LOCUS       NM_133306               3751 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus oxidized low density lipoprotein receptor 1
            (Olr1), mRNA.
ACCESSION   NM_133306
VERSION     NM_133306.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Arkelius,K., Wendt,T.S., Andersson,H., Arnou,A., Gottschalk,M.,
            Gonzales,R.J. and Ansar,S.
  TITLE     LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of
            Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic
            Stroke
  JOURNAL   Circ Res 134 (8), 954-969 (2024)
   PUBMED   38501247
  REMARK    GeneRIF: LOX-1 and MMP-9 Inhibition Attenuates the Detrimental
            Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute
            Ischemic Stroke.
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Lei,H., Guo,W., Pan,Y., Lu,X. and Zhang,Q.
  TITLE     LOX-1 regulation of H-type vascular endothelial cell regeneration
            in hyperglycemia
  JOURNAL   Acta Diabetol 61 (4), 515-524 (2024)
   PUBMED   38244081
  REMARK    GeneRIF: LOX-1 regulation of H-type vascular endothelial cell
            regeneration in hyperglycemia.
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Aoki,Y., Dai,H., Furuta,F., Akamatsu,T., Oshima,T., Takahashi,N.,
            Goto,Y.I., Oka,A. and Itoh,M.
  TITLE     LOX-1 mediates inflammatory activation of microglial cells through
            the p38-MAPK/NF-kappaB pathways under hypoxic-ischemic conditions
  JOURNAL   Cell Commun Signal 21 (1), 126 (2023)
   PUBMED   37268943
  REMARK    GeneRIF: LOX-1 mediates inflammatory activation of microglial cells
            through the p38-MAPK/NF-kappaB pathways under hypoxic-ischemic
            conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Zhang,Y., Zhang,R., Lu,L., Zhou,N., Lv,X., Wang,X. and Feng,Z.
  TITLE     Knockdown of lectin-like oxidized low-density lipoprotein-1
            ameliorates alcoholic cardiomyopathy via inactivating the p38
            mitogen-activated protein kinase pathway
  JOURNAL   Bioengineered 13 (4), 8926-8936 (2022)
   PUBMED   35333694
  REMARK    GeneRIF: Knockdown of lectin-like oxidized low-density
            lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating
            the p38 mitogen-activated protein kinase pathway.
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Akamatsu,T., Sugiyama,T., Oshima,T., Aoki,Y., Mizukami,A.,
            Goishi,K., Shichino,H., Kato,N., Takahashi,N., Goto,Y.I., Oka,A.
            and Itoh,M.
  TITLE     Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1-Related
            Microglial Activation in Neonatal Hypoxic-Ischemic Encephalopathy:
            Morphologic Consideration
  JOURNAL   Am J Pathol 191 (7), 1303-1313 (2021)
   PUBMED   33964218
  REMARK    GeneRIF: Lectin-Like Oxidized Low-Density Lipoprotein
            Receptor-1-Related Microglial Activation in Neonatal
            Hypoxic-Ischemic Encephalopathy: Morphologic Consideration.
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Lucarelli,M., Borrelli,V., Fiori,A., Cucina,A., Granata,F.,
            Potenza,R.L., Scarpa,S., Cavallaro,A. and Strom,R.
  TITLE     The expression of native and oxidized LDL receptors in brain
            microvessels is specifically enhanced by astrocytes-derived soluble
            factor(s)
  JOURNAL   FEBS Lett 522 (1-3), 19-23 (2002)
   PUBMED   12095612
  REMARK    GeneRIF: expression pattern of LOX1-R in brain microvessels
            endothelial cells and its modulation by astrocytes
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Li,D.Y., Chen,H.J., Staples,E.D., Ozaki,K., Annex,B., Singh,B.K.,
            Vermani,R. and Mehta,J.L.
  TITLE     Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in
            human atherosclerotic lesions
  JOURNAL   J Cardiovasc Pharmacol Ther 7 (3), 147-153 (2002)
   PUBMED   12232563
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Nagase,M., Abe,J., Takahashi,K., Ando,J., Hirose,S. and Fujita,T.
  TITLE     Genomic organization and regulation of expression of the
            lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene
  JOURNAL   J Biol Chem 273 (50), 33702-33707 (1998)
   PUBMED   9837956
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Hoshikawa,H., Sawamura,T., Kakutani,M., Aoyama,T., Nakamura,T. and
            Masaki,T.
  TITLE     High affinity binding of oxidized LDL to mouse lectin-like oxidized
            LDL receptor (LOX-1)
  JOURNAL   Biochem Biophys Res Commun 245 (3), 841-846 (1998)
   PUBMED   9588202
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Nagase,M., Hirose,S. and Fujita,T.
  TITLE     Unique repetitive sequence and unexpected regulation of expression
            of rat endothelial receptor for oxidized low-density lipoprotein
            (LOX-1)
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1417-1422 (1998)
   PUBMED   9494115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BC097290.1.
            
            On Sep 11, 2012 this sequence version replaced NM_133306.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB005900.1, BC097290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000004.1  164634501-164634547 c
            48-3001             BC097290.1         1-2954
            3002-3751           JAXUCZ010000004.1  164612463-164613212 c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3751
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /note="oxidized low density lipoprotein receptor 1"
                     /db_xref="GeneID:140914"
                     /db_xref="RGD:620515"
     exon            1..164
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1186
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /note="ox-LDL receptor 1; lectin-like oxLDL receptor 1;
                     lectin-like oxidized LDL receptor 1; lectin-type oxidized
                     LDL receptor 1; Lectin-like oxidized low-density
                     lipoprotein receptor-1; oxidised low density lipoprotein
                     (lectin-like) receptor 1; oxidized low density lipoprotein
                     (lectin-like) receptor 1; lectin-like oxidized low-density
                     lipoprotein receptor"
                     /codon_start=1
                     /product="oxidized low-density lipoprotein receptor 1"
                     /protein_id="NP_579840.2"
                     /db_xref="GeneID:140914"
                     /db_xref="RGD:620515"
                     /translation="MNLEMAFDDKMKPVNGQPDQKSCGKKPKGLHLLSSTWWCPAAVT
                     LAILCLVLSVTLIVQQTQLLQVSDLLKQYQANLTQQDHILEGQMSAQKKAENASQESK
                     RELKEQIDTLTWKLNEKSKEQEKLLQQNQNLQEALQRAVNASEESKWELKEQIDILNW
                     KLNGISKEQKELLQQNQNLQEALQKAEKYSEESQRELKEQIDTLSWKLNEKSKEQEEL
                     LQQNQNLQEALQRAANSSGPCPQDWIWHKENCYLFHGPFNWEKSRENCLSLDAQLLQI
                     STTDDLNFVLQATSHSTSPFWMGLHRKNPNHPWLWENGSPLSFQFFRTRGVSLQMYSS
                     GTCAYIQGGVVFAENCILTAFSICQKKANLLLTQ"
     exon            165..266
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..512
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..650
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..788
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..925
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1041
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..3751
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Oldlr1; Oldr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttaaactg catcagaagc tcgagcactg gcagttggct gactgaggtc ctctactgtt
       61 tcagtttccc attcttggca tgaatttgga aatggctttt gatgacaaga tgaagcctgt
      121 gaatggccag cctgatcaga agtcatgtgg caagaagcct aaagggctgc atttgctttc
      181 ttccacatgg tggtgccctg ctgctgtgac tctggccatc ctttgcctag tgttatcagt
      241 gacccttatt gtacagcaga cacagttact ccaggtatct gacctcctaa agcaatacca
      301 agcaaacctt actcagcagg atcatatcct ggaggggcag atgtcagccc agaagaaagc
      361 agaaaatgct tcacaagaat caaagaggga actgaaggaa cagatagaca ccctcacctg
      421 gaagctaaac gagaaatcca aagagcagga gaagcttctg cagcagaatc agaacctcca
      481 agaagccctg cagagagctg tgaacgcttc agaggagtcc aagtgggaac tgaaggaaca
      541 aatagacatt ctcaactgga agctgaatgg gatatccaaa gagcagaagg agcttctgca
      601 gcagaatcag aacctccaag aagccctgca gaaagctgag aaatattcag aggagtccca
      661 gagagaactg aaggaacaga tagacaccct cagctggaag ctaaacgaga aatccaaaga
      721 gcaggaggag cttctgcagc agaatcagaa tcttcaagaa gccctgcaga gagctgcaaa
      781 ctcttcaggt ccttgtccac aagactggat ctggcataaa gaaaactgtt acctcttcca
      841 tgggcccttt aactgggaaa aaagtcggga gaattgccta tctttagatg cccagttact
      901 acaaattagt accacagatg atctgaactt cgtcttacaa gcaacttccc attccacctc
      961 cccattttgg atgggattac atcggaaaaa tcccaaccac ccatggctat gggagaacgg
     1021 ctctcctttg agttttcaat tctttaggac caggggcgtt tctttacaga tgtactcatc
     1081 aggcacctgt gcatatattc aaggaggagt tgtgtttgct gaaaactgca ttttaactgc
     1141 attcagcata tgtcagaaga aggcaaattt attgctaact cagtgaaact aaggattctg
     1201 gagaagaaca ggagaagacc tttaactgtt gttttgaaat ttaagctatc ctttcttggg
     1261 tgtaaaacat gtggccttga cagctgtcag ttactttcta actgcagttc acctcaacag
     1321 agacaaagac cagaagcaaa aacccggggg tccagctgat ggcatctttg tatcaaaagt
     1381 tgtgaattca attgtttatc catgtacact ggccccgccc ctcccaagac tcccaaccaa
     1441 cctgcaatcc tttttttctt tcttgtttta aactatgcct cctgtctgac ctgggggatg
     1501 ctttctgctc aatttcctct acctcaggta tgccttctgt tgctgcatga aagacagaat
     1561 gtagaaaacc ttcttcaagt gcaggcagag agctcaaagt taaaaacatg cctaagaaat
     1621 agcatgcaaa gaaacagaac tggaaaagct acactgtacg caggagctca tggtctctaa
     1681 aaagctatgg cttgatcttc acgacttggg tccatctcca gactgcacca tttacacatt
     1741 tatgtttttt tattttattt ttattgtgtg tttatggata gttggcctat atgtatctct
     1801 gtgtaccaca tgagtgtctc cattcagaag agggcatcag attctctgaa actggaactg
     1861 cagatggctg taagctacta catagatgta aagaattgaa ttcatgtcct ctgaaagaac
     1921 agtcagtact cttaaccatg aactatttct ccaggtcccg tgatcatttc ttgtatcagc
     1981 tatttcttca catttgctct accaaagaac agagcttaaa acagtatttt ataaagccat
     2041 agaatatggc cccaaaacaa aactagaatt tttcccttaa attgcatact ttgtagacag
     2101 tctctccttg accctgccat gccatgctat gacttagaaa catacatgac caaaatggat
     2161 gaaactcagt tgaagaacaa gttcttagaa tcacctgagc tgggtataaa aatattgttc
     2221 tatgggaaca gatggattta gaaatatcta ttatcagggc ctccaccatc cccacaagtc
     2281 acagactctt ccatttcaaa ggaagctttc cattatgcta gaggtaatat agcatatatg
     2341 tcatgtatat gagtgtgtat ttgtgtgtgt gagtgtgtgt gttcatatgc tagatacgtc
     2401 cttgagaaga tgagacattg gcagctttgt gtgtaatgaa tttgcaataa tccaaatttg
     2461 taagtagttt ccatggttcc ttatagtgat gacatcacca cagccaagat gatgagcata
     2521 cctgttgttt ctgccccttt ccaatgcttc ctccctagaa caaacaccaa tctgttgtca
     2581 gttgtcattt catagagttt ataatcttgt ttttaagaga gaatctcatt atatagttct
     2641 gactgccctg ggactcacta cacagaccag cctggcctcc accttccaga gttcctcctg
     2701 cctttgactc acaagtgcta acactgaagg agtgcaccgc catgtatggc tcatgcagtt
     2761 tatgtgaatg gaatagtata acacatccag attttctcag ttcagtttct tccacttggt
     2821 gctattattt tggtattcat acatctctgc ctcagtgttt gtatcagttc ttcaattttt
     2881 ttaaaatgtt gatcattccc ctggtgggta catattgtca tttttatctg tgtatttgtt
     2941 gatgtcattt gggttgtttt tgtttggggt cacctacaaa taaagctgct atgaatgccc
     3001 atggacgatt ctggtttctc atgtaagcac ctctgagtgt gacacttggg tcattcagtg
     3061 tgtgaatata tggttggcca tgttaaccat tgctttttga aattttcaat ttttttttaa
     3121 aattagtcga ctttacatct caactccaat ttccttccct cctctcctct caatcttcac
     3181 ccacctccct ctcctacccc catccactct tccctttctc ttcagaaaag aggaggcttc
     3241 ccacagatgt caaccagcct tagcgtatca agttgcagta agaataggtt tatcatcttc
     3301 tatgaaagcc ttaattttta gacttatcac tgtatatgca gtattttgtt tgcatgtatg
     3361 tattggtacc acatatatgc ctaataccag aggaagtcag aagagggcat ggtatcttct
     3421 gagactggaa ttacagacat ttttgagcca tcctacagac tctggaaatt gaacccagga
     3481 tttctggaaa gttaggcagt gctcttaacc cctgaaccat ctcttcaggc cctatagcaa
     3541 tctttattga tatgtaactg tgtataattg cacttttagt ttgaagttct taaatggcaa
     3601 atagtcttga atttattttc atgttatcat ttactgtctg tacattttct gtaatgaaat
     3661 aactaagcat atcttttgag aattttattt tcttacattt taaatctgaa ggatttacat
     3721 acatactgga gaataaaaac agcctaatgt g
//
