LOCUS       NM_001399653            3167 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus outer mitochondrial membrane lipid metabolism
            regulator OPA3 (Opa3), mRNA.
ACCESSION   NM_001399653
VERSION     NM_001399653.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Wells,T., Davies,J.R., Guschina,I.A., Ball,D.J., Davies,J.S.,
            Davies,V.J., Evans,B.A. and Votruba,M.
  TITLE     Opa3, a novel regulator of mitochondrial function, controls
            thermogenesis and abdominal fat mass in a mouse model for Costeff
            syndrome
  JOURNAL   Hum Mol Genet 21 (22), 4836-4844 (2012)
   PUBMED   22869679
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Powell,K.A., Davies,J.R., Taylor,E., Wride,M.A. and Votruba,M.
  TITLE     Mitochondrial localization and ocular expression of mutant Opa3 in
            a mouse model of 3-methylglutaconicaciduria type III
  JOURNAL   Invest Ophthalmol Vis Sci 52 (7), 4369-4380 (2011)
   PUBMED   21613372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Davies,V.J., Powell,K.A., White,K.E., Yip,W., Hogan,V.,
            Hollins,A.J., Davies,J.R., Piechota,M., Brownstein,D.G., Moat,S.J.,
            Nichols,P.P., Wride,M.A., Boulton,M.E. and Votruba,M.
  TITLE     A missense mutation in the murine Opa3 gene models human Costeff
            syndrome
  JOURNAL   Brain 131 (Pt 2), 368-380 (2008)
   PUBMED   18222992
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Reynier,P., Amati-Bonneau,P., Verny,C., Olichon,A., Simard,G.,
            Guichet,A., Bonnemains,C., Malecaze,F., Malinge,M.C.,
            Pelletier,J.B., Calvas,P., Dollfus,H., Belenguer,P., Malthiery,Y.,
            Lenaers,G. and Bonneau,D.
  TITLE     OPA3 gene mutations responsible for autosomal dominant optic
            atrophy and cataract
  JOURNAL   J Med Genet 41 (9), e110 (2004)
   PUBMED   15342707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.1108.1,
                                           SRR26643299.1437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18614015, 12865426
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000001.1  88009412-88009614
            204-3167            JAXUCZ010000001.1  88025696-88028659
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3167
                     /gene="Opa3"
                     /note="outer mitochondrial membrane lipid metabolism
                     regulator OPA3"
                     /db_xref="GeneID:308409"
                     /db_xref="RGD:1309147"
     exon            1..203
                     /gene="Opa3"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..601
                     /gene="Opa3"
                     /note="optic atrophy 3 protein homolog; OPA3, outer
                     mitochondrial membrane lipid metabolism regulator"
                     /codon_start=1
                     /product="optic atrophy 3 protein"
                     /protein_id="NP_001386582.1"
                     /db_xref="GeneID:308409"
                     /db_xref="RGD:1309147"
                     /translation="MVVGAFPMAKLFYLGIRQVSKPLANRIKDAARRSEFFKTYICLP
                     PAQLYHWVEMRTKMRIMGFRGTAIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYW
                     RHQTQQRNKEEEQRAAWNALQDEVGRLALTLEALQAQTQAMPSLSALEELREELQEVR
                     GQVCNAHCTPKCQAASSRK"
     exon            204..3167
                     /gene="Opa3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggtcgg cggcgccccg cccagtcagc aaggttgcgc gtgcccaggg cggccgccaa
       61 gatggtggtg ggcgcgttcc ccatggcgaa gctgttctac ttgggcatcc ggcaagttag
      121 caagccgctg gccaaccgca tcaaggatgc cgcccgccgc agcgagttct tcaaaaccta
      181 catctgcctg cctccagccc agctgtacca ctgggtggaa atgcggacca agatgcgcat
      241 aatgggtttc cggggcacag ccatcaagcc gctgaatgag gaggcagcag cagagctggg
      301 tgctgagctg ctgggtgagg ccaccatctt cattgtgggc ggaggctgcc tggtcctgga
      361 gtactggcgc caccagactc agcagcgaaa taaggaggag gagcagcggg cagcctggaa
      421 tgcactgcag gatgaggtgg gccgcctggc actgacccta gaggcactgc aggctcagac
      481 acaagcgatg ccctccttga gtgccctgga ggagctgcgt gaggagctgc aggaggtgcg
      541 tgggcaggtc tgcaatgccc actgtactcc caagtgccag gcagcgtctt ccaggaaata
      601 accagctgct ggggcctgga catgtctgtc gccatgtggc cccaataggg ccttctcctc
      661 acacctcctg gcctagcaga aaccacgagg accttgatgt agctctgacg tgtggtcacc
      721 ctttagtgac agaatccggg catttccccc tgggagcact cagcagaaga agcattcaga
      781 cagagtccat ccagcctctg actcagccct cagccccacc aggaaccaca ttggacctcc
      841 aaggacttag ccgacctatc tcagtcccca ctgctgtaac aaaggcaaaa gcgaacccag
      901 ggctcaagcc tggtcaggag gtagacaagg tcacctgccc atcattggag cccctccttt
      961 ttttggtgga cacaggccac tgtgagcctt gcctcaggtc agtgcagttc ccatggaggc
     1021 ctcagagtgc aattgatgcc ccactctctc tcctcattct tcctctgggg tcccaagggg
     1081 gtcatgcctg tacagatccc ctcacccctc agcctgtggc attaccccac tccctccctc
     1141 ggcacagact gacctaattg gctggaatct gacctgtctc agtcgcagcc ctgctgccct
     1201 gtctgagagt ccctgggcct tgtttcaggt ggcacctatt tcctcctgtc cttcagtggc
     1261 atttttcagt tgggtgggtt agatgtcacc cacacatctg tctgcaccct ccatatccct
     1321 gtaggcctgg gtcccccacc ctttctgttg gtcctgcctt ccttgcccac ccccccaccc
     1381 cccagacact cccccccccc cacatatcac taggaatgtg gtggaggaca cagagtaacc
     1441 tgttctccca gcagcagagg tcagctgctt tgttctggct tcagaggctc catatctcct
     1501 ggactctgtg tcctgtcttc atgtggcttt ctcttccccc atctgtctct tgaaaggaca
     1561 cctgccctga ctacaagacc caccctaaat ccagaatgac cacatataca tccctgaaga
     1621 ccctttttct aaatggggac acacaggttc ctggattagg actgaggttt tcttttgaag
     1681 gccctctgtt caacttgttg ccttctgtgg ctctaagaag acacaaggcc ccccgctgtg
     1741 ctgtttgtcc tttggccgcc tgctcacaca cagcttctgg gctgggctaa ccactgcagc
     1801 tccagaaggg ttgtaggtgc agcagtctct gtcatggccg tctagttcct gacagaagga
     1861 gcccaagaat aagaaggctt cctaaggata tatgtgaggc ataattaata tggacctcca
     1921 aactgagcca gtgttcatta acaaaagaga aagccgtgcg tggagacaca cacctagaat
     1981 ttcagcactc agaggctgag gcaggaatga gcctgggtca tcccattgtg agttccagga
     2041 cagcctcctg aaccacagaa agaggccctg tctttaaaaa aaaaaagaca aaaagtaaaa
     2101 aaaatggcaa acaccttgga ggaaagccag aggttttagc tctggggcaa aaggggccaa
     2161 gactcctgtg aactctttcc catattggga aactgaggcc gaggaaaagg gaagctaagg
     2221 gacttggcca agaccccata gctcaggagg ggccagctac aaagggtggg gaggaagaac
     2281 cagaggaccc agatggttct ggctgcaggg caaggtgaga tgaaggcctg acctcttccc
     2341 agtggccaga agcaatgggt ttctgccccc tatcagaaaa gcccaggcca tacccgagct
     2401 ctctgaatgt aggaaacagg ttcaccgacc ctggcccttg tccctagagg tggcacttgc
     2461 acccaagggg gtgaaaatgg cccatgccca ggattcccca gactgaaacc aatactgaga
     2521 ctgtacctgt ttcttctaga agaggcagaa gtaggtatct ttaaacttag gagcggctga
     2581 gttaggcgaa agcctaactg gggacaaggg ctacatggtg aggggaacac agagggaagg
     2641 aagctgccca actgccatgg ttacccctgg ggagtccagt ctggcactaa caggcccagg
     2701 acacctgggc caccctggcc tgggtcagtc ctcagcatta acagcaaagc caagacaggt
     2761 gaagggcgct gagccccatc aggtcagtca ttcctccagc agactggctt cactgttagt
     2821 ctgttgttcc tcaaagaacc ccgtaggaat aatatttgtt ctgcttgctt gggaggaaac
     2881 aggcaccgag atgaaatgtc accttcgggt cacccaagca tgaaagtagg cctctgtccc
     2941 caacctggcc ctgtagagcc ttcacctgtc cctggcgtct gtggagaagg cgaggtctgt
     3001 ggcggcctca cccacagcga cagtgcagga agcagtgtgg tgcggtgtgt ggttcctgaa
     3061 gcctctgcag ggcagagggc cagagcagcg tccacggttc tgacccctgc tcactgcagc
     3121 gttacatatt cctgcaaggg gaggggggga ataaatttat gaatgaa
//
