LOCUS       NM_001395559            2517 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus opticin (Optc), mRNA.
ACCESSION   NM_001395559
VERSION     NM_001395559.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Farran,A., Valverde-Franco,G., Tio,L., Lussier,B., Fahmi,H.,
            Pelletier,J.P., Bishop,P.N., Monfort,J. and Martel-Pelletier,J.
  TITLE     In vivo effect of opticin deficiency in cartilage in a surgically
            induced mouse model of osteoarthritis
  JOURNAL   Sci Rep 8 (1), 457 (2018)
   PUBMED   29323130
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Hoffman,M.J., Flister,M.J., Nunez,L., Xiao,B., Greene,A.S.,
            Jacob,H.J. and Moreno,C.
  TITLE     Female-specific hypertension loci on rat chromosome 13
  JOURNAL   Hypertension 62 (3), 557-563 (2013)
   PUBMED   23817491
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Le Goff,M.M., Lu,H., Ugarte,M., Henry,S., Takanosu,M., Mayne,R. and
            Bishop,P.N.
  TITLE     The vitreous glycoprotein opticin inhibits preretinal
            neovascularization
  JOURNAL   Invest Ophthalmol Vis Sci 53 (1), 228-234 (2012)
   PUBMED   22159013
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Monfort,J., Tardif,G., Roughley,P., Reboul,P., Boileau,C.,
            Bishop,P.N., Pelletier,J.P. and Martel-Pelletier,J.
  TITLE     Identification of opticin, a member of the small leucine-rich
            repeat proteoglycan family, in human articular tissues: a novel
            target for MMP-13 in osteoarthritis
  JOURNAL   Osteoarthritis Cartilage 16 (7), 749-755 (2008)
   PUBMED   18164633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1577739.1,
                                           SRR26360176.136076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000013.1  47917045-47917116   c
            73-352              JAXUCZ010000013.1  47915113-47915392   c
            353-485             JAXUCZ010000013.1  47913863-47913995   c
            486-644             JAXUCZ010000013.1  47912320-47912478   c
            645-847             JAXUCZ010000013.1  47911234-47911436   c
            848-943             JAXUCZ010000013.1  47908094-47908189   c
            944-2517            JAXUCZ010000013.1  47906197-47907770   c
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2517
                     /gene="Optc"
                     /note="opticin"
                     /db_xref="GeneID:304802"
                     /db_xref="RGD:1304916"
     exon            1..72
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            73..352
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1117
                     /gene="Optc"
                     /codon_start=1
                     /product="opticin precursor"
                     /protein_id="NP_001382488.1"
                     /db_xref="GeneID:304802"
                     /db_xref="RGD:1304916"
                     /translation="MYVEWIQPFPLLPFPQNLMKFLTFLSLLTLVLQEAGTASLLGER
                     EREEKSPEEADTYASLHVGNYSLSLEDYSEVIDLSSYEELADYGDQIPEAKTSSPTLP
                     TRTSPTSPVVPRTLPSRLTMAGPTTTGLLNSQSSHGLPTCLVCVCLGSSVYCDDANLE
                     NIPPLPQMTTYLYARFNHISHIQAGDFKGMTKLRRIDLSSNSISSIHNDALRLLPALQ
                     DLILPENQLAALPVLPSGLEFLDVRLNRLQSSGIQPEAFVTLEKLQFLYLADNLLDSI
                     PGPLPLSLRSLHLQNNKIEAMESDTFCDTTEHRHERRRQLEDIRLDGNPINLSLFPEA
                     YFCLPRLPVGRFT"
     exon            353..485
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            486..644
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            645..847
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            848..943
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            944..2517
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcatc cccatcagag tctttgtctc cctggaagct gctggaccag acggaaccaa
       61 aacttctaaa aggatgtacg tcgaatggat tcagccgttc ccactcctac ccttccctca
      121 gaacctcatg aagttcctga ctttcctgag tctgttgacc ctggtgctgc aggaggcagg
      181 gacagcgtct ctcctaggag agagagaaag agaagagaag agccctgagg aagctgacac
      241 ttatgcatcc ctgcatgtgg ggaactatag cctgagccta gaggactaca gtgaagtcat
      301 tgatctgagc agctatgagg aacttgcaga ctatggggac cagatccctg aggccaaaac
      361 aagcagtccg actcttccaa caagaactag tcccactagc cctgtggttc caaggacatt
      421 gccatcacgc ctcacaatgg ccggacctac caccactgga ctactgaact cccagagcag
      481 tcacggcctg cctacctgcc tggtctgcgt gtgccttggc tcttctgtgt actgtgatga
      541 tgcgaacctc gagaacattc ctcctcttcc ccagatgacc acctacctct acgctcgctt
      601 caaccacatc agccacatcc aggctggaga cttcaaaggg atgacaaaac tgaggaggat
      661 cgatctctcc agcaactcca tctcctccat ccacaacgat gccctccgcc tgctgcctgc
      721 cctgcaggat ctgatccttc cagagaacca gctggcagcc ctgcctgtgc tgcccagtgg
      781 cctcgagttc ctggacgtcc gcctgaatcg gctgcagagc tcagggatac agcctgaggc
      841 cttcgtgacg ctggagaagc tgcagtttct ctacctggcg gacaacctgc tggattccat
      901 ccctgggcct ttgcccctca gcctgcgctc cctgcacctg cagaataaca agattgaggc
      961 catggaaagt gacaccttct gtgacaccac ggaacacaga catgagcgcc gccggcagct
     1021 tgaagacatc cgcctggacg ggaaccccat caatctgagc cttttcccag aggcctattt
     1081 ttgcctgcca cggctccccg tgggccgctt cacctagctg ccactggtcc ttgcttgctt
     1141 cccagacagt gcttggaggc tcaccagggg agcactctct ccctgcacct aagaagtgat
     1201 ctgtagccca agttccaggc agcctaggag ccagagagag agagagagag agagagagag
     1261 agagagagag agagaggaga gagagagaga gaagagagag agaaagagag agaaagagag
     1321 agagacagag acagagagag aagacagaga gagaagacag agagaagaga gagacagaca
     1381 gagagagaga cagagagaga gaggacagag agaaagagag acagagagag agacagagaa
     1441 gagacagaga gagagaaaaa gagagagaca gagagagaga cagagagaaa agagagagag
     1501 aagagagaga ggagagagag agaagagaga gagaaagaga gagagacaga gacagaagac
     1561 agagagagaa gacagaagag agagacagag agagagagac agagagagga cagagagaaa
     1621 gagagacaga gagaaagaca gagaagagac agagagagag aaaaagagag agacagagag
     1681 agagacagag agaaaagaga gagagaagag agagagagga gagagagaag agagagagaa
     1741 agagagagag acagagacag agagaagaca gagagagaag acagagagaa gagagagaca
     1801 gagagagaga gagacagaga gaggacagag agaaagagag acagagagag agacagagaa
     1861 gagacagaga gagaaaaaga gagagacaca gagagagaca gagagaaaag agagagagaa
     1921 gagagagagg agagagagag aagagagaga aagagagaca gagacagaga gaagacagag
     1981 agagaagaca gagagaagag agagacagag agagagagac agagagagga cagagagaaa
     2041 gagagacaga gagagagaca gagaagagac agagagagag agaaaaagag agagacagag
     2101 agagagacag agagaaaaga gagagagaga agagagagag agaagagaga gagagagaga
     2161 gagagagaga gcgccttcag ccactgaatt tgcatctctc tctcctcttt ccctacacct
     2221 tatggttcct gactcagagc agcagcgtcc acagcagaga tcttttccac gctctccata
     2281 cccatcttcc cacacagaat tccaggagaa ccatgaaagg aagaggagga agaggaggcg
     2341 gcagagggac agaagctggg atggagggga gggttgggag ggggagagtc atcagtgtgc
     2401 tggagcctgg tctttctgac tggtaggctg acaagactga taattacatt tcccagaatt
     2461 ttgcagttca gttgttaaac acagccatta tgaaaaatta aattacataa ccttgca
//
