LOCUS       XM_039078258            4149 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus 5-oxoprolinase (ATP-hydrolysing)
            (Oplah), transcript variant X8, mRNA.
ACCESSION   XM_039078258
VERSION     XM_039078258.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051342.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039078258.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4149
                     /gene="Oplah"
                     /note="5-oxoprolinase (ATP-hydrolysing); Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 21 ESTs, 1 long SRA read, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 54 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:116684"
                     /db_xref="RGD:620956"
     CDS             249..4115
                     /gene="Oplah"
                     /codon_start=1
                     /product="5-oxoprolinase isoform X4"
                     /protein_id="XP_038934186.1"
                     /db_xref="GeneID:116684"
                     /db_xref="RGD:620956"
                     /translation="MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYA
                     DAPTEGIRRILEQEEGVLLPRGRPLDTSRIASIRMGTTVATNALLERQGERVALLVTR
                     GFRDLLHIGTQARPDLFDLAVPMPEVLYEEVLEVDERVVLYRGEPGAGSPVKGRTGDL
                     LEIQQPVDLEALRGKLEGLLSRGIHSLAVVLMHSYTWAQHEQQVGTLARELGFTHVSL
                     SSEVMPMVRIVPRGHTACADAYLTPTIQRYVQGFRRGFQGQLKNVQVLFMRSDGGLAP
                     MDAFSGSRAVLSGPAGGVVGYSATTYHLEGGQPVIGFDMGGTSTDVSRYAGEFEHVFE
                     ASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVT
                     DANLVLGRLLPASFPCIFGPGEDQPLSPEASRKALEAVAMEVNSFLTNGPCPASQLSL
                     EEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTV
                     HIHRHSGLLSALGLALADVVHEAQEPCSLSYTPETFAQLDQRLSRLEEQCVDALQVQG
                     FPRSQISTESFLHLRYQGTDCALMVSAHQHPATACSPRAGDFGAAFVERYMREFGFII
                     PERPVVVDDVRVRGTGRSGLQLEDTPKIQTGPPHVEKVTQCYFEGGYQETPVYLLGEL
                     GYGHQLQGPCLIIDNNSTILVEPGCQAEVTDTGDIRISVGAEGPSMADTRLDPIQLSI
                     FSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQE
                     TVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHH
                     ADIGGITPGSMPPHSTTLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKISGCSGTR
                     NLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFG
                     TSRQARGLPLEVSAEDHMDDGSPICLRVQINLSQGSAVFDFTGSGSEVFGNLNAPRAI
                     TLSALIYCLRCLVGRDIPLNQGCLAPVRVIIPKGSILDPSPEAAVVGGNVLTSQRVVD
                     VILGAFGACSASQGCMNNVTLGNARMGYYETVAGGAGAGPGWHGRSGVHSHMTNTRIT
                     DPEILESRYPVILRRFELRPGSGGRGRFRGGDGVVRELVFREEALLSVLTERRAFQPY
                     GLHGGEPGARGLNLLIRKDGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPP
                     PGSPPLFPAFPERGSVFEYRRAQEAV"
ORIGIN      
        1 aactggaacc tgaggttgtg aagctgcggg caaacagctg gaagggcaag acactggccg
       61 aactcaagac agaacagcaa tagcgtgcct gcctaaaggt tcttctcggg agtgtgtgac
      121 acagcccaag gctagcttcg aatcccctat gtagcagaga aaggccttga ctgctgactc
      181 ctgcctctga gggtgttctc ccagggttac cagctgaaga gccattcctg gactccagct
      241 tcaacgtcat gggcagccca gaagggcgct tccatttcgc catcgaccgc ggtggcacct
      301 tcacagatgt ctttgcccag tgccctggag ggcatgtgcg tgtcctgaag ctgctctcag
      361 aggaccctgc caactatgca gatgcaccca cagagggcat ccgccgaatt ctagagcagg
      421 aggagggtgt gctgctgcct cgaggccgac cgctagacac cagtcgcatt gccagcatcc
      481 gcatgggtac cacggtggcc accaatgcac tgttggaacg acagggagaa cgggtggcac
      541 tgctggtgac tcggggtttc cgagacctgc tgcatattgg cactcaggcc cgcccggacc
      601 tctttgactt ggctgtgccc atgccagagg ttctgtatga ggaagtgctg gaggtagatg
      661 agcgagtggt gctgtatcgc ggagaaccag gtgccggctc tcctgtcaaa ggccgcacag
      721 gggacctgct agagatacag cagcctgtgg acctggaagc cctgcgtggg aagctggagg
      781 ggctcttgtc tcggggcatt cacagtctgg cagtggtgct catgcattcg tacacgtggg
      841 cccagcatga gcagcaggtg ggcacgctgg cccgggagct gggcttcacg cacgtctcct
      901 tgtcctcgga agtcatgccc atggtacgaa ttgttcctcg gggccataca gcctgtgctg
      961 acgcttacct tactcccacc atccagcgct atgtgcaggg cttccgccga ggcttccagg
     1021 gccagctaaa gaatgtgcaa gttctcttca tgcgctctga tggtggcctc gcacccatgg
     1081 atgctttcag tggttcccgg gctgtgctct ctggccctgc tgggggtgtg gttggctact
     1141 cagctaccac ctaccatctg gaaggcggtc agcctgtcat tggctttgac atgggaggca
     1201 catccacaga cgtgagccgc tatgctggag aatttgagca tgtctttgag gctagcacag
     1261 caggcgttac ccttcaggca ccccagttgg acatcaacac agtggcagct ggcgggggtt
     1321 cccgcctctt cttcagatct ggcctctttg tggttggtcc agagtcagca ggtgcccacc
     1381 caggtcctgc ctgctaccgt aaagggggtc ctgtgacagt gacagatgct aatctggtcc
     1441 tgggtcgcct gctgcctgcc tccttcccct gcatttttgg gccaggagaa gaccagccac
     1501 tgtctcctga ggcttcccga aaggctctag aggctgtggc catggaggtc aacagtttct
     1561 tgaccaatgg accgtgccca gcttcccaac taagtctgga agaggtggcc atggggtttg
     1621 tgcgtgttgc caatgaagcc atgtgccggc ctatccgtgc cctcacacag gcacgaggcc
     1681 atgacccctc agcccatgta ttggcttgct ttggaggagc tggtgggcaa cacgcttgtg
     1741 ccattgcccg ggccctgggg atggatactg tgcacattca caggcacagc gggctgctgt
     1801 cagcactagg actggccttg gcagatgtgg ttcacgaagc acaggagccc tgttccctgt
     1861 cttacacacc tgaaaccttt gcacaactgg accagagact gagccgcctg gaggagcagt
     1921 gtgtggatgc cttgcaggtc cagggcttcc ctaggtctca gatcagcacc gagagcttcc
     1981 tgcatcttcg ctaccaaggc actgactgcg ccctaatggt gtctgcccat cagcatccgg
     2041 ccacagcctg ctcaccccgt gctggtgact ttggagccgc atttgtggag aggtacatga
     2101 gagagtttgg cttcattatc cccgagcggc cggtggtggt agatgatgta cgtgtgaggg
     2161 gaactggccg tagtggactt cagctggagg acacccccaa aatccagact ggacctcccc
     2221 acgtggaaaa ggtgacccag tgctactttg aagggggtta tcaggagact cccgtgtacc
     2281 ttttaggaga actaggctac gggcaccagc tccaagggcc ctgccttatc atcgacaaca
     2341 acagcaccat ccttgtagaa ccgggttgcc aagcagaggt gactgataca ggggacatcc
     2401 gcatttctgt gggagctgag ggtcctagta tggcagatac caggcttgac cccatccagc
     2461 tgtctatttt ctcacaccgc ttcatgagca ttgctgagca gatgggccgc atcctacagc
     2521 gcacagccat ctctaccaac atcaaggaac gcctcgactt ctcctgtgcc ctctttgggc
     2581 cagatggggg cctcgtctcc aatgctcccc acattcctgt gcacctgggt gccatgcaag
     2641 agactgtaca gttccagatt cagcacttag gagccgacct ccatcctggt gatgtgttgc
     2701 tcagcaacca tcccagcgca gggggcagcc atcttcctga cctgactgtc attacaccgg
     2761 tgttttggcc aggccagacg aggcctgtgt tctacgtggc tagccgaggg caccacgcag
     2821 acattggagg aatcacaccg ggctctatgc cgcctcactc caccacgctg caacaggagg
     2881 gtgccgtttt tctgtccttc aaactggtcc agggaggcgt cttccaggaa gaggcagtga
     2941 cagaggccct acgggcacca ggcaagatct ctggctgtag tggaaccagg aacctgcatg
     3001 acaacctgtc ggatcttcgt gcccaggtgg cagctaacca gaaaggcatc cagctggtgg
     3061 gagagctgat cggacagtat ggcttagatg tggtgcaggc ctatatgggc catattcagg
     3121 cgaatgctga gctagcagtg agagacatgc tccgggcttt tggaacttcc cggcaggcca
     3181 ggggcctgcc cctggaggtg tctgcagagg atcacatgga tgatggctct cccatctgtc
     3241 tgcgtgttca gatcaacctg agtcagggca gtgcggtatt tgacttcact ggttccgggt
     3301 ctgaggtgtt tggcaatctc aatgccccga gagccataac actgtctgct ctcatctatt
     3361 gcttacgctg tctagtgggc cgtgacatcc cacttaacca gggttgcctg gctcctgtgc
     3421 gtgtcataat tcccaaaggc tccatattgg atccatcccc agaggcagca gtggtcggcg
     3481 gcaacgtgct cacatctcag cgagtagtgg atgtcattct gggggctttt ggggcctgtt
     3541 cagcctccca gggctgcatg aacaatgtga ccctgggcaa tgcccgtatg ggctactatg
     3601 agacagtggc tggtggtgcc ggtgcgggcc ctggctggca tgggcgcagt ggtgtacaca
     3661 gtcacatgac caacacacgc attacggatc cagagattct ggagagtcgg tatccagtta
     3721 tcctgcgccg ctttgagctg aggccaggct ccgggggccg aggtcgcttc cggggaggtg
     3781 atggcgtagt ccgagagctg gtctttcggg aagaggcgct gttgtctgtg ctcaccgagc
     3841 gccgggcctt ccagccttac ggcctccacg ggggagagcc tggtgcgcgt ggcttaaacc
     3901 tcctgatcag aaaagatggg cgcacagtga atttgggcgg caagacatct gtgaccgtgt
     3961 accccgggga cgtgttctgc ctccacacgc ctgggggtgg gggctacgga gacccggagg
     4021 atccagcgcc accaccaggc tcgcccccgc tatttccagc cttccccgag cgcggcagtg
     4081 tattcgagta ccgccgcgcc caggaagccg tatgagtgcc ccacaataaa gatcctttga
     4141 atcgcacga
//
