LOCUS       NM_001014024            1824 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus ORAI calcium release-activated calcium modulator
            3 (Orai3), mRNA.
ACCESSION   NM_001014024 XM_219357
VERSION     NM_001014024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Angulo,J., Fernandez,A., Sevilleja-Ortiz,A., Sanchez-Ferrer,A.,
            Rodriguez-Manas,L. and El Assar,M.
  TITLE     Upregulation of Orai Channels Contributes to Aging-Related Vascular
            Alterations in Rat Coronary Arteries
  JOURNAL   Int J Mol Sci 24 (17), 13402 (2023)
   PUBMED   37686206
  REMARK    GeneRIF: Upregulation of Orai Channels Contributes to Aging-Related
            Vascular Alterations in Rat Coronary Arteries.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Wu,Q., Fang,Y., Huang,X., Zheng,F., Ma,S., Zhang,X., Han,T., Gao,H.
            and Shen,B.
  TITLE     Role of Orai3-Mediated Store-Operated Calcium Entry in
            Radiation-Induced Brain Microvascular Endothelial Cell Injury
  JOURNAL   Int J Mol Sci 24 (7), 6818 (2023)
   PUBMED   37047790
  REMARK    GeneRIF: Role of Orai3-Mediated Store-Operated Calcium Entry in
            Radiation-Induced Brain Microvascular Endothelial Cell Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Wang,Y., Bai,S., Zhang,R., Xia,L., Chen,L., Guo,J., Dai,F., Du,J.
            and Shen,B.
  TITLE     Orai3 exacerbates apoptosis of lens epithelial cells by disrupting
            Ca2+ homeostasis in diabetic cataract
  JOURNAL   Clin Transl Med 11 (3), e327 (2021)
   PUBMED   33784009
  REMARK    GeneRIF: Orai3 exacerbates apoptosis of lens epithelial cells by
            disrupting Ca(2+) homeostasis in diabetic cataract.
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Keck,M., Flamant,M., Mougenot,N., Favier,S., Atassi,F., Barbier,C.,
            Nadaud,S., Lompre,A.M., Hulot,J.S. and Pavoine,C.
  TITLE     Cardiac inflammatory CD11b/c cells exert a protective role in
            hypertrophied cardiomyocyte by promoting TNFR2- and Orai3-
            dependent signaling
  JOURNAL   Sci Rep 9 (1), 6047 (2019)
   PUBMED   30988334
  REMARK    GeneRIF: Cardiac inflammatory CD11b/c cells exert a protective role
            in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3-
            dependent signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Liu,S., Sahid,M.N., Takemasa,E., Kiyoi,T., Kuno,M., Oshima,Y. and
            Maeyama,K.
  TITLE     CRACM3 regulates the stability of non-excitable exocytotic vesicle
            fusion pores in a Ca(2+)-independent manner via molecular
            interaction with syntaxin4
  JOURNAL   Sci Rep 6, 28133 (2016)
   PUBMED   27301714
  REMARK    GeneRIF: CRACM3 affects cell exocytosis by influencing the
            activity-dependent fusion pore open time. Extracellular loop 3 and
            the C-terminus of CRACM3 are critical for binding the N-peptide of
            syntaxin-4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Saliba,Y., Keck,M., Marchand,A., Atassi,F., Ouille,A., Cazorla,O.,
            Trebak,M., Pavoine,C., Lacampagne,A., Hulot,J.S., Fares,N.,
            Fauconnier,J. and Lompre,A.M.
  TITLE     Emergence of Orai3 activity during cardiac hypertrophy
  JOURNAL   Cardiovasc Res 105 (3), 248-259 (2015)
   PUBMED   25213556
  REMARK    GeneRIF: Cardiac Orai3 is the essential partner of STIM1 and drives
            voltage-independent Ca(2+) entry in adult cardiomyocytes.
            Arachidonic acid-activated currents supported by Orai3 are present
            in adult cardiomyocytes and increased during hypertrophy.
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Zhang,X., Gonzalez-Cobos,J.C., Schindl,R., Muik,M., Ruhle,B.,
            Motiani,R.K., Bisaillon,J.M., Zhang,W., Fahrner,M., Barroso,M.,
            Matrougui,K., Romanin,C. and Trebak,M.
  TITLE     Mechanisms of STIM1 activation of store-independent leukotriene
            C4-regulated Ca2+ channels
  JOURNAL   Mol Cell Biol 33 (18), 3715-3723 (2013)
   PUBMED   23878392
  REMARK    GeneRIF: The second coiled-coil domain of STIM1 is required for
            coupling to either Orai3 or Orai3/Orai1 channels.
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Gonzalez-Cobos,J.C., Zhang,X., Zhang,W., Ruhle,B., Motiani,R.K.,
            Schindl,R., Muik,M., Spinelli,A.M., Bisaillon,J.M., Shinde,A.V.,
            Fahrner,M., Singer,H.A., Matrougui,K., Barroso,M., Romanin,C. and
            Trebak,M.
  TITLE     Store-independent Orai1/3 channels activated by intracrine
            leukotriene C4: role in neointimal hyperplasia
  JOURNAL   Circ Res 112 (7), 1013-1025 (2013)
   PUBMED   23349245
  REMARK    GeneRIF: Orai channels are activated by different agonists/pathways
            and uncover a mechanism whereby leukotrieneC4 acts through hitherto
            unknown intracrine mode to elicit store-independent Ca(2+)
            signaling that promotes vascular occlusive disease.
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Soboloff,J., Rothberg,B.S., Madesh,M. and Gill,D.L.
  TITLE     STIM proteins: dynamic calcium signal transducers
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 549-565 (2012)
   PUBMED   22914293
  REMARK    Review article
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001014024.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079355.1, SRR26360176.2190328.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               JAXUCZ010000001.1  191811671-191812051
            382-1824            JAXUCZ010000001.1  191815088-191816530
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1824
                     /gene="Orai3"
                     /gene_synonym="CRACM3; RGD1306538"
                     /note="ORAI calcium release-activated calcium modulator 3"
                     /db_xref="GeneID:309000"
                     /db_xref="RGD:1306538"
     exon            1..381
                     /gene="Orai3"
                     /gene_synonym="CRACM3; RGD1306538"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1026
                     /gene="Orai3"
                     /gene_synonym="CRACM3; RGD1306538"
                     /note="calcium release-activated calcium modulator 3
                     protein; transmembrane protein 142C"
                     /codon_start=1
                     /product="protein orai-3"
                     /protein_id="NP_001014046.1"
                     /db_xref="GeneID:309000"
                     /db_xref="RGD:1306538"
                     /translation="MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQH
                     SLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACT
                     TVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTF
                     LFLAEVVLVGWVKFVPIGAPMDKPAPVVPMSQVPPVTVSLSLASNLTPSSASVATTQQ
                     PPKACPPRQVCGSAHGPGWQAAMASTAIMVPVGLVFMAFALHFYRSLVAHKTDRHKQE
                     LEELSRLQGELQAV"
     exon            382..1824
                     /gene="Orai3"
                     /gene_synonym="CRACM3; RGD1306538"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccttcta gacgcatcgg taactattcc cgctggctct gccttactgc ctggaatggg
       61 gtcccgcccg cacttgggcc gtcccttctt ggggctacaa ggcgcctcgg cccctccttg
      121 accgtcagcg tttgtggtgt agctgctctc agaatgaagg gcggcgaggg ggacacgggc
      181 gaacaggccc ccctgaaccc ggaggtggac agccccgcgg gctcagccac gtaccgggag
      241 ttcgtgcacc gcggctacct cgaccttatg ggggccagtc agcactctct gcgggcgctc
      301 agctggcgcc gcctctacct cagccgggct aagctcaaag cctccagtcg cacttctgct
      361 ctgctgtcgg gcttcgccat ggtggcaatg gtggaggtac agctggagag cgatcatgaa
      421 tacccaccag gcctgctagt ggcatttagt gcctgcacca ctgtgttagt agctgtgcac
      481 ctgtttgcac tcatggtctc cacatgtctg ctgccccata ttgaagccgt gagcaacatc
      541 cacaatctca actctgtcca ccagtcacca caccaacgac tccaccgata tgtggagctg
      601 gcctggggct tttctactgc tttgggcacc tttctcttcc tggctgaagt tgttttggtg
      661 ggctgggtca agtttgtgcc cattggggca cccatggaca aaccagctcc tgtggtacct
      721 atgtcccagg tgccacccgt cactgtctcc cttagtttag cttctaacct cacaccatca
      781 tctgcttctg tagccacaac acagcagcct cccaaagcct gtccacctcg gcaagtgtgt
      841 ggtagtgctc atggacctgg ctggcaggca gctatggcct ccacggcaat catggtacct
      901 gtgggactag tgtttatggc ctttgcccta catttctacc gatccttggt ggcccacaag
      961 acagaccgcc acaagcagga actggaggaa ctcagtcgcc tgcaggggga gctgcaggct
     1021 gtgtgagccc agctttagac tgttgcaagc attgcctcag aagccccagg tatctatgga
     1081 cctcattcct tgtcctaggc tggagccacc tcctgtaacc tactctcagg tagaagccaa
     1141 attcctgctc agagtcccat gctcccagtg acgatcccca tcacgttcca gtgggttttg
     1201 taagttctct gcttgaggaa caaaagagga agtagactgt ctcagtctaa gcatcctggg
     1261 ttagatgaga ggaaaggagg ccctagtgag atccttggta gtgttgagaa gttgcttgct
     1321 cctctccagg aaggtgacat atctgcacaa ctgtccccaa ggcaggcagc ccttgcttac
     1381 ctgtaatgtg ctttacagtt ggcatcctgg gagagatttt acataggctc ctcagatgaa
     1441 ccactttaca cttggtgact tgtggtggtg tgtcccactg ccctgagcac ttagagtctt
     1501 tggctagagc cggggaagga gagatctttg aagacttgag attgtgcagc tagcttgaca
     1561 agggttgggt gagtttgagg gggagaattt agcccttaga atgcagagct cttcttcaga
     1621 cactgatttt tttcaagcca gagtatcact gtttgttgct ctgactgtcc tggaactctg
     1681 tagaccaggc tggccttgta ctcacagaga tccacttgcc tctgcctccc atgtgctggg
     1741 attaaaggca tgcaccacca ccgccctgct cagacactga gtttttgatg caccttgttt
     1801 tgtaaataaa gtgtctctca cata
//
