LOCUS       NM_001106103            2650 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus osteoglycin (Ogn), mRNA.
ACCESSION   NM_001106103 XM_001054599 XM_001054654 XM_001054725 XM_008771559
            XM_214441
VERSION     NM_001106103.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Wang,Z., Zhuang,X., Chen,B. and Wei,M.
  TITLE     Osteoglycin knockdown promotes vascular smooth muscle cell
            proliferation and migration in aortic dissection via the
            VEGF/VEGFR2 axis
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33215216
  REMARK    GeneRIF: Osteoglycin knockdown promotes vascular smooth muscle cell
            proliferation and migration in aortic dissection via the
            VEGF/VEGFR2 axis.
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   de Oliveira,G., Freire,P.P., Omoto,A.C.M., Cury,S.S.,
            Fuziwara,C.S., Kimura,E.T., Dal-Pai-Silva,M. and Carvalho,R.F.
  TITLE     Osteoglycin post-transcriptional regulation by miR-155 induces
            cellular architecture changes in H9c2 cardiomyoblasts
  JOURNAL   Gene 676, 9-15 (2018)
   PUBMED   29990505
  REMARK    GeneRIF: Study reveals that Ogn is post-transcriptionally regulated
            by miR-155 in the maintenance of the cardiac cell morphology in
            physiological and pathological conditions.
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 2650)
  AUTHORS   Gu,X.S., Lei,J.P., Shi,J.B., Lian,W.L., Yang,X., Zheng,X. and
            Qin,Y.W.
  TITLE     Mimecan is involved in aortic hypertrophy induced by sinoaortic
            denervation in rats
  JOURNAL   Mol Cell Biochem 352 (1-2), 309-316 (2011)
   PUBMED   21519924
  REMARK    GeneRIF: concluded that down-regulation of mimecan was involved in
            aortic hypertrophy induced by sinoaortic denervation in rats
REFERENCE   8  (bases 1 to 2650)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   9  (bases 1 to 2650)
  AUTHORS   Petretto,E., Sarwar,R., Grieve,I., Lu,H., Kumaran,M.K.,
            Muckett,P.J., Mangion,J., Schroen,B., Benson,M., Punjabi,P.P.,
            Prasad,S.K., Pennell,D.J., Kiesewetter,C., Tasheva,E.S.,
            Corpuz,L.M., Webb,M.D., Conrad,G.W., Kurtz,T.W., Kren,V.,
            Fischer,J., Hubner,N., Pinto,Y.M., Pravenec,M., Aitman,T.J. and
            Cook,S.A.
  TITLE     Integrated genomic approaches implicate osteoglycin (Ogn) in the
            regulation of left ventricular mass
  JOURNAL   Nat Genet 40 (5), 546-552 (2008)
   PUBMED   18443592
  REMARK    GeneRIF: These data implicate Ogn as a key regulator of LVM in
            rats, mice and humans, and suggest that Ogn modifies the
            hypertrophic response to extrinsic factors such as hypertension and
            aortic stenosis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008771559.1, XM_214441.3, XM_001054599.1, XM_001054725.1,
            XM_001054654.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: FQ213759.1, FQ221052.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN16676784, SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2650
                     /gene="Ogn"
                     /note="osteoglycin"
                     /db_xref="GeneID:291015"
                     /db_xref="RGD:1308171"
     exon            1..95
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     exon            96..342
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1065
                     /gene="Ogn"
                     /note="mimecan"
                     /codon_start=1
                     /product="mimecan precursor"
                     /protein_id="NP_001099573.1"
                     /db_xref="GeneID:291015"
                     /db_xref="RGD:1308171"
                     /translation="MKTVHPTLLLLLFVPLTQQTPQTQLDSHVNSKYGTDNSEETKFI
                     QDYEDKYLDGKNIKEKETMIIPDEKSLQLQKDEVIPSVPTKKENDEMPTCLLCVCLSG
                     SVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIED
                     GTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKYNKIKSKGIKANTFKKLNKLSFL
                     YLDHNDLESVPPNLPESLRVIHLQFNSISSITDDTFCKANDTRYIRERMEEIRLEGNP
                     IALGKHPNSFICLKRLPTGSYF"
     exon            343..436
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     exon            437..595
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     exon            596..798
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     exon            799..894
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
     exon            895..2650
                     /gene="Ogn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagcagttt gaagcaattc cacagctttg ctcattcact ctcccacttg ggactaatgc
       61 acaggaaaac tcagggactt caaccagata ctacgggaaa aaagaggttt gttccacagt
      121 catcaggtca gtaatttcct aacttctagt caccttgtgt ttgctgcaat gaagactgtg
      181 catcctacgc ttctcctgct attgttcgtg cctctgacac agcaaacacc acaaactcag
      241 ctggactcac acgttaactc taagtatgga acagataatt ctgaagaaac caaatttatc
      301 caggattatg aagataaata cctggatggg aaaaatatta aggaaaaaga aactatgata
      361 attcctgatg agaaaagtct tcagttacaa aaagatgaag tcataccatc agtgcccacc
      421 aagaaagaaa atgatgaaat gcccacatgc ctgttgtgtg tctgtttaag tggctctgtc
      481 tactgtgaag aagttgacat tgatgctgta ccaccactgc caaaagaatc agcttatctt
      541 tatgcacgat tcaacaaaat taaaaagctg actgccaagg attttgcaga catgcctaac
      601 ttaagaagac ttgattttac gggaaatttg atagaagaca tagaagatgg tactttttca
      661 aaactttctc tgttagaaga acttacactt gctgaaaacc aactactaag acttccagtt
      721 cttcctccaa agcttacttt actcaatgcc aaatacaaca aaatcaagag taaaggaatt
      781 aaagcaaaca cattcaaaaa actgaataaa ctctcttttc tctatttgga ccataatgat
      841 ctggaatctg tgcctcctaa tttaccagaa agtctacgtg taattcacct tcagtttaac
      901 agcatatctt caattaccga tgatacattc tgcaaggcta atgacactcg gtacattcgg
      961 gagcgcatgg aagagatccg cctggagggc aatccgattg ctctgggaaa gcatccaaac
     1021 agctttatct gcttaaaaag attacccaca gggtcatact tttaaccttc atcagtgcat
     1081 ttataatctg aggtacatgc acctgatgtc taaaggaaca tacacattag tttaacatta
     1141 tcgttttatc tcactatgat ggaatcttat gttttaacaa agatgtccaa atttctgaaa
     1201 tgtaattata aaaataatcc agcctgaatc tcctagttca aaacaaagta acgtgaacat
     1261 aaacagcatt agaaacctcc gtggttgtag cagaccgcca tctaaacagt gcgcttttac
     1321 acaaacactc gctcacacac accattgcca tgactaatga agtcagagaa ttccaaaaaa
     1381 actctcaact ttgtcttcct taacatttac tgtgtctcaa aggcatttaa gacagatgct
     1441 ccagaacctg tgcacagcca agtgctccca gtgaccttcc cctgactcta tgactcaccg
     1501 gtgttctctg taaagcagaa acttactttc tgtccaggca gctacttcac tgtatttctc
     1561 acttagccta aggaaagggg agccacatgt aggcaatcat ttccagagga agtaaaattt
     1621 tgctctttgg tacagagcca acttagcaaa gttcaatctc ctgctttgtg gtcacgtgca
     1681 tagtctttag tcaattactt aaaaaaaact ttgtcagaaa aaaagtaaaa ttcctaccca
     1741 tttctcaaag aataaggttc cttcgcttta aagattctta ttccaatttt agtgtatgtg
     1801 ttgcgaaagc aagcacaaag attctgaaat atgaaattag ctatacactt tctcacagta
     1861 tatttattca aatataagaa atgaaaacaa aataccccat tatgctgtgt gcagtttcac
     1921 ctgtacatac atgttcacct gaacaaactg aatattccca ttctagccca agagtaccat
     1981 ttctcactgg ccaagatctc tacatatatg taatagtgaa aacccagtct ccagtctgat
     2041 agtgagagcg atgcacacta aggttccaaa cggaactgca gaggaagggc atagcccact
     2101 cacaaatatt actttattac tttggtgatg aatacaaaat gatcagtgtc ttagaaatta
     2161 ttcatctttt atatataaaa gtaccaatat catttccact ataagctata catcagactc
     2221 tacatgttca tcctagaaca tccattttaa gcatttggtt gttttgtttc aacccagact
     2281 gaccattctc tcatctgtta gggttaaccc cagatgaaac ttttcatcat taaagcatct
     2341 gtgatctata aggccacaac tattgctcta ataatgtcta ctagtttatt tgtttttata
     2401 agttaattat agtaacttta tctctctgta tcattttgtt cgcaggcctc attttctctg
     2461 actgaatgct caccaagagc actgaacaca gttctacttt tatgatactt aataccatat
     2521 ttcagctaaa tatacaataa acactgtaaa atctatccaa atagaagggt tctgtttata
     2581 tggaaaaaac aaattagtat agtcttgaat aaatcaacag aaataaagtg acaagtttaa
     2641 gaacggtcaa
//
