LOCUS       NM_053340               2060 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus opioid growth factor receptor (Ogfr), mRNA.
ACCESSION   NM_053340
VERSION     NM_053340.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Zagon,I.S., Sassani,J.W., Purushothaman,I. and McLaughlin,P.J.
  TITLE     Dysregulation of the OGF-OGFr pathway correlates with elevated
            serum OGF and ocular surface complications in the diabetic rat
  JOURNAL   Exp Biol Med (Maywood) 245 (15), 1414-1421 (2020)
   PUBMED   32640891
  REMARK    GeneRIF: Dysregulation of the OGF-OGFr pathway correlates with
            elevated serum OGF and ocular surface complications in the diabetic
            rat.
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Titunick,M.B., Lewis,G.S., Cain,J.D., Zagon,I.S. and
            McLaughlin,P.J.
  TITLE     Blockade of the OGF-OGFr pathway in diabetic bone
  JOURNAL   Connect Tissue Res 60 (6), 521-529 (2019)
   PUBMED   30931654
  REMARK    GeneRIF: Blockade of the OGF-OGFr pathway in diabetic bone.
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Zagon,I.S. and McLaughlin,P.J.
  TITLE     Gene expression of OGFr in the developing and adult rat brain and
            cerebellum
  JOURNAL   Brain Res Bull 63 (1), 57-63 (2004)
   PUBMED   15121239
  REMARK    GeneRIF: OGFr was detected in whole brain at embryonic day 20 and
            birth, and was at least twofold greater than neonatal levels during
            the first week of life.
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   Zagon,I.S., Ruth,T.B., Leure-duPree,A.E., Sassani,J.W. and
            McLaughlin,P.J.
  TITLE     Immunoelectron microscopic localization of the opioid growth factor
            receptor (OGFr) and OGF in the cornea
  JOURNAL   Brain Res 967 (1-2), 37-47 (2003)
   PUBMED   12650964
  REMARK    GeneRIF: Opioid growth factor receptor colocalizes with opioid
            growth factor in the paranuclear cytoplasm and cell nuclei in
            basal, as well as suprabasal, cells of adult rat corneal
            epithelium.
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Zagon,I.S., Verderame,M.F. and McLaughlin,P.J.
  TITLE     The biology of the opioid growth factor receptor (OGFr)
  JOURNAL   Brain Res Brain Res Rev 38 (3), 351-376 (2002)
   PUBMED   11890982
  REMARK    Review article
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Zagon,I.S., Verderame,M.F., Allen,S.S. and McLaughlin,P.J.
  TITLE     Cloning, sequencing, expression and function of a cDNA encoding a
            receptor for the opioid growth factor, [Met(5)]enkephalin
  JOURNAL   Brain Res 849 (1-2), 147-154 (1999)
   PUBMED   10592296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV778659.1, BC101898.1 and BP501519.1.
            
            On Oct 20, 2010 this sequence version replaced NM_053340.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV778659.1, BC101898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                EV778659.1         1-19
            20-2055             BC101898.1         1-2036
            2056-2060           BP501519.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2060
                     /gene="Ogfr"
                     /note="opioid growth factor receptor"
                     /db_xref="GeneID:83525"
                     /db_xref="RGD:69324"
     exon            1..173
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1748
                     /gene="Ogfr"
                     /note="zeta-type opioid receptor"
                     /codon_start=1
                     /product="opioid growth factor receptor"
                     /protein_id="NP_445792.2"
                     /db_xref="GeneID:83525"
                     /db_xref="RGD:69324"
                     /translation="MDDPDCDSTWEEESEEDGEDGQADDTTDEDTGDDDGDAEEARPS
                     LFQSRMTGYRNWRAMQDMQRYRHNYPDLTDQDCNGDMCNLSFYKNEICFQPNGALIED
                     ILQNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLKEVEAFKSSKEVRERLVRA
                     YELMLGFYGIHLEDRGTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKSLGELGLEHY
                     QAPLVRFFLEETLVQHKLPSVRQSALDYFLFAVRCRHQRRELVYFAWEHFKPRREFVW
                     GPRDKLRRFKPQTIPQPLTGPGQADKDEGSRDPSQEAGTQGRTCGSGRDLSGDSGTAE
                     DPSLLNTKPSDGGTLDGNQRDEAKSLSPKESKKRKLEGNRQEQVPGEADPQGVSEVEK
                     IALNLEECALSPISQEPREAEPPCPVARVANEVRKRRKVEEGAEGDGVVSNTQMQASA
                     LPPTPSECPEAQKDGNGPEDSNSQVGAEDSKSQVGPEDPNSQVGLEDPNSQVGPEDPN
                     SQVGPEDPNSQVGPEDPNSQVVGPEQAASKSPVEDPDSDTMGTSVDESEELARIEASA
                     EPPKP"
     exon            174..242
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     exon            243..321
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     exon            322..400
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     exon            401..467
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     exon            468..616
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
     exon            617..2057
                     /gene="Ogfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagaaag cgggtcctcc tgcttgtcga gtatggacga cccggactgc gattccacct
       61 gggaggagga gagcgaggag gacggcgagg atggccaagc ggatgatacg accgatgagg
      121 acacgggcga cgatgacggc gacgcggagg aggcacggcc aagcctgttc cagtccagga
      181 tgacagggta ccgaaactgg cgtgctatgc aggacatgca aagataccgg cacaactacc
      241 cggatttgac agatcaagac tgcaatggtg acatgtgcaa cctgagcttc tacaaaaatg
      301 agatctgctt ccagccaaat ggggctctca tcgaggacat tcttcagaac tggaaagaca
      361 actatgacct cctggaagag aatcactcct acatccagtg gctgtttcct ctgcgggaac
      421 caggagtgaa ctggcacgcc aagcccctca ccctgaagga ggttgaggca tttaaaagct
      481 ccaaggaagt cagagagcgt cttgtccggg cctatgagct catgctgggc ttctatggga
      541 tccaccttga ggaccggggc acgggtgctg tatgccgtgc acagaacttc cagccgcgct
      601 tccacaatct gaacagccac agccacaaca acctgcgtat tacacgcatc ctcaagtcac
      661 tgggtgagct gggcttagaa cactaccagg cacccctggt ccgcttcttc ctggaggaga
      721 cccttgtaca gcacaaactg cccagcgtgc gccagagtgc cctggactac ttcctgttcg
      781 ctgtgcgctg ccggcaccag cgccgggagc ttgtgtactt tgcctgggag cacttcaagc
      841 ctcgccgaga gtttgtctgg gggccccgtg acaagctgcg gagattcaag ccccagacca
      901 taccccagcc actgacggga ccagggcagg cagataaaga tgagggctcc agggacccct
      961 cccaagaggc tggcacccag ggtcggacct gtggatctgg aagggacctg agtggggaca
     1021 gtggaacagc tgaggatccc tcactgctga acacaaagcc ctcagatggg ggaaccttgg
     1081 atgggaacca gagggatgaa gctaagtccc tgagtcccaa ggagagcaag aaaaggaagt
     1141 tggaggggaa caggcaggag caggtcccag gggaggcaga tccccagggt gtctctgagg
     1201 tagagaaaat tgcccttaac cttgaggagt gtgcccttag ccctatcagc caggagccca
     1261 gggaggctga accgccctgt cctgtggcca gggtggctaa tgaggtaaga aagcggagga
     1321 aggtggagga aggggctgag ggtgatggag tagtcagtaa cactcaaatg caggccagtg
     1381 ccctgcctcc taccccttca gagtgtcctg aggcccaaaa ggatgggaat gggccagagg
     1441 actcaaacag ccaggttggg gcagaggatt ccaaaagcca ggtggggccg gaggatccaa
     1501 acagccaggt ggggctggag gacccaaaca gccaggtcgg gccagaggac ccaaacagcc
     1561 aggtcgggcc agaggaccca aacagccagg tcgggccaga ggacccaaac agccaggtgg
     1621 tggggccaga gcaagctgcc tctaagagcc ctgtggagga ccctgactct gacactatgg
     1681 gaacctcagt ggatgagtca gaggagttgg caaggattga ggcctctgct gaacccccaa
     1741 agccttagag gtgcatctca gtcctactca gcccactgca gggggtttct gagtccagag
     1801 ctctgccgta ggctcttctt ggtgccccac agtgctggcc tctccctagt ggtcactgag
     1861 gtggccacca gagggactga ggccctgccc tcagggaagg ccaaggcctt cagaaccctc
     1921 cttacctcac tgtgtcctcc tccactgccc tctgagccct gcgttgtgat cagaccctaa
     1981 gggtctagag ggaggggcct cttcattagt ctggtgccaa gtgaggcctt ttctgaataa
     2041 actctttaga ctttgtcaaa
//
