LOCUS       NM_199092               1755 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Rattus norvegicus origin recognition complex, subunit 4 (Orc4),
            mRNA.
ACCESSION   NM_199092 XM_215731
VERSION     NM_199092.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Bronze-da-Rocha,E., Lin,C.M., Shimura,T. and Aladjem,M.I.
  TITLE     Interactions of MCP1 with components of the replication machinery
            in mammalian cells
  JOURNAL   Int J Biol Sci 7 (2), 193-208 (2011)
   PUBMED   21383955
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Shen,Z., Sathyan,K.M., Geng,Y., Zheng,R., Chakraborty,A.,
            Freeman,B., Wang,F., Prasanth,K.V. and Prasanth,S.G.
  TITLE     A WD-repeat protein stabilizes ORC binding to chromatin
  JOURNAL   Mol Cell 40 (1), 99-111 (2010)
   PUBMED   20932478
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Siddiqui,K. and Stillman,B.
  TITLE     ATP-dependent assembly of the human origin recognition complex
  JOURNAL   J Biol Chem 282 (44), 32370-32383 (2007)
   PUBMED   17716973
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Springer,J., Kneissl,M., Putter,V. and Grummt,F.
  TITLE     Identification and characterization of MmORC4 and MmORC5, two
            subunits of the mouse origin of replication recognition complex
  JOURNAL   Chromosoma 108 (4), 243-249 (1999)
   PUBMED   10460412
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Quintana,D.G., Hou,Zh., Thome,K.C., Hendricks,M., Saha,P. and
            Dutta,A.
  TITLE     Identification of HsORC4, a member of the human origin of
            replication recognition complex
  JOURNAL   J Biol Chem 272 (45), 28247-28251 (1997)
   PUBMED   9353276
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Langnaese,K., Seidenbecher,C., Wex,H., Seidel,B., Hartung,K.,
            Appeltauer,U., Garner,A., Voss,B., Mueller,B., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Protein components of a rat brain synaptic junctional protein
            preparation
  JOURNAL   Brain Res Mol Brain Res 42 (1), 118-122 (1996)
   PUBMED   8915587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060516.1.
            
            [WARNING] On Apr 29, 2024 this sequence was replaced by
            NM_199092.2.
            
            On Jan 1, 2004 this sequence version replaced XM_215731.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060516.1, SRR8487227.300530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..1755
                     /gene="Orc4"
                     /note="origin recognition complex, subunit 4"
                     /db_xref="GeneID:295596"
                     /db_xref="RGD:735212"
     exon            1..102
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            103..169
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1423
                     /gene="Orc4"
                     /codon_start=1
                     /product="origin recognition complex subunit 4"
                     /protein_id="NP_954523.1"
                     /db_xref="GeneID:295596"
                     /db_xref="RGD:735212"
                     /translation="MSNRKSKNNIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKH
                     LIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQ
                     TNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFD
                     LFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNS
                     FDFPQYLKIFKEQLSLPAEFPDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQS
                     LHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHLN
                     DIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVN
                     SQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL"
     exon            170..246
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            247..337
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            338..413
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..499
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            500..548
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            549..700
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            701..874
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            875..961
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1070
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1166
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1234
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1647
                     /gene="Orc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggctgcc gcaggtgaaa cagagctggg aaggcggtga acaatcctgg gtccttacag
       61 tcggcggagg ctgcccgatt taggcaggct ttattgagag agatttgagt tagtcaagat
      121 gagcaatcgt aaaagcaaga ataacataca tgcagagtgt ctttcccagg tacaaagaat
      181 tttacgtgaa aggttttgtc atcatactcc tcatagcaac ctatttggag tgcaagtaca
      241 atacaagcat ttaattgagc tactcaaaag aactgctatc tatggagaaa gtaattcttt
      301 actcattgtt ggaccacgag gatcaggaaa gaccacgtta ttaaatcatg ccttgaaaga
      361 gctcatgcaa ataggagaca tgagtgaaaa tgtgttacaa gttcacttaa atggactgct
      421 acagacaaat gataaaattg ctctgaaaga gatcacaaga caattaaatc tagaaaatgt
      481 agttggagat aaagtttttg gaagctttgc tgaaaacctt tcgtttcttc tggaagcttt
      541 gcagaaaggt aaccggacta gcagttgccc agtgatcttc atactggatg aatttgatct
      601 ttttgctcat cagaaaaacc aaacactcct ttataatctt tttgacattt ctcaatctgc
      661 acagacacca atagcagtta ttggccttac atgtagactg gatattttgg aactcttaga
      721 aaagagagtg aagtcacgat tttctcaccg gcagatacat ttaatgaatt catttgattt
      781 tccgcaatat ttgaaaatat ttaaagaaca attatctcta cctgcagaat tcccagataa
      841 gatttttgct gagaaatgga atgagaatgc tcattgtctc tccgaagatt caactgtgct
      901 tgaagttcta cagaagcatt tcaatgtcaa caaaaacttg caatcattac atatgctatt
      961 gatgcttgct ttaaatcgag taaccgtgac acacccattt atgacctcag cagatctgat
     1021 ggaggcgcag cacttgtgta gcttggatgc caaagcgagt attgtacatg gtctgtcagt
     1081 cttggaaatc tgtcttataa tagcaatgaa acatttaaat gacatatatg aagaggagcc
     1141 ctttaatttt caaatggtgt ataatgaatt tcagaaattc attcaaagaa aggcccattc
     1201 tgtttataac tttgagaaac ctgtggtcat gaaggcattt gagcacttac aacaattgga
     1261 attaataaaa cccatggaaa gaacctcagt caattctcag agagaatacc agctagtcaa
     1321 actacttttg gataatactc agattatgaa tgccctacag aaatactcca actgccctac
     1381 agatgtcagg cagtgggcaa catcctcgct cagctggctg tgaagatttt aagtacattt
     1441 ctgtgaagac ctaaaactag tgttctttaa taagatacgc tactacatta ctttgtttat
     1501 aaatattgtt tatgggaaac ctgcacttag tatcttgact atgttttgaa tattgactgt
     1561 gcatggacag tttcattaat ttaaattaca ccatacaagt aacaattcaa aataataaaa
     1621 tgtgcttatt ttacgggtga tccataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaa
//
