LOCUS       NM_138860               2258 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus opsin 4 (Opn4), mRNA.
ACCESSION   NM_138860
VERSION     NM_138860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Liu,M., Dai,J., Liu,W., Zhao,C. and Yin,Z.Q.
  TITLE     Overexpression of melanopsin in the retina restores visual function
            in Royal College of Surgeons rats
  JOURNAL   Mol Med Rep 13 (1), 321-326 (2016)
   PUBMED   26572076
  REMARK    GeneRIF: during retinal degeneration, the expression of melanopsin
            was significantly decreased, while vector-mediated overexpression
            of melanopsin delayed the loss of visual function in rats.
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Jagannath,A., Hughes,S., Abdelgany,A., Pothecary,C.A., Di
            Pretoro,S., Pires,S.S., Vachtsevanos,A., Pilorz,V., Brown,L.A.,
            Hossbach,M., MacLaren,R.E., Halford,S., Gatti,S., Hankins,M.W.,
            Wood,M.J., Foster,R.G. and Peirson,S.N.
  TITLE     Isoforms of Melanopsin Mediate Different Behavioral Responses to
            Light
  JOURNAL   Curr Biol 25 (18), 2430-2434 (2015)
   PUBMED   26320947
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Nadal-Nicolas,F.M., Madeira,M.H., Salinas-Navarro,M.,
            Jimenez-Lopez,M., Galindo-Romero,C., Ortin-Martinez,A.,
            Santiago,A.R., Vidal-Sanz,M. and Agudo-Barriuso,M.
  TITLE     Transient Downregulation of Melanopsin Expression After Retrograde
            Tracing or Optic Nerve Injury in Adult Rats
  JOURNAL   Invest Ophthalmol Vis Sci 56 (8), 4309-4323 (2015)
   PUBMED   26176868
  REMARK    GeneRIF: Following ON injury or retrograde tracing there is a
            transient melanopsin downregulation that should be taken into
            account when assessing m(+)RGC survival.
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Fahrenkrug,J., Falktoft,B., Georg,B., Hannibal,J., Kristiansen,S.B.
            and Klausen,T.K.
  TITLE     Phosphorylation of rat melanopsin at Ser-381 and Ser-398 by
            light/dark and its importance for intrinsically photosensitive
            ganglion cells (ipRGCs) cellular Ca2+ signaling
  JOURNAL   J Biol Chem 289 (51), 35482-35493 (2014)
   PUBMED   25378407
  REMARK    GeneRIF: Data indicate that the phosphorylation status of
            melanopsin influences its functions.
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Hong,J., Zeng,Q., Wang,H., Kuo,D.S., Baldridge,W.H. and Wang,N.
  TITLE     Controlling the number of melanopsin-containing retinal ganglion
            cells by early light exposure
  JOURNAL   Exp Eye Res 111, 17-26 (2013)
   PUBMED   23541830
  REMARK    GeneRIF: Early light exposure can increase the number of melanopsin
            immunopositive retinal ganalion cells through a process dependent
            on intrinsic photosensitive spiking activity.
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Fahrenkrug,J., Nielsen,H.S. and Hannibal,J.
  TITLE     Expression of melanopsin during development of the rat retina
  JOURNAL   Neuroreport 15 (5), 781-784 (2004)
   PUBMED   15073514
  REMARK    GeneRIF: During rat retinal development melanopsin is expressed at
            prenatal day 18 in cells of the inner neuroblast layer. and During
            early postnatal development a melanopsin immunoreactive dendritic
            network is formed in the inner plexiform layer.
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Gooley,J.J., Lu,J., Fischer,D. and Saper,C.B.
  TITLE     A broad role for melanopsin in nonvisual photoreception
  JOURNAL   J Neurosci 23 (18), 7093-7106 (2003)
   PUBMED   12904470
  REMARK    GeneRIF: Melanopsin expression defines a subset of RGCs that play a
            broad role in regulation of nonvisual photoreception, providing
            projections that contribute to circadian entrainment, negative
            masking, regulation of sleep-wake states, and the pupillary reflex
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Hattar,S., Lucas,R.J., Mrosovsky,N., Thompson,S., Douglas,R.H.,
            Hankins,M.W., Lem,J., Biel,M., Hofmann,F., Foster,R.G. and Yau,K.W.
  TITLE     Melanopsin and rod-cone photoreceptive systems account for all
            major accessory visual functions in mice
  JOURNAL   Nature 424 (6944), 76-81 (2003)
   PUBMED   12808468
REFERENCE   9  (bases 1 to 2258)
  AUTHORS   Beaule,C., Robinson,B., Lamont,E.W. and Amir,S.
  TITLE     Melanopsin in the circadian timing system
  JOURNAL   J Mol Neurosci 21 (1), 73-89 (2003)
   PUBMED   14500998
  REMARK    GeneRIF: Melanopsin, in itself, is not necessary for circadian
            photoreception. In fact, it appears that of the known photoreceptor
            systems, none, in and of itself, is necessary for circadian
            photoreception.
REFERENCE   10 (bases 1 to 2258)
  AUTHORS   Hattar,S., Liao,H.W., Takao,M., Berson,D.M. and Yau,K.W.
  TITLE     Melanopsin-containing retinal ganglion cells: architecture,
            projections, and intrinsic photosensitivity
  JOURNAL   Science 295 (5557), 1065-1070 (2002)
   PUBMED   11834834
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY072689.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY072689.1, SRR8487227.266736.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p15"
     gene            1..2258
                     /gene="Opn4"
                     /note="opsin 4"
                     /db_xref="GeneID:192223"
                     /db_xref="RGD:621701"
     exon            1..342
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1623
                     /gene="Opn4"
                     /codon_start=1
                     /product="melanopsin"
                     /protein_id="NP_620215.1"
                     /db_xref="GeneID:192223"
                     /db_xref="RGD:621701"
                     /translation="MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLS
                     VSPTTPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLR
                     TPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGETGCKFYAFCGAVFGIVSMIT
                     LTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLL
                     TSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESP
                     LRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAV
                     IAKASAIHNPIIYAITHPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSS
                     QSSDLSWISGQKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAP
                     SSPQEQKSKTPKTKRHLPSLDRRM"
     exon            343..488
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            489..622
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            623..826
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..998
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1154
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1262
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1443
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1584
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2258
                     /gene="Opn4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactcattcc tttgcgcttc attagacatt gagcagtcag cagcccaaac agcagctcca
       61 ggctggatct aggctgggga tgtgaacagg gagccggtgg gccaggccac ggtgttaagg
      121 atgctgtaaa gccagctggg gaccgatctg gacaatccct gagcttccca tgcctttaag
      181 tcctccaaga gcctgagcat gaactctcct tcagaatcaa gagtcccttc aagcttaact
      241 caggatccca gctttaccgc cagccctgcc ctcctacaag gcatttggaa cagcactcag
      301 aacatctccg tcagagtcca gcttctatcc gttagcccca cgacacctgg gcttcaggct
      361 gctgcctggg tccccttccc cacagtcgac gtcccagatc atgctcacta taccctaggc
      421 acggtgatcc tgctggtggg actcacaggg atgctgggta acctgacagt catctacacc
      481 ttctgcagga atagaggcct gcggacaccg gcaaacatgc tcatcatcaa cctggcagtc
      541 agcgacttcc ttatgtcgtt cactcaggcc ccggtcttct ttgccagcag cctctacaag
      601 aagtggctct tcggggagac aggttgcaag ttctatgcct tctgtggggc tgtctttggc
      661 atcgtttcca tgatcaccct gacagccata gccatggacc gctatctggt gatcacacgt
      721 ccactggcca ccatcggcat gagatccaag agacggacgg cactagtcct gctaggtgtc
      781 tggctctatg ccctggcctg gagtctgccg cctttctttg gctggagcgc ctacgtgccc
      841 gaggggctgc tgacatcctg ctcctgggac tacgtgacct tcacgcccct cgtgcgcgcc
      901 tacaccatgc tgctcttctg ctttgtcttc ttcctccctc tgctcattat catcttctgc
      961 tacatcttca tcttcagggc cattcgagag acaggccggg cctgtgaggg ctgtggtgag
     1021 tcccctctgc ggcggcggca gtggcagcgg ctacagagtg aatggaagat ggccaaggtc
     1081 gcactgatcg tcattctcct ctttgtgctg tcctgggctc cctactccac tgtggccctg
     1141 gtgggctttg ctgggtactc gcacatcctg acgccctaca tgagctcggt gccagccgtc
     1201 attgccaagg cctcggccat ccacaatcct atcatctatg ccatcactca ccccaagtac
     1261 agggcggcca ttgctcagca cttgccttgc cttggggtgc ttcttggagt atcaggccag
     1321 cgcagccacc cctccctcag ctaccgctct acccatcgct ccacactgag cagccagtcc
     1381 tcagacctca gctggatctc tgggcagaag cgccaagagt ccctgggttc tgagagtgaa
     1441 gtgggctgga cagacacaga aacaacagct gcgtggggag ctgcccagca agcaagtgga
     1501 caatccttct gcagtcatga cctggaagat ggagaagtca aggctccttc cagcccccag
     1561 gaacagaaat ccaagactcc caagaccaag agacacctcc ccagtctgga ccgaaggatg
     1621 taggatgccc agtcccgtcc cctccctatc acatgcacag acccgggatt atctcacaag
     1681 cctggaagct ttgaaggtgt tcctgtcact cgtgctacac tggacacact ctccagctcc
     1741 tttccacacc atgaagcacc gtcgccgctt ctcagctcgg cagccacacc tgggctccgc
     1801 ctgaagcatg aacccaggtt ttcctttcca gcttcgcttc cagcagctgt cgcctctcct
     1861 cagacgctgt atgccgcgat tgtccaggca aggacaatgg cgatggcgct ggggaacacg
     1921 tcatttattt atgagccaag catcttagcc agcctttgca accaggccgg acatctcatt
     1981 ggttcagaaa gttctttcct gcgtctcctg ctgccagtgc tcaaaagctg aagacagact
     2041 ctgctttgtg caccaggaat actttggctc tagctccccc atagcattca cggtgttgcc
     2101 cacactcata tgttcgcggg caccggcagg cacataggta cctatttgca tgcacagcca
     2161 gcacatgtgt gcgcaccctg cacgtactgt ttcgtgtcag tggtctaagt tccttccaga
     2221 tgtggatctg acaaggcacg ggaaaataaa aaaaaaaa
//
