LOCUS       NM_031569               2999 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus opioid related nociceptin receptor 1 (Oprl1),
            transcript variant 1, mRNA.
ACCESSION   NM_031569
VERSION     NM_031569.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   Al Yacoub,O.N., Zhang,Y., Patankar,P.S. and Standifer,K.M.
  TITLE     Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and
            Nociceptin Opioid Peptide Receptor Expression within 24 Hours
  JOURNAL   Int J Mol Sci 25 (3), 1658 (2024)
   PUBMED   38338936
  REMARK    GeneRIF: Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and
            Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Borruto,A.M., Fotio,Y., Stopponi,S., Petrella,M., De Carlo,S.,
            Domi,A., Ubaldi,M., Weiss,F. and Ciccocioppo,R.
  TITLE     NOP receptor antagonism attenuates reinstatement of alcohol-seeking
            through modulation of the mesolimbic circuitry in male and female
            alcohol-preferring rats
  JOURNAL   Neuropsychopharmacology 46 (12), 2121-2131 (2021)
   PUBMED   34285372
  REMARK    GeneRIF: NOP receptor antagonism attenuates reinstatement of
            alcohol-seeking through modulation of the mesolimbic circuitry in
            male and female alcohol-preferring rats.
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   Chang,H.W., Ho,W.C., Huang,C.L. and Wang,R.Y.
  TITLE     Precision therapeutic opioid dosing implications from genetic
            biomarkers and craving score
  JOURNAL   Medicine (Baltimore) 99 (22), e20429 (2020)
   PUBMED   32481444
REFERENCE   4  (bases 1 to 2999)
  AUTHORS   Sener,E.F., Taheri,S., Sahin,M.C., Bayramov,K.K., Marasli,M.K.,
            Zararsiz,G., Mehmetbeyoglu,E., Oztop,D.B., Canpolat,M., Canatan,H.
            and Ozkul,Y.
  TITLE     Altered Global mRNA Expressions of Pain and Aggression Related
            Genes in the Blood of Children with Autism Spectrum Disorders
  JOURNAL   J Mol Neurosci 67 (1), 89-96 (2019)
   PUBMED   30519864
REFERENCE   5  (bases 1 to 2999)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (bases 1 to 2999)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (bases 1 to 2999)
  AUTHORS   Lachowicz,J.E., Shen,Y., Monsma,F.J. Jr. and Sibley,D.R.
  TITLE     Molecular cloning of a novel G protein-coupled receptor related to
            the opiate receptor family
  JOURNAL   J Neurochem 64 (1), 34-40 (1995)
   PUBMED   7798930
REFERENCE   8  (bases 1 to 2999)
  AUTHORS   Wick,M.J., Minnerath,S.R., Lin,X., Elde,R., Law,P.Y. and Loh,H.H.
  TITLE     Isolation of a novel cDNA encoding a putative membrane receptor
            with high homology to the cloned mu, delta, and kappa opioid
            receptors
  JOURNAL   Brain Res Mol Brain Res 27 (1), 37-44 (1994)
   PUBMED   7877452
REFERENCE   9  (bases 1 to 2999)
  AUTHORS   Wang,J.B., Johnson,P.S., Imai,Y., Persico,A.M., Ozenberger,B.A.,
            Eppler,C.M. and Uhl,G.R.
  TITLE     cDNA cloning of an orphan opiate receptor gene family member and
            its splice variant
  JOURNAL   FEBS Lett 348 (1), 75-79 (1994)
   PUBMED   8026588
REFERENCE   10 (bases 1 to 2999)
  AUTHORS   Chen,Y., Fan,Y., Liu,J., Mestek,A., Tian,M., Kozak,C.A. and Yu,L.
  TITLE     Molecular cloning, tissue distribution and chromosomal localization
            of a novel member of the opioid receptor gene family
  JOURNAL   FEBS Lett 347 (2-3), 279-283 (1994)
   PUBMED   8034018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000003.1.
            
            On Jan 15, 2016 this sequence version replaced NM_031569.3.
            
            Summary: The protein encoded by this gene is a member of the 7
            transmembrane-spanning G protein-coupled receptor family, and
            functions as a receptor for the endogenous, opioid-related
            neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system
            modulates a variety of biological functions and neurobehavior,
            including stress responses and anxiety behavior, learning and
            memory, locomotor activity, and inflammatory and immune responses.
            Alternatively spliced transcript variants have been found for this
            gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1) results from translation termination at the upstream
            UGA stop codon, while the longer isoform (1x) results from UGA stop
            codon readthrough to the downstream UAG termination codon. This
            RefSeq represents the shorter isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L33916.1, SRR26643298.20928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000003.1  189211509-189211707
            200-456             JAXUCZ010000003.1  189212175-189212431
            457-812             JAXUCZ010000003.1  189214803-189215158
            813-2999            JAXUCZ010000003.1  189215240-189217426
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2999
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /note="opioid related nociceptin receptor 1"
                     /db_xref="GeneID:29256"
                     /db_xref="RGD:68438"
     exon            1..199
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..456
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1336
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptide receptor; nociceptin receptor ORL1; seven
                     transmembrane G protein-coupled receptor; orphanin FQ
                     receptor-a; orphanin FQ receptor-e; orphanin FQ
                     receptor-b; kappa-type 3 opioid receptor; ROR-C; opioid
                     receptor-like 1; opiate receptor-like 1"
                     /codon_start=1
                     /product="nociceptin receptor isoform 1"
                     /protein_id="NP_113757.1"
                     /db_xref="GeneID:29256"
                     /db_xref="RGD:68438"
                     /translation="MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLP
                     LGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLP
                     FQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT
                     SSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFL
                     FSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPV
                     QVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCAS
                     SLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA"
     exon            457..812
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2999
                     /gene="Oprl1"
                     /gene_synonym="KOR-3; KOR3; LC132; MOR-C; OFQR; Oprl;
                     ORL1; XOR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgccgca ccggctgctg cgtctagtca atatcttatc ttccgagcag gagctaggag
       61 ccattcccag ccgcagcaga ccccaatcta gagtgagagt cattgctcag tccactgtgc
      121 tcctgcctgc ccgcctttct gctaagcatt ggggtctatt ttggcccagc ttctgaagag
      181 gctgtgtgtg ccgttggagg aactgtactg agtggctttg cagggtgaca gcatggagtc
      241 cctctttcct gctccatact gggaggtctt gtatggcagc cactttcaag ggaacctgtc
      301 cctcctaaat gagaccgtac cccaccacct gctcctcaat gctagtcaca gcgccttcct
      361 gccccttgga ctcaaggtca ccatcgtggg gctctacttg gctgtgtgca tcggggggct
      421 cctggggaac tgcctcgtca tgtatgtcat cctcaggcac accaagatga agacagctac
      481 caacatttac atatttaatc tggcactggc tgataccctg gtcttgctaa cactgccctt
      541 ccagggcaca gacatcctac tgggcttctg gccatttggg aatgcactct gcaagactgt
      601 cattgctatc gactactaca acatgtttac cagcactttt actctgaccg ccatgagcgt
      661 agaccgctat gtggctatct gccaccctat ccgtgccctt gatgttcgga catccagcaa
      721 agcccaggct gttaatgtgg ccatatgggc cctggcttca gtggttggtg ttcctgttgc
      781 catcatgggt tcagcacaag tggaagatga agagatcgag tgcctggtgg agatccctgc
      841 ccctcaggac tattggggcc ctgtattcgc catctgcatc ttcctttttt ccttcatcat
      901 ccctgtgctg atcatctctg tctgctacag cctcatgatt cgacgacttc gtggtgtccg
      961 tctgctttca ggctcccggg agaaggaccg aaacctgcgg cgtatcactc gactggtgct
     1021 ggtagtggtg gctgtgtttg tgggctgctg gacgcctgtg caggtgtttg tcctggttca
     1081 aggactgggt gttcagccag gtagtgagac tgcagttgcc atcctgcgct tctgcacagc
     1141 cctgggctat gtcaacagtt gtctcaatcc cattctctat gctttcctgg atgagaactt
     1201 caaggcctgc tttagaaagt tctgctgtgc ttcatccctg caccgggaga tgcaggtttc
     1261 tgatcgtgtg cggagcattg ccaaggatgt tggccttggt tgcaagactt ctgagacagt
     1321 accacggcca gcatgactag gcgtggacct gcctatggtg cctgtcagcc cacagagccc
     1381 atctacaccc aacacggagc tcacacaggt cactgctctc taggttgacc ctgaaccttg
     1441 agcatctgga gccttgaatg gcttttcttt tggatcagga tgctcagtcc tagaggaaga
     1501 ccttttagca ccatgggaca ggtcaaagca tcaaggtggt ctccatggcc tctgtcagat
     1561 taagttccct ccctggtata ggaccagaga ggaccaaagg aactgaatag aaacatccac
     1621 aacacagtgg acatgcctgg tgagcccatg taggtattca tgcttcactt gactcttctc
     1681 tggcttctcc ctgctgccct ggctctagct gggctcaacc tgaggtattg tagtggtcat
     1741 gtagtcactc ttgtgactac atgttgtgtg ctgttgctct cggcctttca gtatttccac
     1801 aggactgctg aacatacctg gtattgcagt ggggagcatt aattttcttt taaagtgaga
     1861 ctggccctta agcttggcgt tgccttggag cgtcttctac ttctgacttc actgatgcag
     1921 tcagattacc cgagggtgag catcagtggt ttcttggatg gctgttttct gaagattctt
     1981 cccatccagt acatggagtc tatgaagggg agtcacaatt catctggtac tgccactacc
     2041 tgctctataa tcctgggcta tcttcttggc aagatgacag tgggggagac aagacacaga
     2101 gcttccctaa ggctctttcc ctccaaaacc actgtgaact cttatcctac agactgttcg
     2161 gcaagcactg cttctaggtg tgtgggaggt aatcaggaga aagctttgtg gcctctgtag
     2221 gctgctcaca acatggaggc accacatgct ggtcttgcct gcttagtaca ggcaggacag
     2281 agcagaatat gctctctctc gattctctac aaactccctc agttctccag cagagtctct
     2341 tttacttgct atcagaggtc aggagttgta ctgctagaag catacttgta gcttgggaag
     2401 agtggcagtc aggatgtgtt ctactctata tccacagtga ccacctgctt catatatagg
     2461 gttaggacat atctgagtaa ggcctgagtg tgctgccaaa ttggaggttg gcatgagagc
     2521 tgatgcctaa agtggctcat ttgcaaggac tattatggtt tggaatagca atggggggca
     2581 tgggaagaag agtctatacc ttggagatct atttgatggt tcacagaaga ggttttgtaa
     2641 acgccctttc tatgggtcag atatcaaaat accagcaacg ttggatagat tctgaccttt
     2701 tactgagacc tcggtcagat ggtttcatgt catgcagaga acctaggctg gttcctgtgt
     2761 cagagagacc tgggcttctg gggaggccag ggttcttcct ttgacacttg tgcgggagcc
     2821 gttagctcta gagttttctt gctaatgcta agaaactttg tgaatttgta tatctttatg
     2881 tatttaagca tgcaacaagt gtcatttcca tgcatgtagc tagccctgaa cctgcctctg
     2941 gggtaatgaa ggagtgctca taataaacac ttatccagtg accagtactg tccatagaa
//
