LOCUS       NM_001134704            1157 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ORMDL sphingolipid biosynthesis regulator 1
            (Ormdl1), mRNA.
ACCESSION   NM_001134704
VERSION     NM_001134704.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Siow,D., Sunkara,M., Dunn,T.M., Morris,A.J. and Wattenberg,B.
  TITLE     ORMDL/serine palmitoyltransferase stoichiometry determines effects
            of ORMDL3 expression on sphingolipid biosynthesis
  JOURNAL   J Lipid Res 56 (4), 898-908 (2015)
   PUBMED   25691431
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Breslow,D.K., Collins,S.R., Bodenmiller,B., Aebersold,R.,
            Simons,K., Shevchenko,A., Ejsing,C.S. and Weissman,J.S.
  TITLE     Orm family proteins mediate sphingolipid homeostasis
  JOURNAL   Nature 463 (7284), 1048-1053 (2010)
   PUBMED   20182505
REFERENCE   3  (bases 1 to 1157)
  AUTHORS   Hjelmqvist,L., Tuson,M., Marfany,G., Herrero,E., Balcells,S. and
            Gonzalez-Duarte,R.
  TITLE     ORMDL proteins are a conserved new family of endoplasmic reticulum
            membrane proteins
  JOURNAL   Genome Biol 3 (6), RESEARCH0027 (2002)
   PUBMED   12093374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 31, 2017 this sequence version replaced NM_001134704.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166795.1, DN933531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000009.1  55745149-55745186   c
            39-219              JAXUCZ010000009.1  55743172-55743352   c
            220-355             JAXUCZ010000009.1  55741105-55741240   c
            356-1157            JAXUCZ010000009.1  55735355-55736156   c
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..1157
                     /gene="Ormdl1"
                     /note="ORMDL sphingolipid biosynthesis regulator 1"
                     /db_xref="GeneID:100188936"
                     /db_xref="RGD:2300146"
     exon            1..38
                     /gene="Ormdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            39..219
                     /gene="Ormdl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..414
                     /gene="Ormdl1"
                     /codon_start=1
                     /product="ORM1-like protein 1"
                     /protein_id="NP_001128176.2"
                     /db_xref="GeneID:100188936"
                     /db_xref="RGD:2300146"
                     /translation="MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVFLSIPFCS
                     VPVAWTLTNIIHNLVSPCILAGEVAQDIWCREPGTPHHRQALTEEVLRPQRESKKLQD
                     AGRRQPILATGTTDTENSDA"
     exon            220..355
                     /gene="Ormdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1157
                     /gene="Ormdl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggatttgt cctgtaacct gccaggagct ggcggccgag cagacatgaa tgttggagtt
       61 gcccacagtg aggtaaaccc caatactcgt gtaatgaata gccgtggtat gtggctgaca
      121 tatgctttgg gagttggcct gcttcacatt gtatttctca gcatcccctt ctgcagtgtt
      181 cctgttgcct ggaccttaac aaacataata cataatctgg tgtccccgtg tattcttgct
      241 ggtgaggtcg cgcaggacat ttggtgccga gaacccggga cgccacacca tcgccaggcg
      301 ctgacagagg aggtcctccg tccgcagaga gaatccaaaa agctgcagga cgcgggaaga
      361 agacaaccca ttctggctac cggaacgact gacacggaga attctgacgc ctaaaaatga
      421 ctcctggatg gatccctcgg aaactacctc tagccctcac actgcctctt tggatttgga
      481 ttcctagtac ttcaaagaat gagtgggggt ggctctgttt ggtgcagccc tatgctgtgg
      541 attagtgttc atgctatggt tggtttgcaa actcagatct caacagaaac gtgacaaggc
      601 cgttatcact caagcacttg tggccattga acaaggggcc tcccctaaaa tttggttatc
      661 tatcttcaaa aattagtcgg tatctgagtt ctctgctctt gcaccccatg gatctgtgga
      721 tccattgcac tgggatgcga gagacttaat gattctttga tcagcccttc tacatcgctg
      781 aggtttcctc attgcacgcg atagggtgat catgatttcc ccactaactc attttctggc
      841 tggcctcttt ttagagttcg ccctaggtca tttaacagtt actgtcacac agcactgcgg
      901 tatccagaga cgggcaactt tcctcatgca cagaccaatc taagacacgg ggcccagtgg
      961 cgatagggtt acccttcgac ggataaggct gtgacataga ggaacgacct aagacaggag
     1021 ccacagcaga tggacgtaac tgcagggacc tagaccagcc tagacaataa tttattgtta
     1081 ttaataaaat aataaggggg agatgtagag ggccgcaata acattcgcca ccacaagatg
     1141 gcgctggctt ccactgc
//
