LOCUS       NM_177931               2560 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus origin recognition complex, subunit 1 (Orc1),
            mRNA.
ACCESSION   NM_177931
VERSION     NM_177931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Shen,Z., Sathyan,K.M., Geng,Y., Zheng,R., Chakraborty,A.,
            Freeman,B., Wang,F., Prasanth,K.V. and Prasanth,S.G.
  TITLE     A WD-repeat protein stabilizes ORC binding to chromatin
  JOURNAL   Mol Cell 40 (1), 99-111 (2010)
   PUBMED   20932478
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Shu,M.Q., Qin,Y.L. and Jiang,M.H.
  TITLE     RNA interference targeting ORC1 gene suppresses the proliferation
            of vascular smooth muscle cells in rats
  JOURNAL   Exp Mol Pathol 84 (3), 206-212 (2008)
   PUBMED   18499104
  REMARK    GeneRIF: ORC1 gene silencing causes rat VSMCs to enter a reversible
            G(0) quiescent, growth arrested state; thus, ORC1 gene may be an
            important new target for suppressing VSMCs proliferation.
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Siddiqui,K. and Stillman,B.
  TITLE     ATP-dependent assembly of the human origin recognition complex
  JOURNAL   J Biol Chem 282 (44), 32370-32383 (2007)
   PUBMED   17716973
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Minami,H., Takahashi,J., Suto,A., Saitoh,Y. and Tsutsumi,K.
  TITLE     Binding of AlF-C, an Orc1-binding transcriptional regulator,
            enhances replicator activity of the rat aldolase B origin
  JOURNAL   Mol Cell Biol 26 (23), 8770-8780 (2006)
   PUBMED   16982680
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Miyake,Y., Mizuno,T., Yanagi,K. and Hanaoka,F.
  TITLE     Novel splicing variant of mouse Orc1 is deficient in nuclear
            translocation and resistant for proteasome-mediated degradation
  JOURNAL   J Biol Chem 280 (13), 12643-12652 (2005)
   PUBMED   15634681
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Natale,D.A., Li,C.J., Sun,W.H. and DePamphilis,M.L.
  TITLE     Selective instability of Orc1 protein accounts for the absence of
            functional origin recognition complexes during the M-G(1)
            transition in mammals
  JOURNAL   EMBO J 19 (11), 2728-2738 (2000)
   PUBMED   10835370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB105378.1.
            
            On Jun 3, 2003 this sequence version replaced NM_177931.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2560
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="origin recognition complex, subunit 1"
                     /db_xref="GeneID:313479"
                     /db_xref="RGD:631435"
     CDS             1..2547
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /codon_start=1
                     /product="origin recognition complex subunit 1"
                     /protein_id="NP_808792.1"
                     /db_xref="GeneID:313479"
                     /db_xref="RGD:631435"
                     /translation="MPSYVTRQKTRQTFSWVGRPLPNRKQFYQMYKEICMKINGCSEI
                     HIKVGQFVLIQGEDNQKPYVAKLIELFENGSEVPPKKYARVQWFVRFCEIPIPKRHLL
                     GRRPSAQEIFWYDCSDCDNDIHVETIIGPVQVVALAPEDEIPVNQKSEETLFVKLSWN
                     KKNFAPLPPEELAALRRLECQKPLEAKTKSVKSPSWSTAEQEVKRIESSHSTSRSYQD
                     PAHTVTPNAMKSLECGGFTRKPNMRLSRKILCDSLDSQKTCKRRAAFSETTSPPKKPQ
                     PGEIKTSSALETLGKNGHTQPFFAKSSMVLRTRGTAVKTTKLTVESALSPVRSRSRYS
                     VAPSVGLTPQYIGRKAKEQETHKEPIHTSLRARRRSSLLTLKRIKQQLWLLDDDKSDQ
                     EEEESISSVEVSDSSSEEEDESVPSPPTGKPVGQSRTRRTASKPSSQTPSKSPKKTFR
                     PRPPLHATPQIRDRNLAVQEPASVLEEARLRLHVSAVPDSLPCREQEFQDIYSFVESK
                     LLDGTGGCMYISGVPGTGKTATVHEVIRCLQQAAQTNDVPPFEYVEVNGMKLTEPHQV
                     YVQILQKLTGQKATANHAAELLAKQFCSRGSQKETTVLLVDELDLLWTHKQDVLYNLF
                     DWPTHKGARLVVLTIANTMDLPERIMMNRVASRLGLTRMSFQPYSHSQLKQILVSRLK
                     HLKAFEDDAVQLVARKVAALSGDARRCLDICRRATEICEVSHQRGDSQCLVTVAHLME
                     AIDEMFSSSYITAIKNSSVLEQSFLRAIIAEFRRSGLEEATFQQIYSQHVALCRMEGL
                     PYPTMSETMAVCSRLGSCRILLVEPSRNDLLLRVRLNVSQNDVLYALKEE"
     exon            1..95
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            96..220
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            221..399
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            400..703
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1043
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1148
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1344
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1442
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1544
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1716
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1824
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1974
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2094
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2264
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2352
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2560
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccgtcct atgtcacaag gcagaagacc agacaaactt tctcatgggt tggcaggcca
       61 ttgccgaatc gaaaacagtt ctaccaaatg tacaaagaaa tttgtatgaa aatcaatggt
      121 tgttctgaga ttcacatcaa ggttggacag tttgtattga ttcaagggga agataatcaa
      181 aagccctatg ttgctaaact gattgaatta tttgaaaatg ggtctgaagt tcctcccaag
      241 aaatatgcgc gagtacaatg gtttgtccga ttctgtgaga ttcctatccc taaaaggcat
      301 ttgttaggac ggagaccttc tgcacaggag atattctggt atgactgttc tgactgtgat
      361 aacgacattc atgtggagac catcattggc cctgttcagg tagtggcatt agccccagaa
      421 gacgagatcc ctgtgaatca gaaaagtgag gagacactgt ttgtgaagct gtcctggaat
      481 aaaaagaact ttgcgccact gccaccagaa gaacttgcag cattgaggag actggagtgc
      541 caaaaacctt tagaagccaa gactaagagt gttaaaagcc cttcctggag cacagcagaa
      601 caagaggtca aaaggattga atcaagtcat tccacttcca gatcttacca ggatcctgct
      661 catactgtca ctcccaacgc aatgaagtct ctggaatgtg gtggttttac caggaagcct
      721 aacatgaggc tgtcacggaa gatcttgtgt gattccttgg attctcaaaa aacatgtaaa
      781 cgaagagcag ccttctctga gaccacctca ccacctaaaa agcctcaacc tggtgaaatc
      841 aagacctcct cagctttgga aactctagga aaaaatgggc atactcaacc cttttttgcc
      901 aaaagtagca tggttctgag aacccggggc acagctgtga agaccacaaa gcttactgtg
      961 gagagtgcac ttagccctgt caggagcagg tcgaggtact cagtggcacc ctctgtgggt
     1021 ctgacacctc aatacattgg gaggaaggca aaagaacaag aaactcacaa agaacccatc
     1081 catacttctc ttcgtgcccg tagaaggagt tctctcttga ctttgaagcg gattaagcaa
     1141 cagctttggc ttctagatga tgataaaagt gaccaagaag aggaagagtc catatcctct
     1201 gtggaagtgt cagactccag tagtgaggag gaagatgagt ctgttccctc ccctccaaca
     1261 ggaaaacccg tggggcagtc caggacccgg agaactgcct ctaagccatc atcacagacc
     1321 ccctccaagt caccaaagaa aacttttaga cctagaccac ctcttcatgc tactcctcag
     1381 atccgagaca gaaacttggc tgtccaagag ccagctagtg tgcttgaaga ggcccggctc
     1441 aggctgcatg tttctgccgt gcctgactct cttccctgtc gagagcagga gttccaagac
     1501 atctacagct ttgtggaaag taaacttctt gatggaaccg gagggtgtat gtacatttct
     1561 ggggtccctg ggacagggaa gacagccact gtgcatgaag tcatacgctg tctgcagcag
     1621 gcagcacaaa caaatgatgt tcctcccttt gaatacgttg aggttaatgg gatgaagctg
     1681 acagaacccc accaggtcta tgtgcagatt ttacagaaac tgacaggcca gaaggcaaca
     1741 gctaatcatg cagcagaact gctggcaaag caattctgca gccgagggtc ccagaaggaa
     1801 accactgtgc tgcttgtgga tgagcttgac cttctttgga ctcacaaaca agatgtgttg
     1861 tacaacctct ttgattggcc tactcacaaa ggagcccggt tggtcgtgtt gactattgcc
     1921 aataccatgg accttccaga gaggatcatg atgaaccgtg tggctagccg cctgggcctc
     1981 accaggatgt ctttccaacc ctactctcac agccaactga aacaaatctt agtgtcccga
     2041 ctgaagcatt taaaggcctt tgaggatgat gccgtccagt tggtagccag aaaggtagca
     2101 gccctttctg gagatgcccg gcgctgcctg gacatctgca ggcgtgccac agagatctgc
     2161 gaggtttccc atcagcgtgg tgactctcag tgcctggtga ctgtggccca cttaatggaa
     2221 gctatagatg aaatgttttc ctcatcctat attactgcca tcaaaaactc ttctgtcctg
     2281 gaacagagct tcctgagagc catcattgcg gaattccgtc gatcaggact ggaggaagct
     2341 acatttcaac agatatacag tcagcatgtg gctctgtgca gaatggaggg actgccttac
     2401 ccaaccatgt cagagaccat ggccgtgtgc tcgcgtctgg gttcttgccg cattcttctg
     2461 gtggagccta gcaggaatga cctactcctt cgagtgagac tcaatgttag ccagaatgat
     2521 gtgctgtatg ctctcaaaga agagtgaagg acttaacaaa
//
