LOCUS       NM_001017386            2694 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus oligodendrocytic myelin paranodal and inner loop
            protein (Opalin), mRNA.
ACCESSION   NM_001017386 XM_342050
VERSION     NM_001017386.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2694)
  AUTHORS   de Faria,O. Jr., Dhaunchak,A.S., Kamen,Y., Roth,A.D., Kuhlmann,T.,
            Colman,D.R. and Kennedy,T.E.
  TITLE     TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by
            Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques
  JOURNAL   Sci Rep 9 (1), 3606 (2019)
   PUBMED   30837646
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2694)
  AUTHORS   Yoshikawa,F., Sato,Y., Tohyama,K., Akagi,T., Hashikawa,T.,
            Nagakura-Takagi,Y., Sekine,Y., Morita,N., Baba,H., Suzuki,Y.,
            Sugano,S., Sato,A. and Furuichi,T.
  TITLE     Opalin, a transmembrane sialylglycoprotein located in the central
            nervous system myelin paranodal loop membrane
  JOURNAL   J Biol Chem 283 (30), 20830-20840 (2008)
   PUBMED   18490449
  REMARK    GeneRIF: highly sialylglycosylated Opalin has a role in an
            intermembranous function of the myelin paranodal loops in the
            central nervous system
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001017386.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092200.1, SRR26360176.1320377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984016 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000001.1  249858164-249858190 c
            28-63               JAXUCZ010000001.1  249853576-249853611 c
            64-99               JAXUCZ010000001.1  249850368-249850403 c
            100-219             JAXUCZ010000001.1  249847646-249847765 c
            220-276             JAXUCZ010000001.1  249845109-249845165 c
            277-2694            JAXUCZ010000001.1  249840539-249842956 c
FEATURES             Location/Qualifiers
     source          1..2694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2694
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /note="oligodendrocytic myelin paranodal and inner loop
                     protein"
                     /db_xref="GeneID:361757"
                     /db_xref="RGD:1307776"
     exon            1..27
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..453
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /note="transmembrane protein 10"
                     /codon_start=1
                     /product="opalin"
                     /protein_id="NP_001017386.1"
                     /db_xref="GeneID:361757"
                     /db_xref="RGD:1307776"
                     /translation="MSFSLNFTLPLNTTSSPVATSAKATDCGPSVGLAAGIPSLLATA
                     LLVALLFTLIQRRRTTDEPIEETEAPCEISELYDNPKISENPRQSPTHEMNPRGAQEG
                     HIYVKTVSGSEEPLPDTYRPPEEVERRRGLWWLVPRLSLE"
     exon            28..63
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
     exon            64..99
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
     exon            100..219
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
     exon            220..276
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
     exon            277..2694
                     /gene="Opalin"
                     /gene_synonym="Tmem10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgccaag ggagcctgtc agaaatgagt ttttcactga actttacact gccattgaat
       61 acaacttcct ctccagttgc cacgagtgcc aaagccacag actgtggtcc gtctgttgga
      121 ctggcagctg gaatcccatc cctgctggcc acagctctgc tggtagcctt gctgtttacc
      181 ctgatccagc gaagaagaac caccgatgag cccatcgagg agactgaggc tccatgtgaa
      241 atttcagaac tctatgacaa tcccaagata tccgagaatc ctaggcagtc acccacgcat
      301 gaaatgaacc cacgaggtgc tcaagaaggt cacatatatg tgaagactgt ctcaggaagt
      361 gaggagcccc tgcccgacac ctaccgtcct cctgaagaag tagagagaag aagaggtctt
      421 tggtggctcg tgcccagact gagcctggaa tgatgtcatc gactcaggga acagacgcag
      481 cactggaacg gggctggaaa cctgggatcc gtgctcaggg tccatgcttg gagaggtgag
      541 aggccagcag cctctcaatc cacgtcaatt tcattcatag atcctggaca catctggctg
      601 ccttgcctcc ttaggggatg gctgcattga ggttcattca aactcagacc ttgcagtgtg
      661 atcagcgacg caacctgggt gagttgcttg tacacccaga tgagccccac atgtcctatt
      721 tgtgaatcta gaggagtctg cctttaggaa atggcttctg agtgtcctgg cttctcctct
      781 acctgctcca gctgttatct ttaaaggaaa aaaaatttaa agctgtggga gttggctttt
      841 ctgggtgcat tgaccaaggt caggttggca caagttagga catgagtaaa actttacaga
      901 agacgtgtga aagaagccat ttctatctca gggtagagtt cacacagagc catacatgcc
      961 ctacccaaca cgaggaagca catggctgat ttgtgtcata cgacagagaa cgggatatgg
     1021 acctcctagt cagacaggtc actgagcact tctgagaatt ctgatgagct tacctaccct
     1081 ccctaagcct gttctgggtt ttataaaagg ggagcaaata ttctgtgctt catttggcca
     1141 ttggagagat tacaaaagga ataaaggaag cgatttccac ttagtggaca tcagagatac
     1201 tagttatcct ccttacctgg ctcttacccc cccttcccat cccacttggc ctatcaagtc
     1261 aggcagccgc tcttcggtat ttgttatcta tagttacgaa gtcaacaagg aagtctaaag
     1321 cttctcagga gcctgcaatc taaattgttg acatttgaaa ataactctag ttgtcactag
     1381 cagtcttctc acttcaactc tggacaccat ttgtccttgg gtgtcaacaa gttccaaatc
     1441 gcaagtacag agacctgtgt tacacattac acattaacct ttaggatgct caagtcttgg
     1501 gtggttaatc ttcactgtca acttgatggg atttagaatc accaaggaga cacgcctcca
     1561 gaaagattta actgagcagg aagatctgcc tgaatgtggg cagcatcatt ccatagcctg
     1621 cagttctgga ctaaataaaa gggaactcaa gttgagcaca cagaattcat tgctatctgc
     1681 ttcctgacta cagataaagt gtatcccagc ttgcctcaca ctcctgctgt catgcctttc
     1741 ctgccatggt ggaccgaacc gtcaaactat gagccaaaat aaatatctcc acccttaagt
     1801 tggttttatt gtaacactga gagaagtaac taatataaac tgatatgcat gttttaatga
     1861 cttttctttg caatggggta tttgcttcga agtactgtaa cgaaaagatg tttgtgaggg
     1921 agagacatcg ggaagaccaa agaggatcac aggatcaaag gaattcaagg gacatctagg
     1981 gacagcttca tcaggccgtg ctaaacagtg ggagagctga ggcctcagag catctccgaa
     2041 aacatccaca atctccatga gccacctcga tgtcccagag aaccatcttt cctctcatgg
     2101 ggcctctggt tgttcagaaa tagtccaatt cttgagcaac aggaaatggt tctataaacc
     2161 taatggccat cacatgttaa cagctgcctt tcaaagcccc tctgaaaatc aattttctgt
     2221 tgttcatggg cccagatctt agataagcat atttgaacat cttcaattag ctatgcccag
     2281 gtatgctgaa ggtccacttc tcttacatga tggggaaaga ccttgggctc ccagagaact
     2341 tgaggagact gtggcattga cagatttgga tttcagctcc agcctagaat gctggtcgcc
     2401 tagatcttca gttttatgct tacaaaactg acccccaagg gcagctgtga ggcctgattg
     2461 aaatacacag atgagtaagc cttgtaactt acaaaataag ttatgatttg ttgtttttct
     2521 gggttttttg cttttttgtt ttttgttttt gattcttcat cttacttcta ttacagtcga
     2581 ctgcttagaa tcttcatttc aagttgtttt cactaaactt gcaaggttca ggatttctgt
     2641 tggtacaaag acttattttg taataaataa acggctattg tatggaccta caaa
//
