4407 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus oxysterol binding protein (Osbp), mRNA.
ACCESSION   NM_001108927 XM_001075837 XM_344995
VERSION     NM_001108927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4407)
  AUTHORS   Hussain,S.S., Harris,M.T., Kreutzberger,A.J.B., Inouye,C.M.,
            Doyle,C.A., Castle,A.M., Arvan,P. and Castle,J.D.
  TITLE     Control of insulin granule formation and function by the ABC
            transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP
  JOURNAL   Mol Biol Cell 29 (10), 1238-1257 (2018)
   PUBMED   29540530
REFERENCE   2  (bases 1 to 4407)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
REFERENCE   3  (bases 1 to 4407)
  AUTHORS   Sierra,B., Triska,P., Soares,P., Garcia,G., Perez,A.B., Aguirre,E.,
            Oliveira,M., Cavadas,B., Regnault,B., Alvarez,M., Ruiz,D.,
            Samuels,D.C., Sakuntabhai,A., Pereira,L. and Guzman,M.G.
  TITLE     OSBPL10, RXRA and lipid metabolism confer African-ancestry
            protection against dengue haemorrhagic fever in admixed Cubans
  JOURNAL   PLoS Pathog 13 (2), e1006220 (2017)
   PUBMED   28241052
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4407)
  AUTHORS   Mesmin,B., Bigay,J., Moser von Filseck,J., Lacas-Gervais,S.,
            Drin,G. and Antonny,B.
  TITLE     A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P
            exchange by the ER-Golgi tether OSBP
  JOURNAL   Cell 155 (4), 830-843 (2013)
   PUBMED   24209621
REFERENCE   5  (bases 1 to 4407)
  AUTHORS   Vlassaks,E., Mencarelli,C., Nikiforou,M., Strackx,E., Ferraz,M.J.,
            Aerts,J.M., De Baets,M.H., Martinez-Martinez,P. and Gavilanes,A.W.
  TITLE     Fetal asphyxia induces acute and persisting changes in the ceramide
            metabolism in rat brain
  JOURNAL   J Lipid Res 54 (7), 1825-1833 (2013)
   PUBMED   23625371
REFERENCE   6  (bases 1 to 4407)
  AUTHORS   Auweter,S.D., Yu,H.B., Arena,E.T., Guttman,J.A. and Finlay,B.B.
  TITLE     Oxysterol-binding protein (OSBP) enhances replication of
            intracellular Salmonella and binds the Salmonella SPI-2 effector
            SseL via its N-terminus
  JOURNAL   Microbes Infect 14 (2), 148-154 (2012)
   PUBMED   21988961
REFERENCE   7  (bases 1 to 4407)
  AUTHORS   Thorsen,K., Schepeler,T., Oster,B., Rasmussen,M.H., Vang,S.,
            Wang,K., Hansen,K.Q., Lamy,P., Pedersen,J.S., Eller,A.,
            Mansilla,F., Laurila,K., Wiuf,C., Laurberg,S., Dyrskjot,L.,
            Orntoft,T.F. and Andersen,C.L.
  TITLE     Tumor-specific usage of alternative transcription start sites in
            colorectal cancer identified by genome-wide exon array analysis
  JOURNAL   BMC Genomics 12, 505 (2011)
   PUBMED   21999571
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4407)
  AUTHORS   Furuita,K., Jee,J., Fukada,H., Mishima,M. and Kojima,C.
  TITLE     Electrostatic interaction between oxysterol-binding protein and
            VAMP-associated protein A revealed by NMR and mutagenesis studies
  JOURNAL   J Biol Chem 285 (17), 12961-12970 (2010)
   PUBMED   20178991
REFERENCE   9  (bases 1 to 4407)
  AUTHORS   Romeo,G.R. and Kazlauskas,A.
  TITLE     Oxysterol and diabetes activate STAT3 and control endothelial
            expression of profilin-1 via OSBP1
  JOURNAL   J Biol Chem 283 (15), 9595-9605 (2008)
   PUBMED   18230613
  REMARK    GeneRIF: Oxysterol and diabetes activate STAT3 and control
            endothelial expression of profilin-1 via OSBP1
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001108927.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.7320.1,
                                           SRR26643292.5870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000001.1  218313455-218313702
            249-457             JAXUCZ010000001.1  218318254-218318462
            458-708             JAXUCZ010000001.1  218321228-218321478
            709-907             JAXUCZ010000001.1  218325343-218325541
            908-1010            JAXUCZ010000001.1  218325777-218325879
            1011-1065           JAXUCZ010000001.1  218326314-218326368
            1066-1197           JAXUCZ010000001.1  218326551-218326682
            1198-1443           JAXUCZ010000001.1  218330752-218330997
            1444-1564           JAXUCZ010000001.1  218331241-218331361
            1565-1668           JAXUCZ010000001.1  218337099-218337202
            1669-1764           JAXUCZ010000001.1  218338416-218338511
            1765-1946           JAXUCZ010000001.1  218339681-218339862
            1947-2167           JAXUCZ010000001.1  218340716-218340936
            2168-4407           JAXUCZ010000001.1  218341019-218343258
FEATURES             Location/Qualifiers
     source          1..4407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4407
                     /gene="Osbp"
                     /note="oxysterol binding protein"
                     /db_xref="GeneID:365410"
                     /db_xref="RGD:1308069"
     exon            1..248
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            249..457
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2310
                     /gene="Osbp"
                     /codon_start=1
                     /product="oxysterol-binding protein 1"
                     /protein_id="NP_001102397.1"
                     /db_xref="GeneID:365410"
                     /db_xref="RGD:1308069"
                     /translation="MRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVER
                     QRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDL
                     IAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQT
                     HSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGSTGSGKEQC
                     CSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEET
                     KKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHEL
                     LDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLC
                     EQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTW
                     KKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTD
                     PSGKVHFALLGTWDEKMDCFKVQPASGENGGDARQRGHEAEESRVMLWKRNPLPKNAE
                     NMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKK
                     REAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHVYRGEYWECKEKQDWGSCPDIF
                     "
     exon            458..708
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            709..907
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1010
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1065
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1197
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1443
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1564
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1668
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1764
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1946
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2167
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..4407
                     /gene="Osbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacgcgg ggcccggctc tggggtggca ggcgcgacgg ctgcgacggc cggcggcccg
       61 ggccccgggg ccggaggagt ggcggcaggc ggcccgggct ctgcaccgcc agccgcgggc
      121 tcgggcggtt cgggcgccgg gggctcgggc tcggctagag agggctggct cttcaaatgg
      181 accaattaca tcaaaggcta ccagcgtcga tggttcgtgc tgagcaacgg gctcctgagc
      241 tactacaggt ccaaggcaga gatgaggcac acctgccgag gcaccatcaa ccttgccaca
      301 gccaacatca ctgtggaaga ctcttgcaac ttcatcattt ccaatggcgg tgctcagacc
      361 taccacttga aggccagctc ggaagtggag cgtcagcgct gggtgacagc cctagaactg
      421 gccaaggcca aggctgtgaa gatgctggct gagtcagatg aatcaggaga tgaggagtct
      481 gtctcacaaa ctgacaagac tgagctccag aataccctcc ggacactctc cagcaaagtg
      541 gaggacctga gcacgtgcaa tgacttgata gctaaacatg gcaccgccct gcagcgttcc
      601 ctcagcgagc tggagtctct gaagctgcct gctgagagca atgagaaaat caaacaggtc
      661 aatgaacgag ccacactctt taggataaca tccaatgcca tgatcaatgc ctgcagagat
      721 ttcctcatgt tagcccagac gcatagtaag aagtggcaga agtccctgca gtatgaacgg
      781 gaccagcgta tccgactgga agaaactctt gagcagctgg cgaagcagca caatcacctg
      841 gagagagcct tccggggagc cacagtgctg ccagcaaaca ctccgggcag cactgggtct
      901 ggtaaagagc agtgctgttc tggcaaaggg gacatgagcg atgaagatga cgagaacgaa
      961 ttctttgacg caccagagat tatcaccatg cctgaaaact tgggccacaa acgtactggt
     1021 agcaatatca gtggagccag cagtgacatc agccttgatg aacagtacaa gcatcagctg
     1081 gaggagacca agaaggaaaa gagaaccaga ataccatata agccaaacta cagcctcaac
     1141 ttgtggagca tcatgaagaa ctgcattgga aaagagctct ctaagatccc aatgccggta
     1201 aactttaatg agcccttgtc catgcttcag cgccttactg aagatctgga ataccatgag
     1261 ctgttagacc gagctgccaa gtgtgagaac tctctagaac agctctgcta tgtggcagcc
     1321 ttcaccgttt cctcctattc cactactgtc ttccgaacca gcaagccatt caaccctctc
     1381 cttggggaga catttgaact agaccgactg gaggagaatg ggtatcgatc cctctgtgag
     1441 caggtgagtc atcatccccc tgctgctgcg caccatgctg aatccaaaaa tggctggaca
     1501 ttgcgtcagg aaattaaaat caccagcaag tttcgaggca aatacctctc cattatgccc
     1561 cttggtacca tccactgcat tttccacgca actgggcacc attacacttg gaaaaaagtt
     1621 accacaacag tacacaacat tattgtgggc aagttgtgga tagatcagtc tggtgagatt
     1681 gacattgtaa atcacaagac aggagacaag tgtaatctta aatttgttcc ttatagctac
     1741 ttctctcggg atgtagcaag aaaggtgaca ggtgaagtga cagacccatc aggaaaagtt
     1801 cactttgccc tcctggggac atgggatgag aaaatggatt gtttcaaagt acaaccagcc
     1861 tctggggaaa atggaggtga tgctcggcag agaggccatg aagcagaaga aagtagggtc
     1921 atgctatgga agaggaatcc attaccgaag aatgcagaaa acatgtacta cttctcagag
     1981 cttgcgctca ctctcaatgc ctgggaaggt ggcactgctc ctacagacag ccggctgcgg
     2041 cctgaccaga gactgatgga aaatgggcgc tgggatgaag caaatgctga gaagcagcgt
     2101 ctggaggaaa aacagcgact ttctaggaag aagagagaag cagaagctat gaaagccaca
     2161 gaagatggca caccatatga cccctataaa gcactgtggt ttgagcggaa gaaggaccct
     2221 gtcaccaagg agctaaccca tgtttatagg ggcgagtact gggaatgtaa ggaaaagcag
     2281 gactggggtt cttgcccaga cattttctga agcagctgta actcaaagga agagggctga
     2341 tcggagaaga cggcagagga tgtccgtgaa ggctggcagc tgggactctt accaagtgct
     2401 ttcctcaaat ttgtctgtct taaccaatca ctttttccaa atcaatcacc agaagcagac
     2461 acccatggtg gtgattggct ggttgcctta gctgattgat gctgaaatcg acgtagtaga
     2521 tacccatgtg tataagggag aggtttagtg gctgaaagtt agtgttattc tacatctgca
     2581 aaggcaagta agtgttctcc ctctgcctca tatgagatgg tgtcatccac ccttaccttg
     2641 tagtatcctg cccagccaag atctgcatac gattgtgatt catgagcatt tggtgctgtt
     2701 cagagcaaga actgatttta aagttccttt caaaagaaac acgtaagatt taaccagcag
     2761 aggcatcgtg cacaggtctc aatgttagga aatgtactcc cacgtgggct tggtttaaca
     2821 gggcatcgtg tggtaactaa ggttttggag catctgcagg aaagattgtt ctctagggct
     2881 tgagtattga gttactttcc gggagacttt accttcactt gcattcagta ccctctgtgt
     2941 tctgtctgct ttgacagcaa ccagaggcct ctgtggtggt tgataagagg gtgacactat
     3001 cctcagaaag gggtttatgg actccctcag gtggagaacc tctgagaaca caggcagggt
     3061 ggaagaagac tgctactcct tgtaccttcc cagtccctcc ttgtcctgtc tctcattgcc
     3121 tttctggctt ctctttcctg gcacaatgcc atttgagttt gtgccacagt ctggagcaaa
     3181 cattgcctga cccattctgc acacttcaga atatggaaga agtttctctg caacagatgt
     3241 tttcatcttg gaagtcccag tagaatggag ccacttctgg aataatgtgt tcaatcatct
     3301 gtatattata tatatatata tgtgtgtgtg gagagaaaat ctaatttttt tttttttttt
     3361 ggttctcccc tttctcatga agaatcttgg ttttttaata tcacctgtct cctgggactc
     3421 tcaaatgcgc gttaatatgg gttggtgcac ctctgctttc catgtttgag gggcgttgca
     3481 gccccaggca gggtcatgtg tggcagttgc tgaacaggga tgaggagaag ggttttgtca
     3541 cctacctgct gctgcctcag ctcagctttt ctgatcacat gcggctcttg gaaaggaagt
     3601 cctagtcttt ttcctgcctc agtttccttc cctaggagga gtacgggtag aaagtcaaga
     3661 gggtgatttc tagcttcctt atatcccagc cagctcaggc taaatcccaa aagaattttc
     3721 ttctaaggat gtgagctaag agccctcatg ccctgtggga actgctcctg ctggcgctgg
     3781 catccttcag tttttcttta tgagttctag tgtcctgttc agaaatataa cccttgtgca
     3841 acccactctt ggttgagggt cataaattga ggtgccttcc ttgtgtactt tttgttagtg
     3901 tttttgtttt tgttccttaa ctgttgagcc tcagccagtg tgggtccttg gggaaaatac
     3961 cattccagag gacgctatcc ctccagggaa attggatttt actgggtaaa ttagtattct
     4021 cagtccttcc ctaccggctc tccttcccta gataaaaaat gatcaaagaa tgagcactag
     4081 ggaatttcct cctaagaaga ctttccccag cacaaggggt tactccaggg aggcccataa
     4141 aatgggcacc atctctggag gctttggata gagtggaaat ttcccaagga acctccttgc
     4201 tttagcccct tcccctctat ctgcactaca tttctagctt gatttcccag atccctgcta
     4261 acggaagaag cttagaagtc ctgaagatgg aataaagtca catgaaagca aaataagact
     4321 atatatatat ctatatatat tttcagtttt tttgccttat tgcttttttt caaaaaaaaa
     4381 aactactaaa ttaaataatt tttaaaa
//
