LOCUS       NM_001025282            2154 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus origin recognition complex, subunit 3 (Orc3),
            mRNA.
ACCESSION   NM_001025282 XM_232883
VERSION     NM_001025282.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Coulombe,P., Nassar,J., Peiffer,I., Stanojcic,S., Sterkers,Y.,
            Delamarre,A., Bocquet,S. and Mechali,M.
  TITLE     The ORC ubiquitin ligase OBI1 promotes DNA replication origin
            firing
  JOURNAL   Nat Commun 10 (1), 2426 (2019)
   PUBMED   31160578
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Ma,S., Kwon,H.J., Johng,H., Zang,K. and Huang,Z.
  TITLE     Radial glial neural progenitors regulate nascent brain vascular
            network stabilization via inhibition of Wnt signaling
  JOURNAL   PLoS Biol 11 (1), e1001469 (2013)
   PUBMED   23349620
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Kwon,H.J., Ma,S. and Huang,Z.
  TITLE     Radial glia regulate Cajal-Retzius cell positioning in the early
            embryonic cerebral cortex
  JOURNAL   Dev Biol 351 (1), 25-34 (2011)
   PUBMED   21185282
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Cappuccio,I., Colapicchioni,C., Santangelo,V., Sale,P.,
            Blandini,F., Bonelli,M., Niccolini,C., Busceti,C., Bucci,D.,
            Nicoletti,F. and Melchiorri,D.
  TITLE     The origin recognition complex subunit, ORC3, is developmentally
            regulated and supports the expression of biochemical markers of
            neuronal maturation in cultured cerebellar granule cells
  JOURNAL   Brain Res 1358, 1-10 (2010)
   PUBMED   20674557
  REMARK    GeneRIF: The data of this study suggested that ORC3 supports
            neuronal maturation by inhibiting the Rho signaling pathway, and
            mediates the differentiating activity of mGlu4 receptors in
            cultured cerebellar granule cells.
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Shen,Z., Sathyan,K.M., Geng,Y., Zheng,R., Chakraborty,A.,
            Freeman,B., Wang,F., Prasanth,K.V. and Prasanth,S.G.
  TITLE     A WD-repeat protein stabilizes ORC binding to chromatin
  JOURNAL   Mol Cell 40 (1), 99-111 (2010)
   PUBMED   20932478
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Siddiqui,K. and Stillman,B.
  TITLE     ATP-dependent assembly of the human origin recognition complex
  JOURNAL   J Biol Chem 282 (44), 32370-32383 (2007)
   PUBMED   17716973
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB219142.1.
            
            On Jul 13, 2005 this sequence version replaced XM_232883.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB219142.1, SRR8487227.334061.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..2154
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /note="origin recognition complex, subunit 3"
                     /db_xref="GeneID:313138"
                     /db_xref="RGD:1308457"
     CDS             1..2136
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /codon_start=1
                     /product="origin recognition complex subunit 3"
                     /protein_id="NP_001020453.1"
                     /db_xref="GeneID:313138"
                     /db_xref="RGD:1308457"
                     /translation="MATSSVSKGCFVFKPDFKKRKISVPIEDYFNNEELDSEDSKLRF
                     ETYRLLWQRIKSETEQLQEGLNENLFDNLVDFLQKSHSEFQKNSGNWGSQMRLREIPT
                     AALILGVNVTDHDVIFRSLTETLHNNVTPYVVSLQAKDCPDVKHFLQKLTSELIDCCV
                     DRNSKEEKNDKALRRTSYSMDSLSSWYSTVAQKTGPKMTSKKRATCSQWQSPPVVLIL
                     KNMESFSTKVLQDFIIISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCIELFQ
                     SLSCKEHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSIQNFIKGLKLSLLEH
                     FYSQPLSVLCCDLSEAKKRINVFSVNQCEKIRRLPSFRRYVENQPLEKQVALLTNETF
                     LKEETQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWDSE
                     EYESALQLLRMLAKDELMGILEQCVKVLNSSTEKQLSNTAQKIKGFLTQFQNLDDSKE
                     EEDACGSQPKGLQKTDLYHLQKSLLEMKELRRTTKKPTKFEMLRENVINFIDNLVRDY
                     LLPPEGQPLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPS
                     VAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDTNSTVSEEMSEIIHARFIR
                     AVSELELLGFIKPTKQKTDHVARLTWGGC"
     exon            1..24
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            25..79
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            80..177
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            178..322
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            323..427
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            428..576
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            577..710
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            711..870
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            871..984
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1118
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1182
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1299
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1379
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1513
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1590
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1691
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1833
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1950
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2030
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2154
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccacct cctccgtgtc caagggctgt tttgtgttta aaccagactt caaaaaaaga
       61 aagatctctg tgccaataga ggactatttt aataatgagg aacttgactc agaagacagt
      121 aaacttcgat ttgaaacata tcgcttgcta tggcaacgga taaaatctga aacagagcaa
      181 ttacaggagg gattaaatga aaatctgttt gataacctag ttgactttct gcagaagtcc
      241 cattctgaat ttcagaaaaa ttcaggaaac tggggctctc agatgagact cagagaaatt
      301 ccaacagctg ctcttattct tggcgtgaac gtcacagatc atgacgtgat attcaggagt
      361 ctaacagaga cccttcacaa taatgtcaca ccgtatgtcg tctccctgca agctaaggat
      421 tgtccagatg tgaaacattt tttacagaag ttgacctctg agttgataga ctgctgtgta
      481 gatagaaatt ccaaggagga gaaaaatgac aaagccctga ggaggaccag ttattccatg
      541 gattcgcttt ctagttggta ttcgacggtt gcacagaaga caggccccaa aatgacaagc
      601 aaaaagagag cgacttgtag ccaatggcag tcccctcctg tggtgcttat cttaaagaac
      661 atggagagtt tcagcacaaa agtactgcag gacttcataa ttatcagcag tcagcatctg
      721 catgagtttc ctctaattct catttttggg atcgccacat ctcctgttat tatccaccga
      781 ctgcttcctc attcagtgtc atctctgttg tgtatagaac tgttccagtc tctgtcttgc
      841 aaggaacacc tgacagtagt tcttgataag ctgcttctta cccctcagtt tccctttaaa
      901 ttgagtaaaa aggcattaca agttctgacc aacatctttt tgtatcatga tttctcaatt
      961 caaaacttca tcaaaggact taagctttct ctactagaac atttttattc tcagccccta
     1021 agtgttctgt gctgtgatct ctcagaagcc aaaaaaagaa taaatgtttt ctcagtcaat
     1081 caatgtgaaa aaatccggcg ccttccttca tttaggaggt acgtggaaaa tcaacctttg
     1141 gaaaagcaag ttgcactgtt gaccaatgag acctttttaa aggaggaaac gcaatcattg
     1201 ttggaagacc tgcatgttta ccatatcaat tacttccttg ttttgagatg tcttcataat
     1261 tttacctctt ctcttcccaa gtacccactg ggtcgacaga ttagggagct gtattgtaca
     1321 tgtttggaaa agaagatatg ggattcggag gagtacgaat cagccttgca gttgctgaga
     1381 atgctggcaa aggacgaact gatgggcata cttgagcagt gtgttaaggt tttgaattcc
     1441 tctactgaaa agcagcttag caacacagca cagaaaataa agggcttcct gacccagttt
     1501 cagaaccttg atgatagcaa agaggaagag gatgcttgtg gttcacagcc aaaggggctg
     1561 cagaagacgg acctgtacca ccttcagaag tccttactgg aaatgaaaga gctaaggaga
     1621 acaactaaga agccaaccaa gtttgaaatg ctcagagaaa atgttataaa cttcatcgac
     1681 aacctggtga gagactacct tctgcctccc gagggccagc ctctgcatga ggtagtgtac
     1741 ttcagtgctg ccaacacact ccgagagcac ttaaatgctg ctccaagaat cgccctccac
     1801 actgcactca acaaccctta ctattaccta aagaatgaag cattgaaaag tgaggaaggc
     1861 tgcattccaa gtgttgcccc tgacatctgc atagcatata aactgcacct ggagtgtagt
     1921 cggctgatta accttgtcga ctggtcagag gcttttgcaa cagttgtgac agctgctgag
     1981 aaaatggata caaattctac agtctccgaa gaaatgagtg aaatcatcca tgctcgattt
     2041 attagagctg tttctgaatt agaactttta ggctttataa aacctacgaa acagaagact
     2101 gaccatgttg caaggctcac atggggaggc tgctaaaaag caaatgtgtg aaga
//
