LOCUS       NM_001106669            1839 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus OMA1 zinc metallopeptidase (Oma1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001106669 XM_001063646 XM_216446
VERSION     NM_001106669.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Garcia,I., Calderon,F., la Torre,P., Vallier,S.S., Rodriguez,C.,
            Agarwala,D., Keniry,M., Innis-Whitehouse,W. and Gilkerson,R.
  TITLE     Mitochondrial OPA1 cleavage is reversibly activated by
            differentiation of H9c2 cardiomyoblasts
  JOURNAL   Mitochondrion 57, 88-96 (2021)
   PUBMED   33383158
  REMARK    GeneRIF: Mitochondrial OPA1 cleavage is reversibly activated by
            differentiation of H9c2 cardiomyoblasts.
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Murata,D., Yamada,T., Tokuyama,T., Arai,K., Quiros,P.M.,
            Lopez-Otin,C., Iijima,M. and Sesaki,H.
  TITLE     Mitochondrial Safeguard: a stress response that offsets extreme
            fusion and protects respiratory function via flickering-induced
            Oma1 activation
  JOURNAL   EMBO J 39 (24), e105074 (2020)
   PUBMED   33200421
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Desmurs,M., Foti,M., Raemy,E., Vaz,F.M., Martinou,J.C., Bairoch,A.
            and Lane,L.
  TITLE     C11orf83, a mitochondrial cardiolipin-binding protein involved in
            bc1 complex assembly and supercomplex stabilization
  JOURNAL   Mol Cell Biol 35 (7), 1139-1156 (2015)
   PUBMED   25605331
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E.,
            Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A.,
            Enriquez,J.A., Zorzano,A. and Lopez-Otin,C.
  TITLE     Loss of mitochondrial protease OMA1 alters processing of the GTPase
            OPA1 and causes obesity and defective thermogenesis in mice
  JOURNAL   EMBO J 31 (9), 2117-2133 (2012)
   PUBMED   22433842
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S.,
            Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and
            Langer,T.
  TITLE     Regulation of OPA1 processing and mitochondrial fusion by m-AAA
            protease isoenzymes and OMA1
  JOURNAL   J Cell Biol 187 (7), 1023-1036 (2009)
   PUBMED   20038678
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der
            Bliek,A.M.
  TITLE     Inducible proteolytic inactivation of OPA1 mediated by the OMA1
            protease in mammalian cells
  JOURNAL   J Cell Biol 187 (7), 959-966 (2009)
   PUBMED   20038677
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216446.4, XM_001063646.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1839
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /note="OMA1 zinc metallopeptidase"
                     /db_xref="GeneID:298282"
                     /db_xref="RGD:1304821"
     exon            1..59
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            60..515
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1593
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /note="overlapping with the m-AAA protease 1 homolog; OMA1
                     homolog, zinc metallopeptidase; zinc metallopeptidase
                     homolog"
                     /codon_start=1
                     /product="metalloendopeptidase OMA1, mitochondrial"
                     /protein_id="NP_001100139.1"
                     /db_xref="GeneID:298282"
                     /db_xref="RGD:1304821"
                     /translation="MNFLYGLQSATRNQFLSGVNTLARRRTWTPPAGCPLASRLPAVN
                     ANWGLSTVSHCYSVILLPRNLHFCRTLKNKRSRCLSSAQSKEMGVLTYNWTVWGDASC
                     SPNYAAIREVRSFHTSAPRQAAPVPLLMLILKPVQKLLAIIVGRGIRKWWQALPPDKK
                     ALFKDSVKRNKWRLLLGLSAFGLLFVVFYFTHLEVSPVTGRSKLLLVGKEHFRLLSDL
                     EYEVWMEEFKNDLLPEEDPRYLTVKKVVYHLTQCNQDVPGVSEINWVVHVVHSPKVNA
                     FVLPNGQVFVFTGLLNSVTDMHQLSFLLGHEIAHAVLGHAAEKASLVHLLDFLGMIFL
                     TMIWAICPRDSLAVLGQWIQSKLQEYMFDRPYSRTLEAEADKIGLQLAAKACVDVRAS
                     SVFWQQMEFSESLHGYPKLPEWLSTHPSHGNRAEYLDRLIPQALKLREVCNCPPLSGP
                     DPRLLFRLTVKHLLEDSEKEDLNITVKKQKPDALPIQKQEQIPLTYALGKRTAG"
     exon            516..744
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            745..918
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1026
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1155
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1230
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1380
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1839
                     /gene="Oma1"
                     /gene_synonym="RGD1304821"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgcgcgg agccagcagc tggatccggc tccggctgcg gctcgagtgc gcgctcacga
       61 taaccaagca gaggtaagat gaacttcctt tatggactgc agtctgccac aagaaatcag
      121 tttctctctg gagtgaatac gctggcccgc aggagaacgt ggaccccacc agcaggctgt
      181 ccactggcat cgaggctccc agcagtaaat gcaaactggg gacttagcac agtcagtcac
      241 tgttattcag tgatcttact gcccagaaac cttcatttct gtaggactct caagaacaaa
      301 agatcaagat gcctctcaag tgcccaaagc aaggaaatgg gggtgctcac ctacaattgg
      361 acggtttggg gtgatgcctc atgttctccg aactatgccg ccataagaga ggtccggagt
      421 ttccacacat ctgcgccacg tcaggccgct ccagtccctc tcttgatgct cattctgaaa
      481 ccagtgcaaa agctccttgc tatcattgtg ggcaggggca taaggaaatg gtggcaagca
      541 cttccccctg acaagaaggc gctatttaaa gacagcgtga agaggaacaa gtggaggctg
      601 ctccttggtc tgagtgcctt tggactgctg tttgtggtgt tttatttcac tcacctggaa
      661 gtgagccctg tcactggaag gagcaaacta ctgttagtgg ggaaagaaca cttcagactc
      721 ctgtcagacc tggaatatga agtgtggatg gaagagttta aaaatgatct gctgcctgag
      781 gaagaccccc ggtacctgac tgtcaagaag gtggtttatc atctaacaca gtgcaatcaa
      841 gatgtcccag gggtctctga gatcaactgg gtggttcacg tggtccattc gcccaaggtc
      901 aatgccttcg tgcttccaaa cggacaagtg tttgttttca ctgggctttt gaatagcgtg
      961 accgatatgc accagctttc cttcctcctg ggccatgaga tcgcgcatgc ggtcctgggg
     1021 catgccgcag aaaaggctag cttggttcat ttactggatt tccttggcat gatttttctc
     1081 acaatgattt gggccatttg tccaagagac agcttggcag ttctgggcca gtggatacag
     1141 tcaaagttgc aggagtatat gtttgataga ccatacagta gaacattgga ggccgaagct
     1201 gacaaaattg gactacagct ggctgcaaag gcatgtgtgg acgtaagagc tagttcagtg
     1261 ttttggcagc agatggagtt ctcagagagc cttcatggct accccaagtt gccagagtgg
     1321 ctatcaacac atccttctca cgggaaccga gctgagtact tggacagact cataccacag
     1381 gctctcaaac ttcgggaggt ctgtaattgc ccaccactct ctggaccaga ccctcggtta
     1441 ctgttcagac ttactgtgaa acatttactt gaagactccg agaaagagga cctaaacatc
     1501 actgtcaaaa agcagaaacc ggatgctctg cccattcaga agcaggagca gataccactg
     1561 acatacgcac ttgggaaaag aactgcaggt tgaactgaac cgaatgaatc ttgggttccg
     1621 tgaggagcac agtgagcctt ttcattctta tgcaactctc aaaaacgatg ttttcaagga
     1681 aaaaaatgga tgttcaaaga tcaaatcatg tatattacag ataatatccg gatttttcta
     1741 gatttttatc tttcatgaaa tattgatgtg ttttaatcta ctttaaaata ctgccaacga
     1801 ggacaatgtc acagaataaa tcgatgttac gcatttcac
//
