LOCUS       NM_021770               2143 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus oligodendrocyte transcription factor 1 (Olig1),
            mRNA.
ACCESSION   NM_021770
VERSION     NM_021770.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Zhao,H., Gao,X.Y., Liu,Z.H., Lin,J.W., Wang,S.P., Wang,D.X. and
            Zhang,Y.B.
  TITLE     Effects of the transcription factor Olig1 on the differentiation
            and remyelination of oligodendrocyte precursor cells after focal
            cerebral ischemia in rats
  JOURNAL   Mol Med Rep 20 (5), 4603-4611 (2019)
   PUBMED   31702031
  REMARK    GeneRIF: The data of the present study may help clinicians
            understand the expression pattern of Olig1 and its potential role
            in endogenous remyelination after ischemia, which may have
            implications for the treatment of diseases that lead to
            demyelination.
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Song,P., Xia,X., Han,T., Fang,H., Wang,Y., Dong,F., Zhang,R., Ge,P.
            and Shen,C.
  TITLE     BMSCs promote the differentiation of NSCs into oligodendrocytes via
            mediating Id2 and Olig expression through BMP/Smad signaling
            pathway
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30143582
  REMARK    GeneRIF: these data strongly suggest that bone marrow stromal cells
            (BMSCs) can promote the differentiation of Neural stem cells (NSCs)
            into oligodendrocytes through mediating Id2 and Olig1/2 expression
            by blocking the BMP/Smad signaling pathway
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Dai,J., Bercury,K.K., Ahrendsen,J.T. and Macklin,W.B.
  TITLE     Olig1 function is required for oligodendrocyte differentiation in
            the mouse brain
  JOURNAL   J Neurosci 35 (10), 4386-4402 (2015)
   PUBMED   25762682
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Zhu,W.H., Gao,Y., Lou,L.X. and Zhu,L.Q.
  TITLE     [Effect of Yishen Daluo Decoction on the expression of PLP, Olig1,
            and Olig2 in mice with experimental autoimmune encephalomyelitis]
  JOURNAL   Zhongguo Zhong Xi Yi Jie He Za Zhi 34 (5), 562-565 (2014)
   PUBMED   24941845
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Fang,F., Zhang,H., Zhang,Y., Xu,H., Huang,Q., Adilijiang,A.,
            Wang,J., Zhang,Z., Zhang,D., Tan,Q., He,J., Kong,L., Liu,Y. and
            Li,X.M.
  TITLE     Antipsychotics promote the differentiation of oligodendrocyte
            progenitor cells by regulating oligodendrocyte lineage
            transcription factors 1 and 2
  JOURNAL   Life Sci 93 (12-14), 429-434 (2013)
   PUBMED   23973956
  REMARK    GeneRIF: Olig1 and Olig2 expression are enhanced during
            antipsychotic drug induced differentiation of oligodendrocyte
            progenitor cells.
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Cheng,X., Wang,Y., He,Q., Qiu,M., Whittemore,S.R. and Cao,Q.
  TITLE     Bone morphogenetic protein signaling and olig1/2 interact to
            regulate the differentiation and maturation of adult
            oligodendrocyte precursor cells
  JOURNAL   Stem Cells 25 (12), 3204-3214 (2007)
   PUBMED   17872503
  REMARK    GeneRIF: Overexpression of olig1 and olig2 inhibits astrocyte
            differentiation and promotes oligodendrocyte differentiation of
            adult oligodendrocyte precursor cells.
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Lu,Q.R., Sun,T., Zhu,Z., Ma,N., Garcia,M., Stiles,C.D. and
            Rowitch,D.H.
  TITLE     Common developmental requirement for Olig function indicates a
            motor neuron/oligodendrocyte connection
  JOURNAL   Cell 109 (1), 75-86 (2002)
   PUBMED   11955448
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Zhou,Q. and Anderson,D.J.
  TITLE     The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and
            glial subtype specification
  JOURNAL   Cell 109 (1), 61-73 (2002)
   PUBMED   11955447
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Wegner,M.
  TITLE     Expression of transcription factors during oligodendroglial
            development
  JOURNAL   Microsc Res Tech 52 (6), 746-752 (2001)
   PUBMED   11276127
  REMARK    Review article
REFERENCE   10 (bases 1 to 2143)
  AUTHORS   Lu,Q.R., Yuk,D., Alberta,J.A., Zhu,Z., Pawlitzky,I., Chan,J.,
            McMahon,A.P., Stiles,C.D. and Rowitch,D.H.
  TITLE     Sonic hedgehog--regulated oligodendrocyte lineage genes encoding
            bHLH proteins in the mammalian central nervous system
  JOURNAL   Neuron 25 (2), 317-329 (2000)
   PUBMED   10719888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 9, 2017 this sequence version replaced NM_021770.3.
            
            Summary: This gene is a member of the oligodendrocyte lineage gene
            family which encode basic helix-loop-helix transcription factors.
            Studies in mice show that it is coexpressed with Olig2 in neural
            progenitors, and has a role in the development and maturation of
            oligodendrocytes. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22399484.1377726.1,
                                        SRR26643298.66116.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2143              JAXUCZ010000011.1  44000450-44002592
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2143
                     /gene="Olig1"
                     /gene_synonym="Olg1; oligo1"
                     /note="oligodendrocyte transcription factor 1"
                     /db_xref="GeneID:60394"
                     /db_xref="RGD:621129"
     exon            1..2143
                     /gene="Olig1"
                     /gene_synonym="Olg1; oligo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..879
                     /gene="Olig1"
                     /gene_synonym="Olg1; oligo1"
                     /note="Olg-1 bHLH protein"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 1"
                     /protein_id="NP_068538.2"
                     /db_xref="GeneID:60394"
                     /db_xref="RGD:621129"
                     /translation="MYYAVSQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPIS
                     SSSSTSSSSTASLLPKPAREKPEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINS
                     RERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQE
                     LRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPP
                     CGQFALPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK"
ORIGIN      
        1 gcgcaggtcc gcggggaggg cgatctgccg accggcccac cctcgggcgt cagtgaaggg
       61 cgccctcggt cgcccccaca gcccccgccc cagatgtact atgcggtttc ccaggcgcgt
      121 gtgaacgcgg ctcccgcgac catgttgcgg ccacagcggc ccggagatgt gcagctcggg
      181 gcttcgttgt acgagctggt gggttacagg cagccaccca tctcgtcatc ctcctccacc
      241 tcctcctcct ctaccgcgtc ccttctccct aaacctgcgc gtgagaagcc tgaagctccg
      301 ctcgctgagc ctcggggacc agcgccggag tccgggggcg cccgggccga cgccaaagag
      361 gagcagcagc agcagcagct gaggcgcaag atcaacagcc gcgagcggaa gcgcatgcag
      421 gacctgaact tggccatgga cgcgctgcgc gaagttatcc taccctactc cgcggcgcac
      481 tgccagggcg cgccgggccg taagctctcc aagatcgcta cgctgctgct cgcccgcaac
      541 tacatcctgc tgctgggcag ctctctgcag gagctgcgcc gcgcgctcgg cgacggtgcg
      601 ggacccgccg ccccgcgcct gctccttgcg ggcctgcccc tgctggccgc cgcgccgggc
      661 tctgtgctgc tggcaccggg cgccgtggga ccccccgaaa cgctgcgccc caccaagtac
      721 ctgtctctag cgctcgacga gccaccgtgc ggccagttcg ctctccccgc tggtggcgcg
      781 ggtagccccg gcctctgctc ctgtgcggtg tgcaagttcc cgcatctggt ccccgccggc
      841 ctgggcttgg cagcggtgca ggctcagttc tccaagtgag ggctggctgg tcccggggcg
      901 gggcgcgacc tcagccaatc ttcccgcgcc ctcgcgtcct ggatctaggg agagctggcc
      961 ccagaaagga ggacatttcc agacttctca cccagacgac agactgtagg gcgccttctt
     1021 ccccgccccc actccctggc aattaaagtg acccaagcgg gtgttccaag gagcgacgca
     1081 gttgcctggg attctagatg aatcccacca gtttagagcc agaagtcatt gcctccccac
     1141 cataagctca cccagtagcg gaggtgacac ctccacccgg tggtctggtt ttgtacccgc
     1201 gagcatcgcg gagaccggga ggatggtagc cggcgatgcg gtacaatggg gttggggttg
     1261 ccctgggtgc agcgaaaggc tgtccccgag cttggtgccc tggcatccgc cagttccctg
     1321 gcctaagagc tgctccccaa cagtgtccac tcagaggggc ctctttcctt gtctggggcc
     1381 tgagcgcata ggctcccttg ctctcaccag ccaagcccat gcggatctag gaggtctaga
     1441 aagcccaggc cacgagtaca aacatcaagg gtgttgccga tgggccgctc cgaaaagccc
     1501 agagtccggt gtcccgcgag tgcgcgtggt gacagcgcct cggtcgttgg gtttcggagt
     1561 ggagaagttc ctctggctgg cctcacagtt ctgtctttca ggctcgcaca cccaggtgtt
     1621 ttgttgcaat ttacactcct tagtctctgc ttcccctaat ggtagcttaa ccaacatttg
     1681 agcttgcttg aaaacaaaat tccaaccacg ttccacgcca tcggtgttct ggacttacta
     1741 aaatagatag caaggcatgt cgtagcgtag gcttgtgaag ctcggtaatt aacgttctca
     1801 ctaaagtaag cgggcgagga tcccaaaccg ccggtgggtg gacaaaccca gctcccctgg
     1861 ctgcaggcag gaagacgctg gttgttaacc acagcaaggc agctgaagaa ctccttggac
     1921 cagtgcatgc gtcgatgccg cgtctgcgtc ttggcttgtg attagcgtta gcaaattacc
     1981 caagattatt gcataatctc caccagcttg ctttgatttt tttttttatg ttggaagttt
     2041 tgggttgttg acagtagccg aatttaactg gcgttttatt tgacctctaa ctctgtcccc
     2101 ctgaactgta cagaaaccac aaaataaaac gtcaacagtc gaa
//
