LOCUS       NM_022705               1525 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus oleoyl-ACP hydrolase (Olah), mRNA.
ACCESSION   NM_022705
VERSION     NM_022705.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Ritchie,M.K., Johnson,L.C., Clodfelter,J.E., Pemble,C.W. 4th,
            Fulp,B.E., Furdui,C.M., Kridel,S.J. and Lowther,W.T.
  TITLE     Crystal Structure and Substrate Specificity of Human Thioesterase
            2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY
            ACID SYNTHASE
  JOURNAL   J Biol Chem 291 (7), 3520-3530 (2016)
   PUBMED   26663084
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Mogi,K., Funabashi,T., Mitsushima,D., Hagiwara,H. and Kimura,F.
  TITLE     Sex difference in the response of melanin-concentrating hormone
            neurons in the lateral hypothalamic area to glucose, as revealed by
            the expression of phosphorylated cyclic adenosine
            3',5'-monophosphate response element-binding protein
  JOURNAL   Endocrinology 146 (8), 3325-3333 (2005)
   PUBMED   15905320
  REMARK    GeneRIF: Sex differences in the response of MCH neurons to glucose
            correlated well with the gonadal steroid milieu.
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Tai,M.H., Chirala,S.S. and Wakil,S.J.
  TITLE     Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II
            and of the C-terminal region of the enzyme in its interaction with
            fatty acid synthase
  JOURNAL   Proc Natl Acad Sci U S A 90 (5), 1852-1856 (1993)
   PUBMED   8446599
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Naggert,J., Williams,B., Cashman,D.P. and Smith,S.
  TITLE     Cloning and sequencing of the medium-chain S-acyl fatty acid
            synthetase thioester hydrolase cDNA from rat mammary gland
  JOURNAL   Biochem J 243 (2), 597-601 (1987)
   PUBMED   3632637
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Randhawa,Z.I. and Smith,S.
  TITLE     Complete amino acid sequence of the medium-chain S-acyl fatty acid
            synthetase thio ester hydrolase from rat mammary gland
  JOURNAL   Biochemistry 26 (5), 1365-1373 (1987)
   PUBMED   3567174
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Safford,R., de Silva,J., Lucas,C., Windust,J.H., Shedden,J.,
            James,C.M., Sidebottom,C.M., Slabas,A.R., Tombs,M.P. and
            Hughes,S.G.
  TITLE     Molecular cloning and sequence analysis of complementary DNA
            encoding rat mammary gland medium-chain S-acyl fatty acid
            synthetase thio ester hydrolase
  JOURNAL   Biochemistry 26 (5), 1358-1364 (1987)
   PUBMED   3105579
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Randhawa,Z.I., Naggert,J., Blacher,R.W. and Smith,S.
  TITLE     Amino acid sequence of the serine active-site region of the
            medium-chain S-acyl fatty acid synthetase thioester hydrolase from
            rat mammary gland
  JOURNAL   Eur J Biochem 162 (3), 577-581 (1987)
   PUBMED   3104035
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Libertini,L.J. and Smith,S.
  TITLE     Purification and properties of a thioesterase from lactating rat
            mammary gland which modifies the product specificity of fatty acid
            synthetase
  JOURNAL   J Biol Chem 253 (5), 1393-1401 (1978)
   PUBMED   627544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022705.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16200.1, SRR26643295.55158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000017.1  79786832-79786935
            105-345             JAXUCZ010000017.1  79787865-79788105
            346-476             JAXUCZ010000017.1  79791832-79791962
            477-615             JAXUCZ010000017.1  79804417-79804555
            616-715             JAXUCZ010000017.1  79806770-79806869
            716-885             JAXUCZ010000017.1  79807303-79807472
            886-968             JAXUCZ010000017.1  79810689-79810771
            969-1525            JAXUCZ010000017.1  79811124-79811680
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1525
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /note="oleoyl-ACP hydrolase"
                     /db_xref="GeneID:64669"
                     /db_xref="RGD:621115"
     exon            1..104
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..345
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1105
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /EC_number="3.1.2.14"
                     /note="thioesterase domain-containing protein 1;
                     medium-chain S-acyl fatty acid synthetase thio ester
                     hydrolase (MCH); thioesterase domain containing 1;
                     thioesterase II; medium-chain S-acyl fatty acid synthetase
                     thioester hydrolase"
                     /codon_start=1
                     /product="S-acyl fatty acid synthase thioesterase, medium
                     chain"
                     /protein_id="NP_073196.1"
                     /db_xref="GeneID:64669"
                     /db_xref="RGD:621115"
                     /translation="METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAK
                     WGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSF
                     GSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFG
                     GTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIE
                     GWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT"
     exon            346..476
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..615
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..715
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..885
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..968
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1525
                     /gene="Olah"
                     /gene_synonym="Mch; Thedc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttgctgt gcctctcact gtggttcgat ctctcctctg gaaggagcat agctgaaagc
       61 tgatcttctg gtctccagaa cgcttctgag attttgccat cgagtccatt tccttctctt
      121 cttccctatc tctttttctt cactgccctt taaaagcagg attctgagtg acagccatag
      181 tcaacaggtt aaaaagaaag ctggtccctt ggtatactga aggcttactg gagatttttg
      241 tgcccagagg ggaattgaat tcagcgtgga cacagaaggt tgaaggagca acaaccccta
      301 atcaactcac agaatggaga cagcagtcaa tgctaagagt cccaggaatg aaaaggtttt
      361 gaactgtttg tatcaaaatc ctgatgcagt tttcaagctg atctgcttcc cttgggcagg
      421 aggcggctcc atccattttg ccaagtgggg ccaaaagatt aacgactctc tggaagtgca
      481 tgctgtaaga ctggctggaa gagaaacccg acttggagaa cctttcgcaa atgacatcta
      541 ccagatagct gatgaaatcg tgaccgccct gttgcccatc attcaggata aagcttttgc
      601 gttttttggc cacagttttg gatcctacat tgctcttatt actgctctgc tcctaaagga
      661 gaaatacaaa atggagccac tgcatatttt tgtatccggt gcatccgccc ctcactcaac
      721 atcccggcct caagttcctg atcttaacga attgacagaa gaacaagtca gacatcacct
      781 tctggatttc ggaggcacgc ccaagcatct catagaagac caggatgttc tgaggatgtt
      841 cattcctttg ctgaaggcag atgctggcgt tgtgaaaaaa ttcatctttg acaagccctc
      901 caaagctctt ctctctctgg acataacggg cttccttgga tctgaagata caataaagga
      961 catagaaggc tggcaagacc taaccagtgg gaagtttgat gtccacatgc tgccaggtga
     1021 ccacttttat ctgatgaagc ccgacaacga gaactttatc aagaactaca tagccaagtg
     1081 cttggaactc tcgtcactca cttgactact tttagatgag ctttctttgg ggctgtggat
     1141 atgcagacgg ttcaaaagct gctcctctgg gtccagcttt tagttcttag aggttggaaa
     1201 ggtgcatatt aatgaatttc ttcgtggagc atttatctct ctggggaaag gacacggctg
     1261 aagaggcgca caggcactat tgggagctaa cagaggggag aggggggtgg ttttctttgg
     1321 ggggatgttg ccctcagtag gtacccatgc tccagtaaat gacactacac ccttgtgcca
     1381 catgcaggca gctctaatca gactcagtgg gaagttggga ggcatacatg ttgggggaca
     1441 tctgtcacgg ggcttggaaa gacaagtgag ggtctgatca aaacctgctg tttacatttt
     1501 caaagaataa ataaaaaata ttgct
//
