LOCUS       NM_145081               4074 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus optineurin (Optn), mRNA.
ACCESSION   NM_145081 XM_006254263
VERSION     NM_145081.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4074)
  AUTHORS   Evans,C.S. and Holzbaur,E.L.
  TITLE     Degradation of engulfed mitochondria is rate-limiting in
            Optineurin-mediated mitophagy in neurons
  JOURNAL   Elife 9, e50260 (2020)
   PUBMED   31934852
  REMARK    GeneRIF: Degradation of engulfed mitochondria is rate-limiting in
            Optineurin-mediated mitophagy in neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4074)
  AUTHORS   Shim,M.S., Kim,K.Y., Noh,M., Ko,J.Y., Ahn,S., An,M.A., Iwata,T.,
            Perkins,G.A., Weinreb,R.N. and Ju,W.K.
  TITLE     Optineurin E50K triggers BDNF deficiency-mediated mitochondrial
            dysfunction in retinal photoreceptor cell line
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2690-2697 (2018)
   PUBMED   30100066
  REMARK    GeneRIF: Overexpression of E50K-mutated optineurin triggered BDNF
            deficiency, leading to Bax activation in a retinal photoreceptor
            cell line.
REFERENCE   3  (bases 1 to 4074)
  AUTHORS   Senoo,K., Yamashiro,K., Yamamoto,T., Myokai,F., Kawamura,M. and
            Takashiba,S.
  TITLE     Expression of optineurin isolated from rat-injured dental pulp and
            the effects on inflammatory signals in normal rat kidney cells
  JOURNAL   Odontology 106 (2), 135-144 (2018)
   PUBMED   28776281
  REMARK    Erratum:[Odontology. 2018 Apr;106(2):223. doi:
            10.1007/s10266-017-0334-1.. PMID: 29274049]
REFERENCE   4  (bases 1 to 4074)
  AUTHORS   Hu,X., Dai,Y. and Sun,X.
  TITLE     Parkin overexpression protects retinal ganglion cells against
            glutamate excitotoxicity
  JOURNAL   Mol Vis 23, 447-456 (2017)
   PUBMED   28761318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4074)
  AUTHORS   Fifita,J.A., Williams,K.L., Sundaramoorthy,V., Mccann,E.P.,
            Nicholson,G.A., Atkin,J.D. and Blair,I.P.
  TITLE     A novel amyotrophic lateral sclerosis mutation in OPTN induces ER
            stress and Golgi fragmentation in vitro
  JOURNAL   Amyotroph Lateral Scler Frontotemporal Degener 18 (1-2), 126-133
            (2017)
   PUBMED   27534431
REFERENCE   6  (bases 1 to 4074)
  AUTHORS   Melki,R., Belmouden,A., Akhayat,O., Brezin,A. and Garchon,H.J.
  TITLE     The M98K variant of the OPTINEURIN (OPTN) gene modifies initial
            intraocular pressure in patients with primary open angle glaucoma
  JOURNAL   J Med Genet 40 (11), 842-844 (2003)
   PUBMED   14627677
REFERENCE   7  (bases 1 to 4074)
  AUTHORS   Vittitow,J. and Borras,T.
  TITLE     Expression of optineurin, a glaucoma-linked gene, is influenced by
            elevated intraocular pressure
  JOURNAL   Biochem Biophys Res Commun 298 (1), 67-74 (2002)
   PUBMED   12379221
REFERENCE   8  (bases 1 to 4074)
  AUTHORS   Rezaie,T., Child,A., Hitchings,R., Brice,G., Miller,L.,
            Coca-Prados,M., Heon,E., Krupin,T., Ritch,R., Kreutzer,D.,
            Crick,R.P. and Sarfarazi,M.
  TITLE     Adult-onset primary open-angle glaucoma caused by mutations in
            optineurin
  JOURNAL   Science 295 (5557), 1077-1079 (2002)
   PUBMED   11834836
REFERENCE   9  (bases 1 to 4074)
  AUTHORS   Pruitt,K.D. and Maglott,D.R.
  TITLE     RefSeq and LocusLink: NCBI gene-centered resources
  JOURNAL   Nucleic Acids Res 29 (1), 137-140 (2001)
   PUBMED   11125071
REFERENCE   10 (bases 1 to 4074)
  AUTHORS   Moreland,R.J., Dresser,M.E., Rodgers,J.S., Roe,B.A., Conaway,J.W.,
            Conaway,R.C. and Hanas,J.S.
  TITLE     Identification of a transcription factor IIIA-interacting protein
  JOURNAL   Nucleic Acids Res 28 (9), 1986-1993 (2000)
   PUBMED   10756201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_006254263.3, NM_145081.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223875.1, SRR26643429.52964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000017.1  78118869-78119042
            175-351             JAXUCZ010000017.1  78127874-78128050
            352-554             JAXUCZ010000017.1  78129067-78129269
            555-770             JAXUCZ010000017.1  78136104-78136319
            771-844             JAXUCZ010000017.1  78140165-78140238
            845-979             JAXUCZ010000017.1  78142385-78142519
            980-1079            JAXUCZ010000017.1  78146989-78147088
            1080-1195           JAXUCZ010000017.1  78148068-78148183
            1196-1345           JAXUCZ010000017.1  78149246-78149395
            1346-1439           JAXUCZ010000017.1  78150410-78150503
            1440-1598           JAXUCZ010000017.1  78152272-78152430
            1599-1729           JAXUCZ010000017.1  78161970-78162100
            1730-1812           JAXUCZ010000017.1  78164426-78164508
            1813-4074           JAXUCZ010000017.1  78167282-78169543
FEATURES             Location/Qualifiers
     source          1..4074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..4074
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /note="optineurin"
                     /db_xref="GeneID:246294"
                     /db_xref="RGD:628886"
     exon            1..174
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            175..351
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1943
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /note="14.7K-interacting protein 2; FIP-2-like protein"
                     /codon_start=1
                     /product="optineurin"
                     /protein_id="NP_659549.3"
                     /db_xref="GeneID:246294"
                     /db_xref="RGD:628886"
                     /translation="MSHQPLSCLTEKGDSSCETPGNGPSNMVHPNLDTFTPEELLQQM
                     KELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSH
                     ENERLKEELGKLKEKSERPFEDITGRCGFPRTDLEQEVEQLKRQVEQEVEHLKNQVRR
                     LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMTEGEAEGAMKEMRNSAGPTRTDSI
                     SMGKCTEDARTCVEFEELTVSQLLLCLREGNQKVERLEIALREAKERISDFEKKANGH
                     SAIETQTEGSTQKEEEDKDPESVGIEVETLNVQVASLFKELQEAHTKLSEAELMKKRL
                     QEKCQALERKNSATPSELNEKQELVYSNRKLELQVESMRSEIKMEQAKTEEEKSRLAT
                     LQATHDKLLQEHNKALRTIEELTKQQAEKVDKVQLQELSEKLELAEQALASKQLQMDE
                     MKQTIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENN
                     DFEDGGSRQSLMEMQCRHGARTSDSDQQAYLFQRGAEDMSWQHGQQPRSIPIHSCPKC
                     GEVLPDIDTLQIHVMDCII"
     exon            352..554
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..770
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..844
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..979
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1079
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1195
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1345
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1439
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1598
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1729
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1812
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..4074
                     /gene="Optn"
                     /gene_synonym="Fip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgggcg ctgcggtcag ctgagcggcg cctggcgggt cgcgaggccg cgcgtcaccg
       61 tccagctgcc cggtcgccgc cccctggccg gtccctggcg ggcgtcggca tccagagctt
      121 tgggacaaga tgccaacgaa gcagtgacct gagaggagcg gatctctgtg gccggacctg
      181 ttaccatgtc ccatcaacct ctgagctgcc tgactgagaa gggggacagc tcctgtgaga
      241 ccccaggaaa tggaccctcc aatatggttc accccaacct ggacacattc actcctgagg
      301 agctgctgca gcaaatgaaa gaactcctgg tcgagaacca ccagctgaaa gaagccatga
      361 agctaaataa tcaagctatg aaagggcgat ttgaggagct ttctgcctgg acagagaagc
      421 agaaggaaga acgccagttg tttgagatac aaagcaaaga ggctaaggag cgcctcaagg
      481 ccctgagtca tgaaaatgag aggctgaagg aagagcttgg aaaactaaaa gagaaatcag
      541 aaaggccatt tgaagacatc acaggtagat gcgggtttcc cagaaccgac ttggagcagg
      601 aagtggagca actgaagagg caggtggagc aggaagtgga gcatctgaag aaccaggtga
      661 ggcgccttca ggctgagaaa gcggacctgc tgggcatcgt ctcagaactg cagctcaagc
      721 tcaactccag cggctcctca gaagactcct tcgtggagat caggatgact gaaggagagg
      781 cggaaggggc aatgaaggag atgaggaaca gcgctggacc cacaaggaca gactccatca
      841 gcatgggcaa atgtacagag gacgccagga cttgtgtgga gtttgaggaa ctgactgtga
      901 gccaactcct gctttgcctc agggaaggaa accaaaaggt ggagagactc gagatcgcgc
      961 tcagagaagc caaagaaaga atttcagatt ttgaaaagaa agcaaacggc cattctgcga
     1021 ttgagaccca gacagagggg agcacacaaa aagaagagga ggacaaagac ccagagagtg
     1081 tgggaatcga agtggaaact ctgaatgttc aagtggcctc tctgtttaag gagcttcaag
     1141 aggcgcacac aaagctcagt gaggccgagc tgatgaagaa gagacttcaa gaaaagtgtc
     1201 aggctctgga aaggaagaac tctgcaaccc catcggagct gaatgaaaag caagagctcg
     1261 tttacagtaa caggaagtta gagctgcagg tggagagcat gcgctcggaa atcaagatgg
     1321 agcaggccaa gacagaggag gagaaatcca ggttagccac tcttcaggca acacacgaca
     1381 agcttcttca ggaacacaat aaagctctga gaacaattga agaactaacc aaacaacagg
     1441 cagaaaaagt ggacaaggtg cagctgcagg agctcagcga gaagctggag ctggcggagc
     1501 aggctctggc gtccaagcag ctccagatgg atgagatgaa gcagaccatc gccaagcagg
     1561 aggaggacct ggagaccatg gccgtcctca gggctcagat ggaggtgtac tgttcagatt
     1621 tccatgctga gagggcagca agggagaaga tccatgagga aaaggagcag ctggccttgc
     1681 agctcgccat tttgctgaaa gagaacaatg actttgaaga tggaggcagt aggcagtcct
     1741 tgatggaaat gcagtgccgg catggggcga gaaccagcga ctctgaccag caggcttacc
     1801 tgtttcaaag aggagccgag gacatgagct ggcagcatgg gcagcagccc cggagtattc
     1861 ccattcactc gtgccccaag tgtggggagg tcctgccgga cattgacacg cttcagatac
     1921 atgtgatgga ctgtatcatc tgagggccct ccactcccca aagctgttgg taaacgccag
     1981 atttctgctc caacacttgt acttctgtct tctttgttgt cacgcaaata tttttgccac
     2041 attatcctaa tctctggaga aaggaagtgt acccctccta aggagagcat cttctggact
     2101 gacaggaagt cacaacgaag aatctaatta gtgcccttcc agtaagatag ccagtgtttt
     2161 tatgttctgc tcatgagagt ctctgagagc agtcagccag aatgggacac caagtgacca
     2221 agctcacgaa tgacatggga gaaattcact gacatgtggt tgagaacctg tgagagacag
     2281 gaaattgaaa tggtcgggaa tcatgactgc agtgtttttc taggtaaatc ttcacctagc
     2341 aggatcttgt tgttctgtgt gtaattatgt ggaaattacg tgtggttctt tctgactgaa
     2401 cacggtggta tctgttgatc ccgggacagg tgagaatggg gaatgcagct caggcccagg
     2461 gtacttccct aagctgttca gtgtggcgtt accgtcagcc tctctgtgta ctggaggtgt
     2521 acagggttta tttttaaaag aacagctatt ttctttgcag gtgaggtagc agcttacaga
     2581 tctcagttat tacaaagtaa acttttgtga catatctgtc ccactgctca tatgtgacca
     2641 gcaacactgt aatgtgtcta ttctgcattg agctcactag acttgatttg gtcatgagaa
     2701 gtaggagcag atccttttaa aggagggcca gtgcatgtct gaatagattc ccgataaaaa
     2761 agtacagaga gccaagcatg ctggtgcagg gcacacccgc atgggagacc gaggcagcag
     2821 atcccccagc tcatgaccag acacgtctac acataataaa tggggatttg ccatattttg
     2881 tgttaaaaat gttagcaaga actaaacaaa tccaaaagta aacagcattg agtcctaaaa
     2941 catttgagaa gtcttgtgtt tagcacagga cctctggtta aatacacaca gacgtgtatg
     3001 taaacaaaat cagaatagtt cattcatctc aaaggaacat agtgttcaga taagttatct
     3061 tcacctgaac agttacccct ccaagacagt agaacactgc actgtgcatc agtcattaga
     3121 tcccctcaga ccctagaagc cattagatta gattcctcct cagaccctag gagccattag
     3181 attagacccc cctcagaccc taggagccat tagattagat cccctcagac cctaggagcc
     3241 attagattag atcccctcag accctaggag ccattagatt agatcccctc agaccctagg
     3301 agccattaga ttagatcccc ctcagaccct agggacaata ttcgatagtg acatttctaa
     3361 aattacattt ttccttttct tattctttct agtataaatt tctttatatt ttatactgga
     3421 taaagtaggt ttctatagta ccccagacac aggaggaaac cagtttcaca atgaagttac
     3481 tggggaaatc ctttttactt tgttcaagta taattatctg ataaatctaa actgtgaatt
     3541 gaaaacccaa atggtcttag taatgctatg accaaagcat ttgtttgatc atgaagaaga
     3601 ttacagatga aggcatgttc agactaagat tgttggagag agatcagtgt acagcatctt
     3661 ccacagcagc taggatacag ggcagcctag gcatccattg ctggagtttg gatagggaaa
     3721 acacagtaca cagataaagt gaaacagtat ccagccttgg gaaagaaggg gattctatca
     3781 cttgataaca tagatggacc tggagaggac atcatgtcaa gtgaagtaag ccaggcacga
     3841 atatcacatg atgtcactta catgtggacc ctgaagaaac atagttcata gatattgaga
     3901 gctgaatagt ggtttgcagg acaggaggga aggtgtggga agggtgagat gttgctcaaa
     3961 ggtacgaagt ctcaggaggg ataaactgta gtgatctact gtacagaaga gtgactgtaa
     4021 taatttgtat attaaggcta tatccccagt ttagtaaaca acttgtaaac cctc
//
