LOCUS       NM_053288                769 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus orosomucoid 1 (Orm1), mRNA.
ACCESSION   NM_053288
VERSION     NM_053288.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 769)
  AUTHORS   Cheng,X., Liu,D., Xing,R., Song,H., Tian,X., Yan,C. and Han,Y.
  TITLE     Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and
            Apoptosis in Cardiomyocytes via Nrf2 Signaling
  JOURNAL   Biomed Res Int 2020, 5923572 (2020)
   PUBMED   33134382
  REMARK    GeneRIF: Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative
            Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling.
            Erratum:[Biomed Res Int. 2022 Jul 4;2022:9828942. doi:
            10.1155/2022/9828942.. PMID: 35832841]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 769)
  AUTHORS   Astrup,L.B., Skovgaard,K., Rasmussen,R.S., Iburg,T.M.,
            Agerholm,J.S., Aalbaek,B., Jensen,H.E., Nielsen,O.L.,
            Johansen,F.F., Heegaard,P.M.H. and Leifsson,P.S.
  TITLE     Staphylococcus aureus infected embolic stroke upregulates Orm1 and
            Cxcl2 in a rat model of septic stroke pathology
  JOURNAL   Neurol Res 41 (5), 399-412 (2019)
   PUBMED   30707086
  REMARK    GeneRIF: Although infarct volumes did not differ, septic embolic
            stroke caused higher mortality than sterile embolic stroke. Brain
            abscesses were observed only in the septic group. Approximately
            400-500 fold increases were observed for Orm1 and Cxcl2
            respectively in the septic group compared to the sterile group, and
            these were the most dramatically regulated genes in septic embolic
            stroke compared to sterile embolic stroke.
REFERENCE   3  (bases 1 to 769)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 769)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 769)
  AUTHORS   Lei,H., Sun,Y., Luo,Z., Yourek,G., Gui,H., Yang,Y., Su,D.F. and
            Liu,X.
  TITLE     Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5
            to Enhance Muscle Endurance
  JOURNAL   Sci Rep 6, 18839 (2016)
   PUBMED   26740279
  REMARK    GeneRIF: fatigue upregulates the level of ORM1, which in turn
            functions as an anti-fatigue protein to enhance muscle endurance
            via the CCR5 pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 769)
  AUTHORS   Chauvelot-Moachon,L., Delers,F., Pous,C., Engler,R., Tallet,F. and
            Giroud,J.P.
  TITLE     Alpha-1-acid glycoprotein concentrations and protein binding of
            propranolol in Sprague-Dawley and Dark Agouti rat strains treated
            by phenobarbital
  JOURNAL   J Pharmacol Exp Ther 244 (3), 1103-1108 (1988)
   PUBMED   3252025
REFERENCE   7  (bases 1 to 769)
  AUTHORS   Liao,Y.C., Taylor,J.M., Vannice,J.L., Clawson,G.A. and
            Smuckler,E.A.
  TITLE     Structure of the rat alpha 1-acid glycoprotein gene
  JOURNAL   Mol Cell Biol 5 (12), 3634-3639 (1985)
   PUBMED   2943986
REFERENCE   8  (bases 1 to 769)
  AUTHORS   Reinke,R. and Feigelson,P.
  TITLE     Rat alpha 1-acid glycoprotein. Gene sequence and regulation by
            glucocorticoids in transfected L-cells
  JOURNAL   J Biol Chem 260 (7), 4397-4403 (1985)
   PUBMED   3838547
REFERENCE   9  (bases 1 to 769)
  AUTHORS   Ricca,G.A. and Taylor,J.M.
  TITLE     Nucleotide sequence of rat alpha 1-acid glycoprotein messenger RNA
  JOURNAL   J Biol Chem 256 (21), 11199-11202 (1981)
   PUBMED   6270146
REFERENCE   10 (bases 1 to 769)
  AUTHORS   Ricca,G.A., Hamilton,R.W., McLean,J.W., Conn,A., Kalinyak,J.E. and
            Taylor,J.M.
  TITLE     Rat alpha 1-acid glycoprotein mRNA. Cloning of double-stranded cDNA
            and kinetics of induction of mRNA levels following acute
            inflammation
  JOURNAL   J Biol Chem 256 (20), 10362-10368 (1981)
   PUBMED   6169718
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J00696.1.
            
            On Aug 30, 2012 this sequence version replaced NM_053288.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J00696.1, V01216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-769               J00696.1           2-770
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..769
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /note="orosomucoid 1"
                     /db_xref="GeneID:24614"
                     /db_xref="RGD:67390"
     exon            1..152
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..653
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /note="alpha-1-acid glycoprotein"
                     /codon_start=1
                     /product="alpha-1-acid glycoprotein precursor"
                     /protein_id="NP_445740.1"
                     /db_xref="GeneID:24614"
                     /db_xref="RGD:67390"
                     /translation="MALHMVLVVLSLLPLLEAQNPEPANITLGIPITNETLKWLSDKW
                     FYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQR
                     ENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQ
                     QAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP"
     exon            153..295
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
     exon            296..366
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
     exon            367..471
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
     exon            472..575
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
     exon            576..769
                     /gene="Orm1"
                     /gene_synonym="AAG; AGP; Agpa1; OMD; Orm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcctgg gccggtgcct ctgagtgtct tcggcatggc gctgcacatg gttcttgtcg
       61 ttttgagcct cctgcccttg ttggaagctc agaacccaga acctgccaac atcaccctag
      121 gcatacctat taccaatgag accctgaaat ggctctcaga caaatggttt tacatgggag
      181 cagctttccg agaccccgtg ttcaagcagg cagttcaaac gatacagacg gaatattttt
      241 accttacccc caacttgata aacgacacaa ttgaacttcg ggagtttcag accacagacg
      301 accagtgtgt ctataacttc acccatctag gagtccagag agagaatggg accttatcca
      361 agtgtgcagg agcagtgaaa atctttgccc atttgatagt gctgaagaaa catgggacct
      421 tcatgcttgc ctttaacctg acagatgaga accgggggct gtccttctat gctaaaaagc
      481 cagacttgtc cccagagctg cggaaaatat tccagcaggc tgtcaaagat gtgggcatgg
      541 atgaatcaga aatcgtattt gtcgactgga caaaggataa gtgcagtgag cagcagaagc
      601 agcagctgga gctggagaag gagactaaga aggagaccaa gaaggatcct taggccaagc
      661 atgaactcag ctctctgaac tccggggact gtccccatgc ccactctacc cccactcctg
      721 tgcacctcga ttctattttc cacaataata aaggtttggt taaacaatc
//
