LOCUS       NM_053848               2339 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Rattus norvegicus opioid binding protein/cell adhesion
            molecule-like (Opcml), mRNA.
ACCESSION   NM_053848
VERSION     NM_053848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2339)
  AUTHORS   Sugimoto,C., Morita,S. and Miyata,S.
  TITLE     Overexpression of IgLON cell adhesion molecules changes
            proliferation and cell size of cortical astrocytes
  JOURNAL   Cell Biochem Funct 30 (5), 400-405 (2012)
   PUBMED   22374746
REFERENCE   2  (bases 1 to 2339)
  AUTHORS   Sugimoto,C., Maekawa,S. and Miyata,S.
  TITLE     OBCAM, an immunoglobulin superfamily cell adhesion molecule,
            regulates morphology and proliferation of cerebral astrocytes
  JOURNAL   J Neurochem 112 (3), 818-828 (2010)
   PUBMED   19943852
  REMARK    GeneRIF: The results of this study suggested that OBCAM is
            responsible for controlling the cell proliferation and growth in
            cortical astrocytes
REFERENCE   3  (bases 1 to 2339)
  AUTHORS   Hashimoto,T., Maekawa,S. and Miyata,S.
  TITLE     IgLON cell adhesion molecules regulate synaptogenesis in
            hippocampal neurons
  JOURNAL   Cell Biochem Funct 27 (7), 496-498 (2009)
   PUBMED   19711485
REFERENCE   4  (bases 1 to 2339)
  AUTHORS   Miyata,S., Taguchi,K. and Maekawa,S.
  TITLE     Dendrite-associated opioid-binding cell adhesion molecule localizes
            at neurosecretory granules in the hypothalamic magnocellular
            neurons
  JOURNAL   Neuroscience 122 (1), 169-181 (2003)
   PUBMED   14596858
  REMARK    GeneRIF: OBCAM is synthesized within the somata, attached to
            vasopressin neurosecretory granules, and transported to the
            dendrites. The subcellular localization of OBCAM is changed in an
            activity-dependent manner.
REFERENCE   5  (bases 1 to 2339)
  AUTHORS   Miyata,S., Matsumoto,N., Taguchi,K., Akagi,A., Iino,T., Funatsu,N.
            and Maekawa,S.
  TITLE     Biochemical and ultrastructural analyses of IgLON cell adhesion
            molecules, Kilon and OBCAM in the rat brain
  JOURNAL   Neuroscience 117 (3), 645-658 (2003)
   PUBMED   12617969
REFERENCE   6  (bases 1 to 2339)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
REFERENCE   7  (bases 1 to 2339)
  AUTHORS   Lippman,D.A., Lee,N.M. and Loh,H.H.
  TITLE     Opioid-binding cell adhesion molecule (OBCAM)-related clones from a
            rat brain cDNA library
  JOURNAL   Gene 117 (2), 249-254 (1992)
   PUBMED   1339369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053848.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88711.1, M88710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               JAXUCZ010000008.1  35048040-35048671
            633-865             JAXUCZ010000008.1  35309293-35309525
            866-991             JAXUCZ010000008.1  35449679-35449804
            992-1129            JAXUCZ010000008.1  35539641-35539778
            1130-1250           JAXUCZ010000008.1  35540158-35540278
            1251-1402           JAXUCZ010000008.1  35540803-35540954
            1403-2339           JAXUCZ010000008.1  35557475-35558411
FEATURES             Location/Qualifiers
     source          1..2339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2339
                     /gene="Opcml"
                     /note="opioid binding protein/cell adhesion molecule-like"
                     /db_xref="GeneID:116597"
                     /db_xref="RGD:620635"
     exon            1..632
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1503
                     /gene="Opcml"
                     /note="opioid-binding protein/cell adhesion molecule;
                     OBCAM; opioid-binding cell adhesion molecule"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     precursor"
                     /protein_id="NP_446300.2"
                     /db_xref="GeneID:116597"
                     /db_xref="RGD:620635"
                     /translation="MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAI
                     GRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKI
                     TVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEDTRLATGLDGVRIENKG
                     RISTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLS
                     GTFFAHFFIKF"
     exon            633..865
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     exon            866..991
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1129
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1250
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1402
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2339
                     /gene="Opcml"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttttattt tttatttttt ttacgacatc tcctttctgt cagagacact tgccttcttt
       61 gggttataaa cttttgatgc cagacctctg cagaatgcgc ccaactgaat cttaaagtag
      121 cttcaccgag agaggcagag aacgcacaat ctgtgacctt cgtccctgct ccttttttgt
      181 gttctccctc ctcccgggct ccctccgccc cagggagcgt tgagaaagct cttttttgga
      241 tgcaggaggg ggcatctggt tctgccaggc tggaaagctg aggctggagc agaggaagac
      301 ttattagact ccggagagcc tggactcagc cttgccttct cccgctccca gctcctggtt
      361 tgctctctgt gtgctttcgt ccctcaacac ttccggctat tctgagaggg caggggacaa
      421 ggaccgtgca gctgcaagag ttctaggaag ttgtggctgt cgagaatggg ggtctgtggg
      481 tacctgttcc tgccctggaa gtgcctcgtg gtcgtgtctc tcaggctgct gttccttgta
      541 cccacaggag tgccggtgcg cagcggagat gccacctttc ccaaagctat ggacaacgtg
      601 acggtccggc agggagagag cgccaccctc aggtgtacca tagatgaccg ggtcaccaga
      661 gtagcctggc taaaccgcag cacaatcctc tacgctggga atgacaagtg gtccatagac
      721 cctcgagtga tcatcttggt caacacgcct acccagtaca gtatcatgat ccagaatgtg
      781 gatgtttatg acgaaggtcc gtacacctgc tctgtgcaga cagacaatca ccccaaaacc
      841 tcccgggtcc acctcatagt gcaagttcct ccccagataa tgaacatctc ttcagacatt
      901 actgtgaatg aaggaagcag tgtgaccctg ttatgtctcg caattggcag accagaacca
      961 acagtgacat ggcgacacct gtcagtcaag gaaggccagg gctttgtgag tgaagatgaa
     1021 tacctggaaa tctcagacat caaacgcgac caatctggag agtatgagtg cagcgccttg
     1081 aatgatgtcg ctgcacctga tgttcggaaa gtaaaaatca ctgtaaacta tcctccctat
     1141 atctcaaaag cgaagaacac tggcgtttca gtcggccaga agggcatcct gagctgtgaa
     1201 gcctctgctg tccccatggc tgaattccag tggttcaagg aagataccag gttagccact
     1261 ggcctggatg gcgtgagaat tgagaacaaa ggccgcatat ccactttgac tttcttcaat
     1321 gtctcagaga aggattatgg gaactatacc tgtgtggcca caaacaagct tgggaacacc
     1381 aatgccagca tcaccctgta tgggcctgga gcagtcattg atggtgtaaa ctcggcctct
     1441 agagcactgg cttgtctctg gctctcaggg accttctttg cccacttctt catcaagttt
     1501 tgataagaaa ccttaggtcc tctgagcatc gcctgcttct ccatatcaca gactttaatc
     1561 tacactgcgg aggggcaaac cagtttgggc ttctttttgg ttattttttt gttcttcttg
     1621 actgtttagt tttttggttt gatttctggg attttcaatt tgatttgatt tttctttttt
     1681 cgtttgaatg gacggggttg ggggttggga tgggcagggt tctaccacga gtaggataat
     1741 cattcattgg tgggccccca aatggaatat attcctgcta ccttggcctt ccttttctct
     1801 acttctcttc ctaccaccat taacacacaa acacacaagc acacgcccta aagatggcct
     1861 aaaaaatgtc ccatgacacg caccctgaag gtacaacttg gcccacagtg cagtacacaa
     1921 taagagttgc atctacattt cctgttttct ttgtccttta agttttcaat aagacagttt
     1981 aaaaagagca catccttatc cctatgtttg tatcacctat cccattaagc tgcacacctt
     2041 ttctaagaaa ctttcttact acatcctcaa tgtgcacaca tgtacattct cataaaaatt
     2101 ttaccatctt ctctggccat tctgcttaat ctgcattttt tccactagca gtaagactta
     2161 caggcttgat gaaaatatac atgtatccaa agctacaaat ttaggagtca cgagggaagt
     2221 ctatctaggg gtagtacttc ccttaaaatg ctaatgcaac tcataaaaaa gtgatcaata
     2281 gctagctaat tatatcaagc tatcaaagca atcatattat tatccagtta ctcaattga
//
