LOCUS       NM_001398715            5396 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus O-linked N-acetylglucosamine (GlcNAc) transferase
            (Ogt), transcript variant 2, mRNA.
ACCESSION   NM_001398715 XM_006257056
VERSION     NM_001398715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5396)
  AUTHORS   Sager,R.A., Woodford,M.R., Backe,S.J., Makedon,A.M.,
            Baker-Williams,A.J., DiGregorio,B.T., Loiselle,D.R., Haystead,T.A.,
            Zachara,N.E., Prodromou,C., Bourboulia,D., Schmidt,L.S.,
            Linehan,W.M., Bratslavsky,G. and Mollapour,M.
  TITLE     Post-translational Regulation of FNIP1 Creates a Rheostat for the
            Molecular Chaperone Hsp90
  JOURNAL   Cell Rep 26 (5), 1344-1356 (2019)
   PUBMED   30699359
REFERENCE   2  (bases 1 to 5396)
  AUTHORS   Ohashi,N., Morino,K., Ida,S., Sekine,O., Lemecha,M., Kume,S.,
            Park,S.Y., Choi,C.S., Ugi,S. and Maegawa,H.
  TITLE     Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis
            by Brown Adipose Tissue Through Mitochondrial Biogenesis
  JOURNAL   Diabetes 66 (9), 2351-2362 (2017)
   PUBMED   28637651
REFERENCE   3  (bases 1 to 5396)
  AUTHORS   Willems,A.P., Gundogdu,M., Kempers,M.J.E., Giltay,J.C., Pfundt,R.,
            Elferink,M., Loza,B.F., Fuijkschot,J., Ferenbach,A.T., van
            Gassen,K.L.I., van Aalten,D.M.F. and Lefeber,D.J.
  TITLE     Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients
            with X-linked intellectual disability
  JOURNAL   J Biol Chem 292 (30), 12621-12631 (2017)
   PUBMED   28584052
REFERENCE   4  (bases 1 to 5396)
  AUTHORS   Jo,Y.K., Park,N.Y., Park,S.J., Kim,B.G., Shin,J.H., Jo,D.S.,
            Bae,D.J., Suh,Y.A., Chang,J.H., Lee,E.K., Kim,S.Y., Kim,J.C. and
            Cho,D.H.
  TITLE     O-GlcNAcylation of ATG4B positively regulates autophagy by
            increasing its hydroxylase activity
  JOURNAL   Oncotarget 7 (35), 57186-57196 (2016)
   PUBMED   27527864
REFERENCE   5  (bases 1 to 5396)
  AUTHORS   Ding,X., Jiang,W., Zhou,P., Liu,L., Wan,X., Yuan,X., Wang,X.,
            Chen,M., Chen,J., Yang,J., Kong,C., Li,B., Peng,C., Wong,C.C.,
            Hou,F. and Zhang,Y.
  TITLE     Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively
            Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific
            Protease 7 (USP7)
  JOURNAL   PLoS One 10 (12), e0145023 (2015)
   PUBMED   26678539
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5396)
  AUTHORS   Konrad,R.J., Tolar,J.F., Hale,J.E., Knierman,M.D., Becker,G.W. and
            Kudlow,J.E.
  TITLE     Purification of the O-glycosylated protein p135 and identification
            as O-GlcNAc transferase
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1136-1140 (2001)
   PUBMED   11700029
  REMARK    GeneRIF: Purification of a glycosylated protein p135, and it's
            identification as a O-GlcNAc transferase
REFERENCE   7  (bases 1 to 5396)
  AUTHORS   Akimoto,Y., Kreppel,L.K., Hirano,H. and Hart,G.W.
  TITLE     Localization of the O-linked N-acetylglucosamine transferase in rat
            pancreas
  JOURNAL   Diabetes 48 (12), 2407-2413 (1999)
   PUBMED   10580430
REFERENCE   8  (bases 1 to 5396)
  AUTHORS   Kreppel,L.K. and Hart,G.W.
  TITLE     Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of
            the tetratricopeptide repeats
  JOURNAL   J Biol Chem 274 (45), 32015-32022 (1999)
   PUBMED   10542233
REFERENCE   9  (bases 1 to 5396)
  AUTHORS   Kreppel,L.K., Blomberg,M.A. and Hart,G.W.
  TITLE     Dynamic glycosylation of nuclear and cytosolic proteins. Cloning
            and characterization of a unique O-GlcNAc transferase with multiple
            tetratricopeptide repeats
  JOURNAL   J Biol Chem 272 (14), 9308-9315 (1997)
   PUBMED   9083067
REFERENCE   10 (bases 1 to 5396)
  AUTHORS   Haltiwanger,R.S., Blomberg,M.A. and Hart,G.W.
  TITLE     Glycosylation of nuclear and cytoplasmic proteins. Purification and
            characterization of a uridine
            diphospho-N-acetylglucosamine:polypeptide
            beta-N-acetylglucosaminyltransferase
  JOURNAL   J Biol Chem 267 (13), 9005-9013 (1992)
   PUBMED   1533623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006257056.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.59233.1,
                                           SRR26643297.54698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000021.1  70811366-70811596
            232-412             JAXUCZ010000021.1  70814279-70814459
            413-656             JAXUCZ010000021.1  70815239-70815482
            657-725             JAXUCZ010000021.1  70822757-70822825
            726-842             JAXUCZ010000021.1  70826410-70826526
            843-922             JAXUCZ010000021.1  70832938-70833017
            923-1118            JAXUCZ010000021.1  70834898-70835093
            1119-1259           JAXUCZ010000021.1  70835347-70835487
            1260-1360           JAXUCZ010000021.1  70836104-70836204
            1361-1514           JAXUCZ010000021.1  70838444-70838597
            1515-1616           JAXUCZ010000021.1  70838681-70838782
            1617-1796           JAXUCZ010000021.1  70839179-70839358
            1797-1955           JAXUCZ010000021.1  70840587-70840745
            1956-2045           JAXUCZ010000021.1  70840840-70840929
            2046-2171           JAXUCZ010000021.1  70843124-70843249
            2172-2342           JAXUCZ010000021.1  70843710-70843880
            2343-2459           JAXUCZ010000021.1  70843993-70844109
            2460-2630           JAXUCZ010000021.1  70844203-70844373
            2631-2783           JAXUCZ010000021.1  70845593-70845745
            2784-3036           JAXUCZ010000021.1  70850175-70850427
            3037-3160           JAXUCZ010000021.1  70850658-70850781
            3161-5396           JAXUCZ010000021.1  70853888-70856123
FEATURES             Location/Qualifiers
     source          1..5396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..5396
                     /gene="Ogt"
                     /note="O-linked N-acetylglucosamine (GlcNAc) transferase"
                     /db_xref="GeneID:26295"
                     /db_xref="RGD:62060"
     exon            1..231
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..3335
                     /gene="Ogt"
                     /EC_number="2.4.1.255"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UDP-N-acetylglucosamine--peptide
                     N-acetylglucosaminyltransferase 110 kDa subunit; O-GlcNAc
                     transferase subunit p110; O-linked N-acetylglucosamine
                     transferase 110 kDa subunit; O linked N-acetylglucosamine
                     transferase;
                     UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl
                     transferase; O-linked N-acetylglucosamine (GlcNAc)
                     transferase
                     (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl
                     transferase)"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine--peptide
                     N-acetylglucosaminyltransferase 110 kDa subunit isoform 2"
                     /protein_id="NP_001385644.1"
                     /db_xref="GeneID:26295"
                     /db_xref="RGD:62060"
                     /translation="MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHC
                     MQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKER
                     GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVR
                     SDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAV
                     TLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLID
                     LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA
                     NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP
                     TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA
                     SYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAEQLEKNRLPSVHPH
                     HSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFG
                     NHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKA
                     ADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQE
                     TSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGID
                     LKAFLDSLPDVKIVKMKCPDGGDNADTTNTALNMPVIPMNTIAEAVIEMINRGQIQIT
                     INGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPS
                     TLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRR
                     GQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKS
                     RQEYEDIAVKLGTDLEYLKKIRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAG
                     NKPDHMIKPVEVTESA"
     exon            232..412
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            413..656
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            657..725
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            726..842
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            843..922
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1118
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1259
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1360
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1514
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1616
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1796
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1955
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2045
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2171
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2342
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2459
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2630
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2783
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3036
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3160
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..5396
                     /gene="Ogt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttcaagac agtgcgaggt agatgtctaa caagagttct taagattcga gttcagtata
       61 ttctgccacc ccctaagcct tccaaaacac tgatttggct gctgcccttt ttctgctacc
      121 tctagaaaca ttcttgttag tagtggcggc agtagaagtc aattatcccc ttgttctatc
      181 tcaagaagct ccagatggcg tcttccgtgg gcaacgtggc cgacagcaca gaaccaacga
      241 aacgtatgct ttccttccaa gggttagctg agttggcaca tcgggaatat caggcaggag
      301 actttgaggc agctgagaga cactgcatgc agctctggag acaagagcct gacaatactg
      361 gtgttctttt attactttca tctatacatt tccagtgtcg aaggctggac agatctgctc
      421 actttagcac cttggcaatt aaacagaatc cccttctagc agaagcctat tcgaatttgg
      481 gaaatgtata caaggaaaga gggcaattac aggaagcaat tgagcattat cgacatgctt
      541 tgcggctcaa gcctgatttc attgatggtt atattaacct ggcagcagcc ttggtagcag
      601 caggtgacat ggagggagca gtgcaagcat acgtctctgc tcttcagtac aatcctgatt
      661 tgtactgtgt tcgcagtgac ctggggaacc tgctcaaagc cctgggtcgc ttggaagaag
      721 ccaaggcatg ttatttgaaa gcaattgaga cgcaaccaaa ctttgctgta gcctggagta
      781 atctcggctg tgttttcaat gcacaagggg agatttggct ggcaattcat cactttgaaa
      841 aggctgtcac ccttgaccca aattttctgg atgcttatat caatttagga aatgttttga
      901 aagaggcacg gatttttgac agagctgtgg cagcttatct tcgtgcctta agtttgagcc
      961 caaatcatgc ggtggtacac ggcaacctgg cttgtgtgta ctatgagcaa ggccttatag
     1021 acctggccat tgatacctac aggcgagcta tagaactgca gcctcatttc cctgatgcat
     1081 actgcaacct agcaaatgct ctcaaagaga agggcagtgt tgctgaagca gaagattgtt
     1141 ataacacagc tcttcgtctg tgtcctaccc atgcagactc tttgaataac cttgccaaca
     1201 tcaaacggga acagggcaat attgaagagg cagttcgcct gtatcgcaaa gcattagagg
     1261 tcttcccaga gtttgctgct gcacattcca atttagcaag tgtactgcaa cagcagggca
     1321 agctgcagga agcactgatg cactataagg aagccataag aatcagtcct acatttgctg
     1381 atgcttattc caatatggga aacactttaa aggagatgca ggatgttcag ggagctttgc
     1441 agtgttatac tcgtgccatc cagattaatc ctgccttcgc agatgcacac agcaatctgg
     1501 cttccattca caaggattca gggaatattc cagaagcaat agcttcttac cgcacagctc
     1561 tgaaacttaa gcctgacttt cctgatgctt attgtaactt ggctcattgc ctacagattg
     1621 tctgtgattg gacagactat gatgagcgga tgaagaaatt ggttagtatt gtagctgagc
     1681 agctagagaa gaataggctg ccttctgtcc atcctcatca cagcatgctg taccctcttt
     1741 cccatggctt caggaaggcc attgcagaga ggcatgggaa tctctgcttg gataagatta
     1801 atgtccttca taaaccacca tatgagcatc caaaagactt gaagctcagt gatggccgat
     1861 tgcgtgtagg ctatgtgagt tctgactttg ggaatcatcc tacttcacac cttatgcagt
     1921 ctattccagg catgcacaac cctgataagt ttgaggtatt ctgctatgcc ttgagcccgg
     1981 atgacggtac aaacttccga gtgaaggtga tggcggaagc caatcacttc attgatcttt
     2041 ctcagattcc gtgcaatgga aaagcagctg accgcatcca ccaagatgga attcacatcc
     2101 ttgtcaatat gaatgggtac accaagggtg cccgaaatga gctctttgct ctcaggccag
     2161 ctcctattca ggctatgtgg ctgggctacc ctgggactag tggcgcactg ttcatggatt
     2221 acatcatcac tgatcaggaa acttccccag ctgaagttgc agagcagtat tctgaaaaac
     2281 tggcttatat gccccatacg ttctttattg gtgatcatgc taatatgttc ccacacctga
     2341 agaaaaaagc agtcatcgat tttaaatcta atgggcacat ttatgacaat cgaatagttt
     2401 tgaatggcat cgatctcaaa gcatttctcg atagtctacc cgatgtgaag attgtcaaga
     2461 tgaaatgtcc tgatggaggt gacaatgcag acaccactaa cacagctctt aacatgcccg
     2521 ttattcccat gaatacgatt gcagaagcag taattgaaat gattaacaga gggcagattc
     2581 agataacaat taatggattc agtattagca atggactggc tactacacag atcaataaca
     2641 aggctgcaac tggagaggaa gttccccgta ccattattgt aaccacccgt tcccagtacg
     2701 ggctaccaga agatgccatt gtgtactgta actttaatca gttatataaa attgaccctt
     2761 ctaccctgca gatgtgggca aatattctga aacgtgtgcc taatagcgtg ctttggctgt
     2821 tgcgttttcc agcagtagga gagcccaata ttcaacaata tgcacaaaat atgggccttc
     2881 cccagaaccg tatcattttc tcacctgtgg ctcctaaaga ggagcatgtc aggagaggtc
     2941 agctggctga tgtctgcctg gatactcctt tgtgtaatgg acataccaca gggatggatg
     3001 ttctctgggc aggaacaccc atggtgacta tgccaggaga gactcttgcc tctcgagttg
     3061 cagcttctca gctcacttgt ctaggatgtc ttgagctcat tgctaaaagc agacaggaat
     3121 atgaagacat agccgtgaaa ctggggaccg atctagaata cctgaagaaa attcgtggca
     3181 aagtatggaa acagagaata tctagccctc tgttcaacac caaacaatac acaatggaat
     3241 tagagcggct gtatctgcag atgtgggagc attatgcagc tggcaacaaa cccgaccaca
     3301 tgattaagcc tgttgaagtc actgagtcag cctgaataaa gactgcgcac aggagaattg
     3361 cccctatacc tgagcctcaa ccttctgggg gaaagggaac tagataacat gctttatgct
     3421 tatctgtata gtactgtgtt gcagatgggt gatatataat gataatagaa tagcacagcc
     3481 agacttgctt cctgcatgat agggagagac aagaaataag aaactactat tccacaagga
     3541 atctctagag ttttgcagca aacaggtggt gcacaggtct ggaatgtttg ctctcctttg
     3601 gtcttccatg gatgcttaat gtggagggag atagagatta accagccatt ttgtgattcc
     3661 gtggattgat caaatcttct gatcctttat ttttttcttt atgttttggg gtttgaagct
     3721 tttaaaaatg tttgctttca ggtatttttt tttcatgtga agtgatcttg attcttctga
     3781 gatgaggttt taaactaaaa tgttgcttcc tgttttagtg tctgaactct gacagggtga
     3841 cagggacctt gctggtgtag tctttttata ggttttataa accacatgag cctatatcag
     3901 tcattttagt gtctgaccta atgcttggca ctgtcagtgc tttgtgtaga tgatgactta
     3961 acatttttca gcctgttttc cacaccccgc cccccagcct ccatttaaat tctcctgtga
     4021 ctgctaacaa aaccaagtct gctttcagac atcccagagt gtttctctta aacacgccat
     4081 ctggtgccaa atgaaaattc ttaggagtga atattaatca tgaaggtcac agttgtggta
     4141 ctgttactga taataatgta gattattttt ttgcctaagt tttacctatt tcaccagtgt
     4201 ttcagccctt gactgcccct cctatgctgc ttccaaaagt gatagtgtgt gataagattt
     4261 ttaccttctt ttctaaagtt tgtttttttt tttaaagtga gtcctgttct tcctatttct
     4321 ttcagcagaa atgaaatccc aggtaagtat ataagtattc gaatatttga ttagtaagtt
     4381 acagttatct ccagtacatt aaataatttt cactgacaga tttagaagtg aaagctctga
     4441 agaaccatct ctctatccag gcagttattt ttagactgtg ttaggatgtg ttgtccggac
     4501 ttagttccaa aatctatgga ttcagccttg gtagcagtga atttgtacca ccacttggtt
     4561 tagactacaa attagacatt ggccctcgtg gagcttgaat tcttgatggt aaaaaacagt
     4621 tgcatttcag taaagggtgg agggcttgag gcttaaacat atgaatatgt ttgtactgct
     4681 ctactgcact tatactctcc agtcacagat cagttttgtc tgttagtagt gctgtagatt
     4741 atgtccttcc aaagcaccta ggcagtgcac ctattctgta gttgcagctc ttgcctgaat
     4801 gtaccttagc tgacaaatta ttgataatta agaacttgaa tttgtgatcc ttactgctaa
     4861 ttaaaaccta agcaaagagt ctcatgtaat tctgatagca gaattgcatt gtgatgaact
     4921 gtgtaccttt agtaatgtaa atcaaggaac atcagttaag agatttctta atttattttt
     4981 taactgaata aatatcagtt aaagattgcc agcatggtta caggtaaact gattttcaaa
     5041 attcactgaa ctactcaatg cgggattgga taatagactt ccagtgccgc taaggctgag
     5101 atctgtggcc atttacacag cacatcattc ctcctatagg aatgagcttt tttctggcac
     5161 gacaagtagc cattctggtt aaagctttgc ttattgtaac aggcttttat ttccaggtaa
     5221 cctgtctgtg gaagacttaa ttctgaatag agtaatagat attactggaa actgatttgt
     5281 ttttcttttc tattatactc tgctttattg aaaaagtaaa gcatttaaaa ttgtgcttca
     5341 gaaattcaga tgttgtcttg cgatctttaa acaataaatg gatgatttcc ccttaa
//
