LOCUS       NM_173293               2887 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus olfactory receptor 59 (Olr59), mRNA.
ACCESSION   NM_173293
VERSION     NM_173293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Kang,T., Zhu,L., Xue,Y., Yang,Q., Lei,Q. and Wang,Q.
  TITLE     Overexpression of olfactory receptor 78 ameliorates brain injury in
            cerebral ischaemia-reperfusion rats by activating Prkaca-mediated
            cAMP/PKA-MAPK pathway
  JOURNAL   J Cell Mol Med 28 (11), e18366 (2024)
   PUBMED   38856956
  REMARK    GeneRIF: Overexpression of olfactory receptor 78 ameliorates brain
            injury in cerebral ischaemia-reperfusion rats by activating
            Prkaca-mediated cAMP/PKA-MAPK pathway.
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Jovancevic,N., Khalfaoui,S., Weinrich,M., Weidinger,D., Simon,A.,
            Kalbe,B., Kernt,M., Kampik,A., Gisselmann,G., Gelis,L. and Hatt,H.
  TITLE     Odorant Receptor 51E2 Agonist beta-ionone Regulates RPE Cell
            Migration and Proliferation
  JOURNAL   Front Physiol 8, 888 (2017)
   PUBMED   29249973
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Matsubara,K., Nakamura,N., Sanoh,S., Ohta,S., Kitamura,S.,
            Uramaru,N., Miyagawa,S., Iguchi,T. and Fujimoto,N.
  TITLE     Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the
            liver of F344 rats by neonatal thyroid hormone disruption
  JOURNAL   J Appl Toxicol 37 (9), 1030-1035 (2017)
   PUBMED   28299817
  REMARK    GeneRIF: Among the up-regulated hepatic genes that were identified,
            the expression of Olr59, Ethe1, and Slc10a2 increased specifically
            in rats neonatally exposed to triiodothyronine.
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Gelis,L., Jovancevic,N., Veitinger,S., Mandal,B., Arndt,H.D.,
            Neuhaus,E.M. and Hatt,H.
  TITLE     Functional Characterization of the Odorant Receptor 51E2 in Human
            Melanocytes
  JOURNAL   J Biol Chem 291 (34), 17772-17786 (2016)
   PUBMED   27226631
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Pluznick,J.L., Protzko,R.J., Gevorgyan,H., Peterlin,Z., Sipos,A.,
            Han,J., Brunet,I., Wan,L.X., Rey,F., Wang,T., Firestein,S.J.,
            Yanagisawa,M., Gordon,J.I., Eichmann,A., Peti-Peterdi,J. and
            Caplan,M.J.
  TITLE     Olfactory receptor responding to gut microbiota-derived signals
            plays a role in renin secretion and blood pressure regulation
  JOURNAL   Proc Natl Acad Sci U S A 110 (11), 4410-4415 (2013)
   PUBMED   23401498
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Neuhaus,E.M., Zhang,W., Gelis,L., Deng,Y., Noldus,J. and Hatt,H.
  TITLE     Activation of an olfactory receptor inhibits proliferation of
            prostate cancer cells
  JOURNAL   J Biol Chem 284 (24), 16218-16225 (2009)
   PUBMED   19389702
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Raming,K., Konzelmann,S. and Breer,H.
  TITLE     Identification of a novel G-protein coupled receptor expressed in
            distinct brain regions and a defined olfactory zone
  JOURNAL   Recept Channels 6 (2), 141-151 (1998)
   PUBMED   9932290
  REMARK    GeneRIF: expressed only in distinct regions of the brain and in
            addition ina defined zone of the olfactory epithelium.
COMMENT     REVIEWED REFSEQ: This record has been curated by Janet Young and
            Barbara Trask (FHCRC). The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173293.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This record was generated from the set of rat
            olfactory receptors mined from Rnor3.1 assembly (NCBI Build 2.1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079864.1, SRR26643294.3459.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               JAXUCZ010000001.1  166610332-166610903 c
            573-2887            JAXUCZ010000001.1  166604979-166607293 c
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2887
                     /gene="Olr59"
                     /gene_synonym="Olfr78; Or51e2; RA1c"
                     /note="olfactory receptor 59"
                     /db_xref="GeneID:170816"
                     /db_xref="RGD:628858"
     exon            1..572
                     /gene="Olr59"
                     /gene_synonym="Olfr78; Or51e2; RA1c"
                     /inference="alignment:Splign:2.1.0"
     exon            573..2887
                     /gene="Olr59"
                     /gene_synonym="Olfr78; Or51e2; RA1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             624..1586
                     /gene="Olr59"
                     /gene_synonym="Olfr78; Or51e2; RA1c"
                     /note="olfactory receptor 78; G-protein coupled receptor
                     RA1c"
                     /codon_start=1
                     /product="olfactory receptor 51E2"
                     /protein_id="NP_775415.2"
                     /db_xref="GeneID:170816"
                     /db_xref="RGD:628858"
                     /translation="MSSCNFTHATFMLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIV
                     VFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLTQMFF
                     IHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPL
                     LIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYF
                     LIIRAVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMG
                     DVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT"
ORIGIN      
        1 ctttacttat gtcacaggca taataaaaca tgacttcatt atataagggg ctatgcttaa
       61 actgaaagag aagtaggaga gagttatgga gatgtgaatg gacctatttt gagctgtgag
      121 gctacatttt aaggtaccta cttagattat aagcctgatg tgaactccaa gagttcaata
      181 atcatgacta ttcatacacc ttgcctgctg tgtctagcag atcaaatgag gaaacactaa
      241 ccttgcggct gactgtagaa attagatcaa tttagaggag tgggaacaca tgtttgttat
      301 caagagactc acatgtgtca ttgtgggaat aggagcagag accttggtcc tttgagattg
      361 ctttcttaga cataaaagtg ggacgctggt gagagaagca cacaagtaga catgattatt
      421 tcactcctct gtctgccaga tccctagagc atcagctggt gttccagcag cttgttcccc
      481 gagcctcctg agtagcatta tagagaggtc tgttccagaa agcgaaagcc agatccagct
      541 gccctcctgg agcagaacaa cacaatttcc aggctgttcc tgtggcctct ccctcttcca
      601 gtctgcccca cttggtgtca gcgatgagct cctgcaactt cactcacgcc accttcatgc
      661 ttatcggtat tccaggactg gaggaagctc acttttggtt tggcttcccc ctactttcca
      721 tgtacgctgt agcattgttt ggaaattgca ttgtggtctt catcgtgagg acagagcgga
      781 gcctgcatgc gcccatgtat ctttttctct gcatgctggc agctattgat ctggctttgt
      841 ccacctctac aatgcccaag attctcgccc tcttttggtt tgactcccgg gagattactt
      901 ttgatgcctg tctcacccag atgttcttca ttcacgctct ctcagcaatt gaatctacca
      961 tcttgctggc catggccttt gaccggtatg tggctatctg ccacccactg cgtcacgctg
     1021 ctgtgctcaa caatacagta acagtccaaa tcggcatggt ggctctggtc cggggatccc
     1081 tattcttttt cccactccca ctgctgatca agcgactggc cttctgccac tccaatgtgc
     1141 tctcccactc ctattgtgtt caccaggatg tgatgaagtt ggcctataca gacacattgc
     1201 ccaatgtagt ctatggtcta actgccattc tgctagtcat gggtgtagat gtcatgttca
     1261 tctccttgtc ctatttcctg attatacgag cagttctgca attgccttcc aagtctgagc
     1321 gagctaaggc atttggaacc tgtgtgtcac acattggtgt agtcctggct ttctatgtcc
     1381 cactcattgg cctgtcagta gtgcaccgtt ttggaaacag cctggatccc attgtgcatg
     1441 ttctcatggg cgatgtctac ctgctgctgc ctcctgtgat caatcccatc atctacggtg
     1501 ctaagaccaa acagatcaga acacgggtgc tggctatgtt caagatcagt tgtgacaagg
     1561 acattgaagc tggaggaaac acgtgaccct taccgttcta tcacccttgt cctacatggc
     1621 ttaatataat gattaataat tcatcacacc ggcctaactc cagtcaccca aaagcacatt
     1681 agtgctttaa cctgaatggg acagtgaact aaagtatggt ttatcttcat catggataca
     1741 atgtgaaata tctatcatgt gttttaaagc ttgtgctata aaatgagacc cattgataat
     1801 actaaatgaa acaactagga tttgtgattt aaactaattg tttgtgattt gaatgagata
     1861 tgttgaaatt actagcaact ttttttattc ctacttcctt tgttgtaaag ctatctgtaa
     1921 tgtttaactt ctgaattgtg gaacatggag ctgacagtat ggtagccaag ggtttcctca
     1981 ctcatttcaa tgctattatt gactacccag gaacatatat gagctctaaa taatatggct
     2041 catgaatgta tcatgtaatg tgttccagtc cctgcgttaa gtgcttttca gactttctgt
     2101 gatcttgctc ttttcccaag gaagatacca ctgttgcctg ccacaacatg tgacaaagac
     2161 tttaatgagt aaagaaactt tcttgaatgt tctgtgccaa gattttaaat taaattggat
     2221 aattgaatac atttgcttta ccaccatgtt atattgcttc ctgtttaaca tctgccatct
     2281 atttcctctg cctattacaa atcctgcttt ctctctgccg tgtgctagca tggacgtctt
     2341 tgtgtttgtg gtaagtgatt aaccctgtcc tggtggaggg caacaaactg ttcagcatga
     2401 cagagtagct gcttcttctc atatgaacag aggagattta aattttttag tctcttacat
     2461 atccttgatt gtgtcctctt tgtattgtgt cctgtagctg tcaaatctct taaatgtata
     2521 acataagata ttgtctgatt cttgacttag gtatcaaaca acataataat ttatcttaaa
     2581 atgttcagta ttatttttac tgttttaatg ttcataagta atgttgggag acatgagtga
     2641 tttcccccag tcctctttac caacagtgca aagggcctgc caggtatggg ttgcacaact
     2701 ataaagatgt tgaatgaact tatgtagaat attccctttg tattgagtgg atgatgaaaa
     2761 tattcttaga ttaggttatt aatgacacct acaaaataat gttaatatat tcgatgtatg
     2821 cataatgctt aaaatgctga gatttatgta gtatgtatct gccacaataa aaaattattt
     2881 aaaataa
//
