LOCUS       NM_131904               5028 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus O-GlcNAcase (Oga), mRNA.
ACCESSION   NM_131904
VERSION     NM_131904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5028)
  AUTHORS   Muthusamy,S., DeMartino,A.M., Watson,L.J., Brittian,K.R., Zafir,A.,
            Dassanayaka,S., Hong,K.U. and Jones,S.P.
  TITLE     MicroRNA-539 is up-regulated in failing heart, and suppresses
            O-GlcNAcase expression
  JOURNAL   J Biol Chem 289 (43), 29665-29676 (2014)
   PUBMED   25183011
  REMARK    GeneRIF: This work identifies the first target of miR-539 in the
            heart and the first miRNA that regulates OGA.
REFERENCE   2  (bases 1 to 5028)
  AUTHORS   Liu,Y., Li,X., Yu,Y., Shi,J., Liang,Z., Run,X., Li,Y., Dai,C.L.,
            Grundke-Iqbal,I., Iqbal,K., Liu,F. and Gong,C.X.
  TITLE     Developmental regulation of protein O-GlcNAcylation, O-GlcNAc
            transferase, and O-GlcNAcase in mammalian brain
  JOURNAL   PLoS One 7 (8), e43724 (2012)
   PUBMED   22928023
  REMARK    GeneRIF: protein O-GlcNAcylation, OGT, and OGA in the rat brain at
            various ages from embryonic day 15 to the age of 2 years
REFERENCE   3  (bases 1 to 5028)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 5028)
  AUTHORS   Lima,V.V., Giachini,F.R., Choi,H., Carneiro,F.S., Carneiro,Z.N.,
            Fortes,Z.B., Carvalho,M.H., Webb,R.C. and Tostes,R.C.
  TITLE     Impaired vasodilator activity in deoxycorticosterone acetate-salt
            hypertension is associated with increased protein O-GlcNAcylation
  JOURNAL   Hypertension 53 (2), 166-174 (2009)
   PUBMED   19139380
REFERENCE   5  (bases 1 to 5028)
  AUTHORS   Ngoh,G.A., Facundo,H.T., Hamid,T., Dillmann,W., Zachara,N.E. and
            Jones,S.P.
  TITLE     Unique hexosaminidase reduces metabolic survival signal and
            sensitizes cardiac myocytes to hypoxia/reoxygenation injury
  JOURNAL   Circ Res 104 (1), 41-49 (2009)
   PUBMED   19023128
  REMARK    GeneRIF: present results provide definitive evidence that
            O-GlcNAcase antagonizes posthypoxic cardiac myocyte survival
REFERENCE   6  (bases 1 to 5028)
  AUTHORS   Toleman,C., Paterson,A.J., Whisenhunt,T.R. and Kudlow,J.E.
  TITLE     Characterization of the histone acetyltransferase (HAT) domain of a
            bifunctional protein with activable O-GlcNAcase and HAT activities
  JOURNAL   J Biol Chem 279 (51), 53665-53673 (2004)
   PUBMED   15485860
  REMARK    GeneRIF: NCOAT may be regulated to reduce the state of
            glycosylation of transcriptional activators while increasing the
            acetylation of histones to allow for the concerted activation of
            eukaryotic gene transcription
REFERENCE   7  (bases 1 to 5028)
  AUTHORS   Van Tine,B.A., Patterson,A. and Kudlow,J.E.
  TITLE     Assignment of N-acetyl-D-glucosaminidase (Mgea5) to rat chromosome
            1q5 by tyramide fluorescence in situ hybridization (T-FISH):
            synteny between rat, mouse and human with Insulin Degradation
            Enzyme (IDE)
  JOURNAL   Cytogenet Genome Res 103 (1-2), 202B (2003)
   PUBMED   15008141
REFERENCE   8  (bases 1 to 5028)
  AUTHORS   Liu,K., Paterson,A.J., Konrad,R.J., Parlow,A.F., Jimi,S., Roh,M.,
            Chin,E. Jr. and Kudlow,J.E.
  TITLE     Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth
            hormone secretion
  JOURNAL   Mol Cell Endocrinol 194 (1-2), 135-146 (2002)
   PUBMED   12242036
  REMARK    GeneRIF: Streptozotocin inhibition of O-GlcNAcase induces an
            insulin secretory defect in isolated rat islet cells, and a growth
            hormone secretory defect, and impairment of intracellular secretory
            vesicle trafficking.
REFERENCE   9  (bases 1 to 5028)
  AUTHORS   Gao,Y., Wells,L., Comer,F.I., Parker,G.J. and Hart,G.W.
  TITLE     Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning
            and characterization of a neutral, cytosolic
            beta-N-acetylglucosaminidase from human brain
  JOURNAL   J Biol Chem 276 (13), 9838-9845 (2001)
   PUBMED   11148210
REFERENCE   10 (bases 1 to 5028)
  AUTHORS   Dong,D.L. and Hart,G.W.
  TITLE     Purification and characterization of an O-GlcNAc selective
            N-acetyl-beta-D-glucosaminidase from rat spleen cytosol
  JOURNAL   J Biol Chem 269 (30), 19321-19330 (1994)
   PUBMED   8034696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 11, 2022 this sequence version replaced NM_131904.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.6200.1, AY039679.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               JAXUCZ010000001.1  254581661-254582269 c
            610-661             JAXUCZ010000001.1  254577479-254577530 c
            662-759             JAXUCZ010000001.1  254577042-254577139 c
            760-890             JAXUCZ010000001.1  254574981-254575111 c
            891-1062            JAXUCZ010000001.1  254572827-254572998 c
            1063-1161           JAXUCZ010000001.1  254570728-254570826 c
            1162-1446           JAXUCZ010000001.1  254568885-254569169 c
            1447-1605           JAXUCZ010000001.1  254567064-254567222 c
            1606-2219           JAXUCZ010000001.1  254564350-254564963 c
            2220-2394           JAXUCZ010000001.1  254563045-254563219 c
            2395-2480           JAXUCZ010000001.1  254559774-254559859 c
            2481-2585           JAXUCZ010000001.1  254558716-254558820 c
            2586-2671           JAXUCZ010000001.1  254555949-254556034 c
            2672-2864           JAXUCZ010000001.1  254555282-254555474 c
            2865-3024           JAXUCZ010000001.1  254551968-254552127 c
            3025-5028           JAXUCZ010000001.1  254547311-254549314 c
FEATURES             Location/Qualifiers
     source          1..5028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5028
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /note="O-GlcNAcase"
                     /db_xref="GeneID:154968"
                     /db_xref="RGD:621077"
     exon            1..609
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..3161
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /EC_number="3.2.1.169"
                     /note="bifunctional protein NCOAT; nuclear cytoplasmic
                     O-GlcNAcase and acetyltransferase; meningioma-expressed
                     antigen 5; beta-hexosaminidase;
                     beta-N-acetylhexosaminidase;
                     N-acetyl-beta-glucosaminidase;
                     N-acetyl-beta-D-glucosaminidase; meningioma expressed
                     antigen 5 (hyaluronidase); protein O-GlcNAcase-like"
                     /codon_start=1
                     /product="protein O-GlcNAcase"
                     /protein_id="NP_571979.1"
                     /db_xref="GeneID:154968"
                     /db_xref="RGD:621077"
                     /translation="MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSG
                     AGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYK
                     HRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQ
                     VSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTE
                     YCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPV
                     IWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKS
                     NMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFG
                     VPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSA
                     LTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAE
                     SKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFY
                     LPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGM
                     FTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFR
                     GGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGV
                     GLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWI
                     PFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSV
                     AKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGR
                     SL"
     exon            610..661
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            662..759
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            760..890
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1062
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1161
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1446
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1605
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..2219
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2394
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2480
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2585
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2671
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2864
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3024
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..5028
                     /gene="Oga"
                     /gene_synonym="Mgea5; Ncoat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggataaac aggaagcggg cggcagaggc agcggcagta gctgcttagg gactccggtg
       61 ggggagatag ccagagaaat aaggctcttt ggagggcggc ggacgttgag gacgagcgaa
      121 ggcgccttct cggccctcct tccgtgaaga cccggaggcg gcctcgccct ccgcttagtc
      181 tcttggcttc cagcgcaggc ggaggcagag gctgacaaag ggctcgagcc ggtgccgccg
      241 cccttctcat ccgggcactc ggggcccccg ccgagaggaa gggggaaggg cggaggggga
      301 ggggaaggag cccaggaggc gcgcgttcgg agccgcggcc ctttgcaggg ctccggacct
      361 gtggcccaac ggaccgaggc cgaaggggag cggcagccgg cggcaggaga atggtgcaga
      421 aggagagcca ggcggcgctg gaggagcggg agagtgagcg caacgccaat cctgcctccg
      481 tctcgggggc ttcgttggag ccgtctgcag ctccggcccc cggagaagac aacccctcgg
      541 gagctggggc ggcggccggg accggggcgg ccggcggggc ccgcaggttc ctgtgcggtg
      601 tagtggaagg gttttatgga agaccttggg ttatggagca gagaaaagag ctctttagaa
      661 ggcttcagaa atgggaatta aatacatact tgtatgctcc gaaggatgac tacaaacata
      721 ggatgttttg gcgagagatg tattcagtgg aagaagctga gcaacttatg actctcatct
      781 ctgctgcacg agaatatgag atagaattca tctatgctat ttctccagga ttagatatca
      841 ctttttctaa cccaaaggaa gtatcaacat tgaaacgcaa attggaccag gtctcccagt
      901 ttgggtgcag gtcatttgct ttgctttttg atgatattga tcataacatg tgtgcagcag
      961 acaaagaagt gttcagttct tttgcacatg cacaagtttc catcacaaat gaaatctatc
     1021 agtacctggg agagccggaa accttcctct tctgtcccac agaatactgc ggcactttct
     1081 gttatccaag tgtatctcag tctccttact tgaggactgt gggtgaaaag ctgctacctg
     1141 gaattgaggt gctttggaca ggtccaaaag ttgtttcaaa agaaattcca gtagaatcta
     1201 ttgaagaagt ttctaagatc attaagagag ccccagtgat ctgggataac attcatgcta
     1261 atgactatga tcagaagagg ctgtttctgg gtccctacaa aggaagatcc acagagctca
     1321 tcccacggtt gaagggagtg ctgactaatc caaattgtga atttgaagcc aactatgttg
     1381 ccatccacac ccttgccact tggtacaagt caaacatgaa cggagtgagg aaggacgtgg
     1441 tgatgactga cagtgaagac agtactgtct caatacagat aaagttagaa aatgaaggca
     1501 gtgatgaaga cattgagact gatgtgctct acagtccaca gatggcttta aagctggcct
     1561 taactgagtg gctgcaggag ttcggtgtac cgcatcagta cagcagtaga caggttgcac
     1621 acagtggagc taagacaagc gtagtggacg ggactccctt ggttgcagca ccttctttaa
     1681 atgccacaac tgtagttaca acagtttacc aggagcccat tatgagccag ggagcagctt
     1741 tgagtggtga gccctcagct ctgaccaagg aagaagaaaa gaaacagcca gatgaggaac
     1801 ccatggatat ggtggtagag aagcaagaag agtcagagca caagagtgac aaccagatac
     1861 taactgagat cgtcgaagct aaaatggcag aggagttgaa accaatggac actgataagg
     1921 aaagcatagc cgagtcaaaa tccccagaga tgtctatgca ggaagactgc attaacgaca
     1981 tcgctcctat gcagacagac gagcaagcaa acaaagagca gtttgtgcca ggtccaaatg
     2041 aaaaaccttt gtacgctgca gaaccagtga ctctggagga tttacagtta cttgctgatc
     2101 tcttctacct tccttatgag catggaccca aaggagcaca gatgctacgg gagttccagt
     2161 ggcttcgagc aaacagtagt gttgtcagtg tcaattgcaa agggaaagac tctgaaaaaa
     2221 ttgaagaatg gcggtcacga gcagccaagt ttgaagaaat gtgcgcacta gtgatgggga
     2281 tgttcacccg gctctccaac tgtgccaaca ggacaatcct ttatgacatg tactcctatg
     2341 tgtgggatat caagagtata atgtctatgg tgaagtcttt tgtgcagtgg ttagggtgtc
     2401 gtagtcattc ttcagcacag ttcttaattg gagaccaaga accctgggcc tttagaggtg
     2461 gtctagcagg agagttccag cgtttgctgc caattgatgg agcaaatgat ctctttttcc
     2521 aaccaccccc actgactcct acctccaagg tttatactat cagaccttat ttccctaaag
     2581 atgaggcttc cgtgtacaag atttgcagag aaatgtatga tgatggagtg ggtttacctt
     2641 ttcaaagtca gcctgacctt attggagaca agttagtagg aggactgctt tccctcagcc
     2701 tggattactg ttttgtcctc gaagatgaag atggtatttg tggttatgcc ttaggcactg
     2761 tagatgtgac ccccttcatt aaaaagtgca aaatttcctg gattcccttc atgcaggaga
     2821 agtatactaa gccaaatgga gacaaagagc tctcagaagc tgagaaaata atgttgagtt
     2881 tccatgaaga gcaggaggta ttaccagaaa ctttccttgc caacttccct tctctgataa
     2941 aaatggatat tcataaaaag gtcactgacc caagtgttgc caaaagcatg atggcttgcc
     3001 tcctgtcttc actaaaggcc aatggctccc ggggggcttt ctgtgaagta agaccagatg
     3061 ataaaaggat tctggaattt tacagcaagt taggctgttt tgaaattgca aaaatggaag
     3121 gatttccaaa ggatgtggtt atacttggtc gaagcctgtg acattgatgg tactgtgaac
     3181 tgtccaaaag tctcttaact ccaccttgtg gttggtggtt gaggtcttca cacagttcag
     3241 tgtctggagc ggcagcagat cagccagttg aattggaaac aaagatgact gtaaaactca
     3301 cccatcccat tttcagccgc tcgctggttg agagaagaca gtactgctgc atgtcctgtg
     3361 cagcttgtga tgtgctcctc tttgggtctc gtgttagtgc cagggcctct tacatggggt
     3421 tctctaggga gagggtctta aataaatgta gtcagcactg ttttctgcat ccagtgtggt
     3481 tgcatttctc acctaagagc aatgaagatc aatcactctc tattctcctt ggtgtgcaga
     3541 gtgaaatgtc tctgttcttt ggagacatgg ctggaatgag aatttagtga gtttcgattt
     3601 gaggcaattt ttctgctttt tgtaaagctc tggacagctg tcccctgtga ctggttggtt
     3661 cagatcgttg tgctttgtta gggacaaatg tgcatttgtt tgtggcaaag gcctaaattg
     3721 acaaacttgt aaatctcttt gtacatagac tagctgtaac ctgactgttc tttgtttact
     3781 gttttatata ttatgttttt ttttcctttg aaactgaaag gtgttgtttt aggatggcac
     3841 tttgaataat gtaaaccagt gagtggtaga tttcctttca tttgtccttt tcttcctgag
     3901 aagttttgtc tttgaagtgc ctcccacatc gggataggcc atgactattt ggggtatgag
     3961 cacctaactt taactcccat ctgttgggaa gtgcggttac ttctgggaat tcaccttaat
     4021 agcagatccg aatgtgaaac attttgacat tgtcaagtaa gggtcagggg actgactagt
     4081 ggtctcattt gcccttagta cacttgtcat ttaatcgcaa agacctgtta actactggtt
     4141 taattgaatc agtctttaat tcttgcatgt ttgtatctaa tttttaagag gaagaataag
     4201 tatatgttaa ccatgagtat acttttcttt tactcagatt ccgaaaactt catgtatttt
     4261 aatttagatt tggtgaattt aagggttttg agcatgaagc tggcagagag cctctgcagg
     4321 attttttttt ttttttttta aatcatggct agctagtaac tagattttca acagtatttt
     4381 gttaccttgc tttcctccag ttttacatca gcttttgaac ttttgagctg aggagggaga
     4441 gagaaaagga agcttgaaac attttctttt atagaactcc agtgtgagct tgtgatatag
     4501 ttttacgttt agcactcttt atagtggacc cagtgacttg caccagaagc ccgggtgtgt
     4561 gttgaaataa gccacctcat tagggtacaa acctttgata ggatgtattg gaaaacttaa
     4621 aatcaagttt ggttttgaag gctggggtga agggcaaaat tgttactagg tgttaagacg
     4681 gtttaatgtt cctctttccg aatacatccc atgccttagt gggaattaca acatttggag
     4741 gatttcagag tttcatactg aatcaggaat tttaaacaag ttgctttttg tttaatgttg
     4801 gctttcagta atcacttggg atgatcttct ggacataact gaaaacctgc ccaggtctgt
     4861 gctgtcatcg ctgtaggcta agtgctatgc catcttccat ggttatgaat atttactgag
     4921 gttggaataa gttcattgat tgtttggatc acagctcagt tcctatagta aaagaactgt
     4981 aaaactatct gcaccatgca agaggcacaa taaaacttga agagaata
//
