LOCUS       NM_001304737            2646 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1i1, mRNA.
ACCESSION   NM_001304737
VERSION     NM_001304737.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1i1) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1) is shorter
            than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU340245.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000001.1  45565371-45565531
            162-831             JAXUCZ010000001.1  45585804-45586473
            832-1184            JAXUCZ010000001.1  45617450-45617802
            1185-1705           JAXUCZ010000001.1  45618567-45619087
            1706-2646           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2646
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..161
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..831
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..1744
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant MOR-1i1;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_001291666.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     exon            832..1184
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..2646
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctg taagctttct ccaagtccgc attccaaaaa
      121 ctggacaggg agatagaaat caagagggga agttacctca gtgcatggag accgaccgac
      181 cgaggaggct gactctctga ttgctttgcg caaaatccac tcctctcctc cctcctctct
      241 agcctctgga tccctcgcag cccgcgcgct ccctcccttc cacccagaga gtggcgcttt
      301 gggaagctag agatgcgcct ctgtgtactt ctaaggtggg agggggctac aagcagagga
      361 gaatatcaga cgctcagacg ttcccttctg cctgccgctc ttctctggtt ccactagggc
      421 tggtccatgt aagaatctga cggagcctag ggcagctgtg agaggaagag gctggggcgc
      481 gtggaacccg aaaagtctga gtgctctcag ttacagccta cctagtccgc agcaggcctt
      541 cagcaccatg gacagcagca ccggcccagg gaacaccagc gactgctcag accccttagc
      601 tcaggcaagt tgctccccag cacctggctc ctggctcaac ttgtcccacg ttgatggcaa
      661 ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc gggaacgaca gcctgtgccc
      721 tcagaccggc agcccttcca tggtcacagc cattaccatc atggccctct actctatcgt
      781 gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat gtgattgtaa gatacaccaa
      841 aatgaagact gccaccaaca tctacatttt caaccttgct ctggcagacg ccttagcgac
      901 cagtacactg ccctttcaga gtgtcaacta cctgatggga acatggccct tcggaaccat
      961 cctctgcaag atcgtgatct caatagatta ctacaacatg ttcaccagca tattcaccct
     1021 ctgcaccatg agcgtggacc gctacattgc tgtctgccac ccagtcaaag ccctggattt
     1081 ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac tggatcctct cttctgccat
     1141 cggtctgcct gtaatgttca tggcaaccac aaaatacagg caggggtcca tagattgcac
     1201 cctcacgttc tcccacccaa cctggtactg ggagaacctg ctcaaaatct gtgtctttat
     1261 cttcgctttc atcatgccgg tcctcatcat cactgtgtgt tacggcctga tgatcttacg
     1321 actcaagagc gttcgcatgc tatcgggctc caaagaaaag gacaggaatc tgcgcaggat
     1381 cacccggatg gtgctggtgg tcgtggctgt atttatcgtc tgctggaccc ccatccacat
     1441 ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc acatttcaga ccgtttcctg
     1501 gcacttctgc attgctttgg gttacacgaa cagctgcctg aatccagttc tttacgcctt
     1561 cctggatgaa aacttcaagc gatgcttcag agagttctgc atcccaacct cgtccacgat
     1621 cgaacagcaa aactccactc gagtccgtca gaacactagg gaacatccct ccacggctaa
     1681 tacagtggat cgaactaacc accagctaga aaatctggag gcagaaactg ctccattgcc
     1741 ctaactgggt ctcacaccat ccagaccctc gctaagctta gaggccgcca tctacgtgga
     1801 atcaggttgc tgtcagggtg tgtgggaggc tctggtttcc tgagaaacca tctgatcctg
     1861 cattcaaagt cattcctctc tggctacttc actctgcaca tgagagatgc tcagactgta
     1921 tcaagtactc agaaagaaga gactaccgga cactcctgaa tccagctcat gtacagaacc
     1981 atctgaaaca cccagtggac cacaatgctc tgtggtatgt gaatttcgat catcatagaa
     2041 ggtgacccct ctctatgtag aatttttatt tttcaagcaa atacttatga cctcatcaaa
     2101 gaaaataatg tcacttgtta aattcactgt agtgatacat aaagtaaatg ctacctctga
     2161 cctctgaccc agtcaccttc tgtagagagt tccagtcctt ttgtgatgga atacatcatt
     2221 tccaacttaa aactttcacc ttgaagttat ggtctagtta agacatcagg ggcacctccg
     2281 tttcttggtt ttgtattgtt tgaaagaaga cgacatcttc ctccttagct gtgtgttgaa
     2341 aatgaaaggg attgaaagca cagtgtcaac tgcagaatgg ttgattctca ctctgaaagg
     2401 atttacttcg agttataatg tgggggttag gagaggggct gttttttcct aattcccacc
     2461 atgtcctcta agtgttcaca aggtcaagtt cagaaggtca cccagtgagt tcatcatgct
     2521 atcattctga gcaggaagcc aagaatttcg ctctcttcat ttttttcagt aatttctcca
     2581 cactgcacgc tcttttgtat tattttccct gatgccttat gaaacagcat gatcaaacaa
     2641 cagatg
//
