LOCUS       NM_001170403            4047 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ORAI calcium release-activated calcium modulator
            2 (Orai2), mRNA.
ACCESSION   NM_001170403 XM_001077075 XM_222288
VERSION     NM_001170403.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4047)
  AUTHORS   Ikeya,M., Yamanoue,K., Mochizuki,Y., Konishi,H., Tadokoro,S.,
            Tanaka,M., Suzuki,R. and Hirashima,N.
  TITLE     Orai-2 is localized on secretory granules and regulates
            antigen-evoked Ca(2) mobilization and exocytosis in mast cells
  JOURNAL   Biochem Biophys Res Commun 451 (1), 62-67 (2014)
   PUBMED   25044118
  REMARK    GeneRIF: Orai-2 is localized on secretory granules in mast
            cells.Orai-2 regulates degranulation by affecting Ca release from
            Ca store.
REFERENCE   2  (bases 1 to 4047)
  AUTHORS   Soboloff,J., Rothberg,B.S., Madesh,M. and Gill,D.L.
  TITLE     STIM proteins: dynamic calcium signal transducers
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 549-565 (2012)
   PUBMED   22914293
  REMARK    Review article
REFERENCE   3  (bases 1 to 4047)
  AUTHORS   Mitchell,C.B., Gasperini,R.J., Small,D.H. and Foa,L.
  TITLE     STIM1 is necessary for store-operated calcium entry in turning
            growth cones
  JOURNAL   J Neurochem 122 (6), 1155-1166 (2012)
   PUBMED   22712562
REFERENCE   4  (bases 1 to 4047)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU644750.1, BC158835.1 and JAXUCZ010000012.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_222288.4, XM_001077075.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU644750.1, BC158835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                EU644750.1         1-96
            97-1669             BC158835.1         1-1573
            1670-4047           JAXUCZ010000012.1  26154664-26157041
FEATURES             Location/Qualifiers
     source          1..4047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..4047
                     /gene="Orai2"
                     /gene_synonym="RGD1310213"
                     /note="ORAI calcium release-activated calcium modulator 2"
                     /db_xref="GeneID:304592"
                     /db_xref="RGD:1310213"
     CDS             1..942
                     /gene="Orai2"
                     /gene_synonym="RGD1310213"
                     /note="calcium release-activated calcium modulator 2
                     protein; CAP-binding protein complex interacting protein
                     2"
                     /codon_start=1
                     /product="protein orai-2"
                     /protein_id="NP_001163874.1"
                     /db_xref="GeneID:304592"
                     /db_xref="RGD:1310213"
                     /translation="MGHVTAAQRCLGSGCGRKEGGGRSSALARLPGHPAPTQTLATSR
                     SGELEPSALRASQPGLVPTMSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVT
                     SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAF
                     SACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTV
                     LGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIH
                     FYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV"
     exon            1..176
                     /gene="Orai2"
                     /gene_synonym="RGD1310213"
                     /inference="alignment:Splign:2.1.0"
     exon            177..414
                     /gene="Orai2"
                     /gene_synonym="RGD1310213"
                     /inference="alignment:Splign:2.1.0"
     exon            415..4047
                     /gene="Orai2"
                     /gene_synonym="RGD1310213"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggtcacg tgacggcggc gcagcgttgc ctaggcagcg gctgcgggcg gaaagaggga
       61 gggggccggt cctccgccct ggcccggctg ccgggccacc cggccccgac acagacgcta
      121 gccacgagcc ggagcggaga actggagcca agcgcgctga gggctagcca gccaggcctg
      181 gtccccacca tgagtgccga gctcaatgtg cccatggacc cctctgcccc cgcctgccct
      241 gaacccggcc acaagggcat ggattaccga gactgggtcc gacgcagcta cctggaactg
      301 gtcacatcca accaccactc ggtgcaggcc ctgtcctgga ggaagctgta cctgagcagg
      361 gccaagctga aggcctccag ccggacctct gccctcctgt ccggcttcgc catggtggcc
      421 atggtggagg tgcagctgga gaccaagtac cagtaccctc agcccctgct catcgccttc
      481 agcgcctgca ccacggtgct ggtagccgtg cacctatttg ccctgctcat cagcacatgc
      541 atcctgccca acgtggaagc cgtgagcaac atccacaacc tcaactccat cagcgagtcg
      601 ccgcacgagc gcatgcaccc gtacatcgag cttgcctggg gcttctctac cgttctgggc
      661 atcctgcttt tcctggctga ggtggtcctg ctctgctgga tcaagttcct cccagtggat
      721 gccaaggatc agccaggctc gcatagccac acgggctggc aggccgctct ggtgtccacc
      781 atcatcatgg tacctgtggg tctcatcttc gtggtcttta ctatccactt ctaccgctcc
      841 ctggtgcgac ataagacaga gcgccacaac cgtgagatcg aggaactgca caagctcaag
      901 gtgcagctgg atgggcacga gagaagccta caggtggtgt gagggacgga ggcctttgtg
      961 gtttgatacc agcctgcacc ggagagcaac cctcaggcca ccacgcagcc ggtaggagta
     1021 gccaaggggg ctgcatgaga tccgccacgc atcacaagag ccacagtggg gattgctaca
     1081 cagactgccc agatgctgct ccaataactc catactcctg tcctcgcatg aatcagggtc
     1141 cgaaaggagt gagaacagca tccatttcat catggaggcc agaagaaaaa acacaaccac
     1201 gtggccctgg ggacttcctg gtccaaacag atcagagagc actggagatc tcagacatct
     1261 ggaccttgtg attggcaggg taggacggcg aattcccaaa gcctgctgtg aggctgggct
     1321 ccagtgggat atcgcagtgc tagggaggtg gaggagggta gaccagatgt tctctgctac
     1381 atggtgagtt tgaggctacc tgaaacagtc agacacatgc acatgcatgc acaagagcag
     1441 acacaaacgt acatatgcac acactcacac acacacacac acacacacac acacacagaa
     1501 taggctgctt gagagtgcag aggtgggccc agggctagca caggacagca tgggttgtga
     1561 taagagacag ggatgtgggg gttggggatt tagctcagtg gtagagcgct tgcctagcaa
     1621 gcgcaaggcc ctgggttcgg tccccagctc cagaaaaaaa aaaaaaaaag agagagacag
     1681 ggatgtgtta actgatctgt agctcaggtt ggttccttcc tcccaactct ggagagggtc
     1741 acagggtgtt caggatcctg gggcacacag cagctcaaca cgggtgacgg atactgttat
     1801 tggatctggg ttgcctggtc ctagagagat ggtgcagtgt gggaggcctg gcatgattga
     1861 ggagaaatgt tctagaaccc cccaccacag gcttgacgga ggtcagagat ggacacacac
     1921 acacacacac acacacacac acacacacac accatgaagc agactctccc acacagaggt
     1981 gtccatctct tagctacaga cctgagccag ccacccttcc ccccacctag actgtgccaa
     2041 cacaggcagg ggcaccatct cagaggccag ccagctcagc tcccttctgt ctgtagcccc
     2101 cagatgttga gaggataaac tgtggagact tcctgttttt gcaaagtggt taggcctgtg
     2161 gctagccctg tggttaggcc tatgggcgtg gcagggaaca gccccagcct aatgtaggca
     2221 ggccatgggc agagaagggg agacctcaac accccattgc tgggctctcc atgcagggcc
     2281 ctgccccatg cttacacagc tgtgcatgag tttggcattg tcactacggg catctggccc
     2341 agctggtgtt gtcatgcata ccctgcggta cagcagcagc ttgcgtggga gccaacgctc
     2401 ccccatttct gcagcattac ctaggggggg ctgtggtctc ttactctgta tataaatggc
     2461 cgctgggctc ccatgagcgc catttccatt tcttacaaca gcttttctct ggagtctgga
     2521 tttggtgccc atgggatcct ggagggcccc accaccatcc cgaggtctct ggaaatggga
     2581 catactgcca agcctaaact taacatgaag agggccctgg ggagccttgt ggagatcttc
     2641 cttgtaagct gtgacatcag tggagaactg ggacatggtg tcttgtgact ccagggaaaa
     2701 ccctcagccc ctgcagacat ctgtctgaga ccccttgtat atcagatttc tgttttcctg
     2761 gggtcttttg ggaagcccag cctagtttgg tttgtttgtt tggcagaaga atgctagaat
     2821 cctgggtgga tgagatggct tcagtgggta aaggcacttg ccaccaagcc tggagacctg
     2881 agctccgccc ccatcctctg acccacaccc aagtaaatat aatgagaaaa agaattgatt
     2941 atcagaatca ccataagatg gtgtgcaggc agggggaagg gaaggtgacc ttttggagtg
     3001 agccgcttcc cactcgggca cgccctgaaa cggcactcat aaatcaaaca tggccgggtg
     3061 tgtctgtcat ctaagcattc aggaggcagg aggatctaga gtccaagttc acaatgagtt
     3121 ctagcttggg ctggacagat tttgtatcaa aaaaaaaggg gggctgcaga tggccccagt
     3181 agttaggaat gcttgctgct cttgcagagg gccagagttc atctcccagc acctacatag
     3241 ggcagcttac gactgcctgt aagtcaagtc ctagaggatc caacaccctc ttctggcctc
     3301 tgcaggcacc cacacagatg tgcatgtaca tatacgacat aaaaagggga ttcttgttgg
     3361 gcgttgggtc cattccttct gcctattttc tgaggccatt tggtccggca cttggtgcag
     3421 tgtgtgactc ccattatccc gttagtcttc ctagtgccaa gcatgggaca accatctgtg
     3481 catgaacatc tgcccatgtg gtgactcaca ggcaggagtc acagggccac cccacagcgc
     3541 tgtcaggagt tgaaggataa gcccttaccg tgaacagtgg cagaagccag taggctcaag
     3601 gctggaagtt tggtttctgg aggcataacc tgattttgaa tcctgttcta actgcggcca
     3661 cgtggctaga actactgtgg gccccctggg gccggcacag gcttgcccta atttcatcta
     3721 tccaagattc agcccttcct ggtgctcaag ggaccagtgt cctcagacac accaaggccc
     3781 ttcccaacat ggcctccttg tacccttggc cacaaagtct ccaaattcaa gtgtttcaac
     3841 ttaagaaact gcaaaggcag accatgattg gtgtcttggt gtcttttggg aaagtctaca
     3901 gaaaataaac tacaggagcg cagaggactc aagattgtgc cactatttat ttccgcagta
     3961 aataattcct ttcctgtgtg tggatttttt ttttttttta gcagttgccc tgggttgagc
     4021 tgaataaact aatacagctt ttaaaac
//
