LOCUS       NM_001100557            2650 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus oligodendrocyte transcription factor 2 (Olig2),
            mRNA.
ACCESSION   NM_001100557 XM_001073459 XM_221668
VERSION     NM_001100557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Zhang,K., Chen,S., Yang,Q., Guo,S., Chen,Q., Liu,Z., Li,L.,
            Jiang,M., Li,H., Hu,J., Pan,X., Deng,W., Xiao,N., Wang,B.,
            Wang,Z.X., Zhang,L. and Mo,W.
  TITLE     The Oligodendrocyte Transcription Factor 2 OLIG2 regulates
            transcriptional repression during myelinogenesis in rodents
  JOURNAL   Nat Commun 13 (1), 1423 (2022)
   PUBMED   35301318
  REMARK    GeneRIF: The Oligodendrocyte Transcription Factor 2 OLIG2 regulates
            transcriptional repression during myelinogenesis in rodents.
            Erratum:[Nat Commun. 2022 Jun 1;13(1):3164. PMID: 35650201]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   Ma,T., Li,B., Le,Y., Xu,Y., Wang,F., Tian,Y., Cai,Q., Liu,Z.,
            Xiao,L. and Li,H.
  TITLE     Demyelination contributes to depression comorbidity in a rat model
            of chronic epilepsy via dysregulation of Olig2/LINGO-1 and
            disturbance of calcium homeostasis
  JOURNAL   Exp Neurol 321, 113034 (2019)
   PUBMED   31415741
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Song,P., Xia,X., Han,T., Fang,H., Wang,Y., Dong,F., Zhang,R., Ge,P.
            and Shen,C.
  TITLE     BMSCs promote the differentiation of NSCs into oligodendrocytes via
            mediating Id2 and Olig expression through BMP/Smad signaling
            pathway
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30143582
  REMARK    GeneRIF: these data strongly suggest that bone marrow stromal cells
            (BMSCs) can promote the differentiation of Neural stem cells (NSCs)
            into oligodendrocytes through mediating Id2 and Olig1/2 expression
            by blocking the BMP/Smad signaling pathway
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Qiu,X., Luo,H., Liu,X., Guo,Q., Zheng,K., Fan,D., Shen,J., Lu,C.,
            He,X., Zhang,G. and Lu,A.
  TITLE     Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune
            Encephalomyelitis Rat
  JOURNAL   J Immunol Res 2018, 2952471 (2018)
   PUBMED   29682587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Tan,B.T., Jiang,L., Liu,L., Yin,Y., Luo,Z.R., Long,Z.Y., Li,S.,
            Yu,L.H., Wu,Y.M. and Liu,Y.
  TITLE     Local injection of Lenti-Olig2 at lesion site promotes functional
            recovery of spinal cord injury in rats
  JOURNAL   CNS Neurosci Ther 23 (6), 475-487 (2017)
   PUBMED   28452182
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Masliah,E., Roberts,E.S., Langford,D., Everall,I., Crews,L.,
            Adame,A., Rockenstein,E. and Fox,H.S.
  TITLE     Patterns of gene dysregulation in the frontal cortex of patients
            with HIV encephalitis
  JOURNAL   J Neuroimmunol 157 (1-2), 163-175 (2004)
   PUBMED   15579294
  REMARK    Erratum:[J Neuroimmunol. 2005 May;162(1-2):197]
REFERENCE   7  (bases 1 to 2650)
  AUTHORS   Fancy,S.P., Zhao,C. and Franklin,R.J.
  TITLE     Increased expression of Nkx2.2 and Olig2 identifies reactive
            oligodendrocyte progenitor cells responding to demyelination in the
            adult CNS
  JOURNAL   Mol Cell Neurosci 27 (3), 247-254 (2004)
   PUBMED   15519240
  REMARK    GeneRIF: Increased expression of Olig2 plays a critically important
            role in the differentiation of adult oligodendrocyte progenitor
            cells into remyelinating oligodendrocytes.
REFERENCE   8  (bases 1 to 2650)
  AUTHORS   Sun,T., Dong,H., Wu,L., Kane,M., Rowitch,D.H. and Stiles,C.D.
  TITLE     Cross-repressive interaction of the Olig2 and Nkx2.2 transcription
            factors in developing neural tube associated with formation of a
            specific physical complex
  JOURNAL   J Neurosci 23 (29), 9547-9556 (2003)
   PUBMED   14573534
REFERENCE   9  (bases 1 to 2650)
  AUTHORS   Lu,Q.R., Sun,T., Zhu,Z., Ma,N., Garcia,M., Stiles,C.D. and
            Rowitch,D.H.
  TITLE     Common developmental requirement for Olig function indicates a
            motor neuron/oligodendrocyte connection
  JOURNAL   Cell 109 (1), 75-86 (2002)
   PUBMED   11955448
REFERENCE   10 (bases 1 to 2650)
  AUTHORS   Sun,T., Echelard,Y., Lu,R., Yuk,D.I., Kaing,S., Stiles,C.D. and
            Rowitch,D.H.
  TITLE     Olig bHLH proteins interact with homeodomain proteins to regulate
            cell fate acquisition in progenitors of the ventral neural tube
  JOURNAL   Curr Biol 11 (18), 1413-1420 (2001)
   PUBMED   11566099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001073459.1, XM_221668.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1841517.1,
                                           SRR26643298.66110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000011.1  43961585-43961831
            248-2650            JAXUCZ010000011.1  43962559-43964961
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2650
                     /gene="Olig2"
                     /note="oligodendrocyte transcription factor 2"
                     /db_xref="GeneID:304103"
                     /db_xref="RGD:1307098"
     exon            1..247
                     /gene="Olig2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..2650
                     /gene="Olig2"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1274
                     /gene="Olig2"
                     /note="oligodendrocyte lineage transcription factor 2"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 2"
                     /protein_id="NP_001094027.1"
                     /db_xref="GeneID:304103"
                     /db_xref="RGD:1307098"
                     /translation="MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTP
                     SDCPPELSSELRGAMGTAGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMT
                     EPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYIL
                     MLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSTPLPTATAHPAAAAHAAHHPAVH
                     HPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGG
                     GGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK"
ORIGIN      
        1 agccgggtga catcagcttc gcagcccctc gggccggccc agctcattgg cgccgctgcc
       61 cctccaggaa aagcacattg ttcccgcccc cgcccggacc accgccaccg ccgtcgccgc
      121 tgcctccacc cagctataaa aaccagcgga accccgaaag gtgtggatgc ttaacagaga
      181 cccgagccaa caccagcgcc cagagccagg ttctctttcg cagcgagcac ctcaaatcga
      241 attcacattc ggaaggttga aaaaggaaag atccttcgaa agcctagatc gtctccgggg
      301 ccatggactc ggacgccagc ctggtgtcta gtcgcccgtc gtcgccagaa cccgatgatc
      361 tttttctgcc ggcccggagc aaggggggaa gcagcagcgg cttcacagga ggaaccgtgt
      421 cctcatccac gccgagcgac tgcccgccag agctgagctc cgagctgcga ggagccatgg
      481 gcacggcggg cgcgcatccc ggggacaaac tgggcggcgg tggcttcaag tcatcttcct
      541 ccagcacctc ctcgtccacg tcgtcggcgg ccacgtcttc caccaagaaa gataagaagc
      601 agatgactga gcccgagctg cagcagctgc gcctgaagat caacagccgc gagcgcaagc
      661 gcatgcacga cctcaacatc gccatggacg gcctgaggga ggtcatgccg tacgcgcacg
      721 gcccgtcggt gcgcaagctc tccaagatcg ccacgctgct gctggcgcga aactacatcc
      781 tgatgctcac caactcgctg gaggagatga agagactggt gagcgagatt tacgggggtc
      841 accacgccgg cttccacccg tcggcctgtg gcgggctggc acactcgacg cctctaccca
      901 ccgccacggc gcaccctgca gccgccgcgc acgccgcgca ccacccggcg gtgcatcacc
      961 ccatcctccc tccagcagcc gcggccgcag ccgccgcagc cgctgccgca gcggtgtcca
     1021 gcgcttctct gccgggctcc gggctgtcct cggtcggatc catccggcct cctcacggcc
     1081 tgctcaagtc tccatcggca gccgcggccg cccctctcgg aggcgggggt ggaggcagcg
     1141 gtggcagcgg tggcttccag cactggggtg gcatgccgtg cccctgcagc atgtgccagg
     1201 tgccgccgcc acaccaccac gtgtcggcta tgggcgccgg caccttgccg cgcctcacct
     1261 ccgacgccaa gtgagcgggc cagcaggggt gcgttctgga gagccgaggg ctgcagagca
     1321 acgcggacag gccagcgctg ggctccggga ctctgttgcc agaaggggag ctgaaccact
     1381 ggctgagcct agggggatta cagggagtcg cgtattattt gggaaccgaa gtagtgagag
     1441 cacttggagc gagggagagg ggcgcattcg ctccagaacc tggttaactc tttggctgaa
     1501 cgaacactcc gtgggtccgg gaggcgccat tgtacaaaat ggccacaaca cgcgggtaca
     1561 tccatccctg gaacttcctg cctgctaccc caggaagtct aaaaactgac tttccggtgt
     1621 acaaagatcg actccccgtc tgggcttaga agagacgcag agcactgggg gacttgattc
     1681 tttttcccca ttttgggcgg ggtaggagac tcccagggac cgcactgcag agaccgctgg
     1741 gccttaccct gcaggtacat ccctggccca gggccaggcc ctaagttaat tgttgctggc
     1801 gtgggtgtca gaaacactta gggtcctgtg gtctcagaag tgtggccttc cctcctgtct
     1861 ctcctgtcga tttgtggttt cctaacgagt ctgtgaatgt tccttttcag accacatgag
     1921 caagctttac agacgcttaa aatagcagca tttgtgaaat ggaataatcc cgaactactg
     1981 atacgggact ggatgctttt tagatcatat tttttaaata gaaccctccc acacacgcac
     2041 aagcgcacgc acacgcatac acgcacattc taggcacacg taatttgctt ttttacccga
     2101 ctggggacgc tgtttttagc acctgagggc ttgacagaag aacatcaaaa agttgctgtg
     2161 aatatagttt gagttatttg ggagggggtg ttctgttggg ttttaaataa tttcttgtgt
     2221 gtgtaaatat aatattaatg aagtgcgcga tgctaagctc tttgttcatg tgacaccccc
     2281 cccccccgcg cctctgtcgt ctaagcccgc tgttttcttt ctgtgtcgtg gcccatacat
     2341 acatacatac atacatacat acatacatac atacatacat actcacacac acacacaccc
     2401 cttttaccac cgttaacacg aggggcaaac cccttcatgg gcgctccccg gcgcgacctg
     2461 catcagcgtg ggctgtactg cgccgcttcc taactttcca cctctcccgc gctgccccgc
     2521 agagtgtatc tatcacttgt tttatttttg taaagaaaaa agaagtgcta aataatattt
     2581 attacttgtt tggttgcata aaacgaaaca aacgatggag tgttgagatt ttaaataaaa
     2641 tttaaagtaa
//
