LOCUS       NM_012617               1418 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus opioid receptor, delta 1 (Oprd1), mRNA.
ACCESSION   NM_012617 XM_001063354
VERSION     NM_012617.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Uenoyama,Y., Nonogaki,M., Tsuchida,H., Takizawa,M., Matsuzaki,S.,
            Inoue,N. and Tsukamura,H.
  TITLE     Central delta/kappa opioid receptor signaling pathways mediate
            chronic and/or acute suckling-induced LH suppression in rats during
            late lactation
  JOURNAL   J Reprod Dev 70 (5), 327-337 (2024)
   PUBMED   39155080
  REMARK    GeneRIF: Central delta/kappa opioid receptor signaling pathways
            mediate chronic and/or acute suckling-induced LH suppression in
            rats during late lactation.
REFERENCE   2  (bases 1 to 1418)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   3  (bases 1 to 1418)
  AUTHORS   Peles,E., Kim,Y., Sason,A., Adelson,M. and Levran,O.
  TITLE     Predictors of treatment retention and survival among
            methadone-maintained patients: A possible role for a functional
            delta opioid receptor gene variant
  JOURNAL   Drug Alcohol Depend 250, 110903 (2023)
   PUBMED   37531661
REFERENCE   4  (bases 1 to 1418)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   5  (bases 1 to 1418)
  AUTHORS   Tsuchida,H., Nonogaki,M., Takizawa,M., Inoue,N., Uenoyama,Y. and
            Tsukamura,H.
  TITLE     Enkephalin-delta Opioid Receptor Signaling Mediates Glucoprivic
            Suppression of LH Pulse and Gluconeogenesis in Female Rats
  JOURNAL   Endocrinology 164 (3) (2023)
   PUBMED   36592113
  REMARK    GeneRIF: Enkephalin-delta Opioid Receptor Signaling Mediates
            Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female
            Rats.
REFERENCE   6  (bases 1 to 1418)
  AUTHORS   Cheng,P.Y., Svingos,A.L., Wang,H., Clarke,C.L., Jenab,S.,
            Beczkowska,I.W., Inturrisi,C.E. and Pickel,V.M.
  TITLE     Ultrastructural immunolabeling shows prominent presynaptic
            vesicular localization of delta-opioid receptor within both
            enkephalin- and nonenkephalin-containing axon terminals in the
            superficial layers of the rat cervical spinal cord
  JOURNAL   J Neurosci 15 (9), 5976-5988 (1995)
   PUBMED   7666182
REFERENCE   7  (bases 1 to 1418)
  AUTHORS   Abood,M.E. and Tao,Q.
  TITLE     Characterization of a delta opioid receptor in rat pheochromocytoma
            cells
  JOURNAL   J Pharmacol Exp Ther 274 (3), 1566-1573 (1995)
   PUBMED   7562535
REFERENCE   8  (bases 1 to 1418)
  AUTHORS   Krishnan-Sarin,S., Portoghese,P.S., Li,T.K. and Froehlich,J.C.
  TITLE     The delta 2-opioid receptor antagonist naltriben selectively
            attenuates alcohol intake in rats bred for alcohol preference
  JOURNAL   Pharmacol Biochem Behav 52 (1), 153-159 (1995)
   PUBMED   7501658
REFERENCE   9  (bases 1 to 1418)
  AUTHORS   Wang,J.B., Johnson,P.S., Imai,Y., Persico,A.M., Ozenberger,B.A.,
            Eppler,C.M. and Uhl,G.R.
  TITLE     cDNA cloning of an orphan opiate receptor gene family member and
            its splice variant
  JOURNAL   FEBS Lett 348 (1), 75-79 (1994)
   PUBMED   8026588
REFERENCE   10 (bases 1 to 1418)
  AUTHORS   Abood,M.E., Noel,M.A., Farnsworth,J.S. and Tao,Q.
  TITLE     Molecular cloning and expression of a delta-opioid receptor from
            rat brain
  JOURNAL   J Neurosci Res 37 (6), 714-719 (1994)
   PUBMED   7519274
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D16348.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001063354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16348.1, U00475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1418
                     /gene="Oprd1"
                     /note="opioid receptor, delta 1"
                     /db_xref="GeneID:24613"
                     /db_xref="RGD:3233"
     exon            1..332
                     /gene="Oprd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1224
                     /gene="Oprd1"
                     /note="DOR-1; opioid receptor A; D-OR-1"
                     /codon_start=1
                     /product="delta-type opioid receptor"
                     /protein_id="NP_036749.1"
                     /db_xref="GeneID:24613"
                     /db_xref="RGD:3233"
                     /translation="MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSAS
                     SLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTL
                     PFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR
                     TPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVF
                     LFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAP
                     IHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR
                     APCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA"
     exon            333..682
                     /gene="Oprd1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1418
                     /gene="Oprd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgctgca gcctgcgacg tcggggccgt ggcctccgtt ttccgcgcgc cactcgctgg
       61 gtccctgcgc ccagggcgca cggtggagac ggacgcggag gcgccatgga gccggtgcct
      121 tctgcccgtg cggagctgca gttttcgctc ctcgccaacg tctcggacac cttccctagc
      181 gccttcccca gtgcgagcgc caatgcgtcg gggtcgccgg gcgcccgcag tgcctcgtcc
      241 ctggctctgg ccatcgccat caccgcgctc tactcggctg tgtgcgccgt ggggctgctg
      301 ggcaacgtgc tcgtcatgtt tggaatcgtc cggtacacta agctgaagac ggccaccaac
      361 atctacatct tcaatctggc cttggcggat gcgctggcca ccagcacact gcccttccag
      421 agcgccaagt acctgatgga aacgtggccg ttcggagagc tgctgtgcaa ggctgtgctc
      481 tccattgact actacaacat gttcaccagc atcttcacgc tcaccatgat gagcgtggac
      541 cgctacattg cggtctgcca ccctgtcaag gccttggact tccggacacc ggccaaggcc
      601 aagctgatca acatatgcat ctgggtcttg gcttcaggtg ttggggtccc catcatggtc
      661 atggcagtga cccaaccccg ggatggagca gtggtatgca cgctccagtt ccccagcccc
      721 agctggtact gggacactgt gaccaagatc tgcgtgttcc tcttcgcctt cgtggtgccc
      781 attctcatca tcaccgtgtg ctatggcctc atgctgctgc gcctgcgcag cgtgcgcctg
      841 ctgtccggct ccaaggagaa ggaccgcagc ctgcggcgca tcacgcgcat ggtgctggtg
      901 gtggtgggag ccttcgtggt gtgctgggcg cccatccaca tcttcgtcat cgtctggacg
      961 ctggtggaca tcaatcggcg cgacccactt gtggtggccg cgctgcactt gtgcattgcg
     1021 ctgggctacg ccaacagcag cctcaacccg gttctctacg ccttcctgga cgagaacttc
     1081 aagcgctgct tccgccagct ctgtcgcgcg ccctgcggcg gccaagaacc cggcagcctc
     1141 cgccgtcccc gccaggccac cgcgcgtgag cgtgtcaccg cctgcacccc ctccgacggc
     1201 ccgggcggtg gcgctgccgc ctgacctacc cggccctctg cttaaacgcc ccacccaagt
     1261 gaagtgatgc agtggccaca ccgagctccc tgggaggcca tggccaccat tgggacagct
     1321 agaatagggc ccacacgggg ggggggaggc ctcccatgag ggccgggcct gaggaatcaa
     1381 aggctccggg ttggaggggt gggggttggg agggcaga
//
