LOCUS       NM_030870               1251 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), mRNA.
ACCESSION   NM_030870
VERSION     NM_030870.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Fazelzadeh,M., Afzalpour,M.E., Fallah Mohammadi,Z. and Falah
            Mohammadi,H.
  TITLE     The effects of voluntary complex and regular wheel running
            exercises on the levels of 8-oxoguanine DNA glycosylase, semaphorin
            3B, H2O2, and apoptosis in the hippocampus of diabetic rats
  JOURNAL   Brain Behav 11 (3), e01988 (2021)
   PUBMED   33471970
  REMARK    GeneRIF: The effects of voluntary complex and regular wheel running
            exercises on the levels of 8-oxoguanine DNA glycosylase, semaphorin
            3B, H2O2, and apoptosis in the hippocampus of diabetic rats.
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Farias,J.G., Zepeda,A., Castillo,R., Figueroa,E., Ademoyero,O.T.
            and Pulgar,V.M.
  TITLE     Chronic hypobaric hypoxia diminishes the expression of base
            excision repair OGG1 enzymes in spermatozoa
  JOURNAL   Andrologia 50 (2) (2018)
   PUBMED   28758699
  REMARK    GeneRIF: chronic hypobaric hypoxia attenuates OGG1 expression in
            rat spermatozoa in a time-dependent fashion, with a greater
            reduction in the mitochondrial isoform OGG1-2a.
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Vela-Guajardo,J.E., Perez-Trevino,P., Rivera-Alvarez,I.,
            Gonzalez-Mondellini,F.A., Altamirano,J. and Garcia,N.
  TITLE     The 8-oxo-deoxyguanosine glycosylase increases its migration to
            mitochondria in compensated cardiac hypertrophy
  JOURNAL   J Am Soc Hypertens 11 (10), 660-672 (2017)
   PUBMED   28882450
  REMARK    GeneRIF: The increase in the oxidative stress in compensated
            cardiac hypertrophy induced the OGG1-2a migration to mitochondria
            to repair mtDNA oxidation, as a mechanism that allows maintaining
            the cardiac function in the compensatory stage.
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Pastukh,V.M., Gorodnya,O.M., Gillespie,M.N. and Ruchko,M.V.
  TITLE     Regulation of mitochondrial genome replication by hypoxia: The role
            of DNA oxidation in D-loop region
  JOURNAL   Free Radic Biol Med 96, 78-88 (2016)
   PUBMED   27091693
  REMARK    GeneRIF: Ogg1 overexpression also reduced binding of mitochondrial
            transcription factor A (TFAM) to both regulatory and coding regions
            of the mitochondrial genome without altering total abundance of
            TFAM in either control or hypoxic cells. These observations suggest
            that oxidative DNA modifications in the D-loop region during
            hypoxia are important for increased TFAM binding and ensuing
            replication of the mitochondrial genome.
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   Freedman,S.D., Katz,M.H., Parker,E.M., Laposata,M., Urman,M.Y. and
            Alvarez,J.G.
  TITLE     A membrane lipid imbalance plays a role in the phenotypic
            expression of cystic fibrosis in cftr(-/-) mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13995-14000 (1999)
   PUBMED   10570187
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Klungland,A., Rosewell,I., Hollenbach,S., Larsen,E., Daly,G.,
            Epe,B., Seeberg,E., Lindahl,T. and Barnes,D.E.
  TITLE     Accumulation of premutagenic DNA lesions in mice defective in
            removal of oxidative base damage
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13300-13305 (1999)
   PUBMED   10557315
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Prieto Alamo,M.J., Jurado,J., Francastel,E. and Laval,F.
  TITLE     Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate
            specificity, kinetics and cleavagemechanism at an apurinic site
  JOURNAL   Nucleic Acids Res 26 (22), 5199-5202 (1998)
   PUBMED   9801319
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Rosenquist,T.A., Zharkov,D.O. and Grollman,A.P.
  TITLE     Cloning and characterization of a mammalian 8-oxoguanine DNA
            glycosylase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7429-7434 (1997)
   PUBMED   9207108
REFERENCE   10 (bases 1 to 1251)
  AUTHORS   Chung,U., Igarashi,T., Nishishita,T., Iwanari,H., Iwamatsu,A.,
            Suwa,A., Mimori,T., Hata,K., Ebisu,S., Ogata,E., Fujita,T. and
            Okazaki,T.
  TITLE     The interaction between Ku antigen and REF1 protein mediates
            negative gene regulation by extracellular calcium
  JOURNAL   J Biol Chem 271 (15), 8593-8598 (1996)
   PUBMED   8621488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF029690.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029690.1, SRR8487230.22178.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132268, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1251
                     /gene="Ogg1"
                     /note="8-oxoguanine DNA glycosylase"
                     /db_xref="GeneID:81528"
                     /db_xref="RGD:621168"
     exon            1..170
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1071
                     /gene="Ogg1"
                     /EC_number="4.2.99.18"
                     /note="8-oxoguanine DNA-glycosylase 1"
                     /codon_start=1
                     /product="N-glycosylase/DNA lyase"
                     /protein_id="NP_110497.1"
                     /db_xref="GeneID:81528"
                     /db_xref="RGD:621168"
                     /translation="MLFSSSLSSSMRHRTLTSSPALWASIPCPRSELRLDLVLASGQS
                     FRWREQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDKGQVGRPTLEELETLHKYFQL
                     DVSLTQLYSHWASVDSHFQSVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVE
                     RLCQAFGPRLVQLDDVTYHGFPNLHALAGPEVETHLRKLGLGYRARYVCASAKAILEE
                     QGGPAWLQQLRVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAH
                     RDYGWQPKTSQTKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQQNLSREPPA
                     KRKKGSKKTEG"
     exon            171..418
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..598
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..780
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..931
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..981
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1251
                     /gene="Ogg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggacgta atgggctggg gactgctatc caaatgttat tcagttccag cctgtctagc
       61 agcatgagac atcgcaccct aacctccagc ccggccctct gggcctctat tccgtgtcca
      121 cgctctgagc tgcgtctgga cctggtttta gcttctggac agtccttccg gtggagggag
      181 caaagccctg ctcactggag tggagtgctg gcagatcaag tgtggacact gactcagacc
      241 gaggatcagc tctattgcac tgtgtaccga ggagacaagg gccaggtcgg caggcctacc
      301 ctagaggagc tggaaacctt acacaagtac tttcagctag atgtcagcct gactcagctc
      361 tatagccact gggcttcggt ggactctcac ttccaaagtg tggctcagaa attccaaggt
      421 gtgaggctgc tgagacaaga ccccactgaa tgccttttct ctttcatctg ttcttccaac
      481 aacaacattg ctcgcatcac tggcatggtg gaacggctgt gccaggcctt tggacctcga
      541 ctcgttcagc ttgatgatgt cacttatcat ggcttcccaa accttcatgc cctggctggt
      601 ccagaagtag agacccacct caggaagttg ggcctggggt accgtgcccg ctatgtatgt
      661 gccagtgcta aagccatcct agaagagcaa ggtgggccgg cttggctgca gcagcttcga
      721 gtggcctctt atgaagaggc ccacaaggcc ctctgcaccc tgcctggagt gggcaccaag
      781 gtggctgact gcatctgctt aatggccctg gacaaacccc aggctgtgcc tgtggacatc
      841 catgtgtggc agattgccca tcgtgactac ggctggcagc ctaagacatc gcagactaag
      901 ggcccgagcc ctctggccaa caaagaactg ggaaactttt tccggaatct gtggggacct
      961 tatgctggct gggcccaagc agtgctgttc agtgctgacc ttcgtcaaca aaacctgtct
     1021 cgggagccac cagcaaagcg caaaaaggga tctaagaaga cagaaggcta ggtagggccc
     1081 aggggacaaa agatgtcact gatattttcc cctttgttct ccatttctct cccttgtcct
     1141 cacccaagtc agaaaggctt aacattccta cctccaaggc aaacatccca aatcaaagtc
     1201 aggttttaca acaggggaca aggaagctat ttgagaaaat ggaactgttt t
//
