LOCUS       NM_001012003            1821 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus origin recognition complex, subunit 2 (Orc2),
            mRNA.
ACCESSION   NM_001012003 XM_217403
VERSION     NM_001012003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Bronze-da-Rocha,E., Lin,C.M., Shimura,T. and Aladjem,M.I.
  TITLE     Interactions of MCP1 with components of the replication machinery
            in mammalian cells
  JOURNAL   Int J Biol Sci 7 (2), 193-208 (2011)
   PUBMED   21383955
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Shen,Z., Sathyan,K.M., Geng,Y., Zheng,R., Chakraborty,A.,
            Freeman,B., Wang,F., Prasanth,K.V. and Prasanth,S.G.
  TITLE     A WD-repeat protein stabilizes ORC binding to chromatin
  JOURNAL   Mol Cell 40 (1), 99-111 (2010)
   PUBMED   20932478
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Ishii,H., Inageta,T., Mimori,K., Saito,T., Sasaki,H., Isobe,M.,
            Mori,M., Croce,C.M., Huebner,K., Ozawa,K. and Furukawa,Y.
  TITLE     Frag1, a homolog of alternative replication factor C subunits,
            links replication stress surveillance with apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 102 (27), 9655-9660 (2005)
   PUBMED   15983387
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Dannenberg,J.H., David,G., Zhong,S., van der Torre,J., Wong,W.H.
            and Depinho,R.A.
  TITLE     mSin3A corepressor regulates diverse transcriptional networks
            governing normal and neoplastic growth and survival
  JOURNAL   Genes Dev 19 (13), 1581-1595 (2005)
   PUBMED   15998811
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Prasanth,S.G., Prasanth,K.V., Siddiqui,K., Spector,D.L. and
            Stillman,B.
  TITLE     Human Orc2 localizes to centrosomes, centromeres and
            heterochromatin during chromosome inheritance
  JOURNAL   EMBO J 23 (13), 2651-2663 (2004)
   PUBMED   15215892
  REMARK    Erratum:[EMBO J. 2005 Mar 9;24(5):1092-4]
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Geng,Y., Yu,Q., Sicinska,E., Das,M., Schneider,J.E.,
            Bhattacharya,S., Rideout,W.M., Bronson,R.T., Gardner,H. and
            Sicinski,P.
  TITLE     Cyclin E ablation in the mouse
  JOURNAL   Cell 114 (4), 431-443 (2003)
   PUBMED   12941272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB164704.1.
            
            On Feb 11, 2005 this sequence version replaced XM_217403.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB164704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1821
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /note="origin recognition complex, subunit 2"
                     /db_xref="GeneID:301430"
                     /db_xref="RGD:1311844"
     exon            1..51
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            52..155
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1792
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /codon_start=1
                     /product="origin recognition complex subunit 2"
                     /protein_id="NP_001012003.1"
                     /db_xref="GeneID:301430"
                     /db_xref="RGD:1311844"
                     /translation="MSTLRLKEAKVPSVQFVGDDDVLSHILDREGGTKLKKEKVQLLV
                     NPQKVIKKAECELEKSDLEVLEDQNYVEVLGRNIQESLGNGSAVDGRNKVYSFQHRKH
                     PEEMTKLALELAKTSGKIDPLASNDPKITKNIARKSKGHSSEKAPLENNNKNEFPSIQ
                     PHNVRKRLIASRSHCDSESEYSASSSEDDEEVAKDDEEDTNVVRCSKKSQGQNRLLPA
                     PVSKEILPKKRKRDKAGDLVEEYFEAHSSSKVLTSDRTLQKLRRARVDQKTLRNLLSK
                     FVPSFSTEIGQLNQQHERLFDKWILQLRLGFNIVLYGLGSKRDLLEKFRTTMLQDSIH
                     VVINGFFPGISVKSILNSITEDVLSHMGTFQSVLDQRDWIMNRFKEDSSLELFLLIHN
                     LDSQMLRGDNSQQILGQLSSLRNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYS
                     PYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKYQLDNQDCPSYIG
                     LSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGTLAD
                     FLEKEEEEES"
     exon            156..299
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            300..389
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            390..479
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            480..508
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            509..569
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            570..763
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            764..862
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            863..972
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1105
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1202
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1349
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1521
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1583
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1702
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1821
                     /gene="Orc2"
                     /gene_synonym="Orc2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttacaggt gactggatgg tcaagccgca gaatgcctag caccttacaa ggttggccac
       61 aatgagcaca ctgcggttaa aggaagccaa ggtgccaagc gttcagtttg tgggagatga
      121 cgatgttctt agtcacattc tggatagaga aggaggaact aaattaaaga aggagaaagt
      181 tcagcttttg gtcaatcccc agaaagtaat aaagaaggca gaatgtgaat tagagaaaag
      241 tgacctggaa gtcttagagg atcagaacta cgtggaagtc ttgggaagaa atattcaaga
      301 atccttggga aatggctctg ctgtagatgg taggaataaa gtttattctt ttcaacacag
      361 aaaacaccct gaagagatga ctaaattggc tttagaactg gcaaaaacat caggaaaaat
      421 tgatccactt gcctcaaacg atcctaaaat cacgaaaaac attgctcgaa aaagcaaagg
      481 gcattcttca gagaaagctc cgctggagaa caataacaaa aatgaatttc cgtcaataca
      541 acctcataat gtaagaaaaa gattaatagc atcaaggtct cattgtgaca gtgaaagtga
      601 atattctgct tccagctcag aagatgatga agaggttgca aaagacgatg aagaagacac
      661 taatgtggtc aggtgctcga aaaagagtca aggtcagaat agactacttc cagctcctgt
      721 ttccaaagag atactgccca agaaaaggaa gagagacaaa gcaggtgact tggtagaaga
      781 atattttgaa gcccacagta gttcaaaagt cttaacgtct gatagaacgc tgcagaagct
      841 gaggagagcg agagtggacc agaaaactct gcgtaactta ctgagcaaat ttgtgccttc
      901 cttttctact gaaattggac agttgaatca acagcatgag agattgtttg ataagtggat
      961 actacagtta cgccttgggt tcaacattgt gctttatggt ttggggtcta agagagattt
     1021 actagaaaag tttcgaacta ccatgcttca agattccatt catgttgtca tcaacggctt
     1081 ctttcctggc atcagtgtaa aatcaatcct gaactctata actgaagatg tcctcagtca
     1141 catgggtact ttccaaagtg ttctggatca gcgagactgg ataatgaaca gatttaaaga
     1201 agattcttct ttagaactct ttcttcttat ccacaatttg gatagccaga tgttaagagg
     1261 agacaatagc cagcaaattc ttggacagtt gtcatcctta cgtaatgtgt atctcatagc
     1321 atctatcgac cacctcaatg ctcctctcat gtgggatcat gcaaagcaga gtctgtacaa
     1381 ttggctgtgg tatgaaacca ctacatacag tccttacacc gaagaaacct cctatgagaa
     1441 ctcccttttg gttaaacagt ctggatctct accactgagt tctctgattc atgtcttacg
     1501 aagccttaca cccaatgcaa gggggatttt caggctactt atgaagtacc aactggataa
     1561 ccaggactgc ccttcctaca ttggactttc ttttcaagat ttttaccagc agtgtcggga
     1621 agcattcctt gttaacagtg atctcacact ccgagcccag ttaactgaat ttagggacca
     1681 caaacttata agaacgaaga agggaactga tggtgtggag tatttattaa ttcctgttga
     1741 cagcggaaca ttggccgatt tcttggagaa ggaggaggag gaggagtcgt agactgtctc
     1801 ttacccttga accttatgtg g
//
