LOCUS       NM_013071               2306 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            1, mRNA.
ACCESSION   NM_013071
VERSION     NM_013071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1 and L20684.1.
            
            On Apr 20, 2007 this sequence version replaced NM_013071.1.
            
            Transcript Variant: This variant (1) lacks several exons and
            contains an alternate terminal exon compared to variant MOR-1C2.
            The encoded isoform (1) is shorter than isoform 1C2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20684.1, D16349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               L13069.1           3-941
            940-2306            L20684.1           763-2129
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2306
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1404
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mu-type opioid receptor; MOR-1; MUOR1; opioid receptor B;
                     M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_037203.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..2306
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accagctaga aaatctggag
     1381 gcagaaactg ctccattgcc ctaactgggt ctcacaccat ccagaccctc gctaagctta
     1441 gaggccgcca tctacgtgga atcaggttgc tgtcagggtg tgtgggaggc tctggtttcc
     1501 tgagaaacca tctgatcctg cattcaaagt cattcctctc tggctacttc actctgcaca
     1561 tgagagatgc tcagactgta tcaagtactc agaaagaaga gactaccgga cactcctgaa
     1621 tccagctcat gtacagaacc atctgaaaca cccagtggac cacaatgctc tgtggtatgt
     1681 gaatttcgat catcatagaa ggtgacccct ctctatgtag aatttttatt tttcaagcaa
     1741 atacttatga cctcatcaaa gaaaataatg tcacttgtta aattcactgt agtgatacat
     1801 aaagtaaatg ctacctctga cctctgaccc agtcaccttc tgtagagagt tccagtcctt
     1861 ttgtgatgga atacatcatt tccaacttaa aactttcacc ttgaagttat ggtctagtta
     1921 agacatcagg ggcacctccg tttcttggtt ttgtattgtt tgaaagaaga cgacatcttc
     1981 ctccttagct gtgtgttgaa aatgaaaggg attgaaagca cagtgtcaac tgcagaatgg
     2041 ttgattctca ctctgaaagg atttacttcg agttataatg tgggggttag gagaggggct
     2101 gttttttcct aattcccacc atgtcctcta agtgttcaca aggtcaagtt cagaaggtca
     2161 cccagtgagt tcatcatgct atcattctga gcaggaagcc aagaatttcg ctctcttcat
     2221 ttttttcagt aatttctcca cactgcacgc tcttttgtat tattttccct gatgccttat
     2281 gaaacagcat gatcaaacaa cagatg
//
