LOCUS       NM_001413293            2035 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ORMDL sphingolipid biosynthesis regulator 3
            (Ormdl3), mRNA.
ACCESSION   NM_001413293 XM_006247345
VERSION     NM_001413293.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Siow,D., Sunkara,M., Dunn,T.M., Morris,A.J. and Wattenberg,B.
  TITLE     ORMDL/serine palmitoyltransferase stoichiometry determines effects
            of ORMDL3 expression on sphingolipid biosynthesis
  JOURNAL   J Lipid Res 56 (4), 898-908 (2015)
   PUBMED   25691431
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Breslow,D.K., Collins,S.R., Bodenmiller,B., Aebersold,R.,
            Simons,K., Shevchenko,A., Ejsing,C.S. and Weissman,J.S.
  TITLE     Orm family proteins mediate sphingolipid homeostasis
  JOURNAL   Nature 463 (7284), 1048-1053 (2010)
   PUBMED   20182505
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Hjelmqvist,L., Tuson,M., Marfany,G., Herrero,E., Balcells,S. and
            Gonzalez-Duarte,R.
  TITLE     ORMDL proteins are a conserved new family of endoplasmic reticulum
            membrane proteins
  JOURNAL   Genome Biol 3 (6), RESEARCH0027 (2002)
   PUBMED   12093374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 29, 2022 this sequence version replaced XM_006247345.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2975740.1,
                                           SRR26360172.1449993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000010.1  84092182-84092300   c
            120-318             JAXUCZ010000010.1  84088956-84089154   c
            319-470             JAXUCZ010000010.1  84088187-84088338   c
            471-2035            JAXUCZ010000010.1  84086317-84087881   c
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2035
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /note="ORMDL sphingolipid biosynthesis regulator 3"
                     /db_xref="GeneID:360618"
                     /db_xref="RGD:1560577"
     exon            1..119
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /inference="alignment:Splign:2.1.0"
     exon            120..318
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..606
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /note="ORM1-like 3; liver regeneration-related protein
                     LRRGT00183"
                     /codon_start=1
                     /product="ORM1-like protein 3"
                     /protein_id="NP_001400222.1"
                     /db_xref="GeneID:360618"
                     /db_xref="RGD:1560577"
                     /translation="MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVS
                     VPVVWTLTNLIHNLGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFL
                     TITPIVLYFLTSFYTKYDQVHFILNTVSLMSVLIPKLPQLHGVRIFGINKY"
     exon            319..470
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /inference="alignment:Splign:2.1.0"
     exon            471..2035
                     /gene="Ormdl3"
                     /gene_synonym="LRRGT00183"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattcggcca gagctgccag cggggtggcc accgccgctg gtttgttaca gctgctggag
       61 cggccgcggc ccgggttctc gggcttctct cccgggccct cgacctccgg cccagcgcga
      121 gcagcagtca agaggggtgg caggatgaat gtgggcacag cacacagtga ggtgaacccc
      181 aacactcggg tgatgaacag ccgtggcatc tggctctcct acgtgctggc catcggactc
      241 ctgcacgtcg tgctgctgag catccccttt gtgagcgtcc ccgtcgtctg gaccctcacc
      301 aaccttatcc ataacctggg catgtacatc tttctgcaca cggtgaaagg gacacccttc
      361 gagactccgg accagggcaa ggcaaggctg ctgacccact gggagcagat ggactatggg
      421 gtccagttca cagcctccag gaagttcttg accatcacgc ccattgtgct gtacttcctc
      481 accagcttct acaccaagta tgaccaagtc cacttcatac tcaacactgt gtccttgatg
      541 agtgtgctca ttcccaagct gccccagctc catggagtcc ggatctttgg aatcaataag
      601 tactgaggtt gtagcccctt ccccagccag gttggcaggg gaagggcaga aggcctttgc
      661 tgtgacgctg aagacaggag cctctggaca ctgccagaga tgggggttgc cctgggcctg
      721 gcttccccct cgcttcccca gtagccgact tggagtagct tgtagtgggg ttagggtggg
      781 gcccttgggc tctaacccat tctgaagttt ttgatctttt ccttttgcct tttgaataga
      841 gatgccatgg gggtggtcag gaaagaggcc gggctctctg gctgactgtg ggcctgagaa
      901 gttgggacag gaagccagga aaaacccctg ttggcttgtt taccctcagg cagccatagc
      961 actttagcct ccggaaaggg ggcagaagga cggtacagct tctgcattga ttgccctcag
     1021 tccttcagta tgtgaagtga gactctgttc tgtctgtatt agagccctgc gcctgctgcc
     1081 tccgcccccc agggagagag cagtcaggct ttgtggactt tcttgcaacc catgatgggt
     1141 aggctgtgga gcaggggaga ttaggaaagg aagatgggtt ggtgggacac ctggaggtgg
     1201 gggacaggat gctgccgcct tggtcctggg gagaggggag ttcagagcag gggtcgggtg
     1261 gggatagtat attgggtctt agaatggaca agatagcagc agccagtatg gatcaatgta
     1321 aaaaaagggg tctgggaggg agaagccaga ctcagcctcc ttttgagatg tgggctggaa
     1381 ggagagctgg cgttgagggt taatttaccc acagaatgat gctgatgggg aagggaggcc
     1441 tctgtgggtt tgaaacccct gggttgcatg agggtgtgca caggctggaa gaggcctgtg
     1501 agccctcaga agcagtctac tttgacactt cccttagtgg tgtgaggaag ctttcagaga
     1561 ggctcttcct taaaactcaa cttgtattct tatgtagatt gggctgggac agtgcctggt
     1621 gtgtggcttg cgtgggaatg gtcaggaggc cacttccaca tgcggtcagt ggtctccaca
     1681 gtgctaagga tccctgccca gacaaggcag tagtagggac agctgcgggc actgtctcct
     1741 cagcccagag tggcaggcag gtcatagagc ccgaggctag gccagagagg agcagtctct
     1801 cccctcgctg gttcgactgg ggcatgttcc tttggatagt gtggctgccc aagccctctc
     1861 ccgggggcca gagggaggtc actcacctgt ttcccccctg accctccttc tgaaccccat
     1921 gtatcatagg gaactttcac cttctggtct ttctaagcaa agtgtgaata ggatttttac
     1981 tccctttgta cagtattctg aacaatgcaa ataaagagca ccgtgtctgt ttcca
//
