LOCUS       NM_022671               2360 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus one cut homeobox 1 (Onecut1), mRNA.
ACCESSION   NM_022671
VERSION     NM_022671.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Peng,Y.C., Lv,T.H., Du,Z.K., Cun,X.N. and Yang,K.M.
  TITLE     Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear
            Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of
            Liver Regeneration
  JOURNAL   Bull Exp Biol Med 170 (1), 40-45 (2020)
   PUBMED   33222081
  REMARK    GeneRIF: Liver Macrophages Stimulate the Expression of Hepatocyte
            Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early
            Stage of Liver Regeneration.
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Falix,F.A., Weeda,V.B., Labruyere,W.T., Poncy,A., de Waart,D.R.,
            Hakvoort,T.B., Lemaigre,F., Gaemers,I.C., Aronson,D.C. and
            Lamers,W.H.
  TITLE     Hepatic Notch2 deficiency leads to bile duct agenesis perinatally
            and secondary bile duct formation after weaning
  JOURNAL   Dev Biol 396 (2), 201-213 (2014)
   PUBMED   25446530
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Wang,Z. and Burke,P.A.
  TITLE     Hepatocyte nuclear factor-4alpha interacts with other hepatocyte
            nuclear factors in regulating transthyretin gene expression
  JOURNAL   FEBS J 277 (19), 4066-4075 (2010)
   PUBMED   20735474
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Margagliotti,S., Clotman,F., Pierreux,C.E., Beaudry,J.B.,
            Jacquemin,P., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early
            liver expansion by controlling hepatoblast migration
  JOURNAL   Dev Biol 311 (2), 579-589 (2007)
   PUBMED   17936262
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Vanhorenbeeck,V., Jacquemin,P., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     OC-3, a novel mammalian member of the ONECUT class of transcription
            factors
  JOURNAL   Biochem Biophys Res Commun 292 (4), 848-854 (2002)
   PUBMED   11944891
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Jacquemin,P., Durviaux,S.M., Jensen,J., Godfraind,C., Gradwohl,G.,
            Guillemot,F., Madsen,O.D., Carmeliet,P., Dewerchin,M., Collen,D.,
            Rousseau,G.G. and Lemaigre,F.P.
  TITLE     Transcription factor hepatocyte nuclear factor 6 regulates
            pancreatic endocrine cell differentiation and controls expression
            of the proendocrine gene ngn3
  JOURNAL   Mol Cell Biol 20 (12), 4445-4454 (2000)
   PUBMED   10825208
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Lannoy,V.J., Burglin,T.R., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding
            properties, contain a bifunctional homeodomain, and define the new
            ONECUT class of homeodomain proteins
  JOURNAL   J Biol Chem 273 (22), 13552-13562 (1998)
   PUBMED   9593691
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Samadani,U. and Costa,R.H.
  TITLE     The transcriptional activator hepatocyte nuclear factor 6 regulates
            liver gene expression
  JOURNAL   Mol Cell Biol 16 (11), 6273-6284 (1996)
   PUBMED   8887657
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Lemaigre,F.P., Durviaux,S.M., Truong,O., Lannoy,V.J., Hsuan,J.J.
            and Rousseau,G.G.
  TITLE     Hepatocyte nuclear factor 6, a transcription factor that contains a
            novel type of homeodomain and a single cut domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9460-9464 (1996)
   PUBMED   8790352
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022671.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.26137.1,
                                           SRR26360194.1473683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1342              JAXUCZ010000008.1  84480305-84481646
            1343-2360           JAXUCZ010000008.1  84506831-84507848
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2360
                     /gene="Onecut1"
                     /gene_synonym="Hnf6"
                     /note="one cut homeobox 1"
                     /db_xref="GeneID:25231"
                     /db_xref="RGD:2811"
     exon            1..1342
                     /gene="Onecut1"
                     /gene_synonym="Hnf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1635
                     /gene="Onecut1"
                     /gene_synonym="Hnf6"
                     /note="one cut domain, family member 1; HNF-6"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 6"
                     /protein_id="NP_073162.2"
                     /db_xref="GeneID:25231"
                     /db_xref="RGD:2811"
                     /translation="MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSH
                     LPPAHPRSMGMASLLDGGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTT
                     YTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLAS
                     MNNLYTPYHKDVAGMGQSLSPLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGF
                     EAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVT
                     GAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNP
                     KPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVF
                     TDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSS
                     NSGNSSSSSSTCTKA"
     exon            1343..2360
                     /gene="Onecut1"
                     /gene_synonym="Hnf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatcctttt tggaaattaa tattaaaaaa gaaaaaaaag aaaagaaaag gcagagggga
       61 aggtaggagc aagagagaag gcaagacaca cacagagaga gcgaaagaca cagatcccca
      121 cagtgagagg aagaaaggcc acagtcgcag gcagccgatg tgaagactgg actctgtgcg
      181 cccctcgccg cctctgcccg gccacatcga tgttgcagcc cgctcacccg catcacgatg
      241 aacgcacagc tgaccatgga ggcgatcggc gagctgcacg gggtgagcca tgagccggtg
      301 cccgcccctg ctgacctgct gggcgggagc cctcacgcgc gcagctccgt ggggcaccgc
      361 ggcagccacc tgcctcccgc tcacccgcgt tccatgggca tggcgtcgct gctggacggc
      421 ggcagcggag gcagcgatta ccaccaccac caccgcgccc ctgagcacag cttggctggc
      481 cccctgcacc ccaccatgac catggcctgt gaaactcccc caggtatgag catgcccacc
      541 acctacacca ccttaacccc tctgcagccg ctgccgccca tctccaccgt gtccgacaag
      601 ttccctcacc accatcacca ccaccatcac caccaccacc cacatcacca ccagcgcctg
      661 gcgggcaacg tgagcggtag tttcacactt atgcgggatg agcgcgggct ggcctccatg
      721 aataacctct atacccccta ccacaaggac gtggctggca tgggccagag cctctcgccc
      781 ctctctggct cgggtctggg cagcattcac aactcccagc aaggacttcc ccactatgct
      841 catcccggcg cggctatgcc caccgacaag atgctcaccc caaatggctt tgaagcccac
      901 caccctgcca tgctcggtcg ccacggggag cagcacctca cgcccacctc ggccggcatg
      961 gtacccatca acggccttcc tccacaccat ccccatgccc acctgaatgc ccagggccac
     1021 ggacagctcc tgggcacagc ccgggagccc aacccttcgg tgaccggcgc gcaggtcagc
     1081 aatggaagta attcagggca gatggaagag atcaatacca aagaggtggc tcagcgtatc
     1141 accaccgagc tcaaacgtta cagcatccca caggccatct tcgcgcagag ggtgctctgc
     1201 cgttcccagg ggaccctttc ggacctgctg cgaaacccca agccctggag caaactcaag
     1261 tccggtcggg agactttccg gaggatgtgg aagtggctgc aggagccgga gttccagcgc
     1321 atgtcggcgc tccgcttagc agcctgcaaa aggaaagagc aagaacacgg gaaggacaga
     1381 ggcaacaccc ccaaaaagcc caggctggtc ttcacagacg tccaacgtcg gactctacat
     1441 gcaatattca aggaaaataa gcgtccgtcc aaagaattac aaatcaccat ttcccagcag
     1501 ctggggttgg agctgagcac tgtcagcaac ttcttcatga atgcgagaag gaggagtctg
     1561 gacaaatggc aggacgaggg cagctccaat tcaggcaact cttcgtcttc atcaagcact
     1621 tgtaccaaag catgaaggaa gaaccacgga ctagaacctc ggtggaaaag ctttaaatta
     1681 aataaaaaaa agtttttaaa gaccaggacc tcaagatagc aggtttatac ttagaaatat
     1741 ttgaaggaaa acaagtggta tttatagtcc aaagaaacca aagactaaaa agctcacctg
     1801 cattctgact ttgttcagag acacatactt cagcggggca agactcggca agaaagatga
     1861 tggagaaaac gtcggatctc gcgccttcaa cccctgcacc tcactgtgct cggctgctca
     1921 gtggctctaa gcacagtaat gtttgagcca tcgagtggac atcttttaag atcagacgtt
     1981 cttatctgtt ccaccacact gcaaaggtgt gtagtgtctc aatatcacgt gtgagtatgt
     2041 gtgtgcatgc gtgcacacgt aaacacacag caacaccagt gtttagggac tcaggcacgg
     2101 ctggtcttca ggaagggttg caccatatga catgaccaag ctggtgtggg atttctaagt
     2161 tcattggatc tgagatgtga gttttctcat ctaagcctag cgtttgaacc tgccaggccc
     2221 acaacctaaa tgcagattca aacccagcaa agaaaatttg aatggcacct aaaccagtac
     2281 gctctctttg tttgttaaga aatgttcaga tatttttaaa aaaaaaatga aacaagagtc
     2341 catccattaa aaaaaaaaaa
//
