LOCUS       NM_017167               4740 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus opioid receptor, kappa 1 (Oprk1), transcript
            variant 1, mRNA.
ACCESSION   NM_017167 XM_346732
VERSION     NM_017167.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Namchuk,A.B., Tsuda,M.C., Lucki,I. and Browne,C.A.
  TITLE     Kappa opioid receptor mediated operant performance in male and
            female rats
  JOURNAL   Pharmacol Biochem Behav 244, 173847 (2024)
   PUBMED   39151827
  REMARK    GeneRIF: Kappa opioid receptor mediated operant performance in male
            and female rats.
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Uenoyama,Y., Nonogaki,M., Tsuchida,H., Takizawa,M., Matsuzaki,S.,
            Inoue,N. and Tsukamura,H.
  TITLE     Central delta/kappa opioid receptor signaling pathways mediate
            chronic and/or acute suckling-induced LH suppression in rats during
            late lactation
  JOURNAL   J Reprod Dev 70 (5), 327-337 (2024)
   PUBMED   39155080
  REMARK    GeneRIF: Central delta/kappa opioid receptor signaling pathways
            mediate chronic and/or acute suckling-induced LH suppression in
            rats during late lactation.
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Shao,J., Fei,Y., Xiao,J., Wang,L., Zou,S. and Yang,J.
  TITLE     The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and
            nicotine withdrawal in male rats
  JOURNAL   Nicotine Tob Res 25 (12), 1856-1864 (2023)
   PUBMED   37455648
  REMARK    GeneRIF: The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence
            and nicotine withdrawal in male rats.
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Ozkan-Kotiloglu,S., Kaya-Akyuzlu,D., Yurdakul,R., Yildirim,M.A. and
            Ozgur-Ilhan,I.
  TITLE     Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use
            disorder and the intensity of depressive symptoms
  JOURNAL   Alcohol Alcohol 58 (4), 404-414 (2023)
   PUBMED   37177778
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (bases 1 to 4740)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (bases 1 to 4740)
  AUTHORS   Simonin,F., Gaveriaux-Ruff,C., Befort,K., Matthes,H., Lannes,B.,
            Micheletti,G., Mattei,M.G., Charron,G., Bloch,B. and Kieffer,B.
  TITLE     kappa-Opioid receptor in humans: cDNA and genomic cloning,
            chromosomal assignment, functional expression, pharmacology, and
            expression pattern in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7006-7010 (1995)
   PUBMED   7624359
REFERENCE   8  (bases 1 to 4740)
  AUTHORS   Yakovlev,A.G., Krueger,K.E. and Faden,A.I.
  TITLE     Structure and expression of a rat kappa opioid receptor gene
  JOURNAL   J Biol Chem 270 (12), 6421-6424 (1995)
   PUBMED   7896774
REFERENCE   9  (bases 1 to 4740)
  AUTHORS   Meng,F., Xie,G.X., Thompson,R.C., Mansour,A., Goldstein,A.,
            Watson,S.J. and Akil,H.
  TITLE     Cloning and pharmacological characterization of a rat kappa opioid
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 9954-9958 (1993)
   PUBMED   8234341
REFERENCE   10 (bases 1 to 4740)
  AUTHORS   Minami,M., Toya,T., Katao,Y., Maekawa,K., Nakamura,S., Onogi,T.,
            Kaneko,S. and Satoh,M.
  TITLE     Cloning and expression of a cDNA for the rat kappa-opioid receptor
  JOURNAL   FEBS Lett 329 (3), 291-295 (1993)
   PUBMED   8103466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000005.1.
            
            On Jan 14, 2016 this sequence version replaced NM_017167.2.
            
            Summary: This gene encodes an opioid receptor, which is a member of
            the 7 transmembrane-spanning G protein-coupled receptor family. It
            functions as a receptor for endogenous ligands, as well as a
            receptor for various synthetic opioids. Ligand binding results in
            inhibition of adenylate cyclase activity and neurotransmitter
            release. This opioid receptor plays a role in the perception of
            pain and mediating the hypolocomotor, analgesic and aversive
            actions of synthetic opioids. Variations in this gene have also
            been associated with alcohol dependence and opiate addiction. A
            recent study provided evidence for translational readthrough in
            this gene, and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2017].
            
            Transcript Variant: This transcript (1) encodes two isoforms, which
            result from the use of alternative in-frame translation termination
            codons. The shorter isoform (1) results from translation
            termination at the upstream UGA stop codon, while the longer
            isoform (1x) results from UGA stop codon readthrough to the
            downstream UGA termination codon. This RefSeq represents the
            shorter isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U00442.1, SRR26360194.1968241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JAXUCZ010000005.1  18675459-18675671   c
            214-516             JAXUCZ010000005.1  18674796-18675098   c
            517-869             JAXUCZ010000005.1  18665100-18665452   c
            870-4740            JAXUCZ010000005.1  18657866-18661736   c
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..4740
                     /gene="Oprk1"
                     /note="opioid receptor, kappa 1"
                     /db_xref="GeneID:29335"
                     /db_xref="RGD:69426"
     exon            1..213
                     /gene="Oprk1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..516
                     /gene="Oprk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1402
                     /gene="Oprk1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kappa-type opioid receptor; KOR-1; K-OR-1"
                     /codon_start=1
                     /product="kappa-type opioid receptor isoform 1"
                     /protein_id="NP_058863.1"
                     /db_xref="GeneID:29335"
                     /db_xref="RGD:69426"
                     /translation="MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGS
                     EDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLA
                     LADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV
                     CHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDE
                     YSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLV
                     LVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLD
                     ENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV"
     exon            517..869
                     /gene="Oprk1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..4740
                     /gene="Oprk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaaccag ccccccgctg ctctcagcct gcctgtccgc tgtgcgcctt gactgaatcc
       61 caaccggcag agcttcttcc agtcttggaa ggcacaagtt aaacatcagg gacgtggacc
      121 catcgaggct gaacagctac cccggagccg aagtggtgac ctggaaaact gacgctgatt
      181 tgggaaggga ggtcggcaat tcgcgatccg gagcccggca agtgccatcg ctcctcggtt
      241 tccagctgca gcactcacca tggagtcccc catccagatt ttccgcggag agccaggccc
      301 tacctgtgct cccagtgctt gcctactccc caacagcagc tcttggttcc ccaactgggc
      361 cgaatcggac agcaatggca gtgtgggctc cgaggaccag cagctggagc ccgcgcacat
      421 ctctccagcc atccctgtta tcatcaccgc tgtctactct gtggtgtttg tggtgggctt
      481 agtgggcaat tccctggtca tgtttgtcat catccgatac acaaagatga agaccgcaac
      541 caacatctac atatttaacc tggctttggc agatgctttg gttactacca ctatgccctt
      601 ccagagtgct gtctacttga tgaattcttg gccttttgga gatgttctgt gcaagattgt
      661 catttccatt gactactaca acatgtttac cagcatattc accttgacca tgatgagtgt
      721 ggaccgctac attgccgtgt gccaccctgt gaaagctttg gatttccgaa cacctttgaa
      781 agcaaagatc atcaacatct gcatttggct actggcatca tctgttggta tatcagcgat
      841 agtccttgga ggcaccaaag tcagggaaga tgtggatgtc attgaatgct ccttgcagtt
      901 tcctgatgat gaatattcct ggtgggacct cttcatgaag atctgtgtct tcgtctttgc
      961 ctttgttatc cctgtcttaa tcatcattgt ctgctacacc ctgatgatcc tgcgcttgaa
     1021 gagtgtccgg ctcctctcgg gctctcgaga gaaggaccga aatctccgcc ggatcaccaa
     1081 gctggtgctg gtagtggttg cagtcttcat catctgttgg acccccatcc acatctttat
     1141 cctggtcgag gctctaggca gcacctccca cagcacagct gtcctctcta gctattactt
     1201 ctgcattgcc ttgggttata ccaacagcag cttgaatcct gttctctatg cctttcttga
     1261 tgaaaacttc aagcggtgtt ttagggactt ctgcttcccc attaagatgc gaatggagcg
     1321 ccagagcaca aacagagtta gaaacacagt tcaggatcct gcttccatga gggatgtggg
     1381 tgggatgaat aagccagtat gactagtcat ggaaatgtct tcctattgtt ctccgggtag
     1441 agaagagttc aatgatcttg gtttaaccca gattaccact gcagtctgaa gaggaaagat
     1501 gaggtattca ataacttagc catgttatgc aatctaaagg tgcagggcac attagtgatc
     1561 tagctgagta ggggcagcaa gtgtgaagaa cagagcacat gtcctggcaa caatacacct
     1621 ctttcctagg acagaggaga aggcaatcta atctcaaccc ttcgataaac agacagcact
     1681 ctttcttctg gccccttgat ttactgcacc tccatctgcg tggcctttct gtgtaacata
     1741 gttccaaagc tctagagaag aaaatgaaag aaaaagtgca tttgatccaa aacttactgg
     1801 gcacccaacc ttcgcgttaa cacaggcaaa accaacttcg tatacaatga ggccatacca
     1861 agggtcatat ccaactcact ttctgctggt gatcatgtct tatgtgtgat gagagtgaaa
     1921 cttaggaaga acctggactc agaccctgac actgggggag agcaccatat tgacatttgt
     1981 gaacctattt aaagttgtgg gtgttctcgt ctcacagtgt ctaatgcctc gaaaaactac
     2041 agttgcttct taaggtctct ggtttttagc atgctattca ggaagataat cttctgagaa
     2101 aacatgaact gatattaaaa ggttgaagct taaataccag caaagtgtgt gtaatttcat
     2161 ctgtaaatag tggtctgtat ataaataagg accaggtttt cctgtccagc ctgtacattt
     2221 ctcaaggatg ccgtagacac acccctggag gcatggaaag ttcatgctgg gatattttgc
     2281 ttcactataa gctactttct tgatttggtc ttggtgtgat ttctactaga ttactcaaac
     2341 atcatttact ctaacactga tcataacttg gtgttaacaa ttccccaaac tttgaattca
     2401 ttctaaagtg ttagcattga tcaaatctac tttgtggtag catctgtttg taaacacaca
     2461 catattgcca gattctctac tcaggtagag gaagttgctt tgatcatgta caccttcaaa
     2521 tgttatgctc tggctttcca cagaaagtgg aattgtttca aaatgcatgc tgaaaaagga
     2581 aataggattt gagatggctt agcacaattt gcatggtatt gagtaagagg gtacctgtgg
     2641 aagttactat ctgagaagcc catttaggat acttttgcta aatcttccaa atgaatataa
     2701 attctccatt ctttccttca aaacttatag ttcagagata ataagagggt ttttttgttt
     2761 tgttttgttt ttgacaattt tccttgaaag aagaaaggca taatttaaaa ataacatcta
     2821 tttcttcagc ttgcacatgg ttagggcagc accccttggg ggctaataga tgatctgatg
     2881 tgtaaacctg gatactgtag gcacagttcc atctgtaagt tctcaccacc agctgtctca
     2941 cgggggttgt tccctcactt tctggagatg gaggcctgta taaaggtatg acacactctc
     3001 cagagtcact gccattatgt ttaactccat atgagacatt tatgcagctg aattcaatga
     3061 caatgacatt gcagagatat ttcatagtga agattaaatg ctcttttgag tatttcttac
     3121 atttcactga ataccttgat gctctggaat tcttttgtaa tgacacatag ctagaactta
     3181 ttaagagaca ggtattaatg tagatttaag catgaagtct gacagaggac aaaagacata
     3241 taaaagaggg acatgcccta gagtggacac aaagttcttt taaaacttgc tgttgatatt
     3301 attattatta ttattattat tattattatt attattattc atgtgagggc atgcattatg
     3361 gcatgcatat agaggtcaga ggacagcttt gcacagtcac ttctcttctc tttctttcac
     3421 atatgttctg gggatggtac gcacatcagc tgtcctgcat tgtcgagtag catgtacctt
     3481 cactgagcta tcttaccagc ccagagtaca gctttcttat aagagagagt caccatcctt
     3541 gcattcttaa aactagatat atagataaga atgacttaaa tattgggaaa tattaaccca
     3601 atagtttaaa actttggcta atatagttaa gatatatata tttggacaaa gcagttcctg
     3661 aacaaatcct tctgaaaagc ctctacagta tagtaagatg cagaagatgc ttatagattc
     3721 ttccccagaa aaacaaagca aaacacaatg tggttatcac atcacctcag gatggactta
     3781 gaatggtgag ttctttatca ttccatgtgc tctcctaata tctctgtttc ctgcactttc
     3841 caatacataa gtttgaatcc catggaaggg acaagaatag ctttactgcc attgagatct
     3901 attctgagct tccccatgac cctcaggttg aaagtgaaga atagatgaca gccactttag
     3961 gatactaatt taaagaataa taaacagact tagacactgg aagggaagta tcaattacat
     4021 ataagtgttc tactgttgaa ctatatacat gtacatgtat acatgaaaga gagcagattc
     4081 atacatatgt gcacatgtgc atgataatag atggcagtgg tcatactact gtgcttgctt
     4141 aatgcaaaca gtgcatttgt ctaactccac atcctcaaac gattcctcat ctttgaggtc
     4201 cccagaagcc ttttccatta aagagagaag gatttgcttg ctatgtctga gaccttgaga
     4261 tcaaccctac ctggcctcta tcttcccatt ctagtagcaa attttgaaaa acaaaatttg
     4321 tctggagata taagaagaat atttgagaaa agtgtttaat tttgtgattg atatgttagg
     4381 ttgttgttaa acttgtttct aacaatttat agatattgca tctaatactg ggacataaaa
     4441 tgaatacaat caaagaatat aggctttaag tgaattttaa ggacagccta tgacaaattt
     4501 gtatgtcatt gtacaaattt tatttttcaa gaaagagttg ttttgatggg tttctatcag
     4561 tatgcaagtc ctataaggtt aaaaattagc tcagaccttg acagttttcc tatctgaaac
     4621 tcaaaagtgt gttctttact atatcaatat tgtttatata ttatactgtt agagagtaat
     4681 tatacattgt atatatgatt gtgtaccttg aaataaaacc aaaattgtac ctgctaaaaa
//
