LOCUS       NM_001007265            2639 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus OS9, endoplasmic reticulum lectin (Os9), mRNA.
ACCESSION   NM_001007265 XM_343218
VERSION     NM_001007265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Iida,Y., Fujimori,T., Okawa,K., Nagata,K., Wada,I. and Hosokawa,N.
  TITLE     SEL1L protein critically determines the stability of the HRD1-SEL1L
            endoplasmic reticulum-associated degradation (ERAD) complex to
            optimize the degradation kinetics of ERAD substrates
  JOURNAL   J Biol Chem 286 (19), 16929-16939 (2011)
   PUBMED   21454652
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Hosokawa,N., Kamiya,Y., Kamiya,D., Kato,K. and Nagata,K.
  TITLE     Human OS-9, a lectin required for glycoprotein endoplasmic
            reticulum-associated degradation, recognizes mannose-trimmed
            N-glycans
  JOURNAL   J Biol Chem 284 (25), 17061-17068 (2009)
   PUBMED   19346256
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Semenza,G.L.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Pan,K., Dai,A.G. and Hu,R.C.
  TITLE     [The cooperation of OS-9 and PHDs in hypoxia-induced pulmonary
            hypertension of rats]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 25 (1), 1-6 (2009)
   PUBMED   21186601
  REMARK    GeneRIF: HIF-1alpha, procollagen-proline dioxygenases and OS-9 are
            all involved in the pathogenesis of hypoxic pulmonary hypertension
            in rats.
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Alcock,F. and Swanton,E.
  TITLE     Mammalian OS-9 is upregulated in response to endoplasmic reticulum
            stress and facilitates ubiquitination of misfolded glycoproteins
  JOURNAL   J Mol Biol 385 (4), 1032-1042 (2009)
   PUBMED   19084021
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Bernasconi,R., Pertel,T., Luban,J. and Molinari,M.
  TITLE     A dual task for the Xbp1-responsive OS-9 variants in the mammalian
            endoplasmic reticulum: inhibiting secretion of misfolded protein
            conformers and enhancing their disposal
  JOURNAL   J Biol Chem 283 (24), 16446-16454 (2008)
   PUBMED   18417469
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Christianson,J.C., Shaler,T.A., Tyler,R.E. and Kopito,R.R.
  TITLE     OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L
            ubiquitin ligase complex for ERAD
  JOURNAL   Nat Cell Biol 10 (3), 272-282 (2008)
   PUBMED   18264092
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Litovchick,L., Friedmann,E. and Shaltiel,S.
  TITLE     A selective interaction between OS-9 and the carboxyl-terminal tail
            of meprin beta
  JOURNAL   J Biol Chem 277 (37), 34413-34423 (2002)
   PUBMED   12093806
  REMARK    GeneRIF: characterized alternatively spliced form and found that
            only the non-spliced form binds to meprin beta, suggesting the
            possible mechanism of the regulation of OS-9 function.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085907.1.
            
            On Nov 26, 2004 this sequence version replaced XM_343218.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2639
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /note="OS9, endoplasmic reticulum lectin"
                     /db_xref="GeneID:362891"
                     /db_xref="RGD:1359574"
     exon            1..191
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2030
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /note="protein OS-9; osteosarcoma amplified 9, endoplasmic
                     reticulum lectin; amplified in osteosarcoma"
                     /codon_start=1
                     /product="protein OS-9 precursor"
                     /protein_id="NP_001007266.1"
                     /db_xref="GeneID:362891"
                     /db_xref="RGD:1359574"
                     /translation="MAAEALLSSLLGLLFLGLLLPAHLTGGVGSLNLEELSEMRYGIQ
                     ILPLPVMGGQSQASDVVVVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELL
                     SPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGDVLYLGYYQSAFNWDDETAK
                     ASKQHRLKRYHSQTYGNGSKCDLNGKPREAEVRFLCDEGAGISGDYIDRVDEPFSCSY
                     VLSIRTSRLCPHPLLRPPASAAPQAILCHPALQPDEYMAYLQRQAESKQHEEKVTEEV
                     QDTDHQVWSGSKAAGAPPKKEDVSPTKEDKESEFWKMLQEPEEQATGTEEAQAGEQDL
                     NHEAAADPAPAPPTDFQNNVQVKLIRSPADLIRLIEELKGAEKGKPSVRQEQPGDDTT
                     EAPQREAEAKGKGGEPRGLVEEEDGDEEEEDEDEDEQQLLGEFEKELEGMLLPSDRER
                     LRSEVKAGMERELENIIQETEKELDPEGLRKESEREQAILALTSTLDKLIKRLQESQS
                     PELVQKYKKRRVVPQKPPPSPHPTEEEPEHRVRVRVTKLRHGGPNQDLTVLEMNRENP
                     QLKQIEGLVTEVLEREGLTAEGKIEIKIVRPGAEGKEEDTRWLTDEDTRNLKEIFFNI
                     LVQGAEEANKERQRQSELESNYRRVWGSPGGEDTGDLDEFDF"
     exon            192..368
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            369..432
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            433..509
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            510..608
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            609..819
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            820..921
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1019
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1074
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1160
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1436
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1626
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1791
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1904
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2617
                     /gene="Os9"
                     /gene_synonym="Os-9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacatctct agcagagacg aagcggaaga tggcggcgga ggcgctgctg tccagtctgt
       61 tgggattgct atttctgggg ctcctgttac ctgcgcatct gacgggcggt gtcgggagcc
      121 tgaatttgga ggagctgagt gagatgcgtt atggcatcca gatcctgccg ttgcctgtca
      181 tgggagggca gagccaagct tcagacgtgg tggttgtgtc ttcaaagtac aaacagcgct
      241 atgagtgccg cctaccagct ggagctattc acttccagcg tgaaagggag gaggagacac
      301 ctgcttacca ggggcccggg attcctgaat tgttgagccc aatgagagat gccccttgtc
      361 tgctgaagac caaggactgg tggacatatg aattctgtta tggacgccat atccagcagt
      421 accatatgga agactcggag atcaaaggtg acgtcctcta ccttggctac taccagtcag
      481 ccttcaactg ggacgatgaa acagccaagg cctccaagca gcatcggctg aaacgctacc
      541 acagccagac ctacggcaat gggtccaaat gcgatctcaa tgggaagccc agagaagctg
      601 aagttcggtt cctgtgtgac gagggcgcgg gcatatctgg ggactacatc gatcgagtag
      661 atgaaccctt ctcctgctcc tacgtactga gcattcggac atcgaggctc tgcccacacc
      721 ctctcctccg cccaccagcc agcgctgccc cacaggctat tctatgtcac ccagccctgc
      781 agcctgacga gtacatggcc tacctccaga ggcaagctga gtcaaagcag catgaagaga
      841 aagtcacaga ggaagttcag gacacagacc accaagtgtg gagtgggagc aaggctgccg
      901 gagcaccccc aaagaaagaa gatgtgagcc ccaccaagga agataaggaa tcagagtttt
      961 ggaaaatgct tcaggagcca gaggagcagg ctacaggaac agaggaagca caggcagggg
     1021 aacaggacct gaaccatgag gctgcagcag acccagctcc agcccctccc actgattttc
     1081 agaataatgt gcaggtcaaa ctcatccgga gtcctgcaga tttgattcga ttgatcgagg
     1141 agctaaaagg tgcagaaaag gggaagccaa gcgtaaggca ggagcagcct ggagatgata
     1201 ccacagaggc cccgcagagg gaagcggagg cgaagggaaa gggtggtgaa ccccggggtc
     1261 tcgtggaaga agaggatggt gacgaggagg aggaggacga ggacgaggat gagcagcagc
     1321 tcctgggaga gttcgagaag gagttggagg ggatgctgct gccctcggac cgagagcgcc
     1381 tgcgctcaga ggttaaggct ggcatggagc gcgagctgga aaacatcatc caggagacag
     1441 agaaggaact ggacccagaa gggctgagga aggagtctga gcgggagcag gcaatattgg
     1501 ctctgacatc cactctggac aaactcatca agaggctgca ggagagccag agtccagagc
     1561 ttgtccagaa atacaagaaa aggagagttg tccctcaaaa gcctccccca tcaccgcacc
     1621 ctacagagga ggagcctgag cacagagtcc gggtccgagt caccaagctc cgtcatggag
     1681 gccccaatca ggacctgact gtcctggaga tgaaccggga aaacccacag ctgaaacaga
     1741 tcgaggggct ggtgacagaa gtgctggaga gggaggggct cacggcggaa ggcaagattg
     1801 agatcaaaat tgtgcgaccc ggggctgaag gtaaggagga ggacacacgc tggctgactg
     1861 atgaggacac aagaaacctt aaggagattt tcttcaatat cttggtgcag ggagcagaag
     1921 aggccaataa agaacgccag cgacagagtg agctggagag caattaccgc cgtgtatggg
     1981 gctctccggg tggagaggat acaggggacc tggatgagtt tgacttctga gaccaccttg
     2041 ctaggccctt taaggattac tgcaacgtcc tgaccagctc tgcctcctta ccccatcctg
     2101 gggccctgga ggcaaagggc agattggaac ccagcactgg atttcagggg cccagcctga
     2161 gggtgtgtga agacccacga gggagacctg ttgcagtccc agggagccac ctaaggccac
     2221 gaccaggcta taggtttcgc tccccaaaca taccctcctt tgctccttta gcttttcctg
     2281 tcccccacct tcttagcact taaccccact ctacccagag acttgatgag accttgtgcg
     2341 tgggagtggc aggaacagca gggctgcagt ttttcagact cccaagaaag cagattccca
     2401 accccacctt gccccaccct accttgatcc ctttggttta gggagctgtt gcctctccct
     2461 tggggcccct acttcctgtc tgctgactgt ctcttgtcac tgagggaact ggagccctta
     2521 ctatcacctc acaaacaatc ccagcgaaaa gggttggaga tggcgccacc cctgttcttc
     2581 agcaatcagg tttctaaata aaagaccgga ctgtcaaaaa aaaaaaaaaa aaaaaaaaa
//
