LOCUS       NM_001000535             927 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus olfactory receptor family 4 subfamily E member 5
            (Or4e2), mRNA.
ACCESSION   NM_001000535 XM_344332
VERSION     NM_001000535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Zhang,R., Pan,Y., Ahmed,L., Block,E., Zhang,Y., Batista,V.S. and
            Zhuang,H.
  TITLE     A Multispecific Investigation of the Metal Effect in Mammalian
            Odorant Receptors for Sulfur-Containing Compounds
  JOURNAL   Chem Senses 43 (5), 357-366 (2018)
   PUBMED   29659735
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Burger,J.L., Jeerage,K.M. and Bruno,T.J.
  TITLE     Direct nuclear magnetic resonance observation of odorant binding to
            mouse odorant receptor MOR244-3
  JOURNAL   Anal Biochem 502, 64-72 (2016)
   PUBMED   27019154
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Block,E., Jang,S., Matsunami,H., Sekharan,S., Dethier,B.,
            Ertem,M.Z., Gundala,S., Pan,Y., Li,S., Li,Z., Lodge,S.N., Ozbil,M.,
            Jiang,H., Penalba,S.F., Batista,V.S. and Zhuang,H.
  TITLE     Implausibility of the vibrational theory of olfaction
  JOURNAL   Proc Natl Acad Sci U S A 112 (21), E2766-E2774 (2015)
   PUBMED   25901328
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Sekharan,S., Ertem,M.Z., Zhuang,H., Block,E., Matsunami,H.,
            Zhang,R., Wei,J.N., Pan,Y. and Batista,V.S.
  TITLE     QM/MM model of the mouse olfactory receptor MOR244-3 validated by
            site-directed mutagenesis experiments
  JOURNAL   Biophys J 107 (5), L5-L8 (2014)
   PUBMED   25185561
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Duan,X., Block,E., Li,Z., Connelly,T., Zhang,J., Huang,Z., Su,X.,
            Pan,Y., Wu,L., Chi,Q., Thomas,S., Zhang,S., Ma,M., Matsunami,H.,
            Chen,G.Q. and Zhuang,H.
  TITLE     Crucial role of copper in detection of metal-coordinating odorants
  JOURNAL   Proc Natl Acad Sci U S A 109 (9), 3492-3497 (2012)
   PUBMED   22328155
COMMENT     REVIEWED REFSEQ: This record has been curated by Janet Young and
            Barbara Trask (FHCRC). The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Aug 30, 2004 this sequence version replaced XM_344332.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-927               JAXUCZ010000015.1  27661127-27662053
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..927
                     /gene="Or4e2"
                     /gene_synonym="Olr1643"
                     /note="olfactory receptor family 4 subfamily E member 5"
                     /db_xref="GeneID:364306"
                     /db_xref="RGD:1334073"
     CDS             1..927
                     /gene="Or4e2"
                     /gene_synonym="Olr1643"
                     /note="olfactory receptor gene Olr1643; olfactory receptor
                     1643"
                     /codon_start=1
                     /product="olfactory receptor Olr1643"
                     /protein_id="NP_001000535.1"
                     /db_xref="GeneID:364306"
                     /db_xref="RGD:1334073"
                     /translation="MGALNQTRVTEFVFLGLTDNWVLEILFFIPFTVTYVLTLLGNVL
                     IVVTIVFTPRLHNPMYFFLSNLSFIDICHSSVTVPKMLEGLLLVRKTISFDNCIAQLF
                     FLHLFACAEIFLLTIMAYDRYVAICIPLHYPNVMNMKVCVQLVFALWLGGTVHSLVQT
                     FLTIRLPYCGPNTIDSYFCDVPPVIKLACTDTYLTGILIVSNSGTISLVCFLALVTSY
                     TVILFSLRKQSAEGRRKALSTCSAHFMVVALFFGPCIFIYTWPDTSFSIDKVVSVFYT
                     VVTPLLNPLIYTLRNEEVKTSMKHLRQRRICS"
     exon            1..927
                     /gene="Or4e2"
                     /gene_synonym="Olr1643"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggagctc taaatcaaac aagagtgact gaatttgtct tcctgggcct cactgacaac
       61 tgggtgttgg agattctgtt tttcatacca ttcacagtca cttatgtgtt aacacttttg
      121 gggaatgtcc tcattgttgt caccatcgtc ttcactccac gtctccacaa tcccatgtac
      181 ttctttctga gcaacctgtc cttcattgac atctgtcact catctgtcac cgtgcccaag
      241 atgctggagg gcttgctttt agtgaggaag accatttcct ttgacaactg catcgcacag
      301 ctcttcttcc tgcatctctt tgcttgtgct gagatctttc tactgacgat tatggcgtac
      361 gatcgttacg tggctatctg tatcccattg cattacccca atgtgatgaa catgaaggtc
      421 tgtgtacagc ttgtcttcgc actctggctg gggggcactg ttcattcgct tgtgcagacc
      481 ttcttgacta ttcgtctacc ctactgtggc ccgaacacca tcgatagcta cttctgtgac
      541 gtacctcctg tcatcaagct ggcctgcaca gatacatacc ttaccgggat tctgatcgtg
      601 tccaatagtg gaaccatctc cctcgtatgt tttctagcct tggtcacttc ctacacagtc
      661 atcctgtttt ctcttcgaaa acagtcagca gaaggtcgtc ggaaagccct gtccacctgc
      721 tcagcccact tcatggtggt tgccctgttc tttgggccat gtatcttcat ctatacttgg
      781 ccagatacca gcttctccat cgacaaggtg gtatccgtct tctacacagt ggtcacccct
      841 ttgctgaacc ctctcattta caccttgagg aatgaggagg tgaaaacttc catgaagcat
      901 ctcaggcaga gacgaatttg ctcatga
//
