LOCUS       NM_001013982            1184 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ORAI calcium release-activated calcium modulator
            1 (Orai1), mRNA.
ACCESSION   NM_001013982 XM_222178
VERSION     NM_001013982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Falcon,D., Calderon-Sanchez,E.M., Mayoral-Gonzalez,I.,
            Martin-Bornez,M., Dominguez-Rodriguez,A., Gutierrez-Carretero,E.,
            Ordonez-Fernandez,A., Rosado,J.A. and Smani,T.
  TITLE     Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1
            channel, which improves cardiac function after myocardial
            infarction
  JOURNAL   Mol Ther 32 (3), 646-662 (2024)
   PUBMED   38291755
  REMARK    GeneRIF: Inhibition of adenylyl cyclase 8 prevents the upregulation
            of Orai1 channel, which improves cardiac function after myocardial
            infarction.
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Zhang,S. and Zang,W.
  TITLE     The Role and Mechanism of STIM1/Orai1-Regulated Ca2+ Influx in
            Myocardial Hypertrophy in Type 2 Diabetes Mellitus
  JOURNAL   Ann Clin Lab Sci 54 (1), 17-25 (2024)
   PUBMED   38514055
  REMARK    GeneRIF: The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+]
            Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Sukkar,B., Oktay,L., Sahaboglu,A., Moayedi,A., Zenouri,S.,
            Al-Maghout,T., Canto,A., Miranda,M., Durdagi,S. and Hosseinzadeh,Z.
  TITLE     Inhibition of altered Orai1 channels in Muller cells protects
            photoreceptors in retinal degeneration
  JOURNAL   Glia 71 (11), 2511-2526 (2023)
   PUBMED   37533369
  REMARK    GeneRIF: Inhibition of altered Orai1 channels in Muller cells
            protects photoreceptors in retinal degeneration.
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   Angulo,J., Fernandez,A., Sevilleja-Ortiz,A., Sanchez-Ferrer,A.,
            Rodriguez-Manas,L. and El Assar,M.
  TITLE     Upregulation of Orai Channels Contributes to Aging-Related Vascular
            Alterations in Rat Coronary Arteries
  JOURNAL   Int J Mol Sci 24 (17), 13402 (2023)
   PUBMED   37686206
  REMARK    GeneRIF: Upregulation of Orai Channels Contributes to Aging-Related
            Vascular Alterations in Rat Coronary Arteries.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1184)
  AUTHORS   Zhu,M., Lv,B., Ge,W., Cui,Z., Zhao,K., Feng,Y. and Yang,X.
  TITLE     Suppression of store-operated Ca2+ entry regulated by silencing
            Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity
            and promoting focal adhesion
  JOURNAL   Cell Cycle 19 (24), 3468-3479 (2020)
   PUBMED   33269647
  REMARK    GeneRIF: Suppression of store-operated Ca(2+) entry regulated by
            silencing Orai1 inhibits C6 glioma cell motility via decreasing
            Pyk2 activity and promoting focal adhesion.
REFERENCE   6  (bases 1 to 1184)
  AUTHORS   Prakriya,M., Feske,S., Gwack,Y., Srikanth,S., Rao,A. and Hogan,P.G.
  TITLE     Orai1 is an essential pore subunit of the CRAC channel
  JOURNAL   Nature 443 (7108), 230-233 (2006)
   PUBMED   16921383
REFERENCE   7  (bases 1 to 1184)
  AUTHORS   Mercer,J.C., Dehaven,W.I., Smyth,J.T., Wedel,B., Boyles,R.R.,
            Bird,G.S. and Putney,J.W. Jr.
  TITLE     Large store-operated calcium selective currents due to
            co-expression of Orai1 or Orai2 with the intracellular calcium
            sensor, Stim1
  JOURNAL   J Biol Chem 281 (34), 24979-24990 (2006)
   PUBMED   16807233
REFERENCE   8  (bases 1 to 1184)
  AUTHORS   Soboloff,J., Spassova,M.A., Tang,X.D., Hewavitharana,T., Xu,W. and
            Gill,D.L.
  TITLE     Orai1 and STIM reconstitute store-operated calcium channel function
  JOURNAL   J Biol Chem 281 (30), 20661-20665 (2006)
   PUBMED   16766533
  REMARK    GeneRIF: suppression of store-operated channels function by Orai1
            overexpression likely reflects a required stoichiometry between
            STIM1 and Orai1 [Orai1]
REFERENCE   9  (bases 1 to 1184)
  AUTHORS   Peinelt,C., Vig,M., Koomoa,D.L., Beck,A., Nadler,M.J.,
            Koblan-Huberson,M., Lis,A., Fleig,A., Penner,R. and Kinet,J.P.
  TITLE     Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
  JOURNAL   Nat Cell Biol 8 (7), 771-773 (2006)
   PUBMED   16733527
REFERENCE   10 (bases 1 to 1184)
  AUTHORS   Vig,M., Peinelt,C., Beck,A., Koomoa,D.L., Rabah,D.,
            Koblan-Huberson,M., Kraft,S., Turner,H., Fleig,A., Penner,R. and
            Kinet,J.P.
  TITLE     CRACM1 is a plasma membrane protein essential for store-operated
            Ca2+ entry
  JOURNAL   Science 312 (5777), 1220-1223 (2006)
   PUBMED   16645049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088225.1.
            
            On Apr 20, 2005 this sequence version replaced XM_222178.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088225.1, EU644749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1184
                     /gene="Orai1"
                     /gene_synonym="RGD1311873"
                     /note="ORAI calcium release-activated calcium modulator 1"
                     /db_xref="GeneID:304496"
                     /db_xref="RGD:1311873"
     exon            1..391
                     /gene="Orai1"
                     /gene_synonym="RGD1311873"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1000
                     /gene="Orai1"
                     /gene_synonym="RGD1311873"
                     /note="calcium release-activated calcium modulator 1;
                     protein orai-1; transmembrane protein 142A"
                     /codon_start=1
                     /product="calcium release-activated calcium channel
                     protein 1"
                     /protein_id="NP_001014004.1"
                     /db_xref="GeneID:304496"
                     /db_xref="RGD:1311873"
                     /translation="MHPEPAPPPNNSNPELPLSGGSSTSGSRRSRRRSGDGEPTGAPP
                     LPPPPAVSYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAM
                     VAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNS
                     VKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPTE
                     PAVVVANSSNNGGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQEL
                     NELAEFARLQDQLDHRGDHSLTPGTHYA"
     exon            392..1160
                     /gene="Orai1"
                     /gene_synonym="RGD1311873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggccgg cggaggtgcg gcgcggcccc ggggccgcag ccttcgcagg cgcccgccgc
       61 cagccgcgcc ttcgcagcgt actccatgca tccggagcct gccccgcccc cgaacaacag
      121 caatccggag cttcccttga gcggcggcag cagcactagc ggcagccgcc ggagccgccg
      181 ccgcagcggg gacggggagc ccacgggggc cccaccgctg ccgccgccgc ccgccgtcag
      241 ctacccggac tggatcggcc agagttactc cgaggtgatg agcctcaacg agcactcgat
      301 gcaggcgctg tcctggcgca agctctactt gagccgcgcc aagctcaaag cctccagccg
      361 aacctccgct ctgctctccg gcttcgccat ggtagcgatg gtggaagtcc agctggacac
      421 ggatcatgac tacccgccag ggttactcat cgtcttcagc gcctgcacca cagtgctggt
      481 ggccgtgcac ctgttcgccc tcatgatcag tacctgcatc ctgcccaaca tcgaggctgt
      541 gagcaacgtc cacaacctca actccgtcaa ggagtcgccg cacgagcgca tgcaccgcca
      601 catcgagctg gcttgggcct tctccaccgt catcgggacg ctgcttttcc tggccgaagt
      661 cgtgctgctc tgctgggtga agttcttacc gctcaagagg caggcgggac agccaagccc
      721 caccaagcca cccaccgaac cggccgtcgt cgtcgccaac agcagcaaca acggtggcat
      781 caccccgggt gaggcggctg ccatcgcctc cactgccatc atggtcccct gtggcctggt
      841 gtttatcgtc tttgccgttc acttctaccg ctcactggtc agccataaga cggaccgaca
      901 gttccaggag ctcaacgagc tggccgagtt tgcccgcttg caggaccagc tggaccacag
      961 aggggaccat tctctaacac cgggcaccca ctatgcctaa gtcctcacct tcccactggc
     1021 cctttgaggc cttggcctta tgcccttccc catgaccttg tcctggccca ctctggagga
     1081 cgggctcgtg cgggcggctg gcttcaccag ggcagagtgt ggaaggaaga ggctttaaaa
     1141 aaaaaaaaaa aatcgctgca aaaaaaaaaa aaaaaaaaaa aaaa
//
