LOCUS       NM_001015017            2024 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus olfactomedin 2 (Olfm2), mRNA.
ACCESSION   NM_001015017 XM_233742
VERSION     NM_001015017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Shi,N., Li,C.X., Cui,X.B., Tomarev,S.I. and Chen,S.Y.
  TITLE     Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and
            Vascular Remodeling Through Mediating Runt-Related Transcription
            Factor 2 Binding to Serum Response Factor
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (3), 446-454 (2017)
   PUBMED   28062493
  REMARK    GeneRIF: Olfactomedin 2 regulates vascular smooth muscle phenotype
            and vascular remodeling by regulating Runx2/serum response factor
            interaction.
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Shi,N., Guo,X. and Chen,S.Y.
  TITLE     Olfactomedin 2, a novel regulator for transforming growth
            factor-beta-induced smooth muscle differentiation of human
            embryonic stem cell-derived mesenchymal cells
  JOURNAL   Mol Biol Cell 25 (25), 4106-4114 (2014)
   PUBMED   25298399
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Sultana,A., Nakaya,N., Dong,L., Abu-Asab,M., Qian,H. and
            Tomarev,S.I.
  TITLE     Deletion of olfactomedin 2 induces changes in the AMPA receptor
            complex and impairs visual, olfactory, and motor functions in mice
  JOURNAL   Exp Neurol 261, 802-811 (2014)
   PUBMED   25218043
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Sultana,A., Nakaya,N., Senatorov,V.V. and Tomarev,S.I.
  TITLE     Olfactomedin 2: expression in the eye and interaction with other
            olfactomedin domain-containing proteins
  JOURNAL   Invest Ophthalmol Vis Sci 52 (5), 2584-2592 (2011)
   PUBMED   21228389
  REMARK    GeneRIF: Highly conserved OLFM2 protein may play an important role
            in the course of retinal and eye development.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092647.1.
            
            On Apr 20, 2005 this sequence version replaced XM_233742.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092647.1, SRR8487231.155758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2024
                     /gene="Olfm2"
                     /note="olfactomedin 2"
                     /db_xref="GeneID:313783"
                     /db_xref="RGD:1309741"
     exon            1..290
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1592
                     /gene="Olfm2"
                     /note="noelin-2"
                     /codon_start=1
                     /product="noelin-2 precursor"
                     /protein_id="NP_001015017.1"
                     /db_xref="GeneID:313783"
                     /db_xref="RGD:1309741"
                     /translation="MSVPLLKIGAVLSTMAMVTNWMSQTLPSLVGLNSTVSRAGSSEK
                     ITLFQSPEEGWQLYTSAQAPDGKCICTAVIPAQSTCARDGRSRELRQLMEKVQNVSQS
                     MEVLELRTYRDLQYVRSMETLMRSLDARLRTADGSVSAKSFQELKDRMTELLPLSSVL
                     EQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLG
                     CGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFI
                     KGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYN
                     NTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKR
                     SAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRE
                     RALYTWNNGHQVLYNVTLFHVISTAGDP"
     exon            291..440
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..587
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..807
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..914
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1998
                     /gene="Olfm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggccaccg cccccttgga cccggtcatc tcgccatcgg gaccccgacc cctccacccc
       61 actggggtgg atagcgacat cttgagtgcc gaggaaaggg gacggaacac ctgctctttt
      121 agggtggtgg tgcggggcat gaggcgaggg gcgcgatgtc ggtgccgctg ctcaagatcg
      181 gggcggtgct gagcaccatg gccatggtca ctaactggat gtcgcagacg ctgccctcgc
      241 tcgtgggact caacagcacc gtgtcccgcg cgggctcctc agagaaaatc actctcttcc
      301 agagcccaga agagggctgg cagctgtaca cgtcagcgca ggcgccggat ggcaaatgca
      361 tctgcacagc tgtgattcct gcacagagca cctgtgcccg agatggtcgg agcagagagc
      421 ttcgccagct catggagaag gtccagaatg tgtctcagtc catggaagtc cttgagctaa
      481 ggacataccg ggatctccag tatgttcgca gcatggagac cctcatgcgg agcctggatg
      541 caaggctcag gacagccgat gggtcagtct cagccaaaag ctttcaggaa ctgaaggaca
      601 ggatgacaga gctgctgccc ctgagttcag tgctggagca gtacaaagca gacacacgga
      661 ccattgtgcg cctgcgggag gaggtgagga acctctcagg caacctggct gccatccagg
      721 aggaaatggg tgcctacggg tacgaggact tgcagcagcg cgtgatggcc ctggaggccc
      781 gactccatgc ctgcgcgcag aagctgggct gcgggaagct gacaggcgtc agtaacccca
      841 ttaccatccg agccatggga tcccgcttcg gctcctggat gactgacacg atggccccca
      901 gtgcagacag tcgggtctgg tacatggatg gttattacaa aggccgccga gtgctggagt
      961 tccgtacttt gggagacttc atcaaaggcc agaacttcat ccagcacctg ctgccgcagc
     1021 catgggcagg tacgggccat gtggtataca atggatctct gttctacaac aagtaccaga
     1081 gcaatgtggt ggttaagtac cacttccggt cccgctccgt gttggtgcag aggagcctcc
     1141 cgggggctgg ttacaataac accttcccct attcctgggg cggcttctcg gacatggact
     1201 tcatggtaga cgagagcggg ctgtgggctg tgtataccac caaccagaac gcgggcaaca
     1261 ttgtggtcag ccggctggac cctcacaccc tggaggtcgt gaggtcctgg gacactgggt
     1321 accctaagcg cagcgccggt gaggccttca tgatctgtgg tgtcctctac gtgaccaact
     1381 ctcacctggc cggagccaag gtctactttg cgtacttcac caacacgtcc agctatgagt
     1441 acacggatgt gcccttccac aaccagtact cgcacatctc catgctggat tacaacccca
     1501 gggagcgggc cctgtatacc tggaacaacg ggcaccaggt gctgtacaac gtcaccctct
     1561 tccacgtcat cagcactgcc ggggacccct aggagaccct ccaagggttg tggggagcct
     1621 tcccacatcg cctgtgacgc acccccctcc cccagccttc tcttggtcat gcccttgcct
     1681 tcctagatac cttctctccc ctttcccagc ccagctttct gttctgtgtc tgtacccatg
     1741 cattttctcc attttatcga tctctgcttt tgatactcca cttctttctg cctttttatg
     1801 gatgcttctt ctcttcctta ttgatcgaat ctctctcctc tccctctgtc cactctccct
     1861 cctcctttcc tagtttccca catcccttat ccctcactcc taccctatcc ctggatctga
     1921 gtgcatggat tttgtttttt aaatttatta tttacacatt ttctttccgg gttgccagaa
     1981 taaactggac ctttgacaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
