LOCUS       NM_001395109            3670 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus oxoglutarate dehydrogenase L (Ogdhl), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001395109 XM_006252584
VERSION     NM_001395109.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Bunik,V., Kaehne,T., Degtyarev,D., Shcherbakova,T. and Reiser,G.
  TITLE     Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in
            brain, but not in heart
  JOURNAL   FEBS J 275 (20), 4990-5006 (2008)
   PUBMED   18783430
  REMARK    GeneRIF: In contrast to the heart complex, where only the known
            OGDH was determined, the band corresponding to the brain OGDH
            component was found to also include the novel 2-oxoglutarate
            dehydrogenase-like (OGDHL) protein.
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Solien,J., Haynes,V. and Giulivi,C.
  TITLE     Differential requirements of calcium for oxoglutarate dehydrogenase
            and mitochondrial nitric-oxide synthase under hypoxia: impact on
            the regulation of mitochondrial oxygen consumption
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 142 (2), 111-117 (2005)
   PUBMED   15972265
  REMARK    GeneRIF: oxoglutarate dehydrogenase and mitochondrial nitric-oxide
            synthase require calcium under hypoxic conditions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006252584.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2137838.1,
                                           SRR26360190.2832096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000016.1  7584666-7584781
            117-172             JAXUCZ010000016.1  7586666-7586721
            173-377             JAXUCZ010000016.1  7588225-7588429
            378-548             JAXUCZ010000016.1  7589422-7589592
            549-651             JAXUCZ010000016.1  7594338-7594440
            652-767             JAXUCZ010000016.1  7594795-7594910
            768-922             JAXUCZ010000016.1  7595069-7595223
            923-1069            JAXUCZ010000016.1  7596014-7596160
            1070-1160           JAXUCZ010000016.1  7597589-7597679
            1161-1340           JAXUCZ010000016.1  7600253-7600432
            1341-1469           JAXUCZ010000016.1  7600575-7600703
            1470-1649           JAXUCZ010000016.1  7602016-7602195
            1650-1802           JAXUCZ010000016.1  7602713-7602865
            1803-1905           JAXUCZ010000016.1  7603464-7603566
            1906-2034           JAXUCZ010000016.1  7604018-7604146
            2035-2185           JAXUCZ010000016.1  7604857-7605007
            2186-2313           JAXUCZ010000016.1  7605925-7606052
            2314-2492           JAXUCZ010000016.1  7606981-7607159
            2493-2564           JAXUCZ010000016.1  7607364-7607435
            2565-2690           JAXUCZ010000016.1  7607522-7607647
            2691-2763           JAXUCZ010000016.1  7607744-7607816
            2764-2927           JAXUCZ010000016.1  7609047-7609210
            2928-3082           JAXUCZ010000016.1  7609359-7609513
            3083-3670           JAXUCZ010000016.1  7610118-7610705
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3670
                     /gene="Ogdhl"
                     /note="oxoglutarate dehydrogenase L"
                     /db_xref="GeneID:290566"
                     /db_xref="RGD:1310916"
     exon            1..116
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            117..172
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            173..377
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..3206
                     /gene="Ogdhl"
                     /EC_number="1.2.4.2"
                     /note="oxoglutarate dehydrogenase-like; OGDC-E1-like;
                     alpha-ketoglutarate dehydrogenase-like; 2-oxoglutarate
                     dehydrogenase complex component E1-like"
                     /codon_start=1
                     /product="2-oxoglutarate dehydrogenase-like,
                     mitochondrial"
                     /protein_id="NP_001382038.1"
                     /db_xref="GeneID:290566"
                     /db_xref="RGD:1310916"
                     /translation="MSQLRLLLFRLGPQARKLLATRDIAAFGGRRRSSGPPTTIPRSR
                     GGVSPSYVEEMYFAWLENPQSVHKSWDNFFQRATKEASVGPAQPQPPAVIQESRASVS
                     SCTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLA
                     FYDLQEADLDKEFRLPTTTFIGGSENTLSLREIIRRLESTYCQHIGLEFMFINDVEQC
                     QWIRQKFETPGVMKFSIEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPA
                     LKTIIDKSSEMGVENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDV
                     KYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMS
                     ILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTD
                     VARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMF
                     TQPLMYKQIHKQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKIL
                     HIKHWLDSPWPGFFNVDGEPKSMTYPTTGIPEDTLSHIGNVASSVPLEDFKIHTGLSR
                     ILRGRADMTKKRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQDV
                     DRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNT
                     AQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPV
                     FTEDFEVSQLYDCNWIVVNCSTPASYFHVLRRQVLLPFRKPLIVFTPKSLLRHPDAKS
                     SFDQMVSGTSFQRMIPEDGPAAQSPERVERLIFCTGKVYYDLVKERSSQGLEKQVAIT
                     RLEQISPFPFDLIMREAEKYSGAELVWCQEEHKNMGYYDYISPRFMTLLGHSRPIWYV
                     GREPAAAPATGNKNTHLVSLRKFLDTAFNLKAFEGKTF"
     exon            378..548
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            549..651
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            652..767
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            768..922
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1069
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1160
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1340
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1469
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1649
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1802
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1905
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2034
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2185
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2313
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2492
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2564
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2690
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2763
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2927
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3082
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3670
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggccgt gtcacgtgac ctaggtagtt gctaccgcgc gccgctcgcg accctccgcg
       61 cattacccgg accttcagcc cccccggacc gcgtggcccg gaacctcggc cagctggtca
      121 cctcaggaaa tcacttccct gactgaggaa ctcacctggc cctccatttc aaaatgagcc
      181 agctgcggct gctgctgttc aggttggggc cacaggccag gaagctcctg gccacacggg
      241 atatcgcagc gttcggtggg cgcaggaggt cttctgggcc acccactacc atcccacgga
      301 gcagaggtgg agtcagcccc agttatgtgg aggagatgta ctttgcctgg ttggaaaacc
      361 ctcagagcgt ccacaagtcc tgggacaact tcttccagag agccactaag gaggcctctg
      421 tgggtcctgc tcagccacag cccccagccg tcatccaaga gagcagggcg tcagtgtcaa
      481 gttgcaccaa gaccagcaag cttgtagaag accacttggc ggtacagtct ctcatccgtg
      541 cctaccagat ccgaggccac catgtggccc agctggaccc cctgggcatc ctggatgcag
      601 acctggactc ctttgtgccc tcggacttga tcacaaccat tgataaattg gccttctatg
      661 acctgcagga ggctgatctg gacaaggagt tccggctgcc caccactact ttcattggtg
      721 gctcggagaa cacactctct cttcgagaga tcatacggcg cctggagagc acctactgcc
      781 agcatattgg cctggagttc atgtttatta acgatgtgga gcagtgccag tggatcagac
      841 agaaatttga aactcctggt gtgatgaagt tttccatcga ggagaagcgg accctgctgg
      901 ccaggctggt gcgctccatg aggtttgaag actttttggc caggaagtgg tcttcagaga
      961 agcggtttgg cctggaaggc tgtgaggtca tgatccctgc tctcaagacc attatcgaca
     1021 aatctagtga gatgggggtt gaaaacgtca tcctggggat gccacacagg ggcaggctga
     1081 atgtgctggc taatgtgatc cgcaaggacc tggaacagat cttctgtcag tttgatccca
     1141 aactggaagc agcagacgag ggctctggtg acgtcaaata ccatctgggc atgtaccatg
     1201 agaggatcaa ccgtgtcacc aacagaaaca tcacactgtc gctggtggcc aacccttccc
     1261 acctggaagc tgtggaccct gtggttcagg ggaagacgaa ggcagagcag ttctaccgtg
     1321 gggatgctca gggtaggaag gtcatgtcca tcctggtcca tggggatgcc gcctttgccg
     1381 gccagggggt cgtctatgag accttccatc tcagcgacct gccttcctat accaccaacg
     1441 gcaccgtgca tgtcgtggtc aataaccaga ttggctttac tacagatccc cgaatggctc
     1501 gctcctcacc ttaccccacg gatgtggcgc gggtggttaa tgcgcccatc ttccacgtga
     1561 acgcggatga cccagaagcc gtgatctatg tgtgcagtgt ggccgccgag tggaggaaca
     1621 ccttcaacaa agatgttgtt gtagacctgg tctgttaccg ccggcgtggc cacaatgaga
     1681 tggacgagcc catgttcacg cagccgctca tgtacaagca gatccacaag caggtacccg
     1741 tgctgaagaa gtacgcagac aagctcatcg ccgagggtac agtcaccctg caggagtttg
     1801 aggaagaaat tgccaaatat gaccgcatct gtgaggaggc ctacggcagg tccaaggata
     1861 aaaagattct gcatataaag cactggctgg actcgccctg gcctggcttc ttcaatgtgg
     1921 atggggagcc caagagcatg acatacccta cgacgggcat ccctgaggac acgctgagcc
     1981 acattggcaa tgtggccagc tctgtgcccc tggaggactt taagatccac acaggtctct
     2041 ctcgcatcct gcgtggccgt gcagacatga ccaagaagcg cacagtggac tgggccttgg
     2101 cagagtacat ggcctttggt tcactgctga aggagggcat ccatgtgcgg ctcagtggcc
     2161 aggatgtgga gaggggcaca ttcagccacc ggcaccatgt tcttcacgac caggacgttg
     2221 accggaggac gtgtgtccca atgaatcacc tgtggcctga ccaggccccc tacactgtgt
     2281 gcaatagctc cctctcagag tatggagttc taggctttga gctgggctat gccatggcca
     2341 gccccaacgc cctggtcctc tgggaagctc agtttggtga tttccacaac acagcccagt
     2401 gtatcattga ccagttcatc agcaccggcc aggccaagtg ggtgcggcac aatggcatcg
     2461 tacttctgct gccccacggc atggagggca tgggtccaga gcactcctca gcgaggccag
     2521 agaggttcct gcaaatgagc aacgacgact cagacgccta ccctgtgttc accgaggact
     2581 tcgaggtgag ccagctctat gactgcaact ggatcgtggt gaactgctct acaccggcta
     2641 gctacttcca cgtgctgcgc cggcaggtcc tgctgccctt ccgcaagcct ctcatcgtct
     2701 tcacacccaa gtctctgctg aggcaccctg atgccaagtc cagctttgac cagatggtgt
     2761 ccggaactag cttccagcgg atgattccag aagacggccc cgcggcacag tctcctgagc
     2821 gcgtagagcg gctcatcttc tgcacaggga aggtgtacta cgacctggta aaggagcgca
     2881 gcagccaggg cctggagaag caagtggcca tcacacgcct ggagcagatc tctccattcc
     2941 ctttcgacct gatcatgcgg gaggcagaga agtactcagg agctgagctg gtgtggtgtc
     3001 aggaagagca taagaacatg ggttattacg actacatcag tccacgcttc atgactctcc
     3061 ttggccactc ccggcccata tggtatgttg gccgggaacc agcagccgcg ccagccactg
     3121 gaaataagaa tactcacttg gtgtcgctga ggaagtttct ggataccgcc ttcaacctga
     3181 aggccttcga gggcaagacg ttttagaacg aggccacgtg tgctcagatc ttgctggggg
     3241 aagttatctg gaaactccgg ggctccagat gaaccacatt catgtagcaa ttgggaccaa
     3301 agagtagcac tgtaggcttt ggtctctgtt agaccatagc cttccttaca tggatgggac
     3361 atagatggcc agccctgcta acctttctgg atgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3421 gtgtgtgtgt gtgtgtgtgt gttggtggtt tctttagctt tactggtcat gtccctagac
     3481 agccactgct cccatcctgg cagacttagt tccgatcacc ccactgtctt cacctgtcaa
     3541 ttcagagatg ctctctgctg tgatcttgga agtagagagc tcagccctaa cagcaggtga
     3601 agctcagcca caccacggga tgcagtgagg tgtggagacc aaagcgtaga ggaataaaga
     3661 cttaagaaag
//
