LOCUS       NM_133585               3200 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus OPA1, mitochondrial dynamin like GTPase (Opa1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133585 XM_346418
VERSION     NM_133585.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Kaur,H., Carrillo,O., Garcia,I., Ramos,I., St Vallier,S., De La
            Torre,P., Lopez,A., Keniry,M., Bazan,D., Elizondo,J., Grishma,K.C.,
            Ann MacMillan-Crow,L. and Gilkerson,R.
  TITLE     Differentiation activates mitochondrial OPA1 processing in myoblast
            cell lines
  JOURNAL   Mitochondrion 78, 101933 (2024)
   PUBMED   38986925
  REMARK    GeneRIF: Differentiation activates mitochondrial OPA1 processing in
            myoblast cell lines.
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Chen,W., DU,H., Sha,Y., Zhou,Y., Liang,J., Chen,Y., Ma,Q., Wu,X.
            and Qian,G.
  TITLE     [Long noncoding RNA H19 promotes vascular calcification by
            repressing the Bax inhibitor 1/optic atrophy 1 pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1469-1475 (2023)
   PUBMED   37814860
  REMARK    GeneRIF: [Long noncoding RNA H19 promotes vascular calcification by
            repressing the Bax inhibitor 1/optic atrophy 1 pathway].
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Garcia,I., Calderon,F., la Torre,P., Vallier,S.S., Rodriguez,C.,
            Agarwala,D., Keniry,M., Innis-Whitehouse,W. and Gilkerson,R.
  TITLE     Mitochondrial OPA1 cleavage is reversibly activated by
            differentiation of H9c2 cardiomyoblasts
  JOURNAL   Mitochondrion 57, 88-96 (2021)
   PUBMED   33383158
  REMARK    GeneRIF: Mitochondrial OPA1 cleavage is reversibly activated by
            differentiation of H9c2 cardiomyoblasts.
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Pang,Y., Qin,M., Hu,P., Ji,K., Xiao,R., Sun,N., Pan,X. and Zhang,X.
  TITLE     Resveratrol protects retinal ganglion cells against ischemia
            induced damage by increasing Opa1 expression
  JOURNAL   Int J Mol Med 46 (5), 1707-1720 (2020)
   PUBMED   32901846
  REMARK    GeneRIF: Resveratrol protects retinal ganglion cells against
            ischemia induced damage by increasing Opa1 expression.
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Rodriguez-Graciani,K.M., Chapa-Dubocq,X.R., MacMillan-Crow,L.A. and
            Javadov,S.
  TITLE     Association Between L-OPA1 Cleavage and Cardiac Dysfunction During
            Ischemia-Reperfusion Injury in Rats
  JOURNAL   Cell Physiol Biochem 54 (6), 1101-1114 (2020)
   PUBMED   33119220
  REMARK    GeneRIF: Association Between L-OPA1 Cleavage and Cardiac
            Dysfunction During Ischemia-Reperfusion Injury in Rats.
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Satoh,M., Hamamoto,T., Seo,N., Kagawa,Y. and Endo,H.
  TITLE     Differential sublocalization of the dynamin-related protein OPA1
            isoforms in mitochondria
  JOURNAL   Biochem Biophys Res Commun 300 (2), 482-493 (2003)
   PUBMED   12504110
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Misaka,T., Miyashita,T. and Kubo,Y.
  TITLE     Primary structure of a dynamin-related mouse mitochondrial GTPase
            and its distribution in brain, subcellular localization, and effect
            on mitochondrial morphology
  JOURNAL   J Biol Chem 277 (18), 15834-15842 (2002)
   PUBMED   11847212
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Aung,T., Ocaka,L., Ebenezer,N.D., Morris,A.G., Brice,G.,
            Child,A.H., Hitchings,R.A., Lehmann,O.J. and Bhattacharya,S.S.
  TITLE     Investigating the association between OPA1 polymorphisms and
            glaucoma: comparison between normal tension and high tension
            primary open angle glaucoma
  JOURNAL   Hum Genet 110 (5), 513-514 (2002)
   PUBMED   12073024
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Aung,T., Ocaka,L., Ebenezer,N.D., Morris,A.G., Krawczak,M.,
            Thiselton,D.L., Alexander,C., Votruba,M., Brice,G., Child,A.H.,
            Francis,P.J., Hitchings,R.A., Lehmann,O.J. and Bhattacharya,S.S.
  TITLE     A major marker for normal tension glaucoma: association with
            polymorphisms in the OPA1 gene
  JOURNAL   Hum Genet 110 (1), 52-56 (2002)
   PUBMED   11810296
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Alexander,C., Votruba,M., Pesch,U.E., Thiselton,D.L., Mayer,S.,
            Moore,A., Rodriguez,M., Kellner,U., Leo-Kottler,B., Auburger,G.,
            Bhattacharya,S.S. and Wissinger,B.
  TITLE     OPA1, encoding a dynamin-related GTPase, is mutated in autosomal
            dominant optic atrophy linked to chromosome 3q28
  JOURNAL   Nat Genet 26 (2), 211-215 (2000)
   PUBMED   11017080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC111071.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_133585.4.
            
            On Jun 10, 2007 this sequence version replaced NM_133585.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111071.1, AY510274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3200
                     /gene="Opa1"
                     /note="OPA1, mitochondrial dynamin like GTPase"
                     /db_xref="GeneID:171116"
                     /db_xref="RGD:708423"
     exon            1..162
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3013
                     /gene="Opa1"
                     /EC_number="3.6.5.5"
                     /note="optic atrophy 1 (autosomal dominant); dynamin-like
                     120 kDa protein, mitochondrial; optic atrophy 1-like
                     protein; optic atrophy 1 homolog; mitochondrial OPA1;
                     optic atrophy protein 1 homolog; RN protein; dynamin-like
                     GTPase OPA1, mitochondrial"
                     /codon_start=1
                     /product="dynamin-like GTPase OPA1, mitochondrial
                     precursor"
                     /protein_id="NP_598269.3"
                     /db_xref="GeneID:171116"
                     /db_xref="RGD:708423"
                     /translation="MWRAGRAALACEVCQSLVKHSSGVQRNVPLQKLHLVSRSIYRSH
                     HPALKLQRPQLRTSFQQFSSLTNLSLHKLKLSPTKYGYQPRRNFWPARLAARLLKLRY
                     IILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPDFIWEIDEYIDLEKIRKALPSSE
                     DLANFAPDLDKIAESLSLLKDFFTAGTPGETAFRATDHGSESDKHYRKVSDKEKIDQL
                     QEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLS
                     DYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEG
                     PHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQ
                     RMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTD
                     LVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNS
                     SESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADS
                     FKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSL
                     WERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQDEFS
                     RFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQ
                     WDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWIYWKNRTQEQCVHNETKNELEKM
                     LKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLC
                     RRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVL
                     EDFAEDGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK"
     exon            163..481
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..578
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..686
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..754
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..808
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..913
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1000
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1114
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1195
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1270
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1342
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1442
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1573
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1646
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1719
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1835
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1900
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1977
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2143
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2296
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2405
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2485
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2626
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2743
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2837
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2948
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3023
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3146
                     /gene="Opa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggctgct ctatgccctt gttgctgagg gccgcttcct gggtcattgc tggagcagga
       61 gtcggagtgg ggccgacacg gggctccccc gtggccgtct cggcgcctgt gtgtggtctg
      121 cgctggcggg atgtggcgag caggtcgggc tgccctggcc tgtgaagtct gccaatcctt
      181 agtgaagcac agctctggag tacaaagaaa cgtaccgctc caaaaactgc atctggtttc
      241 ccgaagtatt tatcgttcac atcatcctgc cctcaagctt caaagacccc aattaaggac
      301 atcttttcag caattctctt ctctaactaa cctttcttta cataaattga aactttctcc
      361 aactaaatat ggctaccaac cccgcaggaa cttttggcca gcaaggttag ctgcaaggct
      421 cttaaaactt cgatatatta tactgggatc tgctgttgga ggtggctata cagccaaaaa
      481 aaccttcgat gaatggaaag atatgatacc agaccttagt gactataagt ggattgtgcc
      541 tgactttata tgggaaattg atgagtatat tgatttggag aaaatcagaa aagcccttcc
      601 cagttcagaa gacctcgcca atttcgctcc tgacctggac aagatcgccg aaagcctcag
      661 cttgttgaag gatttcttca ctgcgggtac acctggagaa acagcattta gagcaacaga
      721 tcatggatcc gaaagtgaca agcactatag gaaggtgtca gacaaagaaa agattgacca
      781 acttcaggaa gaacttctgc atactcagtt aaagtatcag aggatcctgg agcgtttgga
      841 gaaggagaac aaagagttga ggaagttggt gctgcagaag gatgacaaag gcatccacca
      901 caggaagctc aagaaatctc tgatcgatat gtattctgaa gttcttgatg tcctttctga
      961 ctatgatgcc agctacaata cccaagatca tctgccacgg gttgttgtgg ttggagatca
     1021 gagtgctgga aaaacaagtg ttctggaaat gattgctcaa gcacgaatat tcccacgagg
     1081 atccggtgag atgatgacgc gctctccagt gaaggtgact ctcagtgaag gccctcacca
     1141 cgtggccttg tttaaagaca gctcccggga gtttgacctc accaaggagg aagatcttgc
     1201 agcgttaaga catgaaattg aactccggat gagaaaaaat gtgaaagaag gttgtactgt
     1261 tagccctgag accatatctt taaatgtcaa aggccctggg ctgcagagga tggtgctggt
     1321 ggacttgcct ggtgttatca acactgtgac atcaggcatg gctcccgaca caaaggaaac
     1381 tattttcagt atcagcaaag cttacatgca gaatcctaac gccatcatcc tgtgcattca
     1441 agatggatct gtagatgccg agcgcagtat tgttacagac ttggtcagtc aaatggatcc
     1501 gcatggaaga agaaccatat ttgttttgac caaagtagac ctggcagaaa aaaatgtagc
     1561 cagtccaagc agaatacaac agataattga aggcaagctc ttcccaatga aagctctggg
     1621 ttattttgct gtcgtaacag gaaaaggaaa cagctctgaa agcattgaag ctataagaga
     1681 atatgaagag gaattttttc agaattcaaa actgctaaag acaagcatgc taaaggcaca
     1741 ccaggtgacc acgagaaatc taagccttgc cgtgtcagac tgcttttgga aaatggttcg
     1801 agagtcggtt gaacaacagg ctgatagttt taaagcgact cgcttcaacc tggagacaga
     1861 gtggaagaac aactaccccc gcctgcggga gctcgacagg aatgaactat ttgaaaaggc
     1921 taaaaatgag atcctcgatg aagtcatcag tctgagccag gttactccaa agcactggga
     1981 ggagatcctt cagcagtccc tgtgggaacg agtgtcaacg catgtgatcg agaacatcta
     2041 cctcccagct gcccagacca tgaactcagg aacattcaac accacagtgg acatcaagct
     2101 taaacagtgg actgacaagc agcttcctaa taaagcagtc gaggttgctt gggagaccct
     2161 acaagacgaa ttttcccgct tcatgacaga acccaaagga aaggaacacg atgacatatt
     2221 tgacaaactt aaggaggctg tgaaggagga gagtatcaag cggcacaaat ggaacgactt
     2281 cgcagaagac agcttgaggg tcatccagca caacgctctg gaggaccggt ccatatcaga
     2341 taagcaacag tgggacgcag ccatctactt catggaagag gcacttcaag gtcgtctcaa
     2401 ggatactgaa aatgctattg aaaacatgat cgggccagac tggaaaaaga ggtggatata
     2461 ctggaagaat cggacccaag agcagtgtgt tcacaatgaa accaagaatg aattggaaaa
     2521 gatgctgaag gttaatgatg aacacccagc ttatcttgca agtgatgaga ttaccacagt
     2581 ccggaagaac ctggaatctc gaggagtcga agtcgatcca agcctgatta aggatacttg
     2641 gcatcaagtc tatagaagac atttcctaaa aacagctcta aatcactgta acctttgtcg
     2701 gagaggtttt tattactacc agaggcattt tatagactct gagctggagt gcaacgacgt
     2761 ggtcctgttc tggcgaatac agcgcatgct cgctatcact gccaacacgc tgaggcagca
     2821 gctgacaaac accgaagtta ggcggctaga gaaaaacgtt aaagaggtat tagaagattt
     2881 tgctgaagac ggcgagaaga aggttaaatt gcttactggc aaacgagttc agctggcaga
     2941 agatctcaag aaagttagag aaattcaaga aaaacttgat gctttcattg aagctcttca
     3001 ccaggagaag tagacggtgt caaaatcctg ctcatgttaa cacctctgca tacatttgaa
     3061 gaacgaaaac ttcagagtct tgtcctgcct ccttttctcc tgttctaccc ttttcagtgc
     3121 aaaataaagt catagggtaa aagtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa
//
