LOCUS       NM_001001507            2289 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus oncoprotein induced transcript 3 (Oit3), mRNA.
ACCESSION   NM_001001507 XM_228352
VERSION     NM_001001507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Yan,B., Zhang,Z.Z., Huang,L.Y., Shen,H.L. and Han,Z.G.
  TITLE     OIT3 deficiency impairs uric acid reabsorption in renal tubule
  JOURNAL   FEBS Lett 586 (6), 760-765 (2012)
   PUBMED   22306318
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Shen,H.L., Xu,Z.G., Huang,L.Y., Liu,D., Lin,D.H., Cao,J.B.,
            Zhang,X., Wang,Z.Q., Wang,W.H., Yang,P.Y. and Han,Z.G.
  TITLE     Liver-specific ZP domain-containing protein (LZP) as a new partner
            of Tamm-Horsfall protein harbors on renal tubules
  JOURNAL   Mol Cell Biochem 321 (1-2), 73-83 (2009)
   PUBMED   18830570
  REMARK    GeneRIF: The finding that LZP might act as a new partner of THP
            would provide novel insights into renal functions related to THP
            and LZP, such as the urothelial permeability barrier and the host
            defense against the adhesion of pathogens.
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Xu,Z.G., Du,J.J., Cui,S.J., Wang,Z.Q., Huo,K.K., Li,Y.Y. and
            Han,Z.G.
  TITLE     Identification of LZP gene from Mus musculus and Rattus norvegicus
            coding for a novel liver-specific ZP domain-containing secretory
            protein
  JOURNAL   DNA Seq 15 (2), 81-87 (2004)
   PUBMED   15346761
  REMARK    GeneRIF: Sequence analysis revealed that human, rat and mouse LZP
            proteins are highly conserved.
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Xu,Z.G., Du,J.J., Zhang,X., Cheng,Z.H., Ma,Z.Z., Xiao,H.S., Yu,L.,
            Wang,Z.Q., Li,Y.Y., Huo,K.K. and Han,Z.G.
  TITLE     A novel liver-specific zona pellucida domain containing protein
            that is expressed rarely in hepatocellular carcinoma
  JOURNAL   Hepatology 38 (3), 735-744 (2003)
   PUBMED   12939600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY353853.1.
            
            On Aug 30, 2004 this sequence version replaced XM_228352.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY353853.1, AY356356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2289
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /note="oncoprotein induced transcript 3"
                     /db_xref="GeneID:294559"
                     /db_xref="RGD:735082"
     exon            1..166
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1746
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /note="oncoprotein-induced transcript 3 protein;
                     liver-specific zona pellucida domain-containing protein"
                     /codon_start=1
                     /product="oncoprotein-induced transcript 3 protein
                     precursor"
                     /protein_id="NP_001001507.1"
                     /db_xref="GeneID:294559"
                     /db_xref="RGD:735082"
                     /translation="MPLSLLLACLFTTVTLQSPVVLDPCSAYISLNEPWRNTDHQFDE
                     SQSQPLCDNHMDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQR
                     QACASFKGNCCLWNTTVEVKACPGGYYVYRLAKPSVCFHIYCGHFYDICDEDCHGSCL
                     DTTECACSPGTSLGPDGQTCFDENECEHNNGGCSEICVNLKNSHRCACGVGRVLRSDG
                     KTCEDIEGCHSNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVPVLCKSSAIEVS
                     VPRELVGGLELFLTNTSCRGVSNGTHVNIIFSLKTCGTVVDVVNDKIVASNLVTGLPK
                     QTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLE
                     IFKDHEFEEPYRETLPTLKLRDSLYFGIEPLVHVSGLESLVESCFATPTAKVDEILKY
                     YLIRDGCVSDDSVKQYSSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSR
                     CAQGCHRRVRREAGEDEDSAGLQSQTLTGGPISIDWEE"
     exon            167..541
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            542..649
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            650..772
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            773..895
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1056
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1472
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1572
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..2289
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaagactgc agagggatac ttttctctaa gtgcctgaga aaagagcaag gcagaactgt
       61 tgtcacgggc gtcttctgct ccgctctggc agctggatca gaaagatgcc tctgtccctg
      121 ctgctcgcct gcctcttcac cactgtcacc ttgcagtcac ccgtggtcct agatccttgt
      181 tctgcttata tcagtctgaa tgagccctgg aggaacactg accatcagtt cgatgagtcc
      241 caaagtcagc ctctctgcga caaccatatg gatggggagt ggtaccgctt cacaggtatg
      301 gcgggggacg ccatgcccac cttctgcata ccagaaaatc actgcgggac ccatgcacct
      361 gtctggctca atggcagcca ccccctagaa ggggatggca ttgtgcaacg ccaggcctgt
      421 gccagcttca aagggaactg ttgtctgtgg aacaccacgg tggaggtcaa ggcctgccct
      481 ggaggttact atgtgtatcg gctggccaag cccagcgtct gcttccacat ctactgtgga
      541 catttctatg acatctgtga tgaggattgt catggcagct gcttggacac cactgagtgc
      601 gcatgctctc cgggaacctc gctgggccca gatgggcaga cttgcttcga cgaaaatgag
      661 tgtgagcaca acaatggtgg ctgcagtgag atatgtgtga acctcaaaaa ctcacaccgc
      721 tgcgcatgcg gggtcggccg cgtgctcagg agcgacggaa agacttgcga agacatcgaa
      781 ggatgccaca gtaacaatgg cggctgcagc cactcctgcc ttgggtctga gaagggttat
      841 cagtgcgaat gtcctcgggg tttggtgctg tccgaagata accacacttg ccaagtccct
      901 gtgttgtgca agtccagcgc cattgaagtg agtgtccccc gggagctggt tggaggcctg
      961 gagctcttcc tgaccaacac ctcctgtcga ggagtgtcca atggcacaca cgtcaacatc
     1021 atcttctccc tcaagacctg cggcaccgtg gttgacgtgg tgaatgacaa aatcgtggct
     1081 agcaacctcg tgacgggtct gcctaagcag acccctggga gcagcgggga catcatcatt
     1141 cggaccagca aactgctgat cccggtgacc tgcgagttcc cacgcctgta caccatctca
     1201 gaagggtacg tgcccaacct gcgcaacgcc ccactggaaa tcaggagccg gaaccacggc
     1261 atcttcccct tcacactgga gatcttcaag gaccacgagt tcgaggaacc gtaccgggag
     1321 actctgccca cgctcaagct tcgagactca ctctactttg gcatcgagcc cctggttcat
     1381 gtgagcggcc tggagagcct ggtagagagc tgctttgcca cgcctactgc gaaggtggac
     1441 gaaatcctca agtactacct gatccgggac ggctgtgttt ccgatgactc ggtaaagcaa
     1501 tactcatcca gggaccacct agcaaagcac ttccaagtcc ccgtcttcaa gtttgtgggc
     1561 aaagaccaca aggaggtctt tctacactgc cgggtccttg tgtgtggggt gctggatgaa
     1621 cgctcccgct gtgcccaggg gtgccaccgg cgagtgcgtc gagaggctgg tgaagacgag
     1681 gactctgctg ggctgcagag ccagacactg acaggcggcc ccatcagcat cgactgggag
     1741 gagtagttcc tgctccctgg cttccagctg acctctcaag aacgacttcc tgtgtccttg
     1801 gggagcatca gagaacctcc tgagattcca cgatggcttc tttaaatcct gtactgtgag
     1861 tttagacaag cccgctccac gacaggactg gctggctttg tgcctgtgtt ggtccaaatc
     1921 gcagcactgc tggcccatgt ggcctaggtg ggcctcagct tctggattca aagaattgta
     1981 tctgtcctca tgggagggca tcgccttcac ttcctccgtt cctttcttac aatgaaatac
     2041 ctcgtttatg atgtaacagg acctctaaca tgagagttgg gatggcattc caagtcaaaa
     2101 acctaaaata attaattact aaaatataac ccatggcttc ctaagcatct aataattgtg
     2161 acctaactcc aaccccaata tagactattt aaaggagagt tgaaagttta tcaataaaaa
     2221 taatgtgtaa gagaaaacac aataggttaa cgtctcatag taattctgag tgctttcata
     2281 ttgccttga
//
