LOCUS       NM_001106052            2731 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus olfactomedin 4 (Olfm4), mRNA.
ACCESSION   NM_001106052 XM_001073392 XM_224413
VERSION     NM_001106052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2731)
  AUTHORS   Chen,H., Liu,S. and Fang,G.
  TITLE     Knockdown of OLFM4 protects cardiomyocytes from sepsis by
            inhibiting apoptosis and inflammatory responses
  JOURNAL   Allergol Immunopathol (Madr) 52 (5), 15-20 (2024)
   PUBMED   39278846
  REMARK    GeneRIF: Knockdown of OLFM4 protects cardiomyocytes from sepsis by
            inhibiting apoptosis and inflammatory responses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2731)
  AUTHORS   Welin,A., Amirbeagi,F., Christenson,K., Bjorkman,L.,
            Bjornsdottir,H., Forsman,H., Dahlgren,C., Karlsson,A. and Bylund,J.
  TITLE     The human neutrophil subsets defined by the presence or absence of
            OLFM4 both transmigrate into tissue in vivo and give rise to
            distinct NETs in vitro
  JOURNAL   PLoS One 8 (7), e69575 (2013)
   PUBMED   23922742
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2731)
  AUTHORS   Liu,W., Yan,M., Liu,Y., Wang,R., Li,C., Deng,C., Singh,A.,
            Coleman,W.G. Jr. and Rodgers,G.P.
  TITLE     Olfactomedin 4 down-regulates innate immunity against Helicobacter
            pylori infection
  JOURNAL   Proc Natl Acad Sci U S A 107 (24), 11056-11061 (2010)
   PUBMED   20534456
REFERENCE   4  (bases 1 to 2731)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2731)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2731)
  AUTHORS   Liu,W., Chen,L., Zhu,J. and Rodgers,G.P.
  TITLE     The glycoprotein hGC-1 binds to cadherin and lectins
  JOURNAL   Exp Cell Res 312 (10), 1785-1797 (2006)
   PUBMED   16566923
REFERENCE   7  (bases 1 to 2731)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   8  (bases 1 to 2731)
  AUTHORS   Rosenbauer,F., Wagner,K., Zhang,P., Knobeloch,K.P., Iwama,A. and
            Tenen,D.G.
  TITLE     pDP4, a novel glycoprotein secreted by mature granulocytes, is
            regulated by transcription factor PU.1
  JOURNAL   Blood 103 (11), 4294-4301 (2004)
   PUBMED   14962908
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073392.1, XM_224413.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q12"
     gene            1..2731
                     /gene="Olfm4"
                     /note="olfactomedin 4"
                     /db_xref="GeneID:290409"
                     /db_xref="RGD:1311708"
     exon            1..226
                     /gene="Olfm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1564
                     /gene="Olfm4"
                     /codon_start=1
                     /product="olfactomedin-4 precursor"
                     /protein_id="NP_001099522.1"
                     /db_xref="GeneID:290409"
                     /db_xref="RGD:1311708"
                     /translation="MCYSRLLLLSLLFCLGSASGSSRALSSTHSLELTTPTLPETTLP
                     ETTTAWLPSGGTSWTEGGTLSQSLSNFTGSVDSHGTCQCSVSLPDTTFPADRVERLEF
                     TAHTLSQKFEREFSKVKEYVQLISVYEKKLLNLTVRVEVMEKDSISYTELDFELIKLE
                     VKEMHKLVIQLKENFVGSTDIIDMLEVEIRNMTLLVEKLETLDQNNVLSIRRQILALK
                     TKLKECEDSKSGLVPATPPPPAPGSCSHGGVVNISAPFVVQLNFQGFNYKYGAWGRDY
                     SPQHPERTLYWVAPLNTDARVLEYYRLYDSLDNLLLYSHSRQYRILYGQGGGTVAFNN
                     SLYVNWYNGRNIAKIDLTTNGVTVNQPLPQAAYNNRFSYANVNWQDIDLAVDEQALWA
                     IYATEASTGNIVISKLNDTTLEVISTWVTKQYKPSVSNAFIVCGVLYATRTLNTRTEE
                     IFYYYDTNTQREGSLAITMRKMQERIQSINYHPYDHKLYVYNDGYLLNYDLVFLQTPK
                     QPV"
     exon            227..379
                     /gene="Olfm4"
                     /inference="alignment:Splign:2.1.0"
     exon            380..592
                     /gene="Olfm4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..752
                     /gene="Olfm4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..2731
                     /gene="Olfm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccagcat cttagctaag aaggcaagat gtgttacagc cgtcttctcc tcctgtccct
       61 tctgttctgc cttggctctg cctctgggag ttcgagagct ctgagctcta cacattccct
      121 ggaattgacc actccaacat tacctgagac tacattaccc gagactacga ctgcctggct
      181 gccttcggga ggcacgtcgt ggacagaagg tggtactctg tctcagtcac tttccaattt
      241 cactgggtct gtggacagcc atgggacctg ccagtgttct gtttccctgc cggacaccac
      301 ttttcctgct gacagagtgg agcgcttgga gttcacagct cacacccttt ctcagaaatt
      361 tgagagagag ttttctaagg tgaaggagta tgtccagcta ataagtgtgt atgagaagaa
      421 gctcctgaac ctgactgtcc gagtagaggt catggagaag gacagcattt cttatacaga
      481 actggacttt gagttgatca agctagaagt gaaggagatg cacaaactgg tcatacagct
      541 gaaggagaac tttgttggaa gtacagatat tattgacatg cttgaagtgg agataaggaa
      601 tatgactctc ctggtagaga agctggagac gctagaccaa aacaatgtcc ttagcattcg
      661 ccggcagatc ttggctctga agaccaagct gaaggaatgt gaggactcta aaagtggcct
      721 tgtgcctgcc acaccccctc ctcctgctcc tggaagctgt agccatggcg gtgtggtgaa
      781 catcagcgct ccttttgtgg ttcagctcaa ctttcaaggg tttaattata aatatggtgc
      841 ctggggccga gattactctc ctcagcatcc agagagaacc ctgtactggg tggcaccttt
      901 gaatacagat gccagggttc tagagtatta cagactttat gactcactgg ataatctgtt
      961 actctattca cattccagac agtatcggat tctctatggc caagggggtg gtacagtagc
     1021 attcaacaac agcctgtatg tgaattggta caatgggaga aacattgcca aaattgacct
     1081 aactaccaat ggagtcactg tgaatcagcc cctccctcag gctgcctaca ataaccgctt
     1141 ttcatatgct aatgtgaatt ggcaagacat tgaccttgct gtggacgagc aagcactgtg
     1201 ggcaatttat gcaactgagg ccagcactgg taacatagtg attagtaagc tcaatgatac
     1261 cactcttgag gtgataagca cttgggttac caagcagtac aagccatctg tttctaatgc
     1321 cttcattgta tgtggagttc tttacgctac tcgcactttg aacaccagaa cagaagagat
     1381 cttttactac tatgacacaa acacacagag ggaaggcagt ctagccatca caatgagaaa
     1441 gatgcaggaa agaattcaga gcattaatta tcatccctat gaccacaaac tttatgtcta
     1501 caatgatggt tatcttttga actacgatct tgtcttctta cagacaccta agcaacctgt
     1561 ctaagtgtta ggcacttaac taagtgaagg aggaatgaaa agcttgttgg aaattgtttt
     1621 ctccacatgt ttagatatct gcagggaagt ctaggagtgt gtttctttag gcatggtgtt
     1681 agtagagata gttctgtctc aatttgattt ctcttgggaa ccatcatctt ctttggatag
     1741 atttaacaac tgaaataagg tctttccagg taagattctc agatgctagg gatactatga
     1801 gtctaatgaa gtttctagtg aggtgaagtc tagaagttaa agaacttaag gggaactcag
     1861 tgtgaattct gggaatcctt tctcttgaag aatttgcatg gtaaccagtc aacctaccac
     1921 ataggaccat tgaattgtac atgtggaaag gacactgggg cttaattagg taggtcatca
     1981 tcagaaggtc aacatgagat caaatactta gctttgtttt cctcctggct cctggaacct
     2041 gttttgtgta ccagatagtt acatttgcca tcttaaatgg tacctgttat atgttttgaa
     2101 ttttctggag aattggccta ttgtacaggg aaatcagtcc aggaagactt ttcagatgct
     2161 gtacttggct tttcttttct ctcattcttc acctacataa ctcagtagaa ccctttacct
     2221 cataattcag gttccaaggc agacgtaaaa ttagaagcag acttaacaac aagcaccttt
     2281 ctcttactgc ttatgtgttt ttcttaaaca ttgactagtt ttttttatga aacgtgcata
     2341 aaatcaatta actttctttt gtgttatcat gcaatattgg tttatgtaat tacaagactg
     2401 taaaaaaaac cagttgtcag tgacataatg gcagtatttc tagttatata gtaaagattg
     2461 tggagtaagt tgtactggtt tctctcttta agtctggaat ttgcaagaaa gtgaaatttt
     2521 atacatataa acatttatat ataaaaataa tatagaaaag tactttgtag tatctgctta
     2581 atcaatgcac tgcttgagaa catgctaagt gcaaatgcta tggtggcttt ggatggttct
     2641 accatatggt cttggctatt gatgttcaaa tcctaatctt aaaattctgt cttcctattt
     2701 tttttaaata aactattaaa gagtgaactg a
//
