LOCUS       NM_133513               1478 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus opiorphin prepropeptide (Oprpn), mRNA.
ACCESSION   NM_133513 XM_346457
VERSION     NM_133513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Fang,Y., Li,S., Zhou,H., Tian,X., Lv,S. and Chen,Q.
  TITLE     Opiorphin increases blood pressure of conscious rats through
            renin-angiotensin system (RAS)
  JOURNAL   Peptides 55, 47-51 (2014)
   PUBMED   24486428
  REMARK    GeneRIF: Opiorphin may play an important role in the modulation of
            blood pressure through angiotensin II dependent pathways
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Wisner,A., Dufour,E., Messaoudi,M., Nejdi,A., Marcel,A.,
            Ungeheuer,M.N. and Rougeot,C.
  TITLE     Human Opiorphin, a natural antinociceptive modulator of
            opioid-dependent pathways
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17979-17984 (2006)
   PUBMED   17101991
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Albone,E.F., Hagen,F.K., VanWuyckhuyse,B.C. and Tabak,L.A.
  TITLE     Molecular cloning of a rat submandibular gland apomucin
  JOURNAL   J Biol Chem 269 (24), 16845-16852 (1994)
   PUBMED   8207007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 24, 2020 this sequence version replaced NM_133513.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.48522.1,
                                           SRR26643293.56289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000014.1  20001485-20001589   c
            106-174             JAXUCZ010000014.1  20000494-20000562   c
            175-1478            JAXUCZ010000014.1  19986575-19987878   c
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1478
                     /gene="Oprpn"
                     /gene_synonym="Muc10; Prol1; RSM-1"
                     /note="opiorphin prepropeptide"
                     /db_xref="GeneID:65182"
                     /db_xref="RGD:620983"
     exon            1..105
                     /gene="Oprpn"
                     /gene_synonym="Muc10; Prol1; RSM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..174
                     /gene="Oprpn"
                     /gene_synonym="Muc10; Prol1; RSM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1050
                     /gene="Oprpn"
                     /gene_synonym="Muc10; Prol1; RSM-1"
                     /note="mucin 10, submandibular gland salivary mucin;
                     proline rich, lacrimal 1"
                     /codon_start=1
                     /product="opiorphin prepropeptide precursor"
                     /protein_id="NP_598197.2"
                     /db_xref="GeneID:65182"
                     /db_xref="RGD:620983"
                     /translation="MKRETFILGLLALLSYFTPGESHHFQPKPHPYQRLQQPIYHRRH
                     SQVSSIYPRYGQYPRYFYVSQKQQAQKPQILPIQTPWQRVCPPGYTARLLHYHYSRFL
                     CIPNKQLTSDKIETKVTTPAQTTKPTTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTP
                     APTTKPTTDSTTPAPTTKPTTDSTTPAPTNKPTTDSTTPAPTTKPTADSTTPAPTTKP
                     TTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTTKIPTTPKPSTSTAIPTSTNSA
                     NSSSSTTTSSTTIQTTTLSPFQQMLQWLQMYFG"
     exon            175..1478
                     /gene="Oprpn"
                     /gene_synonym="Muc10; Prol1; RSM-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctctttct tctcgaattt tcaaccgtag ctaccaaaac tgaatatttg gcaaaagtaa
       61 gctgaagcaa cagttgattg ttccaaagga gaatctccca ccaaggagca acattaagaa
      121 atgaaaaggg aaactttcat cttgggcctg ttggctcttc tttcatattt tacgcctgga
      181 gaaagtcatc acttccagcc aaaaccacat ccataccaaa ggctacagca acccatttac
      241 cacagacgac attcacaagt ctcttctatt tacccaagat atggtcaata tccacgttat
      301 ttctatgttt cacagaaaca gcaagctcaa aaacctcaaa ttttaccaat tcaaactcca
      361 tggcaacgtg tctgccctcc aggatatact gcgaggctgc tccattacca ttattctagg
      421 tttctatgca ttcctaataa acagttaacc tctgacaaaa tagaaacaaa agtcactaca
      481 ccagcacaga ccaccaagcc taccacagat tcaaccacac cagcaccgac caccaagcct
      541 accacagatt caaccacacc agcaccaacc accaagccta ccacagattc aaccacacca
      601 gcaccgacca ccaagcctac cacagattca accacaccag caccgaccac caagcctacc
      661 acagattcaa ccacaccagc accgaccaac aagcctacca cagattcaac cacaccagca
      721 ccaaccacca agcctaccgc agattcaacc acaccagcac cgaccaccaa gcctaccaca
      781 gattcaacca caccagcacc gaccaccaag cctaccacag attcaaccac accagcaccg
      841 accaccaagc ctaccacaga ttcaaccaca ccagcaccga ccacaaaaat acctactaca
      901 cctaagccta gcacctcaac agccatacct acatcaacta actctgctaa cagctcttcc
      961 tctactacta catcaagtac caccatccaa actacaactc tgtcaccttt tcaacagatg
     1021 cttcagtggc ttcagatgta ctttggttaa agtaggatgg gatgggatgg tctccaaact
     1081 gtcagaacag ttttatctct taggataaat aagcctcaat gatgatttta aagaaatcaa
     1141 cctgatctta ctagaaaatc aaacaaataa aaacaatttg agcaatgaaa tgcatctctt
     1201 tttgtcctga tgactaccat gttatcctgt gttttaccat ctaccaccaa ctgctaaatg
     1261 ggcttcctag aagaaatcag ggagcctttg attgaaaata cctgtctata tacacagatg
     1321 tttacatata tatctattgt aagttgcatg agtttaacta aaaacaaaaa aatacaagag
     1381 ctattaaggc attcaatctt gttccaatga agctggtaag gtacctaggc atggtggggc
     1441 aaagggaata taaaagtaaa taaattaaat taagtaaa
//
