LOCUS       NM_001017461            3266 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus oxoglutarate dehydrogenase (Ogdh), mRNA.
ACCESSION   NM_001017461 XM_573650
VERSION     NM_001017461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Artiukhov,A.V., Grabarska,A., Gumbarewicz,E., Aleshin,V.A.,
            Kahne,T., Obata,T., Kazantsev,A.V., Lukashev,N.V., Stepulak,A.,
            Fernie,A.R. and Bunik,V.I.
  TITLE     Synthetic analogues of 2-oxo acids discriminate metabolic
            contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases
            in mammalian cells and tissues
  JOURNAL   Sci Rep 10 (1), 1886 (2020)
   PUBMED   32024885
  REMARK    GeneRIF: Synthetic analogues of 2-oxo acids discriminate metabolic
            contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases
            in mammalian cells and tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Wang,Y., Guo,Y.R., Liu,K., Yin,Z., Liu,R., Xia,Y., Tan,L., Yang,P.,
            Lee,J.H., Li,X.J., Hawke,D., Zheng,Y., Qian,X., Lyu,J., He,J.,
            Xing,D., Tao,Y.J. and Lu,Z.
  TITLE     KAT2A coupled with the alpha-KGDH complex acts as a histone H3
            succinyltransferase
  JOURNAL   Nature 552 (7684), 273-277 (2017)
   PUBMED   29211711
REFERENCE   3  (bases 1 to 3266)
  AUTHORS   Tsepkova,P.M., Artiukhov,A.V., Boyko,A.I., Aleshin,V.A.,
            Mkrtchyan,G.V., Zvyagintseva,M.A., Ryabov,S.I., Ksenofontov,A.L.,
            Baratova,L.A., Graf,A.V. and Bunik,V.I.
  TITLE     Thiamine Induces Long-Term Changes in Amino Acid Profiles and
            Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat
            Brain
  JOURNAL   Biochemistry (Mosc) 82 (6), 723-736 (2017)
   PUBMED   28601082
  REMARK    GeneRIF: Thiamine Induces Long-Term Changes in Amino Acid Profiles
            and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in
            Rat Brain
REFERENCE   4  (bases 1 to 3266)
  AUTHORS   Denton,R.M., Pullen,T.J., Armstrong,C.T., Heesom,K.J. and
            Rutter,G.A.
  TITLE     Calcium-insensitive splice variants of mammalian E1 subunit of
            2-oxoglutarate dehydrogenase complex with tissue-specific patterns
            of expression
  JOURNAL   Biochem J 473 (9), 1165-1178 (2016)
   PUBMED   26936970
  REMARK    GeneRIF: Tissue-specific expression of OGDH splice variants may
            thus provide a mechanism that tunes the control of the enzyme to
            the specialized metabolic and signalling needs of individual cell
            types
REFERENCE   5  (bases 1 to 3266)
  AUTHORS   Quinlan,C.L., Goncalves,R.L., Hey-Mogensen,M., Yadava,N.,
            Bunik,V.I. and Brand,M.D.
  TITLE     The 2-oxoacid dehydrogenase complexes in mitochondria can produce
            superoxide/hydrogen peroxide at much higher rates than complex I
  JOURNAL   J Biol Chem 289 (12), 8312-8325 (2014)
   PUBMED   24515115
  REMARK    GeneRIF: H2O2 production from Ogdh can be considerable but may
            previously have been misattributed to complex I.
REFERENCE   6  (bases 1 to 3266)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 3266)
  AUTHORS   Sheu,K.F. and Blass,J.P.
  TITLE     The alpha-ketoglutarate dehydrogenase complex
  JOURNAL   Ann N Y Acad Sci 893, 61-78 (1999)
   PUBMED   10672230
  REMARK    Review article
REFERENCE   8  (bases 1 to 3266)
  AUTHORS   Bruschi,S.A., Lindsay,J.G. and Crabb,J.W.
  TITLE     Mitochondrial stress protein recognition of inactivated
            dehydrogenases during mammalian cell death
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13413-13418 (1998)
   PUBMED   9811814
REFERENCE   9  (bases 1 to 3266)
  AUTHORS   Andersson,U., Leighton,B., Young,M.E., Blomstrand,E. and
            Newsholme,E.A.
  TITLE     Inactivation of aconitase and oxoglutarate dehydrogenase in
            skeletal muscle in vitro by superoxide anions and/or nitric oxide
  JOURNAL   Biochem Biophys Res Commun 249 (2), 512-516 (1998)
   PUBMED   9712727
REFERENCE   10 (bases 1 to 3266)
  AUTHORS   Ono,K., Hakozaki,M., Kimura,A. and Kochi,H.
  TITLE     Purification, resolution, and reconstitution of rat liver
            branched-chain alpha-keto acid dehydrogenase complex
  JOURNAL   J Biochem 101 (1), 19-27 (1987)
   PUBMED   3571202
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083811.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083811.1, FQ222842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3266
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /note="oxoglutarate dehydrogenase"
                     /db_xref="GeneID:360975"
                     /db_xref="RGD:1561359"
     exon            1..52
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..300
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..3150
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /EC_number="1.2.4.2"
                     /note="2-oxoglutarate dehydrogenase E1 component,
                     mitochondrial; 2-oxoglutarate dehydrogenase,
                     mitochondrial; alpha-ketoglutarate dehydrogenase; OGDC-E1;
                     2-oxoglutarate dehydrogenase complex component E1;
                     2-oxoglutarate dehydrogenase, mitochondrial-like;
                     oxoglutarate dehydrogenase (lipoamide); oxoglutarate
                     (alpha-ketoglutarate) dehydrogenase (lipoamide);
                     alpha-KGDH-E1; thiamine diphosphate (ThDP)-dependent
                     2-oxoglutarate dehydrogenase"
                     /codon_start=1
                     /product="2-oxoglutarate dehydrogenase complex component
                     E1 precursor"
                     /protein_id="NP_001017461.1"
                     /db_xref="GeneID:360975"
                     /db_xref="RGD:1561359"
                     /translation="MFHLRTCAAKLRPLTASQTVKTFSQNKPAAIRTFQQIRCYSAPV
                     AAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRS
                     SLATMAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSS
                     VPADIISSTDKLGFYGLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHI
                     GVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEK
                     RFGLEGCEVLIPALKTIIDMSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFD
                     SKLEAADEGSGDMKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQ
                     FYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTT
                     DPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCY
                     RRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKIC
                     EEAFTRSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLEEDILTHIGNVASSV
                     PVENFTIHGGLSRILKTRRELVTNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGT
                     FSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNAL
                     VLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERF
                     LQMCNDDPDVLPNLQEENFDISQLYDCNWIVVNCSTPGNFFHVLRRQILLPFRKPLIV
                     FTPKSLLRHPEARTSFDEMLPGTHFQRVIPEDGPAAQNPDKVKRLLFCTGKVYYDLTR
                     ERKARDMAEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQGYYDYVKPR
                     LRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDAFKKFS"
     exon            301..492
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..595
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..711
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..866
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1013
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1104
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1284
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1413
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1593
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1746
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1849
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1978
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2129
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2257
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2436
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2508
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2637
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2710
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2874
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3029
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3237
                     /gene="Ogdh"
                     /gene_synonym="E1o; OGDH-E1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccggagtg gggtgtcggc gcctcactcg ggtggagctg aacaggagac aggtatttgt
       61 ggaaggcttc aggacaaaat gtttcattta aggacttgtg ctgctaagtt aaggccattg
      121 acagcctccc agactgttaa gacattttca caaaacaaac cagcagcaat taggacgttt
      181 caacagattc ggtgctattc tgcacctgta gctgctgaac catttcttag tgggactagt
      241 tcgaactatg tggaggaaat gtactgtgcc tggttggaga atcccaaaag tgtacataag
      301 tcatgggaca tttttttccg aaacaccaat gctggagccc caccgggcac tgcctaccag
      361 agcccccttt ccctgagtcg aagctccctg gctaccatgg ctcatgcaca gtccctggtg
      421 gaagcacagc ctaacgtcga caagctcgtg gaggaccact tggcggtgca gtctctcatc
      481 agggcgtatc agatacgagg gcaccatgta gcacagctgg accccctggg gattttggat
      541 gctgatctgg actcctccgt gcccgctgac attatctcat ccacagacaa acttgggttc
      601 tatggcctac acgagtctga ccttgacaag gtcttccact tacccaccac cactttcatc
      661 gggggacagg agccagcact tcctcttcgg gagatcatcc gtcggctgga gatggcctac
      721 tgccagcaca ttggtgtgga gttcatgttc attaacgatt tggagcaatg ccagtggatc
      781 cggcagaagt ttgagacccc tgggatcatg cagttcacca atgaggagaa gcggaccctg
      841 ctggccaggc ttgtacggtc caccaggttt gaggagttcc tgcagcgaaa gtggtcctct
      901 gagaagcgtt ttggtctgga aggctgtgag gtgctgatcc ctgccctcaa gacaatcatt
      961 gacatgtcaa gtgcaaatgg agtggactat gtgatcatgg ggatgccaca cagaggacga
     1021 ctgaacgtgc tagccaatgt catcaggaag gagctggagc agatattctg tcagtttgac
     1081 tcgaagctgg aggcagctga tgagggttcc ggggacatga agtaccacct gggcatgtat
     1141 caccgaagga tcaaccgtgt gaccgacaga aacatcactc tgtccttggt ggctaaccct
     1201 tcccacttag aggctgctga ccctgtagtg atgggaaaga ccaaagctga acagttctac
     1261 tgtggagaca ctgaagggaa aaaggtgatg tctatcctgc tgcatgggga tgctgccttt
     1321 gctggccagg gtatcgtgta tgagaccttc catctcagcg acctgccatc ctatacaacc
     1381 cacggcaccg ttcacgtggt tgtcaacaac cagattggct tcaccacaga ccctcggatg
     1441 gcccgctctt ctccctaccc cactgatgtg gcccgagtgg tgaacgcccc cattttccat
     1501 gtcaactcag atgaccctga agctgtcatg tatgtatgca aggtggcagc tgagtggaga
     1561 aacaccttcc acaaggatgt tgttgttgat ctggtgtgtt atcgacgaaa tggccacaac
     1621 gagatggatg aacctatgtt cacacagcca ctcatgtaca agcagatccg taagcagaag
     1681 ccggtactgc agaagtatgc agaattgctg gtatcccagg gggtcgtcaa ccagcccgaa
     1741 tatgaggagg aaatctccaa gtacgataag atctgtgagg aagcatttac cagatccaaa
     1801 gatgagaaga tcttgcacat caagcactgg ctggattccc cctggcctgg ctttttcacc
     1861 ctggatggac agcccaggag catgacctgc ccctccactg gcctggagga ggacatcttg
     1921 acccacattg ggaatgtggc cagttctgta cctgtggaga actttaccat ccatggaggg
     1981 ctgagccgga tcttgaagac tcgcagagag cttgtgacaa accggactgt ggactgggcc
     2041 ctggcagagt acatggcgtt cggatcactc ctgaaggaag gcatccatgt ccggctgagt
     2101 ggccaggacg tggagcgggg taccttcagc catcgccacc atgtgctcca tgaccagaat
     2161 gtggacaaaa gaacctgcat ccccatgaac cacctttggc ctaaccaggc cccttacacc
     2221 gtgtgcaaca gctcgttgtc tgagtatggt gtcctgggct ttgaactggg ctttgccatg
     2281 gctagcccta atgctctggt tctctgggag gcccagtttg gtgatttcaa caacatggca
     2341 cagtgcatca ttgaccagtt catctgccca ggacaggcaa agtgggtgcg gcagaatggc
     2401 atcgtgctcc tgctacctca cggcatggaa ggcatgggtc ccgagcattc ctctgcccgt
     2461 ccagagaggt ttctgcagat gtgcaatgat gacccagatg tcctgcctaa cctgcaggag
     2521 gaaaactttg acatcagtca gctctacgac tgcaactgga ttgtcgtcaa ctgctccacc
     2581 cctggcaact tcttccacgt gctgcgacga cagatcttgc tgcccttccg gaagccgtta
     2641 atcgtcttca ctcccaaatc cctcctgcgc caccctgagg caagaactag ctttgatgag
     2701 atgctgccag gaacccactt ccagcgtgtg atcccagaag atggacctgc agctcagaac
     2761 ccagacaaag tcaagaggct tctcttctgc actggcaagg tgtactatga cctcacccga
     2821 gagcgcaaag ccagggacat ggcagaggag gtggctatta caaggattga gcagctgtca
     2881 ccattcccct tcgacctcct gctgaaagag gcacagaagt atcccaatgc tgagctggcc
     2941 tggtgccagg aagagcacaa gaatcaaggc tactatgact atgtcaagcc aagacttcgg
     3001 accaccattg accgtgctaa gcctgtctgg tatgctggcc gagacccagc agccgctcca
     3061 gccactggca acaagaagac ccacctgaca gagctgcagc gctttctgga cacagccttt
     3121 gacctggacg ccttcaagaa attctcttag atgctcctgg agttgatccg gccatggccc
     3181 ccctgtgtcc atgacgctct ttgcttctca actaaagaat agtgcctctg cactgtcaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
