LOCUS       NM_012615               2423 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus ornithine decarboxylase 1 (Odc1), transcript
            variant 1, mRNA.
ACCESSION   NM_012615 XM_006239906
VERSION     NM_012615.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Liu,W., Wu,Y.H., Zhang,L., Liu,X.Y., Wang,Y., Xue,B., Liu,B.,
            Cai,Y., Zhang,B. and Ji,Y.
  TITLE     Effects of lentivirus-mediated ornithine decarboxylase gene on the
            proliferation and apoptosis of fibroblast-like synoviocytes in rats
            with arthritis
  JOURNAL   Life Sci 194, 224-230 (2018)
   PUBMED   28986097
  REMARK    GeneRIF: The results indicated that overexpression of ODC gene
            promotes the proliferation while suppressing apoptosis of
            fibroblast-like synoviocytes in rats with rheumatoid arthritis.
REFERENCE   2  (bases 1 to 2423)
  AUTHORS   Ramos-Molina,B., Lambertos,A., Lopez-Contreras,A.J., Kasprzak,J.M.,
            Czerwoniec,A., Bujnicki,J.M., Cremades,A. and Penafiel,R.
  TITLE     Structural and degradative aspects of ornithine decarboxylase
            antizyme inhibitor 2
  JOURNAL   FEBS Open Bio 4, 510-521 (2014)
   PUBMED   24967154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2423)
  AUTHORS   Zhang,H., Xue,G., Zhang,W., Wang,L., Li,H., Zhang,L., Lu,F.,
            Bai,S., Lin,Y., Lou,Y., Xu,C. and Zhao,Y.
  TITLE     Akt and Erk1/2 activate the ornithine decarboxylase/polyamine
            system in cardioprotective ischemic preconditioning in rats: the
            role of mitochondrial permeability transition pores
  JOURNAL   Mol Cell Biochem 390 (1-2), 133-142 (2014)
   PUBMED   24464033
  REMARK    GeneRIF: These results suggest that IPC upregulates the Ornithine
            decarboxylase/polyamine system and mediates preconditioning
            cardioprotection.
REFERENCE   4  (bases 1 to 2423)
  AUTHORS   Passariello,C.L., Gottardi,D., Cetrullo,S., Zini,M., Campana,G.,
            Tantini,B., Pignatti,C., Flamigni,F., Guarnieri,C., Caldarera,C.M.
            and Stefanelli,C.
  TITLE     Evidence that AMP-activated protein kinase can negatively modulate
            ornithine decarboxylase activity in cardiac myoblasts
  JOURNAL   Biochim Biophys Acta 1823 (4), 800-807 (2012)
   PUBMED   22230191
  REMARK    GeneRIF: The modulation of ODC activity by AMPK represents a
            mechanism that may contribute to control cell growth processes.
REFERENCE   5  (bases 1 to 2423)
  AUTHORS   Wang,J.Y., Viar,M.J., McCormack,S.A. and Johnson,L.R.
  TITLE     Effect of putrescine on S-adenosylmethionine decarboxylase in a
            small intestinal crypt cell line
  JOURNAL   Am J Physiol 263 (4 Pt 1), G494-G501 (1992)
   PUBMED   1415709
REFERENCE   6  (bases 1 to 2423)
  AUTHORS   Van Steeg,H., Van Oostrom,C.T., Hodemaekers,H.M., Peters,L. and
            Thomas,A.A.
  TITLE     The translation in vitro of rat ornithine decarboxylase mRNA is
            blocked by its 5' untranslated region in a polyamine-independent
            way
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 521-526 (1991)
   PUBMED   2006916
REFERENCE   7  (bases 1 to 2423)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
REFERENCE   8  (bases 1 to 2423)
  AUTHORS   Manzella,J.M. and Blackshear,P.J.
  TITLE     Regulation of rat ornithine decarboxylase mRNA translation by its
            5'-untranslated region
  JOURNAL   J Biol Chem 265 (20), 11817-11822 (1990)
   PUBMED   2365701
REFERENCE   9  (bases 1 to 2423)
  AUTHORS   Wen,L., Huang,J.K. and Blackshear,P.J.
  TITLE     Rat ornithine decarboxylase gene. Nucleotide sequence, potential
            regulatory elements, and comparison to the mouse gene
  JOURNAL   J Biol Chem 264 (15), 9016-9021 (1989)
   PUBMED   2722815
REFERENCE   10 (bases 1 to 2423)
  AUTHORS   van Steeg,H., van Oostrom,T.M., van Kranen,H.J. and van Kreijl,C.F.
  TITLE     Nucleotide sequence of the rat ornithine decarboxylase gene
  JOURNAL   Nucleic Acids Res 16 (16), 8173-8174 (1988)
   PUBMED   3419906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M16982.1, BC078882.1, DV728774.1 and FQ151473.1.
            
            On or before Sep 26, 2014 this sequence version replaced
            XM_006239906.2, NM_012615.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            regulatory uORF        :: PMID: 2365701
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-951               M16982.1           120-1070
            952-2024            BC078882.1         691-1763
            2025-2214           M16982.1           2144-2333
            2215-2404           DV728774.1         195-384
            2405-2423           FQ151473.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2423
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /note="ornithine decarboxylase 1"
                     /db_xref="GeneID:24609"
                     /db_xref="RGD:3227"
     exon            1..187
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      154..186
                     /regulatory_class="uORF"
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2365701]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:2365701)"
     exon            188..271
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            272..406
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1690
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /EC_number="4.1.1.17"
                     /note="Ornitine decarboxylase"
                     /codon_start=1
                     /product="ornithine decarboxylase"
                     /protein_id="NP_036747.1"
                     /db_xref="GeneID:24609"
                     /db_xref="RGD:3227"
                     /translation="MGSFTKEEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVAD
                     LGDVLKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLG
                     VPPERIIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDS
                     KAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCV
                     FDMGTEVGFSMYLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPG
                     RYYVASAFTLAVNIIAKKTVWKEQTGSDDEDESNEQTLMYYVNDGVYGSFNCILYDHA
                     HVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCSLPEMHVGDWMLFENMGAYTVA
                     AASTFNGFQRPNIYYVMSRSMWQLMKQIQSHGFPPEVEEQDVGTLPMSCAQESGMDRH
                     PAACASASINV"
     exon            407..580
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            581..753
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            754..888
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            889..970
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1054
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1217
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1330
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1545
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2406
                     /gene="Odc1"
                     /gene_synonym="Odc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odc1"
                     /gene_synonym="Odc"
     polyA_site      2406
                     /gene="Odc1"
                     /gene_synonym="Odc"
ORIGIN      
        1 tgtcagtccc tgcagccgcc gccgccggcc gccttcagtc agcagctcgg cgccacctcc
       61 ggtcggcgac tgcggcgggc tcgacgaggc ggctgacggg gcggcggcgg gaagacggcc
      121 gggtgcgcct tggggtttag tggcggcttc tccatgggtc cagccagccg cttccctgtg
      181 ctgtgagtgt ttccaccact ccaggagaca gcattcagag ttgaccttgt gagagctggc
      241 cataatttaa ttccatctct aggttttctg tcttattgtt tcagaggcac atcgagaacc
      301 aaccatgggc agctttacta aggaagagtt tgactgccat atcctcgatg aaggtttcac
      361 tgctaaggac attctggacc aaaaaatcaa tgaagtttct tcctctgatg ataaggatgc
      421 tttctatgtt gcggacctcg gagacgttct aaagaagcat ctgaggtggc tgaaagctct
      481 tccccgtgtt actcccttct atgctgtcaa gtgtaatgac agcagagcca tagtgagcac
      541 cctggctgcc attgggacag gatttgattg tgcaagcaag actgaaatac agttggtgca
      601 ggggcttggg gtgcctccag agaggattat ctatgcaaat ccttgtaagc aagtgtctca
      661 gatcaagtat gctgccagta atggagtcca gatgatgact tttgacagtg aaattgagtt
      721 gatgaaagtt gccagagcac atccaaaggc aaagttggtt ttgcggattg ccactgatga
      781 ttccaaagca gtttgtcggc tcagtgttaa gtttggtgcc acactgaaaa ccagcaggct
      841 tctcttggaa cgggcaaaag agctaaatat tgatgtcatt ggtgtcagct tccatgtggg
      901 cagtgggtgt actgaccctg agaccttcgt gcaggcagtg tcagatgccc gctgtgtctt
      961 tgacatggga acagaagttg gtttcagcat gtatctgctt gacattggtg gtggctttcc
     1021 tgggtctgaa gacacgaagc ttaaatttga ggagatcacc agtgtaatca acccagctct
     1081 ggacaagtac ttcccatcgg actctggagt gagaatcata gctgagccag gcagatacta
     1141 cgtcgcatca gctttcacac ttgcagtgaa tatcattgcc aaaaaaaccg tgtggaagga
     1201 gcagaccggc tcggacgatg aagatgagtc aaacgagcaa actttgatgt attacgtgaa
     1261 tgatggagtg tatgggtcat ttaactgcat tctttatgac catgcacatg tgaaggccct
     1321 gctgcagaag agacccaagc cagatgagaa gtattactca tccagcatct ggggaccaac
     1381 atgtgatggc cttgatcgga tcgtcgagcg ctgtagcctg cctgaaatgc atgtgggtga
     1441 ttggatgctg tttgagaaca tgggtgcata cactgttgct gctgcttcta ctttcaatgg
     1501 gttccagagg ccaaacatct actacgtaat gtcacggtca atgtggcaac tcatgaagca
     1561 aatccagagc catggcttcc cgccagaagt ggaggagcag gatgttggca ctctgcccat
     1621 gtcttgtgcc caggagagcg ggatggaccg tcaccctgca gcctgtgctt ctgctagtat
     1681 caatgtatag atgccattct tgtagctctt acctgcaagt ttagcttgag ttcacggcat
     1741 ttggggggac catttaactt aattactgct agtttggaat gtctttgtaa gagtagggtt
     1801 ggcaccaatg cagtatggaa agactaggag atgggggtca cacttactgt gttcctatgg
     1861 aaactttgaa tattttatat ggatttttat tcacttttca gacctgatac taatgagtgc
     1921 ccctcggctg ctgagcaagc atttgtagct tgtacattgg cagaatgggc taaaagctta
     1981 tgttgtgacc cattttgaaa ataaagtatc ttgaaatgat tggacattgg agaatgtgtg
     2041 caagtatccc ttacagaagg cacaaacttc tgcacaggct gtgtgttaca gcagtgagtc
     2101 tagcccagca gagatgtgga tgatacaaag ctgtgccccc tctgtacagc atcaatgtgc
     2161 ttagcccatc tcaagtgttt actgtgaact tggtgcccaa agtctcttaa gagtatcatc
     2221 tgcctagtgg cctcttgact tggccacttc ctaaggagag ggcatctgag gctctttgaa
     2281 ccttgcctgc agaaaccctg actgctccct caacccttgg cctcagctgc atcaccacct
     2341 agtaacagtt gaagtatcga acagcacttg gcagtcaact tcctgtaata aattcaacaa
     2401 cagcaaaaaa aaaaaaaaaa aaa
//
